LOCUS       NM_201402               2415 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 17 like family member 2
            (USP17L2), mRNA.
ACCESSION   NM_201402 XM_352721
VERSION     NM_201402.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Jang,S.H., Cho,H.D., Lee,J.H. and Oh,M.H.
  TITLE     Clinicopathological Significance of DUB3 Expression in Non-small
            Cell Lung Cancer and Relationship Between DUB3 Expression and LATS1
            Expression
  JOURNAL   In Vivo 37 (5), 2296-2305 (2023)
   PUBMED   37652526
  REMARK    GeneRIF: Clinicopathological Significance of DUB3 Expression in
            Non-small Cell Lung Cancer and Relationship Between DUB3 Expression
            and LATS1 Expression.
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Su,Y., Wu,C., Chang,Y., Li,L., Chen,Y., Jia,X., Wang,X., Lv,Y.,
            Yu,B. and Yuan,J.
  TITLE     USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance
            in breast cancer cells
  JOURNAL   Breast Cancer Res Treat 196 (1), 31-44 (2022)
   PUBMED   36040642
  REMARK    GeneRIF: USP17L2-SIRT7 axis regulates DNA damage repair and
            chemoresistance in breast cancer cells.
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Zhang,Y., Zuo,D., Qiu,J., Li,K., Niu,Y., Yuan,Y., Qiu,Y., Qiao,L.,
            He,W., Wang,C., Yuan,Y. and Li,B.
  TITLE     NXN suppresses metastasis of hepatocellular carcinoma by promoting
            degradation of Snail through binding to DUB3
  JOURNAL   Cell Death Dis 13 (8), 676 (2022)
   PUBMED   35927236
  REMARK    GeneRIF: NXN suppresses metastasis of hepatocellular carcinoma by
            promoting degradation of Snail through binding to DUB3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Zhang,Q., Zhang,Z.Y., Du,H., Li,S.Z., Tu,R., Jia,Y.F., Zheng,Z.,
            Song,X.M., Du,R.L. and Zhang,X.D.
  TITLE     DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance
            of colorectal cancer
  JOURNAL   Cell Death Differ 26 (11), 2300-2313 (2019)
   PUBMED   30778200
  REMARK    GeneRIF: DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy
            resistance of colorectal cancer.
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Hu,B., Deng,T., Ma,H., Liu,Y., Feng,P., Wei,D., Ling,N., Li,L.,
            Qiu,S., Zhang,L., Peng,B., Liu,J. and Ye,M.
  TITLE     Deubiquitinase DUB3 Regulates Cell Cycle Progression via
            Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung
            Cancer Cells
  JOURNAL   Cells 8 (4), 297 (2019)
   PUBMED   30935108
  REMARK    GeneRIF: DUB3 functions as a novel cyclin A regulator through
            maintaining cyclin A stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Burrows,J.F., McGrattan,M.J. and Johnston,J.A.
  TITLE     The DUB/USP17 deubiquitinating enzymes, a multigene family within a
            tandemly repeated sequence
  JOURNAL   Genomics 85 (4), 524-529 (2005)
   PUBMED   15780755
REFERENCE   7  (bases 1 to 2415)
  AUTHORS   Burrows,J.F., McGrattan,M.J., Rascle,A., Humbert,M., Baek,K.H. and
            Johnston,J.A.
  TITLE     DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks
            proliferation
  JOURNAL   J Biol Chem 279 (14), 13993-14000 (2004)
   PUBMED   14699124
  REMARK    GeneRIF: human DUB-3, like the murine DUB family members, is
            transiently induced in response to cytokines and can, when
            constitutively expressed, block growth factor-dependent
            proliferation.
REFERENCE   8  (bases 1 to 2415)
  AUTHORS   Okada,T., Gondo,Y., Goto,J., Kanazawa,I., Hadano,S. and Ikeda,J.E.
  TITLE     Unstable transmission of the RS447 human megasatellite tandem
            repetitive sequence that contains the USP17 deubiquitinating enzyme
            gene
  JOURNAL   Hum Genet 110 (4), 302-313 (2002)
   PUBMED   11941478
REFERENCE   9  (bases 1 to 2415)
  AUTHORS   Saitoh,Y., Miyamoto,N., Okada,T., Gondo,Y., Showguchi-Miyata,J.,
            Hadano,S. and Ikeda,J.E.
  TITLE     The RS447 human megasatellite tandem repetitive sequence encodes a
            novel deubiquitinating enzyme with a functional promoter
  JOURNAL   Genomics 67 (3), 291-300 (2000)
   PUBMED   10936051
REFERENCE   10 (bases 1 to 2415)
  AUTHORS   Gondo,Y., Okada,T., Matsuyama,N., Saitoh,Y., Yanagisawa,Y. and
            Ikeda,J.E.
  TITLE     Human megasatellite DNA RS447: copy-number polymorphisms and
            interspecies conservation
  JOURNAL   Genomics 54 (1), 39-49 (1998)
   PUBMED   9806828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130366.6.
            
            On Sep 4, 2020 this sequence version replaced NM_201402.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY509884.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333796.4/ ENSP00000333329.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2415              AC130366.6         36785-39199
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..2415
                     /gene="USP17L2"
                     /gene_synonym="DUB-3; DUB3; USP17"
                     /note="ubiquitin specific peptidase 17 like family member
                     2"
                     /db_xref="GeneID:377630"
                     /db_xref="HGNC:HGNC:34434"
                     /db_xref="MIM:610186"
     exon            1..2415
                     /gene="USP17L2"
                     /gene_synonym="DUB-3; DUB3; USP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1682
                     /gene="USP17L2"
                     /gene_synonym="DUB-3; DUB3; USP17"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin carboxyl-terminal hydrolase 17-like
                     protein 2; deubiquitinating enzyme 3; deubiquitinating
                     protein 3; ubiquitin thioesterase 17-like protein 2;
                     deubiquitinating enzyme 17-like protein 2;
                     ubiquitin-specific-processing protease 17-like protein 2;
                     ubiquitin thiolesterase 17-like protein 2; ubiquitin
                     specific peptidase 17-like 2"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 17"
                     /protein_id="NP_958804.2"
                     /db_xref="CCDS:CCDS43713.1"
                     /db_xref="GeneID:377630"
                     /db_xref="HGNC:HGNC:34434"
                     /db_xref="MIM:610186"
                     /translation="MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLS
                     SEARVDLCDDLAPVARQLAPRKKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTP
                     PLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQED
                     AHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFD
                     PYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVL
                     ILVLKRFSDVTGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGH
                     YFSYVKAQEGQWYKMDDAKVTACSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPR
                     ALGAEDTDRRATQGELKRDHPCLQAPELDERLVERATQESTLDHWKFPQEQNKTKPEF
                     NVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESVNTGTLASL
                     QGRTRRSKGKNKHSKRALLVCQ"
     regulatory      2396..2401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP17L2"
                     /gene_synonym="DUB-3; DUB3; USP17"
                     /note="hexamer: AATAAA"
     polyA_site      2415
                     /gene="USP17L2"
                     /gene_synonym="DUB-3; DUB3; USP17"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttgaa gactctcttg gaagagatag cgtcttgctg caacctgcag tcccagcaga
       61 aaaaccttgt gatccttgtt gcgggcgaca tggaggacga ctcactctac ttgggaggtg
      121 agtggcagtt caaccacttt tcaaaactca catcttctcg gccagatgca gcttttgctg
      181 aaatccagcg gacttctctc cctgagaagt caccactctc atctgaggcc cgtgtcgacc
      241 tctgtgatga tttggctcct gtggcaagac agcttgctcc caggaagaag cttcctctga
      301 gtagcaggag acctgctgcg gtgggggctg ggctccagaa tatgggaaat acctgctacg
      361 agaacgcttc cctgcagtgc ctgacataca caccgcccct tgccaactac atgctgtccc
      421 gggagcactc tcaaacatgt cagcgtccca agtgctgcat gctctgtact atgcaagctc
      481 acatcacatg ggccctccac agtcctggtc atgtcatcca gccctcacag gcattggctg
      541 ctggcttcca tagaggcaag caggaagatg cccatgaatt tctcatgttc actgtggatg
      601 ccatgaaaaa ggcatgcctt cccggccaca agcaggtaga tcatcactct aaggacacca
      661 ccctcatcca ccaaatattt ggaggctgct ggagatctca aatcaagtgt ctccactgcc
      721 acgggatttc agacactttt gacccttacc tggacatcgc cctggatatc caggcagctc
      781 agagtgtcaa gcaagctttg gaacagttgg tgaagcccga agaactcaat ggagagaatg
      841 cctatcattg cggtctttgt ctccagaggg cgccggcctc caagacgtta actttacaca
      901 cttctgccaa ggtcctcatc cttgtcttga agagattctc cgatgtcaca ggcaacaaac
      961 ttgccaagaa tgtgcaatat cctgagtgcc ttgacatgca gccatacatg tctcagcaga
     1021 acacaggacc tcttgtctat gtcctctatg ctgtgctggt ccacgctggg tggagttgtc
     1081 acgacggaca ttacttctct tatgtcaaag ctcaagaagg ccagtggtat aaaatggatg
     1141 atgccaaggt cactgcctgt agcatcactt ctgtcctgag tcaacaggcc tatgtcctct
     1201 tttacatcca gaagagtgaa tgggaaagac acagtgagag tgtgtcaaga ggcagggaac
     1261 caagagccct cggcgctgaa gacacagaca ggcgagcaac gcaaggagag ctcaagagag
     1321 accacccctg cctccaggca cccgagttgg acgagcgctt ggtggaaaga gccactcagg
     1381 aaagcacctt agaccactgg aaattccccc aagagcaaaa caaaacgaag cctgagttca
     1441 acgtcagaaa agtcgaaggt accctgcctc ccaacgtact tgtgattcat caatcgaaat
     1501 acaagtgtgg gatgaaaaac catcatcctg aacagcaaag ctccctgcta aacctctctt
     1561 cgacgacccg gacagatcag gagtccgtga acactggcac cctcgcttct ctgcaaggga
     1621 ggaccaggag atccaaaggg aagaacaaac acagcaagag ggctctgctt gtgtgccagt
     1681 gatctcagtg gaagtgccga cccacacgta ggggtgaacg cacacacaca cacgcacaaa
     1741 tacacccaca agcgcgcacg caaacacaca cacacacaca aacacgaaca ccgtcaatcc
     1801 tacataaagt aatgaggagt ccaagtttct gtctctacaa cagggacaac tggatagtga
     1861 tggctgcatc tcaggatgag cccacacatg ggaaacatca agttttgggg tcgtgagtct
     1921 tccgaacctc tggagagact gtctgtgtgt ttgtgttcat ggtagatgac attcactgtg
     1981 tatttctgaa tatgacctac tgacgtgtag gtttgagtgt gaggttattg caggggactc
     2041 ggtttcctat tttctcttgg ggtgtgtttc attcgtcagt tgttgggcgg cacgagaagg
     2101 tgaaattttg ctcatgtggc acatccatgg atcattctcg ccaccttgaa tagtggaaac
     2161 tggaatgcat ttagaagata ggaacggtgc tcttctttct taccctggct caccgttttt
     2221 acattggttt ctgaatggac ctcaggcgcc ctgggacttg tgctcttgct ggaacccaca
     2281 taacgccgga aacagacaga ccgacttgcc tgtttcacga tgtccaattc caatgagtcg
     2341 aaatggaaaa ttttcccact ggcatgtcag tcatttggaa ataagtcgta ttgataataa
     2401 aggaaatcaa acaca
//
