LOCUS       NM_182488               4412 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 12 (USP12), mRNA.
ACCESSION   NM_182488
VERSION     NM_182488.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4412)
  AUTHORS   Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J.,
            Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B.
            and Cao,J.
  TITLE     WDR20 prevents hepatocellular carcinoma senescence by orchestrating
            the simultaneous USP12/46-mediated deubiquitination of c-Myc
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2407904121 (2024)
   PUBMED   39432777
  REMARK    GeneRIF: WDR20 prevents hepatocellular carcinoma senescence by
            orchestrating the simultaneous USP12/46-mediated deubiquitination
            of c-Myc.
REFERENCE   2  (bases 1 to 4412)
  AUTHORS   Liu,X., Wang,B., Chang,M., Zhang,X., Zou,H., Zhang,Z. and Han,G.
  TITLE     USP12 regulates ER stress-associated osteogenesis in human
            periodontal ligament cells under tension stress
  JOURNAL   Cell Signal 114, 111015 (2024)
   PUBMED   38113977
  REMARK    GeneRIF: USP12 regulates ER stress-associated osteogenesis in human
            periodontal ligament cells under tension stress.
REFERENCE   3  (bases 1 to 4412)
  AUTHORS   Chen,C., Xue,N., Liu,K., He,Q., Wang,C., Guo,Y., Tian,J., Liu,X.,
            Pan,Y. and Chen,G.
  TITLE     USP12 promotes nonsmall cell lung cancer progression through
            deubiquitinating and stabilizing RRM2
  JOURNAL   Mol Carcinog 62 (10), 1518-1530 (2023)
   PUBMED   37341611
  REMARK    GeneRIF: USP12 promotes nonsmall cell lung cancer progression
            through deubiquitinating and stabilizing RRM2.
REFERENCE   4  (bases 1 to 4412)
  AUTHORS   Zhan,X., He,Q., Sheng,J., Jiang,X., Lin,L., Huang,Y., He,S.,
            Chen,Y., Li,L., Zeng,Z., Hu,S., Wang,P. and Zhang,Y.
  TITLE     USP12 positively regulates M-MDSC function to inhibit antitumour
            immunity through deubiquitinating and stabilizing p65
  JOURNAL   Immunology 167 (4), 544-557 (2022)
   PUBMED   35898171
  REMARK    GeneRIF: USP12 positively regulates M-MDSC function to inhibit
            antitumour immunity through deubiquitinating and stabilizing p65.
REFERENCE   5  (bases 1 to 4412)
  AUTHORS   Yang,Z., Xu,G., Wang,B., Liu,Y., Zhang,L., Jing,T., Tang,M., Xu,X.,
            Jiao,K., Xiang,L., Fu,Y., Tang,D., Zhang,X., Jin,W., Zhuang,G.,
            Zhao,X. and Liu,Y.
  TITLE     USP12 downregulation orchestrates a protumourigenic
            microenvironment and enhances lung tumour resistance to PD-1
            blockade
  JOURNAL   Nat Commun 12 (1), 4852 (2021)
   PUBMED   34381028
  REMARK    GeneRIF: USP12 downregulation orchestrates a protumourigenic
            microenvironment and enhances lung tumour resistance to PD-1
            blockade.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4412)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   7  (bases 1 to 4412)
  AUTHORS   Cohn,M.A., Kee,Y., Haas,W., Gygi,S.P. and D'Andrea,A.D.
  TITLE     UAF1 is a subunit of multiple deubiquitinating enzyme complexes
  JOURNAL   J Biol Chem 284 (8), 5343-5351 (2009)
   PUBMED   19075014
  REMARK    GeneRIF: two novel multisubunit deubiquitinating enzyme complexes
            containing USP12 and USP46, respectively. Both complexes contain
            the UAF1 protein as a bona fide subunit. Interestingly, UAF1
REFERENCE   8  (bases 1 to 4412)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 4412)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   10 (bases 1 to 4412)
  AUTHORS   Hansen-Hagge,T.E., Janssen,J.W., Hameister,H., Papa,F.R.,
            Zechner,U., Seriu,T., Jauch,A., Becke,D., Hochstrasser,M. and
            Bartram,C.R.
  TITLE     An evolutionarily conserved gene on human chromosome 5q33-q34,
            UBH1, encodes a novel deubiquitinating enzyme
  JOURNAL   Genomics 49 (3), 411-418 (1998)
   PUBMED   9615226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026072.1, AF022789.1 and AL355473.20.
            
            On Nov 23, 2018 this sequence version replaced NM_182488.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022789.1, SRR1803617.159262.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282344.11/ ENSP00000282344.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               BC026072.1         87-716
            631-1711            AF022789.1         566-1646
            1712-4412           AL355473.20        38320-41020         c
FEATURES             Location/Qualifiers
     source          1..4412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..4412
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /note="ubiquitin specific peptidase 12"
                     /db_xref="GeneID:219333"
                     /db_xref="HGNC:HGNC:20485"
                     /db_xref="MIM:603091"
     exon            1..220
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1285
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 12 like 1;
                     ubiquitin-specific-processing protease 12;
                     deubiquitinating enzyme 12; ubiquitin-hydrolyzing enzyme
                     1; ubiquitin thioesterase 12; ubiquitin thiolesterase 12"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 12"
                     /protein_id="NP_872294.2"
                     /db_xref="CCDS:CCDS31952.1"
                     /db_xref="GeneID:219333"
                     /db_xref="HGNC:HGNC:20485"
                     /db_xref="MIM:603091"
                     /translation="MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNF
                     GNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIP
                     PKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDN
                     ENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRG
                     FSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY
                     RVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDD
                     IVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD"
     exon            221..301
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..515
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..745
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..822
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..906
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1104
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1183
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..4412
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4412
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcctgag cgccggcggc gacgacggca gcggcggccc agcgggctcg gtggttgggt
       61 ccgcggcggc tcggggtccg cccgcgggct gcggtgcgag cgggcggccc ggctcccctc
      121 ctcccccgcc cgccgccgcc gctgtgattg ggtggaagat ggcgctggcc ggatggaaat
      181 cctaatgaca gtctccaaat tcgcctccat ctgtaccatg ggcgccaatg cttcggcatt
      241 agagaaagag attggtccag aacagtttcc ggtcaatgag cactattttg gattagtcaa
      301 ttttgggaat acctgctact gcaattcagt tcttcaagca ctttattttt gtcgtccatt
      361 tcgggaaaaa gttcttgcgt ataagagtca acctaggaaa aaggagagcc ttcttacatg
      421 cttagcagat ctcttccata gcatagccac tcagaagaaa aaggttggag taataccccc
      481 taagaagttc atcacaagat tacggaaaga aaatgagctt tttgacaact acatgcaaca
      541 agatgcccat gaattcttaa attacctact aaatacaatt gctgatattt tacaagaaga
      601 gagaaagcag gaaaaacaaa atggtcgttt acctaatggt aatattgata atgaaaataa
      661 taacagcaca ccagacccaa cgtgggttca tgagattttt cagggaacat taactaatga
      721 aaccagatgt cttacttgtg aaactataag cagcaaagat gaagattttt tagacctttc
      781 tgttgacgtg gaacaaaata catcaattac tcactgctta aggggtttca gcaacacaga
      841 aactctgtgc agtgaataca agtattactg tgaagagtgt cgcagcaaac aggaagcaca
      901 caaacggatg aaagttaaaa aactgcccat gattctagct ctacacctga agagatttaa
      961 atatatggat caacttcatc gatatacaaa actctcttac cgggtagttt ttcctttaga
     1021 acttcgtctg tttaacactt caggtgatgc caccaatcca gacagaatgt acgaccttgt
     1081 tgctgttgtg gttcactgtg gaagtggtcc caatcgaggc cattatattg caatagttaa
     1141 gagtcatgat ttttggttgt tgtttgatga cgacattgta gaaaaaatag atgcacaagc
     1201 tattgaagaa ttctacgggt tgacatcaga tatctcaaag aactctgagt ctggttacat
     1261 ccttttctat cagtctcggg actgagaggg aaccgtgatg aagagacact ttctgcctca
     1321 tttcttctct ggttattttg gaaaggatca agcactgatt tttcaagaaa agagaaatgc
     1381 aggaagctca gggggcagta gcacactttg cacacgataa agcaaagacg atggattgac
     1441 aagcccttcc gatcatggta gttgatttat ttgctcaggt atcatgctgt ctgtacagtt
     1501 ccatacaaca aggaggtgaa atcagagata ccagctcctc ttttaaaaca gccttccagt
     1561 cattggcacg cattttctct ttattaattg caccaataat gctttgaatt ccttgggggt
     1621 gcagtagaaa gaatcggaat ctgtgccgta ttgataagga gatgatgttg aacacactgc
     1681 ataaatttgc ctggttcagt atgtatagaa gcatattcag tggtcttttc aagagtaaac
     1741 cagaaatact tttgggccca acacttgcag ttgccttcct gatgtaaaaa ctaacatgct
     1801 agataatcca gtgtcgggaa gacaaagatg ttttgcttct ctgaagaagc ttataataat
     1861 atacagtata tgtatatgta gggagcaatt ggtcaaaagt ggctttttgt ttccccaagg
     1921 ggaaagactg gctttgtaat tataattttt tccttattta ttttacttaa aactggtaga
     1981 gtctaagtat tatatgaagt gcccatgatt ctgtcagtaa atttgaacat atttttatta
     2041 gttaatgtca gtttaagttg tccttttgtt tgtttctatt tttaaggtga attttaattt
     2101 ctatctgaaa tcagttaaga taccttgaga aaaactgcag tgagaggaga taaatatcct
     2161 ttttcaggag gaactgatat ctctggctaa atatttgtcc ttttattatg gtttctaaat
     2221 cagttatttt cttcagcttt aatttcataa aattaaaaaa ctattttaaa aattcctgta
     2281 gttgttggaa taattaaaaa ttctggtgca gtggtggtat accaatcttt agaattctta
     2341 agtattctaa tgtttcaagt tgagatcatg cttgggaaaa tcatgtcata gcatttatgt
     2401 tattttcaga tgccattttt taccctggaa agaagtcata atgttcatca taaccctagc
     2461 agcctggata gtgagctaaa caaacccttc aaagattaaa ttttaatcaa gtagaccggg
     2521 aatacaaaag acaagtcctt ccttcccttc cccccacctt tacaaatctt actggaaggg
     2581 tgttcagaaa ttaaaatctg tgtttgctaa gacttcattc tgttgggggt tttaagaagt
     2641 aatatatgta acataaaata tatgtaaacg attgcagttt ttttggacgt ttttccatgc
     2701 atcagtaagt tgtctgacag tagccaaatg taacttgcag aaaattattg aaaattatat
     2761 tcagaataat agcaatcagg ccttggatgt tctttattaa actcttttca ggcagtaaat
     2821 ttaaaaaaaa ttgtcatttt ctaaagtcct tttgctaaaa ctgttgacta tggaaaacaa
     2881 caaaaaggaa ttttttagtc tgctgctatt attaacattt attatctgta tcttttggct
     2941 caggaaatga cttcacctat tttttccata agcagacctt taacagagtc acttaattgg
     3001 gctgcttaaa cagatgttct gggagaaaat tataatattt agtatttgta caaaatatca
     3061 aaaagtattt tgacaagttt ctttttaaga tagttcctaa agccttaccc tggctagagg
     3121 tgttttgtac aaattatata taagccagcc tgatctacca acatgccaca gagaatcaca
     3181 atcaacagtg tggggaaagt cagggcagtg gaagtggatg cactcttttt attttgaagg
     3241 cttaaaccaa attgtcttgg aattaaagct gtatttctgc agctttcggt acagagaaaa
     3301 agaggaaagt gaagctgtgt cagttttaac attagctata tcaacatgtt taagaaagat
     3361 agatgaagtc atttgcataa aggtacagca ttgaaatact atgttgtgtt tgtttttaca
     3421 tttttgcatt aaaaaaaaac atgccgtaaa agccaagtta aatttcatat taaagcaagt
     3481 tctagtgtat gtgttgagtt cctggtaatc acatacttgt tcacatctac accgtacttc
     3541 atagtatgat ttgtcagggg agggattgtg gggtgacagt tttacattta ctttttcttc
     3601 ttaatgcagc tggatctaag taaaatgttt tgaagtttat cagaaactaa atgtactttt
     3661 aaaacgtata gggtcagggt tgggggaaaa atacaggtat agtaagtaag aaaagtgacc
     3721 catgaagaaa gcatcgtgag gttgtatgtt ggttgactgt gattaaaatg cggggctggt
     3781 gtaagttgta agtggtggct gattgccgtg taactatgta catgattgtt gggatggctg
     3841 tcccatattt tgtatattgg aataaaaatt tctataaatt attgtaacta aaagtaaata
     3901 ttctaaatta agtcccactt cttaagtcac atggcttctg tcttggaaat tttaccttta
     3961 aaagattatt taagacagga accaggaggc ttgggaacag ggaaagaggg aaatgttgta
     4021 ttatgtgggt cttggggcct ctaaccatca gtatagggtt ttttctttcc ttgatggcag
     4081 tagaaagacc tcattttcat aacataacta ctcttgatac tttctttaaa aacacttttt
     4141 attaaagatt ctatcatgag gtatttggct gggagctggg aggctaaagc gctcatgtcc
     4201 tggctcttca gtgaatttaa ctgtgtgacc ttgggcaagt cacttaacct ctctgtgctt
     4261 cagtctccct gtcttgtaaa atgggagtaa tacctacctc acagggttgt tgtggggatt
     4321 aattagagat aatgtctgta aagcatttaa ggttcttgaa gaaggcacta tataaataca
     4381 aaataatatc tattaaagtt ggtttatttg tg
//
