LOCUS       NM_005153               3328 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 10 (USP10), transcript
            variant 2, mRNA.
ACCESSION   NM_005153
VERSION     NM_005153.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Li,F., He,Z., Zhang,X., Gao,D., Xu,R., Zhang,Z., Cao,X., Shan,Q.,
            Liu,Y. and Xu,Z.
  TITLE     USP10 promotes cell proliferation, migration, and invasion in NSCLC
            through deubiquitination and stabilization of EIF4G1
  JOURNAL   Sci Rep 14 (1), 23685 (2024)
   PUBMED   39390016
  REMARK    GeneRIF: USP10 promotes cell proliferation, migration, and invasion
            in NSCLC through deubiquitination and stabilization of EIF4G1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Zhao,Q., Zhang,R., Wang,Y., Li,T., Xue,J. and Chen,Z.
  TITLE     FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced acute
            kidney injury by targeting the CREB5/NF-kappaB signaling axis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167331 (2024)
   PUBMED   38960057
  REMARK    GeneRIF: FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced
            acute kidney injury by targeting the CREB5/NF-kappaB signaling
            axis.
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Wang,J., Gan,L., Liu,F., Yang,Q., Deng,Q., Jiang,D., Zhang,C.,
            Zhang,L. and Wang,X.
  TITLE     USP10 promotes pancreatic ductal adenocarcinoma progression by
            attenuating FOXC1 protein degradation to activate the WNT signaling
            pathway
  JOURNAL   Int J Biol Sci 20 (13), 5343-5362 (2024)
   PUBMED   39430239
  REMARK    GeneRIF: USP10 promotes pancreatic ductal adenocarcinoma
            progression by attenuating FOXC1 protein degradation to activate
            the WNT signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Zhao,M., Zheng,Z., Peng,S., Xu,Y., Zhang,J., Liu,J., Pan,W.,
            Yin,Z., Xu,S., Wei,C., Wang,M., Wan,J. and Qin,J.J.
  TITLE     Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3
            Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting
            Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination
  JOURNAL   J Am Heart Assoc 13 (6), e031283 (2024)
   PUBMED   38456416
  REMARK    GeneRIF: Epidermal Growth Factor-Like Repeats and Discoidin I-Like
            Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by
            Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4
            Deubiquitination.
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Li,P., Yang,L., Park,S.Y., Liu,F., Li,A.H., Zhu,Y., Sui,H., Gao,F.,
            Li,L., Ye,L., Zou,Y., Tian,Z., Zhao,Y., Costa,M., Sun,H. and
            Zhao,X.
  TITLE     Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous
            cell carcinoma proliferation and metastasis through epigenetic
            activation of ANXA2/Wnt signaling
  JOURNAL   Oncogene 43 (12), 899-917 (2024)
   PUBMED   38317006
  REMARK    GeneRIF: Stabilization of MOF (KAT8) by USP10 promotes esophageal
            squamous cell carcinoma proliferation and metastasis through
            epigenetic activation of ANXA2/Wnt signaling.
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   Faus,H., Meyer,H.A., Huber,M., Bahr,I. and Haendler,B.
  TITLE     The ubiquitin-specific protease USP10 modulates androgen receptor
            function
  JOURNAL   Mol Cell Endocrinol 245 (1-2), 138-146 (2005)
   PUBMED   16368182
  REMARK    GeneRIF: The data indicate that USP10 is a new cofactor that binds
            to the androgen receptor (AR) and stimulates the androgen response
            of target promoters. This finding underlines the role of the
            ubiquitin/proteasome system in modulating the AR function.
REFERENCE   7  (bases 1 to 3328)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   8  (bases 1 to 3328)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 3328)
  AUTHORS   Soncini,C., Berdo,I. and Draetta,G.
  TITLE     Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10,
            a novel human ubiquitin specific protease
  JOURNAL   Oncogene 20 (29), 3869-3879 (2001)
   PUBMED   11439350
  REMARK    GeneRIF: Ras-GAP SH3 domain binding protein (G3BP) is a modulator
            of USP10.  G3BP does not appear to be a substrate of USP10; it
            rather inhibits its ability to disassemble ubiquitin chains.
REFERENCE   10 (bases 1 to 3328)
  AUTHORS   D'Andrea,A. and Pellman,D.
  TITLE     Deubiquitinating enzymes: a new class of biological regulators
  JOURNAL   Crit Rev Biochem Mol Biol 33 (5), 337-352 (1998)
   PUBMED   9827704
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000263.1, AC009116.8 and
            BX537402.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005153.2.
            
            Summary: Ubiquitin is a highly conserved protein that is covalently
            linked to other proteins to regulate their function and
            degradation. This gene encodes a member of the ubiquitin-specific
            protease family of cysteine proteases. The enzyme specifically
            cleaves ubiquitin from ubiquitin-conjugated protein substrates. The
            protein is found in the nucleus and cytoplasm. It functions as a
            co-factor of the DNA-bound androgen receptor complex, and is
            inhibited by a protein in the Ras-GTPase pathway. The human genome
            contains several pseudogenes similar to this gene. Several
            transcript variants, some protein-coding and others not
            protein-coding, have been found for this gene. [provided by RefSeq,
            Jan 2013].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' end compared to variant 1. The resulting isoform (2) has a
            shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2049349.1,
                                           SRR1803612.198702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000219473.12/
                                                ENSP00000219473.7
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               BC000263.1         23-715
            694-701             AC009116.8         117077-117084
            702-2973            BC000263.1         724-2995
            2974-3328           BX537402.1         2963-3317
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..3328
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /note="ubiquitin specific peptidase 10"
                     /db_xref="GeneID:9100"
                     /db_xref="HGNC:HGNC:12608"
                     /db_xref="MIM:609818"
     exon            1..112
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2488
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 10; ubiquitin
                     carboxyl-terminal hydrolase 10; ubiquitin thioesterase 10;
                     deubiquitinating enzyme 10; ubiquitin-specific-processing
                     protease 10; ubiquitin thiolesterase 10"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 10 isoform
                     2"
                     /protein_id="NP_005144.2"
                     /db_xref="CCDS:CCDS45537.1"
                     /db_xref="GeneID:9100"
                     /db_xref="HGNC:HGNC:12608"
                     /db_xref="MIM:609818"
                     /translation="MALHSPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQA
                     VDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPD
                     GITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYY
                     SYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDS
                     VSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGT
                     DTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTL
                     PVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPV
                     AIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYS
                     KVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLL
                     TVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNE
                     EEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESAT
                     LQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVL
                     VLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYH
                     HGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDLL
                     "
     exon            113..181
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            182..242
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            243..1283
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1375
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1485
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1541
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1645
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1745
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1923
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2089
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2234
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2300
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..3328
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="USP10"
                     /gene_synonym="UBPO"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtgtat gtgcgggcga gaagatggcg gcggcggggg aagcagcgtg agcagccgga
       61 ggatcgcgga gtcccaatga aacgggcagc catggccctc cacagcccgc agtatatttt
      121 tggagatttt agccctgatg aattcaatca attctttgtg actcctcgat cttcagttga
      181 gcttcctcca tacagtggaa cagttctgtg tggcacacag gctgtggata aactacctga
      241 tggacaagaa tatcagagaa ttgagtttgg tgtcgatgaa gtcattgaac ccagtgacac
      301 tttgccgaga acccccagct acagtatttc aagcacactg aaccctcagg cccctgaatt
      361 tattctcggt tgtacagctt ccaaaataac ccctgatggt atcactaaag aagcaagcta
      421 tggctccatc gactgccagt acccaggctc tgccctcgct ttggatggaa gttctaatgt
      481 ggaggcggaa gttttggaaa atgatggtgt ctcaggtggt cttggacaaa gggagcgtaa
      541 aaagaagaaa aagcggccac ctggatatta cagctatttg aaagatggtg gcgatgatag
      601 tatctccaca gaagccctgg tcaatggcca tgccaattca gcagtcccga acagtgtcag
      661 tgcagaggat gcagaattta tgggtgacat gcccccgtca gttacgccca ggacttgtaa
      721 cagcccccag aactccacag actctgtcag tgacattgtg cctgacagtc ctttccccgg
      781 agcactcggc agtgacacca ggactgcagg gcagccagag gggggccccg gggctgattt
      841 tggtcagtcc tgcttccctg cagaggctgg cagagacacc ctgtcaagga cagctggggc
      901 tcagccctgc gttggtaccg atactactga aaaccttgga gttgctaatg gacaaatact
      961 tgaatcctcg ggtgagggca cagctaccaa cggggtggag ttgcacacca cggaaagcat
     1021 agacttggac ccaaccaaac ccgagagtgc atcacctcct gctgacggca cgggctctgc
     1081 atcaggcacc cttcctgtca gccagcccaa gtcctgggcc agcctctttc atgattctaa
     1141 gccctcttcc tcctcgccgg tggcctatgt ggaaactaag tattcccctc ccgccatatc
     1201 tcccctggtt tctgaaaagc aggttgaagt caaagaaggg cttgttccgg tttcagagga
     1261 tcctgtagcc ataaagattg cagagttgct ggagaatgta accctaatcc ataaaccagt
     1321 gtcgttgcaa ccccgtgggc tgatcaataa agggaactgg tgctacatta atgctacact
     1381 gcaggcattg gttgcttgcc cgccgatgta ccacctgatg aagttcattc ctctgtattc
     1441 caaagtgcaa aggccttgta cgtcaacacc catgatagac agctttgttc ggctaatgaa
     1501 tgagttcact aatatgccag tacctccaaa accccgacaa gctcttggag ataaaatcgt
     1561 gagggatatt cgccctggag ctgcctttga gcccacatat atttacagac tcctgacagt
     1621 taacaagtca agcctgtctg aaaagggtcg acaagaagat gctgaggaat acttaggctt
     1681 cattctaaat ggacttcatg aggaaatgtt gaacctaaag aagcttctct caccaagtaa
     1741 tgaaaaactt acgatttcca acggccccaa aaaccactcg gtcaatgaag aagagcagga
     1801 agaacaaggt gaaggaagcg aggatgaatg ggaacaagtg ggcccccgga acaagacttc
     1861 cgtcacccgc caggcggatt ttgttcagac tccaatcacc ggcatttttg gtggacacat
     1921 caggtctgtg gtttaccagc agagttcaaa agaatctgcc actttgcagc catttttcac
     1981 gttgcagttg gatatccagt cagacaagat acgcacagtc caggatgcac tggagagctt
     2041 ggtggcaaga gaatctgtcc aaggttatac cacaaaaacc aaacaagagg ttgagataag
     2101 tcgaagagtg actctggaaa aactccctcc tgtcctcgtg ctgcacctga aacgattcgt
     2161 ttatgagaag actggtgggt gccagaagct tatcaaaaat attgaatatc ctgtggactt
     2221 ggaaattagt aaagaactgc tttctccagg ggttaaaaat aagaatttta aatgccaccg
     2281 aacctatcgg ctctttgcag tggtctacca tcacggcaac agtgcgacgg gcggccatta
     2341 cactacagac gtcttccaga tcggtctgaa tggctggctg cgcatcgatg accagacagt
     2401 caaggtgatc aaccagtacc aggtggtgaa accaactgct gaacgcacag cctacctcct
     2461 gtattaccgc cgagtggacc tgctgtaaac cctgtgtgcg ctgtgtgtgc gcccagtgcc
     2521 cgcttcgtag gacaccacct cacactcact tcccgcctct ctttagtggc tctttagaga
     2581 gaaactcttt ctccctttgc aaaaatgggc tagaatgaaa aggagatgcc ttggggttcg
     2641 tgcacaacac agcttctgtt gactctaact tccaaatcaa aatcatttgg ttgaaacaga
     2701 ctgttgcttg attttagaaa atacacaaaa acccatattt ctgaaataat gctgattcct
     2761 gagataagaa agtggatttg atccccagtc tcattgctta gtagaataaa tcctgcacca
     2821 gcaacaacac ttgtaaattt gtgaaaatga attttatctt tccttaaaaa agaaattttt
     2881 taatccatca cacttttctt ccctaccctt tagtttttga taaatgataa aaatgagcca
     2941 gttatcaaag aagaactagt tcttacttca aaagaaaaat aaacataaaa aataagttgc
     3001 tggttcctaa caggaaaaat tttaataatt gtactgagag aaactgctta cgtacacatt
     3061 gcagatcaaa tatttggagt taaaatgtta gtctacatag atgggtgatt gtaactttat
     3121 tgccattaaa agatttcaaa ttgcattcat gcttctgtgt acacataatg aaaaatgggc
     3181 aaataatgaa gatctctcct tcagtctgct ctgtttaatt ctgctgtctg ctcttctcta
     3241 atgctgcgtc cctaattgta cacagtttag tgatatctag gagtataaag ttgtcgccca
     3301 tcaataaaaa tcacaaagtt ggtttaaa
//
