LOCUS       NM_001256874            1593 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 17 like family member 4
            (USP17L4), mRNA.
ACCESSION   NM_001256874
VERSION     NM_001256874.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   de la Vega,M., Kelvin,A.A., Dunican,D.J., McFarlane,C.,
            Burrows,J.F., Jaworski,J., Stevenson,N.J., Dib,K., Rappoport,J.Z.,
            Scott,C.J., Long,A. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is essential for GTPase
            subcellular localization and cell motility
  JOURNAL   Nat Commun 2, 259 (2011)
   PUBMED   21448158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Ramakrishna,S., Suresh,B., Lee,E.J., Lee,H.J., Ahn,W.S. and
            Baek,K.H.
  TITLE     Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC
            activity
  JOURNAL   J Biol Chem 286 (12), 10505-10514 (2011)
   PUBMED   21239494
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Ramakrishna,S., Suresh,B., Kang,I.C. and Baek,K.H.
  TITLE     Polyclonal and monoclonal antibodies specific for USP17, a
            proapoptotic deubiquitinating enzyme
  JOURNAL   Hybridoma (Larchmt) 29 (4), 311-319 (2010)
   PUBMED   20715989
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., Scott,C.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes: a gene family within a
            tandemly repeated sequence, is also embedded within the copy number
            variable beta-defensin cluster
  JOURNAL   BMC Genomics 11, 250 (2010)
   PUBMED   20403174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   McFarlane,C., Kelvin,A.A., de la Vega,M., Govender,U., Scott,C.J.,
            Burrows,J.F. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is highly expressed in tumor
            biopsies, is cell cycle regulated, and is required for G1-S
            progression
  JOURNAL   Cancer Res 70 (8), 3329-3339 (2010)
   PUBMED   20388806
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., McGrattan,M.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes, a multigene family within a
            tandemly repeated sequence
  JOURNAL   Genomics 85 (4), 524-529 (2005)
   PUBMED   15780755
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., McGrattan,M.J., Rascle,A., Humbert,M., Baek,K.H. and
            Johnston,J.A.
  TITLE     DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks
            proliferation
  JOURNAL   J Biol Chem 279 (14), 13993-14000 (2004)
   PUBMED   14699124
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Okada,T., Gondo,Y., Goto,J., Kanazawa,I., Hadano,S. and Ikeda,J.E.
  TITLE     Unstable transmission of the RS447 human megasatellite tandem
            repetitive sequence that contains the USP17 deubiquitinating enzyme
            gene
  JOURNAL   Hum Genet 110 (4), 302-313 (2002)
   PUBMED   11941478
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Saitoh,Y., Miyamoto,N., Okada,T., Gondo,Y., Showguchi-Miyata,J.,
            Hadano,S. and Ikeda,J.E.
  TITLE     The RS447 human megasatellite tandem repetitive sequence encodes a
            novel deubiquitinating enzyme with a functional promoter
  JOURNAL   Genomics 67 (3), 291-300 (2000)
   PUBMED   10936051
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Gondo,Y., Okada,T., Matsuyama,N., Saitoh,Y., Yanagisawa,Y. and
            Ikeda,J.E.
  TITLE     Human megasatellite DNA RS447: copy-number polymorphisms and
            interspecies conservation
  JOURNAL   Genomics 54 (1), 39-49 (1998)
   PUBMED   9806828
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC130360.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support. Its representation is therefore inferred, but
            it is supported by paralogous transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000526929.1/ ENSP00000485243.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1593              AC130360.4         25222-26814
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1593
                     /gene="USP17L4"
                     /note="ubiquitin specific peptidase 17 like family member
                     4"
                     /db_xref="GeneID:645402"
                     /db_xref="HGNC:HGNC:37176"
     CDS             1..1593
                     /gene="USP17L4"
                     /codon_start=1
                     /product="inactive ubiquitin carboxyl-terminal hydrolase
                     17-like protein 4"
                     /protein_id="NP_001243803.1"
                     /db_xref="CCDS:CCDS78299.1"
                     /db_xref="GeneID:645402"
                     /db_xref="HGNC:HGNC:37176"
                     /translation="MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLS
                     SETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTL
                     PLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQED
                     VHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFD
                     PYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVL
                     ILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGY
                     YFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPR
                     ALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATEESTLDHWKFPQEQNKMKPEF
                     NVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMNSTDQESMNTGTLASL
                     QGRTRRSKGKNKHSKRSLLVCQ"
     exon            1..1593
                     /gene="USP17L4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggacg actcactcta cttgggaggt gagtggcagt tcaaccactt ttcaaaactc
       61 acatcttctc ggccagatgc agcttttgct gaaatccagc ggacttctct ccctgagaag
      121 tcaccactct catctgagac ccgtgtcgac ctctgtgatg atttggctcc tgtggcaaga
      181 cagctcgctc ccagggagaa gcttcctctg agtagcagga gacctgctgc ggtgggggct
      241 gggctccaga atatgggaaa tacctgctac gagaacgctt ccctgcagtg cctgacatac
      301 acactgcccc ttgccaacta catgctgtcc cgggagcact ctcaaacatg tcagcgtccc
      361 aagtgctgca tgctctgtac tatgcaagct cacatcacat gggccctcca cagtcctggc
      421 catgtcatcc agccctcaca ggcattggct gctggcttcc atagaggcaa gcaggaagat
      481 gtccatgaat ttctcatgtt cactgtggat gccatgaaaa aggcatgcct tcccggccac
      541 aagcaggtag atcatcactc taaggacacc accctcatcc accaaatatt tggaggctgc
      601 tggagatctc aaatcaagtg tctccactgc cacgggattt cagacacttt tgacccttac
      661 ctggacatcg ccctggatat ccaggcagct cagagtgtca agcaagcttt ggaacagttg
      721 gtgaagcccg aagaactcaa tggagagaat gcctatcatt gcggtctttg tctccagagg
      781 gcgccggcct ccaacacgtt aactttacac acttctgcca aggtcctcat ccttgtcttg
      841 aagagattct ccgatgtcgc aggcaacaaa cttgccaaga atgtgcaata tcctgagtgc
      901 cttgacatgc agccatacat gtctcagcag aacacaggac ctcttgtcta tgtcctctat
      961 gctgtgctgg tccacgctgg gtggagttgt cacgacggat attacttctc ttatgtcaaa
     1021 gctcaagaag gccagtggta taaaatggat gatgccgagg tcactgtctg tagcatcact
     1081 tctgtcctga gtcaacaggc ctatgtcctc ttttacatcc agaagagtga atgggaaaga
     1141 cacagtgaga gtgtgtcaag aggcagggaa ccaagagccc ttggcgctga agacacagac
     1201 aggccagcaa cgcaaggaga gctcaagaga gaccaccctt gcctccaggt acccgagttg
     1261 gacgagcact tggtggaaag agccactgag gaaagcacct tagaccactg gaaattcccc
     1321 caagagcaaa acaaaatgaa gcctgagttc aacgtcagaa aagttgaagg taccctgcct
     1381 cccaacgtac ttgtgattca tcaatcaaaa tacaagtgtg ggatgaaaaa ccaccatcct
     1441 gaacagcaaa gctccctgct aaacctctct tcgatgaact cgacagatca ggagtccatg
     1501 aacactggca cactcgcttc tctgcaaggg aggaccagga gatccaaagg gaagaacaaa
     1561 cacagcaaga gatctctgct tgtgtgccag tga
//
