LOCUS       NM_001371072            3196 bp    mRNA    linear   PRI 01-FEB-2025
DEFINITION  Homo sapiens ubiquitin specific peptidase 11 (USP11), mRNA.
ACCESSION   NM_001371072
VERSION     NM_001371072.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3196)
  AUTHORS   Pornour,M., Jeon,H.Y., Ryu,H., Khadka,S., Xu,R., Chen,H.,
            Hussain,A., Lam,H.M., Zhuang,Z., Oo,H.Z., Gleave,M., Dong,X.,
            Wang,Q., Barbieri,C. and Qi,J.
  TITLE     USP11 promotes prostate cancer progression by up-regulating AR and
            c-Myc activity
  JOURNAL   Proc Natl Acad Sci U S A 121 (31), e2403331121 (2024)
   PUBMED   39052835
  REMARK    GeneRIF: USP11 promotes prostate cancer progression by
            up-regulating AR and c-Myc activity.
REFERENCE   2  (bases 1 to 3196)
  AUTHORS   Gao,J., Xu,Z., Song,W., Huang,J., Liu,W., He,Z. and He,L.
  TITLE     USP11 regulates proliferation and apoptosis of human spermatogonial
            stem cells via HOXC5-mediated canonical WNT/beta-catenin signaling
            pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 211 (2024)
   PUBMED   38722330
  REMARK    GeneRIF: USP11 regulates proliferation and apoptosis of human
            spermatogonial stem cells via HOXC5-mediated canonical
            WNT/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3196)
  AUTHORS   Li,T., Huang,J., Zeng,A., Yu,N. and Long,X.
  TITLE     Ubiquitin-specific peptidase 11 promotes development of keloid
            derived fibroblasts by de-ubiquitinating TGF-beta receptorII
  JOURNAL   Burns 50 (3), 641-652 (2024)
   PUBMED   38097445
  REMARK    GeneRIF: Ubiquitin-specific peptidase 11 promotes development of
            keloid derived fibroblasts by de-ubiquitinating TGF-beta
            receptorII.
REFERENCE   4  (bases 1 to 3196)
  AUTHORS   Zhou,F., Deng,Z., Shen,D., Lu,M., Li,M., Yu,J., Xiao,Y., Wang,G.,
            Qian,K., Ju,L. and Wang,X.
  TITLE     DLGAP5 triggers proliferation and metastasis of bladder cancer by
            stabilizing E2F1 via USP11
  JOURNAL   Oncogene 43 (8), 594-607 (2024)
   PUBMED   38182895
  REMARK    GeneRIF: DLGAP5 triggers proliferation and metastasis of bladder
            cancer by stabilizing E2F1 via USP11.
REFERENCE   5  (bases 1 to 3196)
  AUTHORS   Chen,J., Ning,D., Du,P., Liu,Q., Mo,J., Liang,H., Zhang,W.,
            Zhang,M., Jiang,L., Zhang,B. and Chen,X.
  TITLE     USP11 potentiates HGF/AKT signaling and drives metastasis in
            hepatocellular carcinoma
  JOURNAL   Oncogene 43 (2), 123-135 (2024)
   PUBMED   37973952
  REMARK    GeneRIF: USP11 potentiates HGF/AKT signaling and drives metastasis
            in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 3196)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   7  (bases 1 to 3196)
  AUTHORS   Stoddart,K.L., Jermak,C., Nagaraja,R., Schlessinger,D. and
            Bech-Hansen,N.T.
  TITLE     Physical map covering a 2 Mb region in human xp11.3 distal to
            DX6849
  JOURNAL   Gene 227 (1), 111-116 (1999)
   PUBMED   9931462
REFERENCE   8  (bases 1 to 3196)
  AUTHORS   Brandau,O., Nyakatura,G., Jedele,K.B., Platzer,M., Achatz,H.,
            Ross,M., Murken,J., Rosenthal,A. and Meindl,A.
  TITLE     UHX1 and PCTK1: precise characterisation and localisation within a
            gene-rich region in Xp11.23 and evaluation as candidate genes for
            retinal diseases mapped to Xp21.1-p11.2
  JOURNAL   Eur J Hum Genet 6 (5), 459-466 (1998)
   PUBMED   9801870
REFERENCE   9  (bases 1 to 3196)
  AUTHORS   D'Andrea,A. and Pellman,D.
  TITLE     Deubiquitinating enzymes: a new class of biological regulators
  JOURNAL   Crit Rev Biochem Mol Biol 33 (5), 337-352 (1998)
   PUBMED   9827704
  REMARK    Review article
REFERENCE   10 (bases 1 to 3196)
  AUTHORS   Swanson,D.A., Freund,C.L., Ploder,L., McInnes,R.R. and Valle,D.
  TITLE     A ubiquitin C-terminal hydrolase gene on the proximal short arm of
            the X chromosome: implications for X-linked retinal disorders
  JOURNAL   Hum Mol Genet 5 (4), 533-538 (1996)
   PUBMED   8845848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC140849.1 and AB073597.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Protein ubiquitination controls many intracellular
            processes, including cell cycle progression, transcriptional
            activation, and signal transduction. This dynamic process,
            involving ubiquitin conjugating enzymes and deubiquitinating
            enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are
            cysteine proteases that specifically cleave ubiquitin from
            ubiquitin-conjugated protein substrates. This gene encodes a
            deubiquitinating enzyme which lies in a gene cluster on chromosome
            Xp11.23 [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073597.1, U44839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377107.7/ ENSP00000366311.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2835              BC140849.1         144-2978
            2836-3195           BC140849.1         2981-3340
            3196-3196           AB073597.1         3192-3192
FEATURES             Location/Qualifiers
     source          1..3196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3196
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /note="ubiquitin specific peptidase 11"
                     /db_xref="GeneID:8237"
                     /db_xref="HGNC:HGNC:12609"
                     /db_xref="MIM:300050"
     exon            1..211
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2798
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin-specific processing protease 11;
                     deubiquitinating enzyme 11; ubiquitin thiolesterase 11;
                     ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin
                     thioesterase 11"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 11"
                     /protein_id="NP_001358001.1"
                     /db_xref="CCDS:CCDS14277.2"
                     /db_xref="GeneID:8237"
                     /db_xref="HGNC:HGNC:12609"
                     /db_xref="MIM:300050"
                     /translation="MATVAANPAAAAAAVAAAAAVTEDREPQHEELPGLDSQWRQIEN
                     GESGRERPLRAGESWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRL
                     KEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQKVEVYPVELLLVR
                     HNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITV
                     LDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCF
                     MNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSI
                     VPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPD
                     QEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHK
                     RVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFY
                     KLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYG
                     LMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEEDKDDV
                     PGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSN
                     GTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQE
                     CIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKL
                     DTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSG
                     QWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSS
                     EFMDVN"
     exon            212..321
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..452
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..570
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..716
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..778
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..881
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1055
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1214
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1439
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1523
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1618
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1825
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1878
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2121
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2192
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2305
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2455
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2571
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2660
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..3196
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3173..3178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /note="hexamer: TATAAA"
     polyA_site      3196
                     /gene="USP11"
                     /gene_synonym="UHX1"
                     /note="major polyA site"
ORIGIN      
        1 acagctgcgt tggctgtaga agagaacgga cggcgatggc gacggtcgca gcaaatccag
       61 ctgctgctgc ggcggctgtg gcggcggcag cggcggtgac tgaggataga gagccacagc
      121 acgaggagct gccaggcctg gacagccagt ggcgccagat agaaaacggc gagagtgggc
      181 gagaacgtcc actgcgggcc ggcgaaagct ggttccttgt ggagaagcac tggtataagc
      241 agtgggaggc atacgtgcag ggaggggacc aggactccag caccttccct ggctgcatca
      301 acaatgccac actctttcaa gatgagataa actggcgcct caaggaggga ctggtggaag
      361 gcgaggatta tgtgctgctc ccagcagctg cttggcatta cctggtcagc tggtatggtc
      421 tagagcatgg ccagccaccc attgaacgca aggtcataga gctgcccaac atccagaagg
      481 tcgaagtgta cccagtagaa ctgctgcttg tccggcacaa tgatttgggc aaatctcaca
      541 ctgttcagtt cagccatacc gattctattg gcctagtatt gcgcacagct cgggagcggt
      601 ttctggtgga gccccaggaa gacactcggc tttgggccaa gaactcagaa ggctctttgg
      661 ataggttgta tgacacacac atcacggttc tcgatgcggc ccttgagact gggcagttga
      721 tcatcatgga gacccgcaag aaagatggca cttggcccag cgcacagctg catgtcatga
      781 acaacaacat gtcggaagag gatgaggact tcaagggtca gccaggcatc tgtggcctca
      841 ccaatctggg caacacgtgc ttcatgaact cggccctgca gtgcctcagc aatgtgccac
      901 agctcaccga gtacttcctc aacaactgct acctggagga gctcaacttc cgcaacccac
      961 tgggcatgaa gggtgagatc gcagaggcct atgcagacct ggtgaagcag gcgtggtctg
     1021 gccaccaccg ctccattgtg ccacatgtgt tcaagaacaa ggttggccat tttgcatccc
     1081 aatttctggg ctaccagcag catgactctc aggagctgct gtcattcctc ctggacgggc
     1141 tgcatgagga ccttaatcgg gtgaagaaga aggagtatgt ggagctgtgc gatgctgctg
     1201 ggcgaccgga tcaggaggtg gcacaggagg catggcaaaa ccacaaacgg cggaacgatt
     1261 ctgtgatcgt ggacactttc cacggcctct tcaagtccac gctggtgtgc cccgattgtg
     1321 gcaatgtatc tgtgaccttc gaccccttct gctacctcag tgttccactg cctatcagcc
     1381 acaagagggt cttggaggtc ttctttatcc ccatggatcc gcgccgcaag ccagagcagc
     1441 accggctcgt ggtccccaag aaaggcaaga tctcggatct atgtgtggct ctgtccaaac
     1501 acacgggcat ctcgccagag aggatgatgg tggctgatgt cttcagtcac cgcttctata
     1561 agctctatca gctagaggag cctctgagca gcatcttgga ccgtgatgat atcttcgtct
     1621 atgaggtgtc aggtcgcatt gaggccattg agggctcaag agaggacatc gtggttcctg
     1681 tctacctgcg ggagcgcacc cctgcccgtg actacaacaa ctcctactac ggcctgatgc
     1741 tttttggaca ccccctcctg gtatcagtgc cccgggaccg cttcacctgg gagggcctgt
     1801 ataacgtcct gatgtaccgg ctctcacgct acgtgaccaa acccaactca gatgatgagg
     1861 acgatgggga tgagaaagaa gatgacgagg aggataaaga tgacgtccct gggccctcaa
     1921 ctgggggcag cctccgagac cctgagccag agcaggctgg gcccagctct ggagtcacga
     1981 acaggtgccc gttcctcctg gacaattgcc ttggcacatc tcagtggccc ccaaggcgac
     2041 gacgcaagca gctgttcacc ctgcagacgg tgaactccaa tgggaccagc gaccgcacaa
     2101 cctcccctga agaagtccat gcccagccgt acattgctat cgactgggag ccagagatga
     2161 agaagcgtta ctatgacgag gtagaggctg agggctacgt gaagcatgac tgcgtcgggt
     2221 acgtgatgaa gaaggctccc gtgcggctgc aggagtgcat tgagctcttc accactgtgg
     2281 agaccctgga gaaggaaaac ccctggtact gcccttcctg caagcagcac cagctggcaa
     2341 ccaagaagct ggacctgtgg atgctgccgg agattctcat catccacctg aaacgctttt
     2401 cctacaccaa gttctcccga gagaagctgg acaccctcgt ggagtttcct atccgggacc
     2461 tggacttctc tgagtttgtc atccagccac agaatgagtc gaatccggag ctgtacaaat
     2521 atgacctcat cgcggtttcc aaccattatg ggggcatgcg tgatggacac tacacaacat
     2581 ttgcctgcaa caaggacagc ggccagtggc actactttga tgacaacagc gtctcccctg
     2641 tcaatgagaa tcagatcgag tccaaggcag cctatgtcct cttctaccaa cgccaggacg
     2701 tggcgcgacg cctgctgtcc ccggccggct catctggcgc cccagcctcc cctgcctgca
     2761 gctccccacc cagctctgag ttcatggatg ttaattgaga gccctgggtc ctgccacaga
     2821 aaaaaaaaaa aaaaagccct ctctgcaatc tcgcttctcg tgtccgcccc gcttctctta
     2881 ttcgtgttag gtgcccccgc caggcattgc aggcttagtc gtggctactg ttctcctgtg
     2941 ccgctgcatc gctctctccc gggaaagaac aggtcgtgtc tcctcctagc agtgcgcgcc
     3001 ccgcctgtgt ttgcccttcc agcagtgacc ctcccttcta gtctttattt atggtcgtgc
     3061 ccttccctct cctcagccca gagtgttctg cgtgggtggt gatgggggtt cacctgaaca
     3121 cagagtgtat tttcttattg aggccctgta ccttctgctg tgtgtgtgta tatataaagc
     3181 accagtctgc tcccca
//
