LOCUS       NM_001256862            1593 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 17 like family member 21
            (USP17L21), mRNA.
ACCESSION   NM_001256862 XM_002342438
VERSION     NM_001256862.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   de la Vega,M., Kelvin,A.A., Dunican,D.J., McFarlane,C.,
            Burrows,J.F., Jaworski,J., Stevenson,N.J., Dib,K., Rappoport,J.Z.,
            Scott,C.J., Long,A. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is essential for GTPase
            subcellular localization and cell motility
  JOURNAL   Nat Commun 2, 259 (2011)
   PUBMED   21448158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Ramakrishna,S., Suresh,B., Lee,E.J., Lee,H.J., Ahn,W.S. and
            Baek,K.H.
  TITLE     Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC
            activity
  JOURNAL   J Biol Chem 286 (12), 10505-10514 (2011)
   PUBMED   21239494
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Ramakrishna,S., Suresh,B., Kang,I.C. and Baek,K.H.
  TITLE     Polyclonal and monoclonal antibodies specific for USP17, a
            proapoptotic deubiquitinating enzyme
  JOURNAL   Hybridoma (Larchmt) 29 (4), 311-319 (2010)
   PUBMED   20715989
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., Scott,C.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes: a gene family within a
            tandemly repeated sequence, is also embedded within the copy number
            variable beta-defensin cluster
  JOURNAL   BMC Genomics 11, 250 (2010)
   PUBMED   20403174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   McFarlane,C., Kelvin,A.A., de la Vega,M., Govender,U., Scott,C.J.,
            Burrows,J.F. and Johnston,J.A.
  TITLE     The deubiquitinating enzyme USP17 is highly expressed in tumor
            biopsies, is cell cycle regulated, and is required for G1-S
            progression
  JOURNAL   Cancer Res 70 (8), 3329-3339 (2010)
   PUBMED   20388806
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., McGrattan,M.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes, a multigene family within a
            tandemly repeated sequence
  JOURNAL   Genomics 85 (4), 524-529 (2005)
   PUBMED   15780755
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Burrows,J.F., McGrattan,M.J., Rascle,A., Humbert,M., Baek,K.H. and
            Johnston,J.A.
  TITLE     DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks
            proliferation
  JOURNAL   J Biol Chem 279 (14), 13993-14000 (2004)
   PUBMED   14699124
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Okada,T., Gondo,Y., Goto,J., Kanazawa,I., Hadano,S. and Ikeda,J.E.
  TITLE     Unstable transmission of the RS447 human megasatellite tandem
            repetitive sequence that contains the USP17 deubiquitinating enzyme
            gene
  JOURNAL   Hum Genet 110 (4), 302-313 (2002)
   PUBMED   11941478
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Saitoh,Y., Miyamoto,N., Okada,T., Gondo,Y., Showguchi-Miyata,J.,
            Hadano,S. and Ikeda,J.E.
  TITLE     The RS447 human megasatellite tandem repetitive sequence encodes a
            novel deubiquitinating enzyme with a functional promoter
  JOURNAL   Genomics 67 (3), 291-300 (2000)
   PUBMED   10936051
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Gondo,Y., Okada,T., Matsuyama,N., Saitoh,Y., Yanagisawa,Y. and
            Ikeda,J.E.
  TITLE     Human megasatellite DNA RS447: copy-number polymorphisms and
            interspecies conservation
  JOURNAL   Genomics 54 (1), 39-49 (1998)
   PUBMED   9806828
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC108519.4.
            
            On Mar 3, 2012 this sequence version replaced XM_002342438.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support and it is therefore inferred, but it is
            supported by data in PMID:10936051.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506414.1/ ENSP00000422216.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1593              AC108519.4         162322-163914
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..1593
                     /gene="USP17L21"
                     /note="ubiquitin specific peptidase 17 like family member
                     21"
                     /db_xref="GeneID:100287478"
                     /db_xref="HGNC:HGNC:44449"
     CDS             1..1593
                     /gene="USP17L21"
                     /EC_number="3.4.19.12"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 17-like
                     protein 21"
                     /protein_id="NP_001243791.1"
                     /db_xref="CCDS:CCDS59462.1"
                     /db_xref="GeneID:100287478"
                     /db_xref="HGNC:HGNC:44449"
                     /translation="MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLS
                     CETRVDLCDDLAPVARQLAPREKLPLSNRRPAAVGAGLQNMGNTCYVNASLQCLTYTP
                     PLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQED
                     AHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFD
                     PYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVL
                     ILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGH
                     YFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPR
                     ALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEF
                     NVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASL
                     RGRARRSKGKNKHSKRALLVCQ"
     exon            1..1593
                     /gene="USP17L21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggaag actcactcta cttgggaggt gagtggcagt tcaaccactt ttcaaaactc
       61 acatcttctc ggcccgatgc agcttttgct gaaatccagc ggacttctct ccctgagaag
      121 tcaccactct catgtgagac ccgtgtcgac ctctgtgatg atttggctcc tgtggcaaga
      181 cagcttgctc ccagggagaa gcttcctctg agtaacagga gacctgctgc ggtgggggct
      241 gggctccaga atatgggaaa tacctgctac gtgaacgctt ccttgcagtg cctgacatac
      301 acaccgcccc ttgccaacta catgctgtcc cgggagcact ctcaaacgtg tcatcgtcac
      361 aagggctgca tgctctgtac gatgcaagct cacatcacac gggccctcca caatcctggc
      421 cacgtcatcc agccctcaca ggcattggct gctggcttcc atagaggcaa gcaggaagat
      481 gcccatgaat ttctcatgtt cactgtggat gccatgaaaa aggcatgcct tcccgggcac
      541 aagcaggtgg atcatcactc taaggacacc accctcatcc accaaatatt tggaggctac
      601 tggagatctc aaatcaagtg tctccactgc cacggcattt cagacacttt tgacccttac
      661 ctggacatcg ccctggatat ccaggcagct cagagtgtcc agcaagcttt ggaacagttg
      721 gtgaagcccg aagaactcaa tggagagaat gcctatcatt gtggtgtttg tctccagagg
      781 gcgccggcct ccaagatgtt aactttactc acctctgcca aggtcctcat ccttgtattg
      841 aagagattct ccgatgtcac aggcaacaag attgccaaga atgtgcaata tcctgagtgc
      901 cttgacatgc agccatacat gtctcagccg aacacaggac ctctcgtcta tgtcctctat
      961 gctgtgctgg tccacgctgg gtggagttgt cacaacggac attacttctc ttatgtcaaa
     1021 gctcaagaag gccagtggta taaaatggat gatgccgagg tcaccgcctc tagcatcact
     1081 tctgtcctga gtcaacaggc ctacgtcctc ttttacatcc agaagagtga atgggaaaga
     1141 cacagtgaga gtgtgtcaag aggcagagaa ccaagagccc ttggcgcaga agacacagac
     1201 aggcgagcaa cgcaaggaga gctcaagaga gaccacccct gcctccaggc ccccgagttg
     1261 gacgagcact tggtggaaag agccactcag gaaagcacct tagaccactg gaaattcctt
     1321 caagagcaaa acaaaacgaa gcctgagttc aacgtcagaa aagtcgaagg taccctgcct
     1381 cccgacgtac ttgtgattca tcaatcaaaa tacaagtgtg ggatgaagaa ccatcatcct
     1441 gaacagcaaa gctccctgct aaacctctct tcgtcgaccc cgacacatca ggagtccatg
     1501 aacactggca cactcgcttc cctgcgaggg agggccagga gatccaaagg gaagaacaaa
     1561 cacagcaaga gggctctgct tgtgtgccag tga
//
