LOCUS       NM_206933              18938 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens usherin (USH2A), transcript variant 2, mRNA.
ACCESSION   NM_206933
VERSION     NM_206933.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18938)
  AUTHORS   Serra,R., Rallo,V., Steri,M., Olla,S., Piras,M.G., Marongiu,M.,
            Gorospe,M., Schlessinger,D., Pinna,A., Fiorillo,E., Cucca,F. and
            Angius,A.
  TITLE     A large-scale screening identified in USH2A gene the P3272L founder
            pathogenic variant explaining familial Usher syndrome in Sardinia,
            Italy
  JOURNAL   BMC Ophthalmol 24 (1), 306 (2024)
   PUBMED   39044131
  REMARK    GeneRIF: A large-scale screening identified in USH2A gene the
            P3272L founder pathogenic variant explaining familial Usher
            syndrome in Sardinia, Italy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18938)
  AUTHORS   Baux,D., Faugere,V., Larrieu,L., Le Guedard-Mereuze,S., Hamroun,D.,
            Beroud,C., Malcolm,S., Claustres,M. and Roux,A.F.
  TITLE     UMD-USHbases: a comprehensive set of databases to record and
            analyse pathogenic mutations and unclassified variants in seven
            Usher syndrome causing genes
  JOURNAL   Hum Mutat 29 (8), E76-E87 (2008)
   PUBMED   18484607
REFERENCE   3  (bases 1 to 18938)
  AUTHORS   Baux,D., Larrieu,L., Blanchet,C., Hamel,C., Ben Salah,S.,
            Vielle,A., Gilbert-Dussardier,B., Holder,M., Calvas,P., Philip,N.,
            Edery,P., Bonneau,D., Claustres,M., Malcolm,S. and Roux,A.F.
  TITLE     Molecular and in silico analyses of the full-length isoform of
            usherin identify new pathogenic alleles in Usher type II patients
  JOURNAL   Hum Mutat 28 (8), 781-789 (2007)
   PUBMED   17405132
  REMARK    GeneRIF: A previously unrecognized cysteine rich structural domain
            was identified, with three missense mutations that result in the
            loss of one of a pair of the defining cysteine-cysteine pairs.
REFERENCE   4  (bases 1 to 18938)
  AUTHORS   Liu,X., Bulgakov,O.V., Darrow,K.N., Pawlyk,B., Adamian,M.,
            Liberman,M.C. and Li,T.
  TITLE     Usherin is required for maintenance of retinal photoreceptors and
            normal development of cochlear hair cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (11), 4413-4418 (2007)
   PUBMED   17360538
  REMARK    GeneRIF: usherin in photoreceptors is tethered via its C terminus
            to the plasma membrane and its large extracellular domain projects
            into the periciliary matrix, where they may interact with the
            connecting cilium to fulfill important structural or signaling
            roles
REFERENCE   5  (bases 1 to 18938)
  AUTHORS   van Wijk,E., Pennings,R.J., te Brinke,H., Claassen,A., Yntema,H.G.,
            Hoefsloot,L.H., Cremers,F.P., Cremers,C.W. and Kremer,H.
  TITLE     Identification of 51 novel exons of the Usher syndrome type 2A
            (USH2A) gene that encode multiple conserved functional domains and
            that are mutated in patients with Usher syndrome type II
  JOURNAL   Am J Hum Genet 74 (4), 738-744 (2004)
   PUBMED   15015129
  REMARK    GeneRIF: Mutation analysis in 12 unrelated patients with Usher
            syndrome, each with one mutation in exons 1-21, revealed three
            different truncating mutations in four patients and two missense
            mutations in one patient
REFERENCE   6  (bases 1 to 18938)
  AUTHORS   Bhattacharya,G., Miller,C., Kimberling,W.J., Jablonski,M.M. and
            Cosgrove,D.
  TITLE     Localization and expression of usherin: a novel basement membrane
            protein defective in people with Usher's syndrome type IIa
  JOURNAL   Hear Res 163 (1-2), 1-11 (2002)
   PUBMED   11788194
REFERENCE   7  (bases 1 to 18938)
  AUTHORS   Weston,M.D., Eudy,J.D., Fujita,S., Yao,S., Usami,S., Cremers,C.,
            Greenberg,J., Ramesar,R., Martini,A., Moller,C., Smith,R.J.,
            Sumegi,J. and Kimberling,W.J.
  TITLE     Genomic structure and identification of novel mutations in usherin,
            the gene responsible for Usher syndrome type IIa
  JOURNAL   Am J Hum Genet 66 (4), 1199-1210 (2000)
   PUBMED   10729113
  REMARK    Erratum:[Am J Hum Genet 2000 Jun;66(6):2020. Greenburg J [corrected
            to Greenberg J]]
REFERENCE   8  (bases 1 to 18938)
  AUTHORS   Eudy,J.D., Weston,M.D., Yao,S., Hoover,D.M., Rehm,H.L.,
            Ma-Edmonds,M., Yan,D., Ahmad,I., Cheng,J.J., Ayuso,C., Cremers,C.,
            Davenport,S., Moller,C., Talmadge,C.B., Beisel,K.W., Tamayo,M.,
            Morton,C.C., Swaroop,A., Kimberling,W.J. and Sumegi,J.
  TITLE     Mutation of a gene encoding a protein with extracellular matrix
            motifs in Usher syndrome type IIa
  JOURNAL   Science 280 (5370), 1753-1757 (1998)
   PUBMED   9624053
REFERENCE   9  (bases 1 to 18938)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
REFERENCE   10 (bases 1 to 18938)
  AUTHORS   Koenekoop,R., Arriaga,M., Trzupek,K.M. and Lentz,J.
  TITLE     Usher Syndrome Type II
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445650.9, AY481573.1 and
            AC092799.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 13, 2020 this sequence version replaced NM_206933.3.
            
            Summary: This gene encodes a protein that contains laminin EGF
            motifs, a pentaxin domain, and many fibronectin type III motifs.
            The protein is found in the basement membrane, and may be important
            in development and homeostasis of the inner ear and retina.
            Mutations within this gene have been associated with Usher syndrome
            type IIa and retinitis pigmentosa. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (2) is the longer transcript and
            it encodes the longer isoform (B).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY481573.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307340.8/ ENSP00000305941.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL445650.9         61104-61155         c
            53-18935            AY481573.1         1-18883
            18936-18938         AC092799.2         142945-142947
FEATURES             Location/Qualifiers
     source          1..18938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..18938
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /note="usherin"
                     /db_xref="GeneID:7399"
                     /db_xref="HGNC:HGNC:12601"
                     /db_xref="MIM:608400"
     exon            1..235
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..924
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..16048
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /note="isoform B precursor is encoded by transcript
                     variant 2; Usher syndrome 2A (autosomal recessive, mild);
                     usher syndrome type-2A protein; usher syndrome type IIa
                     protein"
                     /codon_start=1
                     /product="usherin isoform B precursor"
                     /protein_id="NP_996816.3"
                     /db_xref="CCDS:CCDS31025.1"
                     /db_xref="GeneID:7399"
                     /db_xref="HGNC:HGNC:12601"
                     /db_xref="MIM:608400"
                     /translation="MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVG
                     AFKKVSIVPTQAVCGLPDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFS
                     AGLSSCITPDKNDLHPNAHSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQG
                     VMCVIEKTVDGQIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQV
                     HQTKISFFINGVEKDHTPFNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLY
                     QVALTNREILEVFSGDLLRLHAQSHCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSR
                     LNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFFSP
                     QPTEIRIQRKKENSLDWEDWQYFARNCGAFGMKNNGDLEKPDSVNCLQLSNFTPYSRG
                     NVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHRYYA
                     VDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQ
                     VYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYF
                     FRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN
                     LQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFN
                     DVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCD
                     TAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTIN
                     GSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICD
                     PISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVC
                     QDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGS
                     KCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYS
                     LLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPG
                     VPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETS
                     ATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVE
                     WSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP
                     QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSL
                     NISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKP
                     YRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLRWFPPEELN
                     GPSPIYQLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKV
                     PEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEI
                     IAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKG
                     FVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLE
                     LHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAF
                     TQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGI
                     PQELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNC
                     RGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVP
                     TPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLT
                     GILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPSSLLLS
                     WNPPKKANGIITQYCLYMDGRLIYSGSEENYIVTDLAVFTPHQFLLSACTHVGCTNSS
                     WVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIW
                     SVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPK
                     AHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRV
                     QACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVL
                     FTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLI
                     TDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTH
                     GFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVP
                     PILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPYTAY
                     KFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLV
                     ENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSS
                     AWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTN
                     VTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS
                     VIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWL
                     YEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVR
                     WAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNG
                     VHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK
                     LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTI
                     RGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKP
                     ESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNH
                     QCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQ
                     KCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKK
                     NDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASME
                     ATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNL
                     KPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKP
                     IQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVV
                     AATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDR
                     RQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTV
                     ELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGG
                     SSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDG
                     SVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNS
                     PVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGD
                     TLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKP
                     ESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAA
                     NHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFS
                     DGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPT
                     VHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTER
                     NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNP
                     QKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQAC
                     TSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYD
                     NKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTL
                     QVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVT
                     ASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLF
                     IRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQ
                     TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKS
                     NPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPT
                     FHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN
                     YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGV
                     IHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVG
                     STASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVY
                     SGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRS
                     KSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLN
                     VYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQL
                     MDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL"
     exon            925..1090
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1223
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1287
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1582
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1767
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1989
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2083
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2279
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2410
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2606
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..3248
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3432
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3596
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3755
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..4250
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4520
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4521..4690
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4835
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..5066
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5067..5197
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5198..5324
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5325..5426
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5606
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5737
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            5738..6011
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6012..6215
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6216..6296
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6297..6488
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6489..6602
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6603..6764
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6765..6924
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            6925..7096
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7097..7244
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7245..7396
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7397..7559
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7560..7739
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7740..7890
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            7891..8033
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            8034..8662
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            8663..8997
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            8998..9120
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            9121..9284
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            9285..9494
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            9495..9697
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            9698..9810
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            9811..10009
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            10010..10178
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            10179..10397
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            10398..10621
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            10622..10826
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            10827..11024
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11025..11179
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11180..11378
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11379..11486
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11487..11670
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11671..11828
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11829..11987
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            11988..12150
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            12151..12505
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            12506..12733
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            12734..14250
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            14251..14572
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            14573..14782
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            14783..15021
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15022..15230
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15231..15407
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15408..15491
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15492..15736
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15737..15958
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     exon            15959..18938
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18915..18920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /note="hexamer: AATAAA"
     polyA_site      18938
                     /gene="USH2A"
                     /gene_synonym="dJ1111A8.1; RP39; US2; USH2"
                     /note="major polyA site"
ORIGIN      
        1 agttccaaga gggccaccaa gcagaccacg ctctgagctt caggtaacca agtgtttgct
       61 ctgcagaata ctttacctgg gcacccaagt cttccttcca gcattcctgc tgctacagcc
      121 tatttgctga gtaaccaggg gttacagcag cgttgccagg caacgaggga cagcggtcct
      181 gttgaagagc catttgtcac actgagggga ctggttgaaa tgcaataaag aaatgatacc
      241 agcagctact catgtcttcg ccattgctaa gaacgtcgtt ggtattacct tactctgaga
      301 acgtgtctgc agtttccaga aaatggagta tcgcaacatc acttaaagta ccctgcttca
      361 aagtattgct ggcaagtggc gtgggcctga ttatttattt agaaatgctt tatcaggagg
      421 agaatgcttt tttgtaaaca tgaattgccc agttctttca ttgggctctg gcttcttgtt
      481 tcaggtcatt gaaatgttga tctttgccta ttttgcttca atatccttga ctgagtcacg
      541 aggtcttttc ccaaggctgg agaacgtggg agctttcaag aaagtttcca tcgtgccaac
      601 ccaagcagta tgtggactcc cagaccgaag cactttttgt cacagctctg ctgctgctga
      661 aagtattcag ttctgtaccc agcggttttg tattcaggat tgcccataca gatcttcaca
      721 ccctacctac actgcccttt tctcagcagg cctcagtagc tgcatcacac cagacaagaa
      781 tgatctgcat cctaacgccc atagcaattc tgcaagtttt atttttggaa atcacaagag
      841 ctgcttttct tctcctcctt ctccaaagct gatggcatca tttaccttag ctgtatggct
      901 gaaacctgag caacaaggtg taatgtgtgt tatagaaaag acagtagatg ggcagattgt
      961 gttcaaactt acaatatctg agaaagagac catgttttat tatcgcacag taaatggttt
     1021 gcaacctcca ataaaagtaa tgacactggg gagaattctt gtgaagaaat ggattcatct
     1081 tagtgtgcag gtgcatcaga caaaaatcag cttctttatc aatggcgtgg agaaggatca
     1141 tacacctttc aatgcaagaa ctctaagtgg ttcaattaca gattttgcat ctggtactgt
     1201 gcaaatagga cagagtttaa atggtttaga gcagtttgtc ggaagaatgc aagattttcg
     1261 attataccaa gtggcactta caaacagaga gattctggaa gtcttctctg gagatcttct
     1321 cagattgcat gcccaatcac attgccgttg ccctggcagc cacccgcggg tccacccttt
     1381 ggcacagcgg tactgcattc ctaatgatgc aggagacaca gctgataata gagtgtcacg
     1441 gttgaatcct gaagcccatc ctctctcttt tgtcaatgat aatgatgttg gtacttcatg
     1501 ggtttcaaat gtgtttacaa acattacaca gcttaatcaa ggagtgacta tttcagttga
     1561 tttggaaaat ggacagtatc aggtgtttta tattatcatt cagttcttta gtccacaacc
     1621 aacggaaata aggattcaaa ggaagaagga aaatagttta gattgggagg actggcaata
     1681 ttttgccagg aattgtggtg cttttggaat gaaaaacaat ggagatttgg aaaaacctga
     1741 ttctgtcaac tgtcttcagc tttccaattt tactccatat tcccgtggca atgtcacatt
     1801 tagcatcctg acacctggac caaattatcg tcctggatac aataacttct ataatacccc
     1861 atctcttcaa gagttcgtaa aagccacgca aataaggttt cattttcatg ggcagtacta
     1921 tacaactgag actgctgtta acctcagaca cagatattat gcagtggacg aaatcaccat
     1981 tagtgggaga tgtcagtgcc atggtcatgc cgataactgc gacacaacaa gccagccata
     2041 tagatgcctc tgctcccagg agagcttcac tgaaggactt cattgtgatc gctgcttgcc
     2101 tctttataat gacaagcctt tccgccaagg tgatcaagtt tacgctttca attgtaaacc
     2161 ttgtcaatgc aacagccatt ccaaaagctg ccattacaac atctctgtag acccatttcc
     2221 ttttgagcac ttcagagggg gaggaggagt ttgtgatgat tgtgagcata acactacagg
     2281 aaggaactgt gagctgtgca aggattactt tttccgacaa gttggtgcag atccttcggc
     2341 catagatgtt tgcaaaccct gtgactgtga tacagttggc actagaaatg gtagcattct
     2401 ttgtgatcag attggaggac agtgtaattg taagagacac gtgtctggca ggcagtgcaa
     2461 tcagtgccag aatggattct acaatctaca agagttggat cctgatggct gcagtccctg
     2521 taactgcaat acctctggga cagtggatgg agatattacc tgtcaccaaa attcaggcca
     2581 gtgcaagtgc aaagcaaacg ttattgggct taggtgtgat cattgcaatt ttggatttaa
     2641 atttctccga agctttaatg atgttggatg tgagccctgc cagtgtaacc tccatggctc
     2701 agtgaacaaa ttctgcaatc ctcactctgg gcagtgtgag tgcaaaaaag aagccaaagg
     2761 acttcagtgt gacacctgca gagaaaactt ttatgggtta gatgtcacca attgtaaggc
     2821 ctgtgactgt gacacagctg gatccctccc tgggactgtc tgtaatgcta agacagggca
     2881 gtgcatctgc aagcccaatg ttgaagggag acagtgcaat aaatgtttgg agggaaactt
     2941 ctacctacgg caaaataatt ctttcctctg tctgccttgc aactgtgata agactgggac
     3001 aataaatggc tctctgctgt gtaacaaatc aacaggacaa tgtccttgca aattaggggt
     3061 aacaggtctt cgctgtaatc agtgtgagcc tcacaggtac aatttgacca ttgacaattt
     3121 tcaacactgc cagatgtgtg agtgtgattc cttggggaca ttacctggga ccatttgtga
     3181 cccaatcagt ggccagtgcc tgtgtgtgcc taatcgtcaa ggaagaaggt gtaatcagtg
     3241 tcaaccaggt ttttatattt ctccaggcaa tgccactggc tgcctgccat gctcatgcca
     3301 tacaactggt gcagttaatc acatctgtaa tagcctgact ggtcagtgtg tttgccaaga
     3361 tgcttccatt gctgggcaac gttgtgacca atgcaaagac cattactttg gatttgatcc
     3421 tcagactgga agatgtcagc cttgtaattg tcatctctca ggagccttga atgaaacctg
     3481 tcacttggtc acaggccagt gtttctgtaa acaatttgtc actggctcaa agtgtgatgc
     3541 ttgtgttccc agtgcaagcc acttggatgt caacaatcta ttgggttgca gcaaaactcc
     3601 attccagcaa cctccgccca gaggacaagt tcaaagttct tctgctatca atctctcctg
     3661 gagtccacct gattctccaa atgcccactg gcttacttac agtttactca gggatggttt
     3721 tgaaatctac acaacagagg atcaataccc atacagtatt caatacttct tagacacaga
     3781 cctgttacca tataccaaat attcctatta cattgagacc accaatgtgc atggttcaac
     3841 aaggagtgta gctgtcactt acaagacaaa accaggggtc ccagagggaa acttgacttt
     3901 aagttatatc attcctattg gctcagactc tgtgacactt acctggacaa cactctcaaa
     3961 tcaatctggt cccatagaga aatatatttt gtcctgtgcc cctttggctg gtggtcagcc
     4021 atgtgtttcc tacgaaggtc atgaaacctc agctaccatc tggaatctgg ttccatttgc
     4081 caagtacgat ttttctgtac aggcgtgtac tagcgggggc tgtttacaca gcttgcccat
     4141 tacagtgacc acagcccagg cccctcccca aagactaagt ccacctaaga tgcagaaaat
     4201 cagttctaca gaacttcatg tagaatggtc tccaccagcg gaactaaatg gaataattat
     4261 aagatatgaa ctatacatga gaagactgag atctactaaa gaaaccacat ctgaggaaag
     4321 tcgagttttt cagagcagtg gttggctcag tcctcattca tttgtagaat cggccaatga
     4381 aaatgcatta aaacctcctc aaacaatgac aaccatcact ggcttggagc catacaccaa
     4441 gtatgagttc agagtcttag ctgtgaatat ggctggaagt gtgtcttctg cctgggtctc
     4501 agaaagaacg ggagaatcag cacctgtatt catgatccct ccttcagtct ttcccctctc
     4561 ttcgtactct ctcaatatct cctgggagaa gccagcagat aatgttacaa gaggaaaagt
     4621 tgtggggtat gacatcaata tgctttctga acaatcacct caacagtcta ttcccatggc
     4681 gttttcacag ctgttgcaca ctgctaaatc ccaagaacta tcttacactg tagaaggact
     4741 gaaaccttat aggatatatg agtttactat tactctctgc aattcagttg gttgtgtgac
     4801 cagtgcttcg ggagcaggac aaactttagc agcagcacca gcacaactga ggccacctct
     4861 ggttaaagga atcaacagca caacaatcca tcttaggtgg tttccacctg aagaactgaa
     4921 tggaccctct cctatatatc agctggaaag gagagagtca tctctaccag ctctgatgac
     4981 cacgatgatg aaaggaatcc gtttcatagg aaatgggtat tgtaaatttc ccagctccac
     5041 tcacccagtc aatacagact tcactggcat taaggccagc tttcgaacaa aagtgcctga
     5101 aggtttgatt gtctttgcag catcacctgg caatcaggaa gagtattttg cacttcagtt
     5161 gaagaaggga cgtctttatt ttctttttga tcctcagggg tcaccagtgg aagtaactac
     5221 aactaatgat catggcaaac aatatagtga tggaaaatgg catgaaataa ttgctattag
     5281 gcatcaggct tttggccaaa tcactctgga tgggatatat acaggttcct ctgccatcct
     5341 gaatggtagt actgttattg gagataacac aggagtcttt ctgggagggc tcccgcgaag
     5401 ttataccatc ctcaggaagg atcctgagat aatccaaaaa ggttttgtgg gctgtctcaa
     5461 ggatgtacat tttatgaaga attacaatcc gtcagctatt tgggaacctc tggattggca
     5521 gagttctgaa gaacaaatca acgtgtataa cagctgggag ggatgtcccg cttcattaaa
     5581 tgagggagct cagttcctag gagcagggtt cctggaactt catccatata tgtttcatgg
     5641 tggaatgaac tttgagattt cctttaagtt cagaactgac caattaaatg gattgcttct
     5701 tttcgtttat aacaaagatg gacctgattt tcttgctatg gagctgaaaa gtggaatatt
     5761 gaccttccgg ttaaatacca gtcttgcctt tacacaagtg gatctattgc tggggctatc
     5821 ctattgtaat ggaaagtgga ataaagtcat tattaaaaag gaaggctctt tcatatcagc
     5881 aagtgtgaat ggactgatga agcatgcatc ggagtccgga gaccagccac tggtggtgaa
     5941 ttcaccagtt tatgtgggag gaatcccaca ggaactgctg aactcttatc aacatttgtg
     6001 tttggaacaa ggtttcggtg gttgcatgaa ggatgttaaa tttacacggg gtgctgtcgt
     6061 taacttggca tctgtgtcca gcggtgctgt cagagtcaat ctggatggat gcctatcaac
     6121 tgacagtgct gttaactgca ggggaaatga ctccatcctg gtttaccagg gaaaagagca
     6181 gagtgtttac gagggtggtc tccagccttt tacagaatac ctgtatcgag tgatagcctc
     6241 gcatgaagga ggttcagtat atagtgattg gagtcgagga cgtacaacag gagcagctcc
     6301 acaaagtgtg ccaactccct caagagtccg cagcttaaat ggatacagca ttgaggtgac
     6361 ctgggatgaa cctgttgtca gaggtgtaat tgagaagtac attctgaaag cctatagtga
     6421 ggacagcacc cgtccacccc gcatgccctc tgccagtgct gaatttgtca atacaagcaa
     6481 cctcacaggc atattgacag gcttgctacc cttcaaaaac tatgcagtaa ccctaactgc
     6541 ttgcactttg gctggctgta ctgagagctc acatgcattg aacatctcta ctccacaaga
     6601 agccccacaa gaggttcagc caccagtagc caaatccctt cccagttctt tgctgctctc
     6661 ctggaaccca cccaaaaagg caaatggtat tataactcag tactgtttat acatggatgg
     6721 gaggctgatc tattcaggca gtgaggagaa ctacatagtc acagatttag cagtatttac
     6781 accccaccag tttctactaa gtgcatgcac acatgtgggc tgtacaaaca gttcctgggt
     6841 cctactgtac acagcacagc tgccaccaga acacgtggat tccccagttc tgactgtcct
     6901 ggattctaga actatacaca tacagtggaa acaaccaaga aaaataagtg ggattctgga
     6961 acgctatgta ttatatatgt caaaccatac acatgatttt acaatttgga gtgtcatcta
     7021 taacagtaca gaacttttcc aggatcatat gctacaatac gttttacctg gtaataaata
     7081 tctcatcaag ctgggagctt gcacaggtgg tgggtgcaca gtgagtgagg ccagtgaggc
     7141 cctaactgac gaggacatac ccgaaggcgt gccagccccc aaagcccact catattcacc
     7201 tgactccttt aatgtctcct ggactgagcc tgaatatccg aatggtgtta tcacgagtta
     7261 tggattatat ctagatggta tattaatcca caattcctca gaactcagct atcgtgctta
     7321 cggatttgct ccttggagtt tacattcctt cagagtccaa gcatgcacgg ccaaaggttg
     7381 tgctctgggc ccactggtgg aaaatcgaac tctagaagct cctcctgaag gaacagtaaa
     7441 tgtgtttgtc aaaacacagg gatcccggaa agcccacgtg aggtgggaag caccttttcg
     7501 ccctaatgga ctcttaacac actcagtcct tttcactggg atattctatg tagacccagt
     7561 aggtaataac tacacccttc tgaatgtcac aaaagtcatg tacagcggag aagagacaaa
     7621 cctttgggtg ctcatcgatg ggctggttcc ttttaccaac tatactgtac aagtgaatat
     7681 ttcaaatagc caaggcagct tgataactga tcctataaca attgcaatgc ctccaggagc
     7741 tccagatggc gtgctgcctc ccaggctttc atctgccact ccaaccagtc ttcaggttgt
     7801 ctggtctaca ccagctcgta ataacgctcc tggctctccc agataccaac tccagatgag
     7861 gtctggcgac tccacccatg gatttctaga gttattttcc aatccttctg catcgttaag
     7921 ctatgaagtg agtgatctcc aaccgtacac agagtatatg tttcggttgg ttgcctccaa
     7981 tggatttggc agtgcacata gttcttggat tccattcatg accgcagagg acaaacctgg
     8041 acctgtagtt cctccgattc ttctggatgt gaagtcaaga atgatgttgg tcacctggca
     8101 gcatcctaga aaatccaatg gggttattac ccattataac atttatctac atggccgtct
     8161 atacttgaga actcctggaa atgtcactaa ttgcacagtg atgcatttac acccatacac
     8221 tgcctataag tttcaggtag aagcctgcac ttcaaaagga tgttcccttt caccagagtc
     8281 ccagactgta tggacactcc caggggcacc ggaagggatc ccaagtccag agctgttctc
     8341 tgatactcca acatctgtga ttatatcttg gcaaccccct acccacccca atggcttggt
     8401 ggagaatttc acaattgaga gaagagtcaa aggaaaggaa gaagttacta ccctggtgac
     8461 tctcccgagg agtcattcca tgaggtttat tgacaagact tctgctctta gcccatggac
     8521 aaaatatgaa tatcgggtac tgatgagcac tcttcatgga ggcacaaaca gcagtgcttg
     8581 ggtagaagtt accacaagac cctcacgacc tgctggggtg cagccacctg tggtgacagt
     8641 gctggaaccc gatgcagtcc aggtcacttg gaaaccccca ctcatccaga acggagacat
     8701 acttagctat gagattcaca tgcctgaccc tcacatcact ttaaccaatg tgacttccgc
     8761 agtgttaagt caaaaagtta ctcatctgat tcctttcact aattattctg tcaccattgt
     8821 tgcttgctca gggggtaatg ggtaccttgg agggtgcaca gagagtttac ctacctatgt
     8881 taccactcac cccaccgtac ctcagaatgt tggcccattg tctgtgattc cactaagtga
     8941 atcatatgtt gtgatttctt ggcaaccacc atccaagcca aatggaccta atttgagata
     9001 tgagcttctg agacgtaaaa tccagcagcc acttgcatca aatcccccag aagatttaaa
     9061 tcggtggcac aatatttatt caggaactca gtggctttat gaagataagg gtcttagcag
     9121 gtttacaacc tatgaatata tgctcttcgt acacaacagt gtgggtttta caccgagccg
     9181 agaagtgact gtgacaacgt tagctggtct tccagagaga ggagccaatc tcactgcgag
     9241 tgtccttaac cacacagcca tcgacgtgag gtgggctaaa ccaactgttc aagacctaca
     9301 aggtgaagtt gaatattaca cacttttttg gagttctgct acctcaaacg actctctaaa
     9361 aatcttgcca gatgtaaact ctcatgtcat tggccaccta aagccaaaca cagagtattg
     9421 gatctttatc tctgtcttca atggagtcca cagcatcaac agtgcaggac ttcatgcaac
     9481 cacttgcgat ggggagcctc agggcatgct tcctccagag gttgtcatca tcaacagtac
     9541 agctgtacgt gtcatctgga catctccttc aaacccaaat ggtgttgtca ctgagtattc
     9601 tatctatgta aataataagc tctacaagac tggaatgaat gtgcctgggt cgtttattct
     9661 gagagacctg tctcccttca ctatctatga cattcaggtt gaagtctgca caatatatgc
     9721 ctgcgtgaaa agcaatggaa cccaaattac cactgtggaa gacactccaa gtgatatacc
     9781 aacacccaca attcgtggca tcacttcaag atctcttcaa attgattggg tgtctccacg
     9841 gaagccaaat ggcatcattc ttggatatga tctcctatgg aaaacatggt atccatgcgc
     9901 taaaactcaa aagttagtgc aggatcagag tgatgagctc tgcaaggcag tgaggtgtca
     9961 aaaacctgaa tctatctgtg gacacatttg ctattcttct gaagctaagg tttgttgtaa
    10021 cggagtgctc tataacccca agcctggaca tcgctgttgt gaagaaaagt atatcccgtt
    10081 tgttctgaat tctactggag tttgttgtgg tggccgaata caggaggcac aaccaaatca
    10141 tcagtgctgc tctgggtatt acgctagaat tctaccaggt gaagtatgct gtccagatga
    10201 acagcacaat cgggtttctg ttggcattgg tgattcctgc tgtggcagaa tgccgtactc
    10261 cacctcagga aaccagattt gctgtgctgg gaggcttcat gatggccatg gccagaagtg
    10321 ctgtggcaga cagattgtga gcaacgattt agagtgttgt ggtggagaag aaggagtggt
    10381 gtacaatcgc cttccaggta tgttctgttg tgggcaggat tatgtgaata tgtcagatac
    10441 catatgctgc tcagcttcca gtggagagtc taaagcacat attaaaaaga atgacccggt
    10501 gccagtaaaa tgctgtgaga ctgaacttat tccaaagagc cagaaatgct gtaatggagt
    10561 tggatataat cctttgaaat atgtttgctc tgacaagatt tcaactggaa tgatgatgaa
    10621 ggaaaccaaa gagtgcagga tcctctgccc agcatctatg gaagccacag aacattgtgg
    10681 caggtgtgac ttcaacttta ccagccacat ttgcactgtg ataagagggt ctcacaattc
    10741 cacagggaag gcatcaattg aagaaatgtg ttcatctgcc gaagaaacca ttcatacagg
    10801 gagtgtaaac acgtactctt acacagatgt gaacctcaag ccctacatga catatgagta
    10861 caggatttct gcctggaaca gctatgggcg aggactcagc aaagctgtga gagccagaac
    10921 aaaagaagat gtgcctcaag gagtgagtcc ccctacgtgg accaaaatag acaatcttga
    10981 agatacaatt gtcttaaact ggagaaaacc tatacaatca aatggtccta ttatttacta
    11041 catccttctt cgaaatggaa ttgaacgttt tcggggaaca tcactgagct tctctgataa
    11101 agagggaatt caaccatttc aggaatattc atatcagctg aaagcttgca cggttgctgg
    11161 ctgtgccacc agtagcaagg tagttgcagc tactacccaa ggagttccgg agagcatcct
    11221 gccaccaagc atcacagccc taagtgcagt ggctctgcat ctgagctgga gtgtccctga
    11281 gaaatcaaac ggcgtcatta aagagtacca gatcaggcag gttgggaaag gtctcatcca
    11341 cactgacacc actgacagga gacagcatac ggtcacaggt ctccagccat acaccaacta
    11401 cagcttcact cttacagctt gtacatctgc tgggtgcact tcaagcgagc cttttctagg
    11461 tcagacactg caggcagctc ctgaaggagt ttgggtgaca cctcgacaca ttatcatcaa
    11521 ttctacaaca gtggaattat attggagtct gccagaaaag cccaatggcc tcgtttctca
    11581 atatcaattg agtcgtaatg gaaacttgct tttcctgggt ggcagtgagg agcagaattt
    11641 cactgataaa aacctggagc ccaatagcag atacacttac aagttagaag tcaaaactgg
    11701 aggtggcagc agtgctagtg atgattacat tgttcaaaca cctatgtcaa caccagaaga
    11761 aatctatcct ccatataata tcacagtaat tgggccttat tctatatttg tagcttggat
    11821 accaccaggg atcctcatcc ccgaaattcc tgtggagtac aatgtcttac tcaatgatgg
    11881 aagtgtaaca cctctggcct tctccgttgg tcatcatcaa tccacccttc tggaaaattt
    11941 gactccattc acacagtatg agataaggat acaagcatgt caaaatggaa gttgtggagt
    12001 tagcagtagg atgtttgtca aaacacctga agcagcccca atggatctta attctcctgt
    12061 tcttaaggca ctggggtcag cttgcataga gattaagtgg atgccacctg aaaaaccaaa
    12121 tggaatcatc atcaactact ttatttacag acgccctgct ggcattgaag aggagtctgt
    12181 tttatttgtc tggtcagaag gagcccttga atttatggat gaaggagaca ccctgaggcc
    12241 tttcacactc tacgaatatc gggtcagagc ctgtaactcc aagggttcag tggagagtct
    12301 gtggtcatta acacaaactc tggaagctcc acctcaagat tttccagctc cttgggctca
    12361 agccacgagt gctcattcag ttctgttgaa ttggacaaag ccagaatctc ccaatggcat
    12421 tatctcccat taccgtgtgg tctaccagga gagacccgac gatcctacat ttaacagccc
    12481 taccgtgcat gctttcacag tgaagggaac aagccatcaa gcccacctgt acgggttaga
    12541 accattcaca acatatcgca ttggtgttgt ggctgcaaac catgcaggag aaattttaag
    12601 cccttggact ctgattcaaa ccttagaatc ttccccaagt ggactgagaa actttatagt
    12661 agaacagaaa gagaatggcc gggcattgct actacagtgg tcagaaccta tgagaaccaa
    12721 tggtgtgatt aagacataca acatcttcag tgacgggttc ctggagtact ctggtttgaa
    12781 tcgtcagttt ctcttccgcc gcctggatcc tttcactctc tacacactga ccctggaggc
    12841 ctgcaccaga gcaggttgtg cacactcggc gcctcagcct ctgtggacag atgaagcccc
    12901 tccagactct cagctggctc ctactgtcca ctctgtgaag tccaccagtg ttgagctgag
    12961 ctggtctgag cctgttaacc caaatggaaa aataattcgc tatgaagtga ttcgcagatg
    13021 cttcgaggga aaagcttggg gaaatcagac aatccaggcc gacgagaaaa ttgttttcac
    13081 agaatataac actgaaagga atacatttat gtataatgac acaggtttgc aaccatggac
    13141 gcagtgtgaa tataaaatct acacttggaa ttcagctggg catacctgta gctcttggaa
    13201 tgtggtgagg acattgcaag cacctccaga aggtctctct ccacctgtga tatcctatgt
    13261 ttctatgaat ccccaaaaac tgctgatttc ctggatccca ccagaacagt ctaatggtat
    13321 tatccagtcc tataggcttc aaaggaatga aatgctctat ccttttagct ttgatcctgt
    13381 gactttcaat tacactgatg aagagcttct tcctttttcc acctatagct atgcactcca
    13441 agcctgcacg agtggaggat gctccaccag caaacccacc agcatcacaa ctctggaggc
    13501 tgctccatca gaagtcagcc ctccagatct ttgggccgtc agtgccactc aaatgaatgt
    13561 atgttggtca ccgcccacag tgcaaaatgg aaagattact aaatatttag ttagatatga
    13621 taataaagag tcccttgctg gccagggcct gtgcctgctg gtttcccacc tgcagcctta
    13681 ctctcagtat aacttctccc ttgtagcctg cacgaatgga ggttgcacag ctagtgtgtc
    13741 aaaatctgcc tggacaatgg aggccctgcc agagaacatg gactctccaa cattgcaagt
    13801 cacaggctca gaatcaatag aaatcacctg gaaacctcca agaaacccaa atggccagat
    13861 cagaagttat gaacttagga gggatggaac cattgtatat acaggcttgg aaacacgcta
    13921 tcgtgatttt actctcaccc caggtgtgga gtatagctac acagtaactg ccagcaacag
    13981 ccaagggggt attttgagtc ctcttgtcaa agatcgaacc agcccctcag caccctcagg
    14041 gatggaacct ccaaaattgc aggccagggg tcctcaggag atcttagtga actgggaccc
    14101 tccagtgaga acaaatggtg atatcatcaa ttataccctc ttcatccgtg aactatttga
    14161 aagagaaact aaaatcatac acataaacac aactcataat tcttttggta tgcagtcata
    14221 tatagtaaac cagctgaagc catttcacag gtatgaaata cgaattcaag cgtgcaccac
    14281 cctgggatgt gcatcaagtg actggacatt catacagacc cctgagattg cacctttgat
    14341 gcaaccccct ccacatctgg aggtacaaat ggctccagga ggattccagc caactgtttc
    14401 tcttttgtgg acaggaccgc tgcagccaaa tggaaaagtt ttgtattacg aattatacag
    14461 aagacaaata gcaactcagc ctagaaaatc caatccagtc ctaatctata acggaagctc
    14521 aacatctttt atagattccg aactattgcc tttcacagag tatgagtatc aggtctgggc
    14581 agtgaattct gcaggaaaag cccccagtag ctggacatgg tgcagaaccg ggccagcccc
    14641 accagaaggt ctcagagccc ccacgttcca tgtgatctct tctacccaag cagtggtcaa
    14701 catcagtgcc cctgggaagc ccaacgggat cgtcagtctc tacaggctgt tctccagcag
    14761 cgcccatggg gctgagacag tgctatccga aggcatggcc acccagcaga ctctccatgg
    14821 ccttcaagcc ttcactaact actctattgg agtagaggcc tgcacctgct tcaactgttg
    14881 cagcaaagga ccgacagctg aactgagaac ccatcctgcc ccaccctcag gactgtcctc
    14941 tccacaaatc gggacgctgg cctcaaggac ggcctccttc cggtggagtc cccccatgtt
    15001 ccccaatggt gtcattcaca gctatgaact ccaattccac gtggcttgcc ctcctgactc
    15061 agccctcccc tgtactccca gccaaataga aacaaagtac acggggctgg ggcagaaagc
    15121 cagccttggg ggtctccagc cctacaccac atacaagctg agagtggtgg cacacaacga
    15181 ggtgggcagt acggcttccg agtggatcag tttcaccacc caaaaagaat tgcctcagta
    15241 ccgagcccca ttttcggtgg acagcaattt gtctgtggtg tgtgtgaact ggagtgacac
    15301 cttcctcctg aacggccaac tgaaggagta cgtgttaacc gacggagggc gacgcgtgta
    15361 cagcggcttg gacaccaccc tctacatacc gagaacggcg gacaaaacct tctttttcca
    15421 ggtcatctgc acgactgacg aaggaagtgt taagacgccg ttgatccaat atgatacctc
    15481 tactggactt ggcttggtcc taacaactcc tgggaaaaag aagggatcgc ggagcaaaag
    15541 cacagagttc tacagcgagc tgtggttcat agtgttaatg gcgatgctgg gcttgatctt
    15601 gttggccatt tttctgtccc tgatactaca aagaaaaatc cacaaagagc catatatcag
    15661 agaaagacct cccttggtac ctcttcagaa gaggatgtct ccattgaatg tttacccacc
    15721 gggggaaaac catatggggt tagccgatac caaaattccc cggtctggga cacctgtgag
    15781 tatccgcagc aaccggagtg catgtgtcct gcgcatcccg agtcaaaacc aaaccagcct
    15841 aacctactcc cagggttctc ttcaccgcag cgtcagccag ctcatggaca ttcaagacaa
    15901 gaaagtcttg atggacaact cactgtggga agccatcatg ggccacaaca gtggactgta
    15961 tgtggatgaa gaggacctga tgaacgccat caaggatttc agctcagtga ctaaggaacg
    16021 caccacattc acagacaccc acctgtaaag gatggaaacc cagaagacgt aaccctggaa
    16081 tgcaaggtct gcacccattt cctcctgggt tatcactcac acatcataaa tgctgaaaag
    16141 ccattgttta ttatcctata attctttaaa gaaatgatga ctgtttttga aagtgttcct
    16201 tcctaataga ggtctaagaa atgatatttt tctcatctta aatgagagag aatattcata
    16261 tgaaaatact tgatttgctc ttattttgta gaagacaaag aagtatgtaa ttgtcacttg
    16321 gttctgtttg gcagtgatgc tcctggttaa ctgaataatc agtggcaatt tcaagatggc
    16381 tcacagttgt tagaagtagt aagttagtta ctggctcaaa aatgattctg ttgaaaggat
    16441 gtcactgctg ttcatttcta tctgccattt ctgtcagggt tgacacaatc ctgcaagaat
    16501 agttattcta atgatcacag ctgctaaatg aatcccaaac tttgcaccag gtcgacaaac
    16561 ttttctgaag gttctattta tttaccatac atagggttac ttaccaaact ttttgacaag
    16621 gctgaaggtt ctatttattt acaatacata gggttactca ccaaactttt tgacaaggca
    16681 acacataact tacacataaa tgtctctgtt cttgcattta tgaattttcc aaaaatctaa
    16741 ggagtaaaca gcttatttat acattttgag gagaaaacaa agtgtttcac taggaacacc
    16801 tctacttgaa ccaatgtttt tatttcatat attttatagt tttgaaacta gtttctcata
    16861 aaattctgtc aattcactga atatcagaga atactgacat cttcaaccta gcacatttca
    16921 aatggaaact actgttctat ttgcaatatt aggctgcgtg aaattttaaa aggaaaaatg
    16981 tatctgttcc ttctagcatt aacatatata catgtagaga caagactata cctatgtgta
    17041 tatatatgta tatcatgtat atattactct gcactatatc ccttcttttt ggagaactag
    17101 ccattatttt agccacagaa tcagtaagaa cagatgatat gcaacagtac caattacggt
    17161 tcaaaaatgt ctgtcacctg ctctagttgg attacaaagt cattggtgaa agtcctatgg
    17221 caagaaaaat tttcttgcaa atcatccaca taaaatcaga tatttaaatt tgttcttcat
    17281 ggaaaacaga gtaagaaaac ctcttgtctt ccttcatcct taaaggtctt tgtgacccca
    17341 ggaaaatatt gactctgtct aacacacaat agtcacaata ctttttgtga atctacaacc
    17401 agagacaggc aaaaacttgt aaagtaaggg atagtcttac ttattctgcc tgaaaacaat
    17461 gtattacccc agggcccaac agtaaaagat tgtggacttt ttgggtattg agatttcatc
    17521 tagctctgtg agagagcagc tcctcagact gaccaactcc tagacaaagt ttgccaacca
    17581 taagtgtcaa aagcacaggc cagtattaag cagaagttct accaccttat tagaactgct
    17641 ataaacaaaa gcatctgaaa taattgtgca catctggcag tgactgtaga aaatacgaaa
    17701 tatatatttc tcgccaagtt tttatacttt ctgaaatgaa aacataggat tgactagttt
    17761 actggttttt attcccatat gccgattctg ggacaataaa gttgtttaaa gctggcacaa
    17821 ataagcatta accaaggctg tgtccacctt ctgtgagcta cttaaggtat ataggaaagg
    17881 agtggtcaca aacttgcatc ctaatccttg gtggactctt ctaagaatac agtttgctag
    17941 tcacaaagaa tagtctacaa atatgctttg ctaggttcag aagattgagt ttatcctgat
    18001 ttttgaaaaa ttaaccaggt atctttatca ctgtgtattt ttccaagcac agtataaaat
    18061 tttaacaacg cacaaaaaaa tacagaactg caggggattt tatcttggat cattatccat
    18121 ttaatcatct aattagacat gaactcagtt agctgaatca tttacatttt gactccatag
    18181 cttagggcag acagaagcct gtatggcttc tgcccagaac tctgtcccct gctacatgtc
    18241 taagtttact tgtatttatt tcagagaaga actctaagat gttgctttgc tactttaagt
    18301 ggtattgcgt gccaagcctc tattatacaa accatgcaga ctcgcctcta gagattctga
    18361 ttcggttgat ctggggtgtg tggctgaggc atcagtactt tttaaagctt ccaggtgttc
    18421 taatgttgag acccactgat gttccacaat ctggaagaaa tcatgtacag gaataatatg
    18481 ctatgcacag ggactatgct ccttggctca ccccttctcc cttataaaca atgagcagtt
    18541 cttgatgaac ctctttaaat ttaaatctcc tgactcacat tttaccaatt gtacatgcca
    18601 cattctcagc ttacgaacta ccatgttttg ttattcttaa tatcaactgt ttggtaagag
    18661 tacagttgtt tttatacact ctaagaaatg tgtttataat ctactgtaat ttccactaaa
    18721 tggaacccaa atattaatgt tatggtacca tatactgatg taaaaatcat gctggcatcc
    18781 atgaacacac cggtaaataa aacatagtcc aagtggaaga attcattaat aaggaacttt
    18841 taattatgtc acaaatgaat agttggtttc caatgcacaa atatcatgta aactaatcta
    18901 aagatggttt gcttaataaa tatttgaatg tgacctaa
//
