LOCUS       NM_001256869            1683 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 17 like family member 7
            (USP17L7), mRNA.
ACCESSION   NM_001256869
VERSION     NM_001256869.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   de la Vega,M., Kelvin,A.A., Dunican,D.J., McFarlane,C.,
            Burrows,J.F., Jaworski,J., Stevenson,N.J., Dib,K., Rappoport,J.Z.,
            Scott,C.J., Long,A. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is essential for GTPase
            subcellular localization and cell motility
  JOURNAL   Nat Commun 2, 259 (2011)
   PUBMED   21448158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   Ramakrishna,S., Suresh,B., Lee,E.J., Lee,H.J., Ahn,W.S. and
            Baek,K.H.
  TITLE     Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC
            activity
  JOURNAL   J Biol Chem 286 (12), 10505-10514 (2011)
   PUBMED   21239494
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Ramakrishna,S., Suresh,B., Kang,I.C. and Baek,K.H.
  TITLE     Polyclonal and monoclonal antibodies specific for USP17, a
            proapoptotic deubiquitinating enzyme
  JOURNAL   Hybridoma (Larchmt) 29 (4), 311-319 (2010)
   PUBMED   20715989
REFERENCE   4  (bases 1 to 1683)
  AUTHORS   Burrows,J.F., Scott,C.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes: a gene family within a
            tandemly repeated sequence, is also embedded within the copy number
            variable beta-defensin cluster
  JOURNAL   BMC Genomics 11, 250 (2010)
   PUBMED   20403174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1683)
  AUTHORS   McFarlane,C., Kelvin,A.A., de la Vega,M., Govender,U., Scott,C.J.,
            Burrows,J.F. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is highly expressed in tumor
            biopsies, is cell cycle regulated, and is required for G1-S
            progression
  JOURNAL   Cancer Res 70 (8), 3329-3339 (2010)
   PUBMED   20388806
REFERENCE   6  (bases 1 to 1683)
  AUTHORS   Burrows,J.F., McGrattan,M.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes, a multigene family within a
            tandemly repeated sequence
  JOURNAL   Genomics 85 (4), 524-529 (2005)
   PUBMED   15780755
REFERENCE   7  (bases 1 to 1683)
  AUTHORS   Burrows,J.F., McGrattan,M.J., Rascle,A., Humbert,M., Baek,K.H. and
            Johnston,J.A.
  TITLE     DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks
            proliferation
  JOURNAL   J Biol Chem 279 (14), 13993-14000 (2004)
   PUBMED   14699124
REFERENCE   8  (bases 1 to 1683)
  AUTHORS   Okada,T., Gondo,Y., Goto,J., Kanazawa,I., Hadano,S. and Ikeda,J.E.
  TITLE     Unstable transmission of the RS447 human megasatellite tandem
            repetitive sequence that contains the USP17 deubiquitinating enzyme
            gene
  JOURNAL   Hum Genet 110 (4), 302-313 (2002)
   PUBMED   11941478
REFERENCE   9  (bases 1 to 1683)
  AUTHORS   Saitoh,Y., Miyamoto,N., Okada,T., Gondo,Y., Showguchi-Miyata,J.,
            Hadano,S. and Ikeda,J.E.
  TITLE     The RS447 human megasatellite tandem repetitive sequence encodes a
            novel deubiquitinating enzyme with a functional promoter
  JOURNAL   Genomics 67 (3), 291-300 (2000)
   PUBMED   10936051
REFERENCE   10 (bases 1 to 1683)
  AUTHORS   Gondo,Y., Okada,T., Matsuyama,N., Saitoh,Y., Yanagisawa,Y. and
            Ikeda,J.E.
  TITLE     Human megasatellite DNA RS447: copy-number polymorphisms and
            interspecies conservation
  JOURNAL   Genomics 54 (1), 39-49 (1998)
   PUBMED   9806828
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC130366.6.
            
            On Nov 26, 2019 this sequence version replaced NM_001256869.1.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support. Its representation is therefore inferred, but
            it is supported by paralogous transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530447.5/ ENSP00000485337.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1683              AC130366.6         41535-43217
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1683
                     /gene="USP17L7"
                     /note="ubiquitin specific peptidase 17 like family member
                     7"
                     /db_xref="GeneID:392197"
                     /db_xref="HGNC:HGNC:37180"
     exon            1..1683
                     /gene="USP17L7"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1683
                     /gene="USP17L7"
                     /note="ubiquitin specific peptidase 17-like 7"
                     /codon_start=1
                     /product="inactive ubiquitin carboxyl-terminal hydrolase
                     17-like protein 7"
                     /protein_id="NP_001243798.1"
                     /db_xref="CCDS:CCDS78305.1"
                     /db_xref="GeneID:392197"
                     /db_xref="HGNC:HGNC:37180"
                     /translation="MEDDSLYLGGDWQFNHFSKLTSSRLDAAFAEIQRTSLSEKSPLS
                     SETRFDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQKIGNTFYVNVSLQCLTYTL
                     PLSNYMLSREDSQTCHLHKCCMFCTMQAHITWALHSPGHVIQPSQVLAAGFHRGEQED
                     AHEFLMFTVDAMKKACLPGHKQLDHHSKDTTLIHQIFGAYWRSQIKYLHCHGVSDTFD
                     PYLDIALDIQAAQSVKQALEQLVKPKELNGENAYHCGLCLQKAPASKTLTLPTSAKVL
                     ILVLKRFSDVTGNKLAKNVQYPKCRDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGH
                     YFSYVKAQEGQWYKMDDAEVTASGITSVLSQQAYVLFYIQKSEWERHSESVSRGREPR
                     ALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATQESTLDHWKFPQEQNKTKPEF
                     NVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTKPTDQESMNTGTLASL
                     QGSTRRSKGNNKHSKRSLLVCQ"
ORIGIN      
        1 ggtcatttga agactctctc ggaagagata gcgtcttgct gcaacctgcg gtcccagcag
       61 aaaaaccttg tgatccttgt tgcgggcgac atggaagacg actcactcta tttgggaggt
      121 gactggcagt tcaatcactt ttcaaaactc acatcttctc ggctagatgc agcttttgct
      181 gaaatccagc ggacttctct ctctgaaaag tcaccactct catctgagac ccgtttcgac
      241 ctctgtgatg atttggctcc tgtggcaaga cagcttgctc ccagggagaa gcttcctctg
      301 agtagcagga gacctgctgc ggtgggggct gggctccaga agataggaaa taccttctat
      361 gtgaacgttt ccctgcagtg cctgacatac acactgccgc tttccaacta catgctgtcc
      421 cgggaggact ctcaaacgtg tcatcttcac aagtgctgca tgttctgtac tatgcaagct
      481 cacatcacat gggccctcca cagtcctggc catgtcatcc agccctcaca ggtattggct
      541 gctggcttcc atagaggtga gcaggaggat gcccatgaat ttctcatgtt tactgtggat
      601 gccatgaaaa aggcatgcct tcccgggcac aagcagctag atcatcactc caaggacacc
      661 accctcatcc accaaatatt tggagcgtat tggagatctc aaatcaagta tctccactgc
      721 cacggcgttt cagacacctt tgacccttac ctggacatcg ccctggatat ccaggcagct
      781 cagagtgtca agcaagcttt ggaacagttg gtgaagccca aagaactcaa tggagagaat
      841 gcctatcatt gtggtctttg tctccagaag gcgcctgcct ccaagacgtt aactttaccc
      901 acttctgcca aggtcctcat tcttgtattg aagagattct ccgatgtcac aggcaacaaa
      961 cttgccaaga atgtgcaata tcctaagtgc cgtgacatgc agccatacat gtctcagcag
     1021 aacacaggac ctcttgtcta tgtcctctat gctgtgctgg tccacgctgg gtggagttgt
     1081 cacaacggac attacttctc ttatgtcaaa gctcaagaag gccagtggta taaaatggat
     1141 gatgccgagg tcactgcctc tggcatcacc tctgtcctga gtcaacaggc ctatgtcctc
     1201 ttttacatcc agaagagtga atgggaaaga cacagtgaga gtgtgtcaag aggcagggaa
     1261 ccaagagccc ttggtgctga agacacagac aggccagcaa cgcaaggaga gctcaagaga
     1321 gaccaccctt gcctccaggt acccgagttg gacgagcact tggtggaaag agccactcag
     1381 gaaagcacct tagaccactg gaaattcccc caagagcaaa acaaaacgaa gcctgagttc
     1441 aacgtcagaa aagttgaagg taccctgcct cccaacgtac ttgtgattca tcaatcaaaa
     1501 tacaagtgtg gtatgaaaaa ccatcatcct gaacagcaaa gctccctgct aaacctctct
     1561 tcgacgaaac cgacagatca ggagtccatg aacactggca cactcgcttc tctgcaaggg
     1621 agcaccagga gatccaaagg gaataacaaa cacagcaaga gatctctgct tgtgtgccag
     1681 tga
//
