LOCUS       NM_001256871            1593 bp    mRNA    linear   PRI 01-SEP-2020
DEFINITION  Homo sapiens ubiquitin specific peptidase 17 like family member 3
            (USP17L3), mRNA.
ACCESSION   NM_001256871
VERSION     NM_001256871.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF,
            Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A and
            Johnston JA.
  TITLE     The deubiquitinating enzyme USP17 is essential for GTPase
            subcellular localization and cell motility
  JOURNAL   Nat Commun 2, 259 (2011)
   PUBMED   21448158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Ramakrishna S, Suresh B, Lee EJ, Lee HJ, Ahn WS and Baek KH.
  TITLE     Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC
            activity
  JOURNAL   J. Biol. Chem. 286 (12), 10505-10514 (2011)
   PUBMED   21239494
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Ramakrishna S, Suresh B, Kang IC and Baek KH.
  TITLE     Polyclonal and monoclonal antibodies specific for USP17, a
            proapoptotic deubiquitinating enzyme
  JOURNAL   Hybridoma (Larchmt) 29 (4), 311-319 (2010)
   PUBMED   20715989
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Burrows JF, Scott CJ and Johnston JA.
  TITLE     The DUB/USP17 deubiquitinating enzymes: a gene family within a
            tandemly repeated sequence, is also embedded within the copy number
            variable beta-defensin cluster
  JOURNAL   BMC Genomics 11, 250 (2010)
   PUBMED   20403174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows
            JF and Johnston JA.
  TITLE     The deubiquitinating enzyme USP17 is highly expressed in tumor
            biopsies, is cell cycle regulated, and is required for G1-S
            progression
  JOURNAL   Cancer Res. 70 (8), 3329-3339 (2010)
   PUBMED   20388806
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Burrows JF, McGrattan MJ and Johnston JA.
  TITLE     The DUB/USP17 deubiquitinating enzymes, a multigene family within a
            tandemly repeated sequence
  JOURNAL   Genomics 85 (4), 524-529 (2005)
   PUBMED   15780755
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Burrows JF, McGrattan MJ, Rascle A, Humbert M, Baek KH and Johnston
            JA.
  TITLE     DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks
            proliferation
  JOURNAL   J. Biol. Chem. 279 (14), 13993-14000 (2004)
   PUBMED   14699124
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Okada T, Gondo Y, Goto J, Kanazawa I, Hadano S and Ikeda JE.
  TITLE     Unstable transmission of the RS447 human megasatellite tandem
            repetitive sequence that contains the USP17 deubiquitinating enzyme
            gene
  JOURNAL   Hum. Genet. 110 (4), 302-313 (2002)
   PUBMED   11941478
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Saitoh Y, Miyamoto N, Okada T, Gondo Y, Showguchi-Miyata J, Hadano
            S and Ikeda JE.
  TITLE     The RS447 human megasatellite tandem repetitive sequence encodes a
            novel deubiquitinating enzyme with a functional promoter
  JOURNAL   Genomics 67 (3), 291-300 (2000)
   PUBMED   10936051
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Gondo Y, Okada T, Matsuyama N, Saitoh Y, Yanagisawa Y and Ikeda JE.
  TITLE     Human megasatellite DNA RS447: copy-number polymorphisms and
            interspecies conservation
  JOURNAL   Genomics 54 (1), 39-49 (1998)
   PUBMED   9806828
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC130365.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support. Its representation is therefore inferred, but
            it is supported by paralogous transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000530484.1/ ENSP00000485323.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1593              AC130365.5         26100-27692
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1593
                     /gene="USP17L3"
                     /gene_synonym="USP17B; USP17F"
                     /note="ubiquitin specific peptidase 17 like family member
                     3"
                     /db_xref="GeneID:645836"
                     /db_xref="HGNC:HGNC:37175"
     CDS             1..1593
                     /gene="USP17L3"
                     /gene_synonym="USP17B; USP17F"
                     /note="ubiquitin specific peptidase 17-like 3; ubiquitin
                     thioesterase 17-like protein 3; deubiquitinating enzyme
                     17-like protein 3; ubiquitin-specific-processing protease
                     17-like protein 3"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 17-like
                     protein 3"
                     /protein_id="NP_001243800.1"
                     /db_xref="CCDS:CCDS78301.1"
                     /db_xref="GeneID:645836"
                     /db_xref="HGNC:HGNC:37175"
                     /translation="MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLS
                     SETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTL
                     PLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALASGFHRGKQED
                     VHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFD
                     PYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVL
                     ILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGH
                     YFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPR
                     ALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEF
                     NVGKVEGTLPPNALVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASL
                     QGRTRRAKGKNKHSKRALLVCQ"
     exon            1..1593
                     /gene="USP17L3"
                     /gene_synonym="USP17B; USP17F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggatg actcactcta cttgggaggt gagtggcagt tcaaccactt ttcaaaactc
       61 acatcttctc ggccagatgc agcttttgct gaaatccagc ggacttctct ccctgagaag
      121 tcaccactct catctgagac ccgtgtcgac ctctgtgatg atttggctcc tgtggcaaga
      181 cagctcgctc ccagggagaa gcttcctctg agtagcagga gacctgctgc ggtgggggct
      241 gggctccaga atatgggaaa tacctgctac gagaacgctt ccctgcagtg cctgacatac
      301 acactgcccc ttgccaacta catgctgtcc cgggagcact ctcaaacatg tcagcgtccc
      361 aagtgctgca tgctctgtac tatgcaagct cacatcacat gggccctcca cagtcctggc
      421 catgtcatcc agccctcaca ggcattggct tctggcttcc atagaggcaa gcaggaagat
      481 gtccatgaat ttctcatgtt cactgtggat gccatgaaaa aggcatgcct tcccggccac
      541 aagcaggtag atcatcactc taaggacacc accctcatcc accaaatatt tggaggctgc
      601 tggagatctc aaatcaagtg tctccactgc cacgggattt cagacacttt tgacccttac
      661 ctggacatcg ccctggatat ccaggcagct cagagtgtca agcaagcttt ggaacagttg
      721 gtgaagcccg aagaactcaa tggagagaat gcctatcatt gcggtctttg tctccagagg
      781 gcgccggcct ccaacacgtt aactttacac acttctgcca aggtcctcat ccttgtcttg
      841 aagagattct ccgatgtcgc aggcaacaaa cttgccaaga atgtgcaata tcctgagtgc
      901 cttgacatgc agccatacat gtctcagcag aacacaggac ctcttgtcta tgtcctctat
      961 gctgtgctgg tccacgctgg gtggagttgt cacgacggac attacttctc ttatgtcaaa
     1021 gctcaagaag gccagtggta taaaatggat gatgccgagg tcactgtctg tagcatcact
     1081 tctgtcctga gtcaacaggc ctatgtcctc ttttacatcc agaagagtga atgggaaaga
     1141 cacagtgaga gtgtgtcaag aggcagggaa ccaagagccc tcggcgctga agacacagac
     1201 aggcgagcaa agcaaggaga gctcaagaga gaccacccct gcctccaggc acccgagttg
     1261 gacgagcact tggtggaaag agccactcag gaaagcacct tagaccactg gaaattcctc
     1321 caagagcaaa acaaaacgaa gcctgagttc aacgtcggaa aagtcgaagg taccctgcct
     1381 cccaacgcac ttgtgattca tcaatcaaaa tacaagtgtg ggatgaaaaa ccatcatcct
     1441 gaacagcaaa gctccctgct aaacctctct tcgacgaccc ggacagatca ggagtccatg
     1501 aacactggca cactcgcttc tctgcaaggg aggaccagga gagccaaagg gaagaacaaa
     1561 cacagcaaga gggctctgct tgtgtgccag tga
//
