LOCUS       NM_003368               3602 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 1 (USP1), transcript
            variant 1, mRNA.
ACCESSION   NM_003368
VERSION     NM_003368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Zhou,H., Deng,C. and Xi,Y.
  TITLE     Mechanism of HOXA10 in nasopharyngeal carcinoma cell proliferation
            through the PTPRG-AS1/USP1 axis
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70025 (2024)
   PUBMED   39445487
  REMARK    GeneRIF: Mechanism of HOXA10 in nasopharyngeal carcinoma cell
            proliferation through the PTPRG-AS1/USP1 axis.
REFERENCE   2  (bases 1 to 3602)
  AUTHORS   Nusawardhana,A., Pale,L.M., Nicolae,C.M. and Moldovan,G.L.
  TITLE     USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent
            DNA strand discontinuities during replication stress
  JOURNAL   Nucleic Acids Res 52 (5), 2340-2354 (2024)
   PUBMED   38180818
  REMARK    GeneRIF: USP1-dependent nucleolytic expansion of PRIMPOL-generated
            nascent DNA strand discontinuities during replication stress.
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Li,N., Zhang,E., Li,Z., Lv,S., Zhao,X., Ke,Q., Zou,Q., Li,W.,
            Wang,Y., Guo,H., Song,T. and Sun,L.
  TITLE     The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer
            through USP1
  JOURNAL   J Biol Chem 300 (3), 105707 (2024)
   PUBMED   38309505
  REMARK    GeneRIF: The P53-P21-RB1 pathway promotes BRD4 degradation in liver
            cancer through USP1.
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Hu,Y., Li,X., Zhang,J., Liu,D., Lu,R. and Li,J.D.
  TITLE     A genome-wide CRISPR screen identifies USP1 as a novel regulator of
            the mammalian circadian clock
  JOURNAL   FEBS J 291 (3), 445-457 (2024)
   PUBMED   37909373
  REMARK    GeneRIF: A genome-wide CRISPR screen identifies USP1 as a novel
            regulator of the mammalian circadian clock.
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Yu,Z., Tong,L., Ma,C., Song,H., Wang,J., Chai,L., Wang,C., Wang,M.,
            Wang,C., Yan,R., Fu,Y., Jia,M., Zhao,W. and Zhao,C.
  TITLE     The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses
  JOURNAL   J Immunol 212 (2), 295-301 (2024)
   PUBMED   38054892
  REMARK    GeneRIF: The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses.
REFERENCE   6  (bases 1 to 3602)
  AUTHORS   Cohn,M.A., Kowal,P., Yang,K., Haas,W., Huang,T.T., Gygi,S.P. and
            D'Andrea,A.D.
  TITLE     A UAF1-containing multisubunit protein complex regulates the
            Fanconi anemia pathway
  JOURNAL   Mol Cell 28 (5), 786-797 (2007)
   PUBMED   18082604
REFERENCE   7  (bases 1 to 3602)
  AUTHORS   Huang,T.T., Nijman,S.M., Mirchandani,K.D., Galardy,P.J., Cohn,M.A.,
            Haas,W., Gygi,S.P., Ploegh,H.L., Bernards,R. and D'Andrea,A.D.
  TITLE     Regulation of monoubiquitinated PCNA by DUB autocleavage
  JOURNAL   Nat Cell Biol 8 (4), 339-347 (2006)
   PUBMED   16531995
REFERENCE   8  (bases 1 to 3602)
  AUTHORS   Nijman,S.M., Huang,T.T., Dirac,A.M., Brummelkamp,T.R.,
            Kerkhoven,R.M., D'Andrea,A.D. and Bernards,R.
  TITLE     The deubiquitinating enzyme USP1 regulates the Fanconi anemia
            pathway
  JOURNAL   Mol Cell 17 (3), 331-339 (2005)
   PUBMED   15694335
  REMARK    GeneRIF: USP1 deubiquitinates FANCD2 protein when cells exit S
            phase or recommence cycling after a DNA damage insult and may play
            a critical role in the Fanconi anemia pathway by recycling FANCD2.
REFERENCE   9  (bases 1 to 3602)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 3602)
  AUTHORS   Fujiwara,T., Saito,A., Suzuki,M., Shinomiya,H., Suzuki,T.,
            Takahashi,E., Tanigami,A., Ichiyama,A., Chung,C.H., Nakamura,Y. and
            Tanaka,K.
  TITLE     Identification and chromosomal assignment of USP1, a novel gene
            encoding a human ubiquitin-specific protease
  JOURNAL   Genomics 54 (1), 155-158 (1998)
   PUBMED   9806842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018745.1, BC050525.1,
            BQ186837.1 and BQ018843.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003368.4.
            
            Summary: This gene encodes a member of the ubiquitin-specific
            processing (UBP) family of proteases that is a deubiquitinating
            enzyme (DUB) with His and Cys domains. This protein is located in
            the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused
            precursors and ubiquitinylated proteins. The protein specifically
            deubiquitinates a protein in the Fanconi anemia (FA) DNA repair
            pathway. Alternate transcriptional splice variants have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.242657.1,
                                           SRR1660803.161992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339950.5/ ENSP00000343526.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               BC018745.1         338-492
            156-2922            BC050525.1         197-2963
            2923-3067           BQ186837.1         7-151
            3068-3602           BQ018843.1         17-551              c
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..3602
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /note="ubiquitin specific peptidase 1"
                     /db_xref="GeneID:7398"
                     /db_xref="HGNC:HGNC:12607"
                     /db_xref="MIM:603478"
     exon            1..352
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            353..591
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2779
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 1; deubiquitinating
                     enzyme 1; ubiquitin specific processing protease 1;
                     ubiquitin thiolesterase 1; hUBP; ubiquitin thioesterase 1;
                     Ubiquitinyl hydrolase 1, Ubiquitin carboxyl-terminal
                     hydrolase 1, ubiquitin thiolesterase 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 1"
                     /protein_id="NP_003359.3"
                     /db_xref="CCDS:CCDS621.1"
                     /db_xref="GeneID:7398"
                     /db_xref="HGNC:HGNC:12607"
                     /db_xref="MIM:603478"
                     /translation="MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQE
                     NEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFC
                     PGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQ
                     ASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLL
                     KKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTE
                     FGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKK
                     SRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTN
                     GCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERR
                     EDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCEN
                     CHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEE
                     WSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKP
                     EPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYN
                     KASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQTGINISGFENKISYVVQSL
                     KEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL"
     exon            592..712
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            713..817
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            818..978
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1670
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1841
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2043
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..3602
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /note="major polyA site"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP1"
                     /gene_synonym="UBP"
                     /note="hexamer: AATACA"
     polyA_site      3602
                     /gene="USP1"
                     /gene_synonym="UBP"
ORIGIN      
        1 gaaaacgcgc caagttcccc tcggtggcgg agtgctaaag accctagcgg ttcaggcgtt
       61 cggcgagcgg ggccgctgct tgttgcgctc ctggctctcc cggggcgggc gcagatgggc
      121 gccgctcccg ggatgtagtt ggtgttggtg caagacggga gcgagcggcg gtcggggttc
      181 ccgctcttgg gagcggatgg tcactccccc gcggggaggg cgagccgacc agattttcct
      241 ggggccgggg acccggcggg ctcggggcag ggactcacct gtcgcaccca cactcattcg
      301 ggttggactt gccggcgtca ccgccgcgga cttcgctttg ggccatgacc agatataatt
      361 ggtgattaca actttcctct ataaattaac tcttgacact ccttgggatt tgaagaaaaa
      421 aatgcctggt gtcataccta gtgaaagtaa tggactttca agaggtagcc cttcaaagaa
      481 aaacagactt tccttaaagt tttttcagaa aaaggaaact aagagagctt tggatttcac
      541 agattctcaa gaaaatgaag aaaaagcttc tgaatataga gcatctgaaa ttgatcaagt
      601 tgttcctgca gcacagtctt cacctataaa ctgtgagaag agagaaaact tgttaccatt
      661 tgtgggactg aataatctcg gcaatacttg ctatcttaat agtatacttc aggtattata
      721 tttttgtccc ggttttaaat ctggagtaaa gcacttattt aatattattt caaggaagaa
      781 agaagctcta aaggatgaag ccaatcaaaa agacaaggga aattgcaaag aagattcttt
      841 ggcaagttat gaattgatat gcagtttaca gtccttaatc atttcggttg aacagctcca
      901 ggctagtttt ctcttaaatc cagagaaata tactgatgaa cttgccactc agccaaggcg
      961 actgcttaac acactgaggg aactcaaccc tatgtatgaa ggatatctac agcatgatgc
     1021 acaggaagta ttacaatgta ttttgggaaa cattcaagaa acatgccaac tcctaaaaaa
     1081 agaagaagta aaaaatgtgg cagaattacc tactaaggta gaagaaatac ctcatccgaa
     1141 agaggaaatg aatggtatta acagcataga gatggacagt atgaggcatt ctgaagactt
     1201 taaagagaaa ctcccaaaag gaaatgggaa aagaaaaagt gacactgaat ttggtaacat
     1261 gaagaaaaaa gttaaattat ccaaggaaca ccagtcattg gaagagaacc agagacaaac
     1321 tagatcaaaa agaaaagcta caagtgatac attagagagt cctcctaaaa taattcccaa
     1381 gtatatttct gaaaatgaga gtccaagacc ctcacaaaag aaatcaagag ttaaaataaa
     1441 ttggttaaag tctgcaacta agcaacccag cattctttct aaattttgta gtctgggaaa
     1501 aataacaaca aaccaaggag tcaaaggaca atctaaagaa aatgaatgtg atcctgaaga
     1561 ggacttgggg aagtgtgaaa gtgataacac aactaatggt tgtggacttg aatctccagg
     1621 aaatactgtt acacctgtaa atgttaatga agttaaaccc ataaacaaag gtgaagaaca
     1681 aattggtttt gagctagtgg agaaattatt tcaaggtcag ctggtattaa ggacgcgttg
     1741 cttggaatgt gaaagtttaa cagaaagaag agaagatttt caagacatca gtgtgccagt
     1801 acaagaagat gagctttcca aagtagagga gagttctgaa atttctccag agccaaaaac
     1861 agaaatgaag accctgagat gggcaatttc acaatttgct tcagtagaaa ggattgtagg
     1921 agaagataaa tatttctgtg aaaactgcca tcattatact gaagctgaac gaagtctttt
     1981 gtttgacaaa atgcctgaag ttataactat tcatttgaag tgctttgctg ctagtggttt
     2041 ggagtttgat tgttatggtg gtggactttc caagatcaac actcctttat tgacacctct
     2101 taaattgtca ctagaagaat ggagcacaaa gccaactaac gacagctatg gattatttgc
     2161 ggttgtgatg catagtggca ttacaattag tagtgggcat tacactgctt ctgttaaagt
     2221 cactgacctt aacagtttag aactagataa aggaaatttt gtggttgacc aaatgtgtga
     2281 aataggtaag ccagaaccat tgaatgagga ggaagcaagg ggtgtggttg agaattataa
     2341 tgatgaagaa gtgtcaatta gagttggtgg aaatacacag ccaagtaaag ttttgaacaa
     2401 aaaaaatgta gaagctattg gacttcttgg aggacaaaag agcaaagcag attatgagct
     2461 atacaacaaa gcctctaatc ctgataaggt tgctagtaca gcgtttgctg aaaatagaaa
     2521 ttctgagact agtgatacta ctgggaccca tgaatctgat agaaacaagg aatccagtga
     2581 ccaaacaggc attaatatta gtggatttga gaacaaaatt tcatacgtag tgcaaagctt
     2641 aaaggagtat gaggggaagt ggttgctttt tgatgattct gaagtcaaag ttactgaaga
     2701 gaaggacttt ctgaattctc tttccccttc tacatctcct acttctactc cttacttgct
     2761 attttataag aaattataga gtgagtgtat tttccttgtg tatatattaa acacacccat
     2821 acaaacattg gtaaagttga ttacatcaaa gaatctttag cttatctttt gaagctactg
     2881 gatattattg gtctctctag gtttttatat aaatagtgaa atttgaatta ctgaaaacca
     2941 tgttaatttt tagaactcat tttcctcagt agagactagt gatgcattag cttctgggaa
     3001 caaacttgta tcggttctta attaaattat ccaaaacgga ggcatttaaa cacttggatt
     3061 tacaccagtc ttttgtgttt gctttttaaa ataaagtgct cgtatttgta ttctccatat
     3121 tttggagtaa ttatctacat gatgtttata gttcctgtgg tttttcaccc aagaagcaga
     3181 atctcattca gtacatttag ttttataaga gtcatgaagc taaatccttg ggctatgtca
     3241 gaggcacaaa gtctagaatg tgtgtattca caatggtgta tgtacatttt gtgccttgat
     3301 tcacttagaa gtgtctcaga aaacctggac agttcgcttc tacacaagaa ttttatatgt
     3361 atttatgaag atgattctgt accctagtat atctttttgg gcatggacta atttgtatct
     3421 gtttaactca tattctgcac gatctgtata tagtacatca aacttagagg tgtgacctta
     3481 aatttaactt tttttaaaaa ctgggaggtc aataaaattt aaactgctta actatgtata
     3541 tgaatatttg aattttttac ttgtatattt ttataaatac agctgagttt tcttaaagcg
     3601 aa
//
