LOCUS       NM_017414               1858 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 18 (USP18), mRNA.
ACCESSION   NM_017414 XM_937636
VERSION     NM_017414.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Geng,L., Liu,F., Yang,L., Liu,Y. and Wu,G.
  TITLE     USP18 promotes the proliferation, invasion, and migration of head
            and neck squamous cell carcinoma by deubiquitinating PLK1
  JOURNAL   Exp Cell Res 442 (2), 114284 (2024)
   PUBMED   39424095
  REMARK    GeneRIF: USP18 promotes the proliferation, invasion, and migration
            of head and neck squamous cell carcinoma by deubiquitinating PLK1.
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Xie,Z., Huang,M., Xu,W., Liu,F. and Huang,D.
  TITLE     USP18 Curbs the Progression of Metabolic Hypertension by
            Suppressing JAK/STAT Pathway
  JOURNAL   Cardiovasc Toxicol 24 (6), 576-586 (2024)
   PUBMED   38691302
  REMARK    GeneRIF: USP18 Curbs the Progression of Metabolic Hypertension by
            Suppressing JAK/STAT Pathway.
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Lee,E.J., Kim,J.Y., Yeo,J.H., Park,S., Bae,Y.J., Kwon,I.J.,
            Seong,S.H., Lee,J. and Oh,S.H.
  TITLE     ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-gamma
            Secretion from CD8+ T Cells in Vitiligo
  JOURNAL   J Invest Dermatol 144 (2), 273-283 (2024)
   PUBMED   37625543
  REMARK    GeneRIF: ISG15-USP18 Dysregulation by Oxidative Stress Promotes
            IFN-gamma Secretion from CD8+ T Cells in Vitiligo.
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Guo,Z. and Guo,L.
  TITLE     Tumor-promoting action of ubiquitin protease 43 in gastric cancer
            progression through deubiquitination and stabilization of
            stress-inducible phosphoprotein 1
  JOURNAL   Exp Cell Res 430 (2), 113714 (2023)
   PUBMED   37442266
  REMARK    GeneRIF: Tumor-promoting action of ubiquitin protease 43 in gastric
            cancer progression through deubiquitination and stabilization of
            stress-inducible phosphoprotein 1.
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Allen,P.C., Roberts,K., Rubio,J.E., Tiwari,H.K., Absher,D.M.,
            Cooper,S.J., Myers,R.M. and Brown,E.E.
  TITLE     Genome-wide DNA methylation analysis implicates enrichment of
            interferon pathway in African American patients with Systemic Lupus
            Erythematosus and European Americans with lupus nephritis
  JOURNAL   J Autoimmun 139, 103089 (2023)
   PUBMED   37506491
  REMARK    GeneRIF: Genome-wide DNA methylation analysis implicates enrichment
            of interferon pathway in African American patients with Systemic
            Lupus Erythematosus and European Americans with lupus nephritis.
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Malakhov,M.P., Malakhova,O.A., Kim,K.I., Ritchie,K.J. and
            Zhang,D.E.
  TITLE     UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  JOURNAL   J Biol Chem 277 (12), 9976-9981 (2002)
   PUBMED   11788588
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Kang,D., Jiang,H., Wu,Q., Pestka,S. and Fisher,P.B.
  TITLE     Cloning and characterization of human ubiquitin-processing
            protease-43 from terminally differentiated human melanoma cells
            using a rapid subtraction hybridization protocol RaSH
  JOURNAL   Gene 267 (2), 233-242 (2001)
   PUBMED   11313150
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 1858)
  AUTHORS   Schwer,H., Liu,L.Q., Zhou,L., Little,M.T., Pan,Z.,
            Hetherington,C.J. and Zhang,D.E.
  TITLE     Cloning and characterization of a novel human ubiquitin-specific
            protease, a homologue of murine UBP43 (Usp18)
  JOURNAL   Genomics 65 (1), 44-52 (2000)
   PUBMED   10777664
  REMARK    Erratum:[Genomics. 2007 Mar;89(3):439]
REFERENCE   10 (bases 1 to 1858)
  AUTHORS   Li,X.L., Blackford,J.A., Judge,C.S., Liu,M., Xiao,W.,
            Kalvakolanu,D.V. and Hassel,B.A.
  TITLE     RNase-L-dependent destabilization of interferon-induced mRNAs. A
            role for the 2-5A system in attenuation of the interferon response
  JOURNAL   J Biol Chem 275 (12), 8880-8888 (2000)
   PUBMED   10722734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008079.24.
            
            On May 17, 2019 this sequence version replaced NM_017414.3.
            
            Summary: The protein encoded by this gene belongs to the
            ubiquitin-specific proteases (UBP) family of enzymes that cleave
            ubiquitin from ubiquitinated protein substrates. It is highly
            expressed in liver and thymus, and is localized to the nucleus.
            This protein efficiently cleaves only ISG15 (a ubiquitin-like
            protein) fusions, and deletion of this gene in mice results in a
            massive increase of ISG15 conjugates in tissues, indicating that
            this protein is a major ISG15-specific protease. Mice lacking this
            gene are also hypersensitive to interferon, suggesting a function
            of this protein in downregulating interferon responses, independent
            of its isopeptidase activity towards ISG15. [provided by RefSeq,
            Sep 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136690.1, BC014896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215794.8/ ENSP00000215794.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC008079.24        81143-81195
            54-316              AC008079.24        88531-88793
            317-413             AC008079.24        91145-91241
            414-559             AC008079.24        92763-92908
            560-639             AC008079.24        98228-98307
            640-786             AC008079.24        98863-99009
            787-882             AC008079.24        100817-100912
            883-1050            AC008079.24        101726-101893
            1051-1182           AC008079.24        104123-104254
            1183-1232           AC008079.24        104766-104815
            1233-1858           AC008079.24        107745-108370
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1858
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /note="ubiquitin specific peptidase 18"
                     /db_xref="GeneID:11274"
                     /db_xref="HGNC:HGNC:12616"
                     /db_xref="MIM:607057"
     exon            1..53
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            54..316
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1278
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 18; ubl thioesterase
                     18; 43 kDa ISG15-specific protease;
                     ISG15-specific-processing protease; ubl thiolesterase 18"
                     /codon_start=1
                     /product="ubl carboxyl-terminal hydrolase 18"
                     /protein_id="NP_059110.2"
                     /db_xref="CCDS:CCDS13752.1"
                     /db_xref="GeneID:11274"
                     /db_xref="HGNC:HGNC:12616"
                     /db_xref="MIM:607057"
                     /translation="MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRER
                     PRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQ
                     MLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHL
                     VERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQ
                     PRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFP
                     QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCF
                     NDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC"
     exon            317..413
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            414..559
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            560..639
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            640..786
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            787..882
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1050
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1182
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1232
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1858
                     /gene="USP18"
                     /gene_synonym="ISG43; PTORCH2; UBP43"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccgacg tggaactcag cagcggaggc tggacgcttg catggcgctt gagagattcc
       61 atcgtgcctg gctcacataa gcgcttcctg gaagtgaagt cgtgctgtcc tgaacgcggg
      121 ccaggcagct gcggcctggg ggttttggag tgatcacgaa tgagcaaggc gtttgggctc
      181 ctgaggcaaa tctgtcagtc catcctggct gagtcctcgc agtccccggc agatcttgaa
      241 gaaaagaagg aagaagacag caacatgaag agagagcagc ccagagagcg tcccagggcc
      301 tgggactacc ctcatggcct ggttggttta cacaacattg gacagacctg ctgccttaac
      361 tccttgattc aggtgttcgt aatgaatgtg gacttcacca ggatattgaa gaggatcacg
      421 gtgcccaggg gagctgacga gcagaggaga agcgtccctt tccagatgct tctgctgctg
      481 gagaagatgc aggacagccg gcagaaagca gtgcggcccc tggagctggc ctactgcctg
      541 cagaagtgca acgtgccctt gtttgtccaa catgatgctg cccaactgta cctcaaactc
      601 tggaacctga ttaaggacca gatcactgat gtgcacttgg tggagagact gcaggccctg
      661 tatacgatcc gggtgaagga ctccttgatt tgcgttgact gtgccatgga gagtagcaga
      721 aacagcagca tgctcaccct cccactttct ctttttgatg tggactcaaa gcccctgaag
      781 acactggagg acgccctgca ctgcttcttc cagcccaggg agttatcaag caaaagcaag
      841 tgcttctgtg agaactgtgg gaagaagacc cgtgggaaac aggtcttgaa gctgacccat
      901 ttgccccaga ccctgacaat ccacctcatg cgattctcca tcaggaattc acagacgaga
      961 aagatctgcc actccctgta cttcccccag agcttggatt tcagccagat ccttccaatg
     1021 aagcgagagt cttgtgatgc tgaggagcag tctggagggc agtatgagct ttttgctgtg
     1081 attgcgcacg tgggaatggc agactccggt cattactgtg tctacatccg gaatgctgtg
     1141 gatggaaaat ggttctgctt caatgactcc aatatttgct tggtgtcctg ggaagacatc
     1201 cagtgtacct acggaaatcc taactaccac tggcaggaaa ctgcatatct tctggtttac
     1261 atgaagatgg agtgctaatg gaaatgccca aaaccttcag agattgacac gctgtcattt
     1321 tccatttccg ttcctggatc tacggagtct tctaagagat tttgcaatga ggagaagcat
     1381 tgttttcaaa ctatataact gagccttatt tataattagg gatattatca aaatatgtaa
     1441 ccatgaggcc cctcaggtcc tgatcagtca gaatggatgc tttcaccagc agacccggcc
     1501 atgtggctgc tcggtcctgg gtgctcgctg ctgtgcaaga cattagccct ttagttatga
     1561 gcctgtggga acttcagggg ttcccagtgg ggagagcagt ggcagtggga ggcatctggg
     1621 ggccaaaggt cagtggcagg gggtatttca gtattataca actgctgtga ccagacttgt
     1681 atactggctg aatatcagtg ctgtttgtaa tttttcactt tgagaaccaa cattaattcc
     1741 atatgaatca agtgttttgt aactgctatt catttattca gcaaatattt attgatcatc
     1801 tcttctccat aagatagtgt gataaacaca gtcatgaata aagttatttt ccacaaaa
//
