LOCUS       NM_001199161            4721 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 19 (USP19), transcript
            variant 2, mRNA.
ACCESSION   NM_001199161
VERSION     NM_001199161.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4721)
  AUTHORS   Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C.,
            Zheng,L. and Chen,S.
  TITLE     Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein
  JOURNAL   J Alzheimers Dis 100 (3), 799-808 (2024)
   PUBMED   38943386
  REMARK    GeneRIF: Deubiquitinating Enzyme USP19 Regulates Ferroptosis and
            Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4
            Protein.
REFERENCE   2  (bases 1 to 4721)
  AUTHORS   Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X.
            and Dou,K.
  TITLE     The deubiquitinating enzyme USP19 facilitates hepatocellular
            carcinoma progression through stabilizing YAP
  JOURNAL   Cancer Lett 577, 216439 (2023)
   PUBMED   37832781
  REMARK    GeneRIF: The deubiquitinating enzyme USP19 facilitates
            hepatocellular carcinoma progression through stabilizing YAP.
REFERENCE   3  (bases 1 to 4721)
  AUTHORS   Zhang,J., van Dinther,M., Thorikay,M., Gourabi,B.M.,
            Kruithof,B.P.T. and Ten Dijke,P.
  TITLE     Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells
  JOURNAL   Cell Mol Life Sci 80 (2), 43 (2023)
   PUBMED   36646950
  REMARK    GeneRIF: Opposing USP19 splice variants in TGF-beta signaling and
            TGF-beta-induced epithelial-mesenchymal transition of breast cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4721)
  AUTHORS   Sarodaya,N., Tyagi,A., Kim,H.J., Kang,J.S., Singh,V., Hong,S.H.,
            Kim,W.J., Kim,K.S. and Ramakrishna,S.
  TITLE     Deubiquitinase USP19 extends the residual enzymatic activity of
            phenylalanine hydroxylase variants
  JOURNAL   Sci Rep 12 (1), 14243 (2022)
   PUBMED   35987969
  REMARK    GeneRIF: Deubiquitinase USP19 extends the residual enzymatic
            activity of phenylalanine hydroxylase variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4721)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4721)
  AUTHORS   Mei,Y., Hahn,A.A., Hu,S. and Yang,X.
  TITLE     The USP19 deubiquitinase regulates the stability of c-IAP1 and
            c-IAP2
  JOURNAL   J Biol Chem 286 (41), 35380-35387 (2011)
   PUBMED   21849505
  REMARK    GeneRIF: The USP19 deubiquitinase regulates the stability of c-IAP1
            and c-IAP2.
REFERENCE   7  (bases 1 to 4721)
  AUTHORS   Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S.
  TITLE     Identification of distinctive patterns of USP19-mediated growth
            regulation in normal and malignant cells
  JOURNAL   PLoS One 6 (1), e15936 (2011)
   PUBMED   21264218
  REMARK    GeneRIF: ability of USP19 to regulate cell proliferation and
            p27(Kip1) levels; complete loss of USP19 function on cell growth
            may arise as a result of oncogenic transformation of cells.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4721)
  AUTHORS   Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S.,
            Zinin,N.V., Masucci,M.G. and Lindsten,K.
  TITLE     The ER-resident ubiquitin-specific protease 19 participates in the
            UPR and rescues ERAD substrates
  JOURNAL   EMBO Rep 10 (7), 755-761 (2009)
   PUBMED   19465887
  REMARK    GeneRIF: USP19 is the first example of a membrane-anchored
            deubiquitinating enzymes involved in the turnover of
            endoplasmic-reticulum-associated degradation substrates.
REFERENCE   9  (bases 1 to 4721)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4721)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC323791.1, DC332671.1,
            BC142660.1, BC014934.1 and BC048269.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001199161.1.
            
            Summary: Protein ubiquitination controls many intracellular
            processes, including cell cycle progression, transcriptional
            activation, and signal transduction. This dynamic process,
            involving ubiquitin conjugating enzymes and deubiquitinating
            enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are
            cysteine proteases that specifically cleave ubiquitin from
            ubiquitin-conjugated protein substrates. This protein is a
            ubiquitin protein ligase and plays a role in muscle wasting.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2017].
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the CDS and an alternate 3' exon, as compared to variant 1. The
            resulting isoform (2) has an internal additional 2 aa and a shorter
            and distinct C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142660.1, SRR18074968.1771459.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417901.6/ ENSP00000395260.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               DC323791.1         116-221
            107-454             DC332671.1         187-534
            455-1976            BC142660.1         440-1961
            1977-4645           BC014934.1         1064-3732
            4646-4721           BC048269.1         1600-1675
FEATURES             Location/Qualifiers
     source          1..4721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4721
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="ubiquitin specific peptidase 19"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
     exon            1..68
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            69..328
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..4359
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 19; deubiquitinating enzyme
                     19; zinc finger MYND domain-containing protein 9;
                     ubiquitin-specific-processing protease 19; ubiquitin
                     carboxyl-terminal hydrolase 19; ubiquitin thioesterase 19;
                     ubiquitin thiolesterase 19"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 19 isoform
                     2"
                     /protein_id="NP_001186090.1"
                     /db_xref="CCDS:CCDS56255.1"
                     /db_xref="GeneID:10869"
                     /db_xref="HGNC:HGNC:12617"
                     /db_xref="MIM:614471"
                     /translation="MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETG
                     SRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGAC
                     EDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQ
                     QWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLKKPLGTQELVPGLRCQ
                     ENGQELSPIALEPGPEPHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCR
                     GPEGDGSRDDPGPRGDAPPFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGE
                     KAVPPGNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYE
                     KGPDSVVVHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVK
                     LRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPAARGAVGGAKVAVPTGPTPLD
                     STPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPK
                     PTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTREL
                     RDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKAS
                     QFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMR
                     NDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSK
                     PIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSP
                     SDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRC
                     YRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVS
                     VFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLP
                     RVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAH
                     TPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECA
                     EDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPN
                     VLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYG
                     GMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSP
                     VERPPRAGHSEHHPDLGPAAEAAASQGLGPGQAPEVAPTRTAPERFAPPVDRPAPTYS
                     NMEEVD"
     exon            329..502
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            503..676
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            677..810
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1113
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1330
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1487
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1559
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1675
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1896
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2092
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2226
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2385
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2496
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2607
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2709
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2850
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2969
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3107
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3421
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3532
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3749
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3902
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4063
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4242
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4721
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4701..4706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="hexamer: AATAAA"
     polyA_site      4721
                     /gene="USP19"
                     /gene_synonym="ZMYND9"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggaac cggaacggag agcgggttgc cagggcccga agagggctgg ctgcggcggt
       61 ctcgctcggc tgtccgttcc ttgctggaga atttggccac aaagagttgc caagatagct
      121 gggccaggaa gaaagcgccg cagccctgac ccagacgctg ttgccgaccc cggggcactc
      181 tggctgtcga ccaagcggct caagatgtct ggcggggcca gtgccacagg cccaaggaga
      241 gggcccccag gactggagga caccactagt aagaagaagc agaaggatcg agcaaaccag
      301 gagagcaagg atggagatcc taggaaagag acagggtctc gatatgttgc ccaggctggt
      361 cttgaacctc tggcctcagg tgatccttct gcctcagcct cccatgcagc tgggatcaca
      421 ggctcacgcc accgtacccg gctgttcttt ccttcatcgt cagggtcagc atccactcct
      481 caagaggagc agaccaaaga gggagcttgt gaagaccctc atgatctctt ggctactccc
      541 actccagagt tgttgctcga ttggaggcag agtgcagaag aggtgattgt caagcttcgt
      601 gtgggagtag gtcccctgca gctggaggat gtagatgctg ctttcacaga tacagactgt
      661 gtggtgcggt ttgcaggtgg tcagcagtgg ggtggtgtct tctatgctga gataaaaagc
      721 tcttgtgcta aagtgcaaac ccgcaagggc agtctcctgc acctgacact gcccaaaaag
      781 gtgcctatgc tcacgtggcc ctccctcctg aagaaacctc tagggaccca ggagctggtg
      841 ccggggctgc ggtgccagga gaatgggcag gaactgtctc ccattgccct ggagccaggc
      901 cctgagcccc accgggctaa gcaggaggcc cggaaccaga agcgggccca gggccgtggt
      961 gaggtaggcg caggggctgg ccccggggcc caggcagggc ccagcgccaa gagggctgtg
     1021 catctctgca gagggccaga gggggacggg tccagggatg accctggacc ccggggtgat
     1081 gccccaccct tcgtggctga cccagccacc caggttgagg ctgatgaaca gctttgcata
     1141 ccaccgctga actcccaaac ctgcctcctg ggctcagagg agaatttagc ccctttggca
     1201 ggagagaaag cagtgcctcc cgggaatgac ccagtctctc cagccatggt ccggagcaga
     1261 aaccctggga aagatgactg tgccaaggag gagatggcag tggcagcaga tgctgcaacc
     1321 ttggtggatg agcccgagtc gatggtgaac ctggcgtttg tcaagaatga ctcgtatgag
     1381 aagggcccgg attcagtggt ggtgcacgtg tacgtgaagg agatctgcag ggacacctca
     1441 agagtacttt tccgtgagca ggacttcacg ctcatcttcc agaccaggga tggaaacttc
     1501 ctgaggctgc acccgggctg tgggccccac accaccttcc gttggcaggt gaagctcagg
     1561 aatctgattg agccagagca gtgcaccttc tgtttcacgg cttctcgcat cgacatctgc
     1621 cttcgtaaga ggcagagtca gcgctggggg ggcctggagg ccccggctgc acgaggtgca
     1681 gtgggtggtg caaaggttgc cgtgccgaca ggtccaaccc ctctggattc aaccccacca
     1741 ggaggtgctc cccaccccct gacaggccag gaggaggccc gggctgtgga gaaggataaa
     1801 tccaaggcac gatctgagga cacagggcta gacagtgtgg caacccgcac acccatggag
     1861 catgtaaccc caaagccaga gacacacctg gcctcgccca agcctacatg catggtgcct
     1921 cccatgcccc acagcccagt tagtggagac agcgtggagg aggaggaaga ggaagagaag
     1981 aaggtgtgtc tgccaggctt cactggcctt gtcaatttag gcaacacctg cttcatgaac
     2041 agcgtcattc agtctctgtc caacactcgg gaactccggg acttcttcca tgaccgctcc
     2101 tttgaggctg agatcaacta caacaaccca ctagggactg gtgggcgtct ggccattggc
     2161 tttgccgtgc tgcttcgggc gctgtggaag ggcacccacc atgccttcca gccttccaag
     2221 ttgaaggcca ttgtggcgag taaggccagc cagttcacag gctatgcaca gcatgatgcc
     2281 caggagttca tggctttcct gctggatggg ctgcacgagg acctgaatcg cattcagaac
     2341 aagccctaca cagagaccgt ggattcagat gggcggcccg atgaggtggt agctgaggaa
     2401 gcatggcagc ggcacaagat gaggaatgac tctttcatcg tggacctatt tcaggggcag
     2461 tacaagtcga agctggtgtg ccctgtgtgt gccaaggtct ccatcacttt tgacccgttt
     2521 ctttatctgc cggtgccctt gccacaaaag caaaaggttc tccctgtctt ttattttgcc
     2581 cgagagcccc acagcaagcc catcaagttc ctggtgagcg tcagcaagga gaactccact
     2641 gcgagcgaag tattggactc cctctctcag agtgttcatg tgaagcctga gaacctgcgt
     2701 ttggcggagg taattaagaa tcgttttcat cgtgtgttcc taccctccca ctcactggac
     2761 actgtgtccc catctgatac gctcctctgc tttgagctgc tatcctcaga gttggctaag
     2821 gagcgggtag tggtgctaga ggtgcaacag cgcccccagg tgcccagcgt ccccatctcc
     2881 aagtgtgcag cctgccagcg gaagcaacag tcggaggatg aaaagctgaa gcgctgtacc
     2941 cggtgctacc gtgtgggcta ctgcaaccag ctctgccaga aaacccactg gcctgaccac
     3001 aagggcctct gccgacctga gaacattggc taccccttcc tggtcagtgt acctgcctca
     3061 cgcctcactt atgcccgcct cgctcagttg ctagagggct atgcccggta ctctgtgagt
     3121 gtattccagc caccctttca gccaggccgc atggccttgg agtctcagag ccctggctgc
     3181 accacactgc tctccacagg ttccctggag gctggggaca gcgagagaga ccccattcag
     3241 ccacctgagc tccagctggt gacccctatg gctgaggggg acacagggct tccccgggtg
     3301 tgggcagccc ctgaccgggg tcctgtgccc agcaccagtg gaatttcttc tgagatgctg
     3361 gccagtgggc ccattgaggt tggctccttg ccagctggcg agagggtgtc ccgacccgaa
     3421 gctgctgtgc ctgggtacca gcatccaagt gaagctatga atgcccacac accccagttc
     3481 ttcatctata aaattgattc atccaaccga gagcagcggc tagaggacaa aggagacacc
     3541 ccactggagc tgggtgacga ctgtagcctg gctctcgtct ggcggaacaa tgagcgcttg
     3601 caggagtttg tgttggtagc ctccaaggag ctggaatgtg ctgaggatcc aggctctgcc
     3661 ggtgaggctg cccgggccgg ccacttcacc ctggaccagt gcctcaacct cttcacacgg
     3721 cctgaggtgc tggcacccga ggaggcctgg tactgcccac agtgcaaaca gcaccgtgag
     3781 gcctccaagc agctgttgct atggcgcctg ccaaatgttc tcatcgtgca gctcaagcgc
     3841 ttctcctttc gtagttttat ctggcgtgac aagatcaatg acttggtgga gttccctgtt
     3901 aggaacctgg acctgagcaa gttctgcatt ggtcagaaag aggagcagct gcccagctac
     3961 gatctatatg ctgtcatcaa ccactatgga ggcatgattg gtggccacta cactgcctgt
     4021 gcacgcctgc ccaatgatcg tagcagtcag cgcagtgacg tgggctggcg cttgtttgat
     4081 gacagcacag tgacaacggt agacgagagc caggttgtga cgcgttatgc ctatgtactc
     4141 ttctaccgcc ggcggaactc tcctgtggag aggcccccca gggcaggtca ctctgagcac
     4201 cacccagacc taggccctgc agctgaggct gctgccagcc agggactagg ccctggccag
     4261 gcccccgagg tggcccccac gcggacagcc cctgaacgct tcgccccccc tgtggatcgg
     4321 ccagccccca cctacagcaa catggaggag gtggattagc aggtccctgg ctgatggggg
     4381 ggactgggtt tgggacaccc acacagaggg ccagctcctt gccgcttctc cttctctaac
     4441 ccagaggaca ctggctctgt caatgggaag ctgaggggta tgatttgggt gtggagacct
     4501 ctcaggttgg gacttcttgt cagcttggac ccctgaccag tgggctttgg cttctccagc
     4561 cgcctccagt gctgcgtgat ttgattctgt tgtaccttca attcttctga cccgcattat
     4621 aaacattata attttattct aaaaattgta attttttttg cattttggaa gtgactgctg
     4681 ctgtttaaat atattttaaa aataaataat aagtaagtag a
//
