LOCUS       NM_001009899           13704 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens upstream transcription factor family member 3 (USF3),
            transcript variant 1, mRNA.
ACCESSION   NM_001009899 XM_291062
VERSION     NM_001009899.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13704)
  AUTHORS   Ye,W., Wang,Y., Hou,S., Mei,B., Liu,X., Huang,H., Zhou,Q., Niu,Y.,
            Chen,Y., Zhang,M. and Huang,Q.
  TITLE     USF3 modulates osteoporosis risk by targeting WNT16, RANKL, RUNX2,
            and two GWAS lead SNPs rs2908007 and rs4531631
  JOURNAL   Hum Mutat 42 (1), 37-49 (2021)
   PUBMED   33058301
  REMARK    GeneRIF: USF3 modulates osteoporosis risk by targeting WNT16,
            RANKL, RUNX2, and two GWAS lead SNPs rs2908007 and rs4531631.
REFERENCE   2  (bases 1 to 13704)
  AUTHORS   Wang,Y., Ye,W., Liu,Y., Mei,B., Liu,X. and Huang,Q.
  TITLE     Osteoporosis genome-wide association study variant c.3781 C>A is
            regulated by a novel anti-osteogenic factor miR-345-5p
  JOURNAL   Hum Mutat 41 (3), 709-718 (2020)
   PUBMED   31883164
  REMARK    GeneRIF: Osteoporosis genome-wide association study variant c.3781
            C>A is regulated by a novel anti-osteogenic factor miR-345-5p.
REFERENCE   3  (bases 1 to 13704)
  AUTHORS   Ni,Y., Seballos,S., Fletcher,B., Romigh,T., Yehia,L., Mester,J.,
            Senter,L., Niazi,F., Saji,M., Ringel,M.D., LaFramboise,T. and
            Eng,C.
  TITLE     Germline compound heterozygous poly-glutamine deletion in USF3 may
            be involved in predisposition to heritable and sporadic epithelial
            thyroid carcinoma
  JOURNAL   Hum Mol Genet 26 (2), 243-257 (2017)
   PUBMED   28011713
  REMARK    GeneRIF: Therefore, USF3 may be involved in the predisposition of
            thyroid cancer. Importantly, the results that glutamine-dependent
            survival and sensitivity to ER stress in USF3-deficient cells
            provide avenues for therapeutic and adjunct preventive
            interventions for both sporadic cancer as well as cancer
            predisposition syndromes with similar mechanisms.
REFERENCE   4  (bases 1 to 13704)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108693.5, AC055740.17 and
            KF457673.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001009899.3.
            
            Summary: This gene encodes a large protein that contains a
            helix-loop-helix domain and a polyglutamine region. A deletion in
            the polyglutamine region was associated with risk for thyroid
            carcinoma. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represent the longer
            transcript and encodes the protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2922747.1,
                                           SRR14038197.346006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316407.9/ ENSP00000320794.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC108693.5         95319-95591
            274-389             AC055740.17        16098-16213
            390-454             AC055740.17        18599-18663
            455-483             AC055740.17        20119-20147
            484-566             AC055740.17        23292-23374
            567-663             AC055740.17        29086-29182
            664-6812            AC055740.17        32070-38218
            6813-7201           KF457673.1         1-389
            7202-13704          AC055740.17        38608-45110
FEATURES             Location/Qualifiers
     source          1..13704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..13704
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /note="upstream transcription factor family member 3"
                     /db_xref="GeneID:205717"
                     /db_xref="HGNC:HGNC:30494"
                     /db_xref="MIM:617568"
     exon            1..273
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     exon            274..389
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     exon            390..454
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..7145
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /codon_start=1
                     /product="basic helix-loop-helix domain-containing protein
                     USF3"
                     /protein_id="NP_001009899.3"
                     /db_xref="CCDS:CCDS43133.1"
                     /db_xref="GeneID:205717"
                     /db_xref="HGNC:HGNC:30494"
                     /db_xref="MIM:617568"
                     /translation="MPEMTENETPTKKQHRKKNRETHNAVERHRKKKINAGINRIGEL
                     IPCSPALKQSKNMILDQAFKYITELKRQNDELLLNGGNNEQAEEIKKLRKQLEEIQKE
                     NGRYIELLKANDICLYDDPTIHWKGNLKNSKVSVVIPSDQVQKKIIVYSNGNQPGGNS
                     QGTAVQGITFNVSHNLQKQTANVVPVQRTCNLVTPVSISGVYPSENKPWHQTTVPALA
                     TNQPVPLCLPAAISAQSILELPTSESESNVLGATSGSLIAVSIESEPHQHHSLHTCLN
                     DQNSSENKNGQENPKVLKKMTPCVTNIPHSSSATATKVHHGNKSCLSIQDFRGDFQNT
                     FVVSVTTTVCSQPPRTAGDSSPMSISKSADLTSTATVVASSAPGVGKATIPISTLSGN
                     PLDNGWTLSCSLPSSSVSTSDLKNINSLTRISSAGNTQTTWTTLQLAGNTIQPLSQTP
                     SSAVTPVLNESGTSPTTSNHSRYVATDINLNNSFPADGQPVEQVVVTLPSCPSLPMQP
                     LIAQPQVKSQPPKNILPLNSAMQVIQMAQPVGSAVNSAPTNQNVIILQPPSTTPCPTV
                     MRAEVSNQTVGQQIVIIQAANQNPLPLLPAPPPGSVRLPINGANTVIGSNNSVQNVPT
                     PQTFGGKHLVHILPRPSSLSASNSTQTFSVTMSNQQPQTISLNGQLFALQPVMSSSGT
                     TNQTPMQIIQPTTSEDPNTNVALNTFGALASLNQSISQMAGQSCVQLSISQPANSQTA
                     ANSQTTTANCVSLTTTAAPPVTTDSSATLASTYNLVSTSSMNTVACLPNMKSKRLNKK
                     PGGRKHLAANKSACPLNSVRDVSKLDCPNTEGSAEPPCNDGLLESFPAVLPSVSVSQA
                     NSVSVSASHSLGVLSSESLIPESVSKSKSAEKSSPPSQESVTSEHFAMAAAKSKDSTP
                     NLQQETSQDKPPSSLALSDAAKPCASANVLIPSPSDPHILVSQVPGLSSTTSTTSTDC
                     VSEVEIIAEPCRVEQDSSDTMQTTGLLKGQGLTTLLSDLAKKKNPQKSSLSDQMDHPD
                     FSSENPKIVDSSVNLHPKQELLLMNNDDRDPPQHHSCLPDQEVINGSLINGRQADSPM
                     STSSGSSRSFSVASMLPETTREDVTSNATTNTCDSCTFVEQTDIVALAARAIFDQENL
                     EKGRVGLQADIREVASKPSEASLLEGDPPFKSQIPKESGTGQAEATPNEFNSQGSIEA
                     TMERPLEKPSCSLGIKTSNASLQDSTSQPPSITSLSVNNLIHQSSISHPLASCAGLSP
                     TSEQTTVPATVNLTVSSSSYGSQPPGPSLMTEYSQEQLNTMTSTIPNSQIQEPLLKPS
                     HESRKDSAKRAVQDDLLLSSAKRQKHCQPAPLRLESMSLMSRTPDTISDQTQMMVSQI
                     PPNSSNSVVPVSNPAHGDGLTRLFPPSNNFVTPALRQTEVQCGSQPSVAEQQQTQASQ
                     HLQALQQHVPAQGVSHLHSNHLYIKQQQQQQQQQQQQQQQQQAGQLRERHHLYQMQHH
                     VPHAESSVHSQPHNVHQQRTLQQEVQMQKKRNLVQGTQTSQLSLQPKHHGTDQSRSKT
                     GQPHPHHQQMQQQMQQHFGSSQTEKSCENPSTSRNHHNHPQNHLNQDIMHQQQDVGSR
                     QQGSGVSSEHVSGHNPMQRLLTSRGLEQQMVSQPSIVTRSSDMTCTPHRPERNRVSSY
                     SAEALIGKTSSNSEQRMGISIQGSRVSDQLEMRSYLDVPRNKSLAIHNMQGRVDHTVA
                     SDIRLSDCQTFKPSGASQQPQSNFEVQSSRNNEIGNPVSSLRSMQSQAFRISQNTGPP
                     PIDRQKRLSYPPVQSIPTGNGIPSRDSENTCHQSFMQSLLAPHLSDQVIGSQRSLSEH
                     QRNTQCGPSSAIEYNCPPTHENVHIRRESESQNRESCDMSLGAINTRNSTLNIPFSSS
                     SSSGDIQGRNTSPNVSVQKSNPMRITESHATKGHMNPPVTTNMHGVARPALPHPSVSH
                     GNGDQGPAVRQANSSVPQRSRHPLQDSSGSKIRQPERNRSGNQRQSTVFDPSLPHLPL
                     STGGSMILGRQQPATEKRGSIVRFMPDSPQVPNDNSGPDQHTLSQNFGFSFIPEGGMN
                     PPINANASFIPQVTQPSATRTPALIPVDPQNTLPSFYPPYSPAHPTLSNDISIPYFPN
                     QMFSNPSTEKVNSGSLNNRFGSILSPPRPVGFAQPSFPLLPDMPPMHMTNSHLSNFNM
                     TSLFPEIATALPDGSAMSPLLTIANSSASDSSKQSSNRPAHNISHILGHDCSSAV"
     exon            455..483
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     exon            484..566
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     exon            567..663
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     exon            664..13704
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13677..13682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /note="hexamer: AATAAA"
     polyA_site      13704
                     /gene="USF3"
                     /gene_synonym="KIAA2018"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagttg aggccgcgct gccgccgggt ctccggcctt gagggctcgg gctcgcagcg
       61 gctgcggtgg ccgcaaaaag aggcggcggg ggcgggggga gaggagggcc tgggcccgcg
      121 ctcccccagc cccggaggag caggcggtgg ccgcggacgg agagattcgc ccagacggtc
      181 agacactcct gccttcccct cctgggatca tgacccaggc gggggtcgcc gccgtcgccg
      241 ccgccaccgc ggccgagacc gcgcagccgg cggtaagaag aaagcataac ccatagacca
      301 tcttctggca gaagatgata catttggatc agaaacggga ggcattggaa gccaggaatc
      361 aaaagtgaag aaactctgca agcccttagg ttcctattac tgtaaccatg ccagaaatga
      421 cagagaatga gacgcctaca aaaaagcagc acagaaagaa aaaccgggag acacacaatg
      481 cagtggagag gcatagaaag aagaaaatta atgctgggat aaacagaata ggagagctga
      541 tcccatgttc tcctgccctg aagcagagca agaatatgat cctggaccaa gcctttaaat
      601 atataacaga attgaaaagg caaaatgatg aactcctgct taatggagga aacaatgaac
      661 aagctgaaga aataaaaaag ctacggaaac aactggaaga aatccaaaaa gaaaatggcc
      721 gatatattga attactgaaa gctaatgaca tatgcttata tgatgacccg acaattcact
      781 ggaaaggaaa tcttaaaaac tcaaaggtct ctgttgttat tcctagtgac caggttcaaa
      841 aaaaaattat tgtttattcc aacgggaatc agcctggtgg aaacagccag ggaacagctg
      901 ttcaggggat aacttttaat gttagtcata atttacaaaa gcagaccgcc aatgtggtgc
      961 cagtacagag gacttgcaat cttgtgactc ctgtatctat ttctggagtt tacccttctg
     1021 aaaacaagcc atggcatcag accacagttc ctgcattggc taccaaccag cctgttcctc
     1081 tttgtcttcc tgctgccatt tctgctcaga gtattctcga gcttcccacc tctgaaagcg
     1141 aatcaaatgt gcttggtgcc actagtggct cactgattgc tgtttcaatt gaatctgagc
     1201 ctcaccaaca tcattctttg cacacatgcc taaatgatca aaattcttct gaaaataaga
     1261 atggacaaga gaaccccaaa gtattgaaga aaatgacccc ttgtgttaca aacatccccc
     1321 acagctcctc agcaactgcc actaaagtgc accatggaaa caagtcctgc ctgagcatac
     1381 aggacttcag aggtgatttt caaaacactt ttgttgtttc agttaccacc acagtctgct
     1441 cgcagcctcc cagaactgca ggtgattctt ctccaatgag cattagtaag agtgcagact
     1501 tgacaagtac agctacagtg gtggcatcat ctgcccctgg agtagggaag gccaccattc
     1561 ctataagcac tctttcggga aaccctttgg acaatggttg gactctttct tgttctttgc
     1621 cttcttcaag tgttagtact tcagatttga aaaacattaa tagccttaca cgaatctctt
     1681 cagctggaaa cacacagaca acgtggacta ctttgcaact ggcaggaaac actattcagc
     1741 ccttaagcca gacaccatct tctgctgtga ctccagtatt aaatgagtct ggtactagcc
     1801 ccaccacaag caaccacagt agatatgtgg ctacagacat caacttgaat aattcctttc
     1861 cagcagatgg gcagccagtt gagcaagtag ttgtaacatt gccttcttgt ccatctttac
     1921 ctatgcagcc actaattgcc cagccacaag ttaaatctca gcctcccaaa aatatccttc
     1981 cactgaattc agcaatgcaa gtgattcaga tggctcagcc agttgggtca gctgttaatt
     2041 cagctccaac taatcaaaat gttataattc ttcagccacc tagcaccacc ccatgcccaa
     2101 cagtgatgag ggcagaagtt tccaaccaaa cagtaggtca acagatagta atcatacagg
     2161 ctgctaatca gaatcctttg ccactcctcc ctgctccacc tcctggttct gttcgactcc
     2221 ccatcaatgg agccaatact gtaatagggt ctaataattc agtgcaaaat gttccaacac
     2281 cacagacttt tggaggaaag catcttgtcc acatattacc aagaccttca tctttatcag
     2341 cgtctaactc aacacaaact ttttctgtta ccatgtcaaa ccaacagcct caaaccattt
     2401 ctttaaatgg acagctcttt gctttgcagc ctgtgatgtc ttcatcagga actacaaatc
     2461 aaacccctat gcaaattatt caacccacca ccagcgaaga tccaaatacc aatgttgccc
     2521 tgaatacatt tggtgctttg gccagcctca atcaaagcat atcacagatg gctgggcaaa
     2581 gctgtgtaca attgtctatt agccagcctg ccaattctca aactgctgca aatagtcaaa
     2641 ccactacagc taactgtgtt tcattaacaa caactgcagc acctcctgtg acaacagata
     2701 gttcagccac actagctagt acttataatc tagtgagtac ttcctcaatg aacactgttg
     2761 cttgtttgcc taacatgaaa tctaaaaggt tgaataagaa gccaggtggc aggaaacact
     2821 tagcagcaaa caagtcagcg tgtcccctga attcagtcag agatgtgagc aagttagact
     2881 gccccaacac tgaaggctca gcagagccac cctgtaatga tggactgcta gaaagcttcc
     2941 ctgctgtgtt accatctgtc tctgtgtctc aggcaaatag tgtgagtgtt tctgcttcac
     3001 attctttggg tgttctaagc tctgaatcat taatacctga gtctgtatcg aaatctaagt
     3061 cagcagaaaa gtccagccca ccctcccaag aatctgtaac aagtgaacat tttgcaatgg
     3121 ccgcagcaaa atccaaagat tctaccccta atctacaaca agagacatct caggataaac
     3181 caccaagtag tttagcatta tcagatgctg ccaaaccctg cgcttcagcc aatgtattga
     3241 ttccatctcc aagtgatcct cacattttgg tttctcaggt tcctggtttg tcatctacaa
     3301 caagcactac aagtactgac tgtgtttctg aggtagaaat cattgctgaa ccttgcagag
     3361 ttgagcaaga ttcatcagat acaatgcaaa ccacaggtct cttaaagggg caaggtttaa
     3421 ctacattgct atctgatctt gctaaaaaaa aaaaccctca gaaatcatct ctttctgatc
     3481 agatggatca tcctgacttt tcttcagaaa atcctaaaat agttgattca agtgtgaatt
     3541 tacatcccaa acaggaacta ttactgatga acaatgatga tagagatcct ccacagcatc
     3601 attcctgcct ccctgatcaa gaggttatta atggttcttt gatcaacggt agacaggccg
     3661 actctcccat gtcaaccagc tctggcagta gtcgtagttt ctcagttgca tccatgcttc
     3721 ctgaaacaac aagagaagat gtgaccagca atgcaacaac taatacatgt gacagctgta
     3781 cctttgtaga gcaaactgat atagtagctc ttgcagcaag agctattttt gaccaggaga
     3841 accttgagaa ggggagagtt ggcctccagg ctgatataag ggaagttgct tcaaagcctt
     3901 ctgaagcatc attgttagag ggagacccac ccttcaaatc acagatacct aaagagagtg
     3961 gcacaggaca ggcagaagca acaccaaatg aatttaattc tcagggttca attgaagcaa
     4021 ctatggagag gccccttgag aaaccaagtt gttctctagg aattaaaaca tcaaatgcat
     4081 ctttacagga ttcaacttct cagccaccaa gcatcaccag tttaagtgtg aataatctta
     4141 tccatcagag cagcatcagc catcctctgg ccagctgtgc gggtttatcc ccaacttcag
     4201 agcaaacaac tgtgcctgca acggttaatc tgaccgtttc atctagctcc tatggcagtc
     4261 aacctcctgg accatctctg atgactgaat attcccaaga acagctaaat actatgacta
     4321 gtaccatacc aaattcacag attcaagagc cactcttaaa gccaagccat gaaagccgta
     4381 aggattctgc taagcgtgct gtccaagatg accttttact gtcttcagct aaacgtcaaa
     4441 agcactgtca gccagccccc ctcaggcttg aaagtatgtc cctgatgagc agaactccag
     4501 acaccatttc tgaccaaact caaatgatgg tcagtcagat ccctcctaat tcttcaaact
     4561 cagttgtgcc tgttagcaac ccagctcatg gagatggcct tacacgatta tttccaccta
     4621 gtaacaactt tgtgactcct gcattgaggc aaactgaagt tcagtgtggt tctcagcctt
     4681 cagttgctga acagcagcaa acccaggcaa gtcagcatct acaggccctg cagcagcatg
     4741 ttccagctca aggtgtatct caccttcata gtaaccatct ctacataaag cagcagcagc
     4801 agcagcagca gcagcagcag cagcaacagc aacaacaaca agcagggcag ttaagagaga
     4861 ggcatcactt atatcaaatg cagcatcatg tacctcatgc agagagctct gtccactctc
     4921 agccccataa tgtccaccaa cagaggactc tgcaacagga agttcagatg cagaaaaaga
     4981 ggaatcttgt tcagggcacc cagacctctc agctttcctt acaaccaaag caccatggaa
     5041 ctgaccaatc ccgatccaag actggccagc cacatcccca ccatcagcag atgcagcaac
     5101 aaatgcagca acactttgga agctcccaga cagagaagag ctgtgaaaac ccttcaacta
     5161 gtcggaacca tcataaccat ccccagaacc atctcaatca agatattatg caccaacagc
     5221 aggatgttgg aagcagacag caaggttcag gggtttcatc tgaacatgta tctggccata
     5281 atccaatgca gaggcttttg acatcaagag gcttagagca gcaaatggtg tcccaaccaa
     5341 gtattgtgac tagatcttca gacatgacct gtactccaca caggccagag agaaatagag
     5401 tttcaagtta ttctgctgag gcactcattg gaaagacatc ttctaattca gagcagagaa
     5461 tggggatatc aattcagggt tccagagttt cagatcagct tgaaatgaga agctatcttg
     5521 atgttcccag aaataagagt ttggctattc ataatatgca gggtcgtgtg gaccatactg
     5581 tggcctcaga tatccgcctt tctgattgtc agacgtttaa accaagtgga gctagtcaac
     5641 agccccagag taattttgaa gtacaatctt caagaaacaa tgaaataggt aaccctgtat
     5701 catcattgcg gagtatgcag tcccaggctt ttcgaattag tcaaaacact ggccccccac
     5761 caattgaccg tcaaaagaga ttatcttacc caccagttca gagcatccca acaggaaatg
     5821 gtattccatc aagggacagt gaaaatactt gtcaccaaag tttcatgcag agcttacttg
     5881 cccctcacct cagtgatcag gtcattggga gccagaggtc actctcagaa catcagagga
     5941 atacacagtg tggtccatcc tctgcaattg aatataattg tcccccaact catgaaaatg
     6001 tccatattag aagagagagt gagagtcaga atagggaaag ttgtgacatg tcgttaggtg
     6061 caattaacac caggaacagc accttgaata ttcctttttc aagttcctct tcctcaggag
     6121 atattcaagg tcgaaacaca agccccaatg tttctgtaca gaaatccaat cccatgagga
     6181 ttactgagag tcatgccacc aagggccaca tgaaccctcc agtcacaacc aacatgcatg
     6241 gggttgcaag gccagcgttg ccacatccat ctgtgtctca tggaaatggc gatcaaggcc
     6301 ctgctgtacg tcaagctaat tcttcagttc cccagagatc aaggcatccc ctgcaagaca
     6361 gcagtggttc caaaattcgt cagcctgaaa ggaatcgttc tggaaaccaa aggcaaagta
     6421 ctgtctttga tccaagtctt ccccatcttc ctctctctac tggtggcagt atgattcttg
     6481 gacgtcaaca acctgccaca gagaagagag gaagtattgt tcgtttcatg cctgatagcc
     6541 cacaagtacc taatgataat tcaggtcctg accagcatac actatcacaa aattttggtt
     6601 tttcttttat tcctgagggt ggcatgaatc caccaataaa tgctaatgct tctttcattc
     6661 cacaggttac tcagcctagt gccactcgaa ctccagccct catcccggta gatccgcaaa
     6721 atactctgcc ctccttctat cctccatact ctcctgctca tcctacactg tccaatgata
     6781 tttcaatccc ctattttcct aatcagatgt tctcaaatcc tagcacagag aaggtaaaca
     6841 gtggaagttt aaataaccga tttggatcaa ttttatctcc tcccagacct gttgggtttg
     6901 ctcaaccaag ttttcctctt ctcccagata tgccaccaat gcacatgacc aactctcact
     6961 tatccaattt taatatgaca tctttgtttc cagaaatagc cacagcgctt cctgatggct
     7021 cagcaatgtc acctttgctt acaatagcaa attcctctgc ctctgactct tccaagcagt
     7081 cctcaaacag acctgcccat aacataagcc atattctagg tcatgattgc agttcagctg
     7141 tttaaatact gataaacaaa atgtaaaggt aatgagtgag attacaaatg tatttgtgcg
     7201 tgcatgtgca cagacatgta catgaagaga aggattgtgt gtgtgtgtct gtataatcag
     7261 ttttcagtta tcttctgaat gtagggaagc catgtcagat gcagatactg ggttgtcaga
     7321 aaacaagtta tctttcgttt tcaactgcat ggtgtacttt tttattttcc aagtagattt
     7381 acatttccaa gttgatattt cctaaatact aattagctgg aaattggggg agatcatctt
     7441 gtcatgtact gggtagtagg agggagccta gactttaaac ttgattgttg ataacttatg
     7501 gaatatgtag gtaagttgct actgaaaaat ataggcagct tgataaaaca cagtggctca
     7561 taatcaagtg ctggctaatg tcagcatcta gaacagcttc ttacctatga cagatgttga
     7621 actgatgttg agtttaatgt ccgtagttaa agtcaagcag ttagcaaata aataaaagca
     7681 atcagccttt attctcaaag tttggtttag atacaggctt ctttctaaat tataacaatg
     7741 cataaattat ctgaatttta tgtcttgttc ttcaaattag ggagctgtgt taccctttaa
     7801 tgtgccaaga ttatttaaag caaaggtctt ccttagacaa ttatttagcc gtaaatatag
     7861 aaagctaaaa agttaagtac atacatattc tccgttttgt gcttgcattt tgcatcgggt
     7921 cataagggta aaagcagtta gttgtattgt ggagttttgc atgggtgcag ttaacaatgg
     7981 atgtttcatc agctgagttt aatttagtat tctctcttca ttctatttat ttggtcttga
     8041 aataaattct tttgcattca tttaaatatt aggattgatc aggaaatagt gtttgtaatc
     8101 tacacgttta tttgagcctt actttaaaaa tatttctgaa cagagattta agctctgtca
     8161 gtattttcat ttactgatag catttatatt ttaaatatgg cattgtatat ttcattatta
     8221 tccttcataa cagaattata atgagaatat gaatttgtta tttttcttgt tggtagatgt
     8281 gaaatggtgc ttcaaaaaat atatagtctt tctgtatgtc tctgtgtgtg taagtatgtg
     8341 tgtgtgtgtg tacacatatt ttaaagtatg aattggtcct ttaaaaacag gcctgccatc
     8401 tgaaaatggg aaattgagac ctgagacctg ctaaagcata gaagaacttg atataggtag
     8461 ggtttttttt tttttttttt ttttaataga tggagtctgg ctctgttgcc caggctggag
     8521 tgcagtggcg tgatctcagc tcactgcaag ctccacctcc cgggttcaag tgattctcct
     8581 gcctcagcct cctgtgtagc tgggactaca ggcacgtgcc accacacctg gctaattttt
     8641 ggtactttta gtagagacgg ggtttcaccg tgttagccag gatggtcttg atctcctgac
     8701 ctcgtgatcc acctgcctcg gcctcccaaa gtgccaggat tacaggcatg agccaccgtg
     8761 cttggcctag gtacaggttt ttaaaagccc cacagaagtt tataatacgt ttaaaaaccc
     8821 atattaaaat ttgaaaactt aaaaaaaaaa ctaagaaaac aatggcatat attccttttc
     8881 ttaaacctgt gaagtccatt actttttgtt cttgttatat tctgccaaaa atgggatggg
     8941 gtgggagaga tgcatagaaa ttgttttatc tgccttgtta acaaagtgaa ctcaaggacc
     9001 agcttttctt ttctttcttc ttttcttttt tttttgagac tctgtcaccc aggctggagt
     9061 gtcgttaggt gcaactaaca ccaggaacag caccttgaat attccttttt caagttcctc
     9121 ttcctcagga gatattcaag gtcactttgt cacccaggct ggagtctaca atggcaggat
     9181 cttggctcac tgcagcctct gcctcctggg ttcaagcaaa ttcttgagcc tcagcctccc
     9241 gagtagctga gattacaggt ctgtgccact acacctggct aatttttata tttttagtag
     9301 agacggggtt tcaccatctt ggccaggctg gtcttgaact cctgatgtca ggtgatccac
     9361 ccacctcggc ctcccaaagt actggaatta caggcatgag tcacccctcc caggcccccc
     9421 cctttttttt taatcctaaa aagcttccta agggttggtc agagcagtta actccagtga
     9481 atacctcttc taaagactca gcaaaagggt catttgtgcc tctttaactg ttcttaccaa
     9541 actgtcctgt ctcttttctg ctgccaacta agcagcttcc tagggacaaa aaaatataca
     9601 atattttttt ttttcttgct tacaaagcaa gaacaacctg tattttcttt cttcaaaatg
     9661 gtcttgggga agaataggag agcttcatga ataagttact caagacaaca gataaacaca
     9721 gtagtcaaaa ctttttattg aggaaaaatg tggcatttat gacttgcttt ttaattctct
     9781 taactgaatt ttaagctgca acgttcaaat ttttctttgt acttgaaagg tccagtgtgc
     9841 caatttcaag aaggacagtt ttccatgtgt ttggctattc atttccctct ctccctctct
     9901 catctgtctg tctctcactg cctctgtctc tgtctctcat acacatatac acacacacac
     9961 acacacacac acacacacac tctctctctc tctctctctc tctccagtgg ctgttaagtt
    10021 ctgaaggact ggggactgct agacataatt gaaagtaagg taacaggcta aggagaagct
    10081 cagtttgaac attgcaatgt aaagtcctca aagcctgtga ctttcaagta tttctgttgc
    10141 attaattgta ttttcctgct tagctgtgtt cagacatagt atttgcattt cttggagctt
    10201 tcattccaac agtctaacat tttgatcttg aaagagtctc aataagcctt atttgaccat
    10261 ctgaggaaaa atgtgaccat ctgtgaataa ttggctcctg cttacgtgta gctctcatta
    10321 ctttacagat gtatgcatgt gtatgtaaga cttcagttca tacatggctt aattctgaaa
    10381 gtgttcagac catagtaccc ttatttgatt taaaagcatg aatatatgag atttactagc
    10441 agtattaagt atttgataga gctacgtgat ttttgggaag aaatttgtta tatggtatgt
    10501 agtgttaatt tggatataat ttttggtaaa gggatggcag aaaacatagt caattttggt
    10561 tataataaac gtaaccttat tcttggcctg ctccatgtga aatagggctc agggaagctg
    10621 gtcttttcct tagcgggatg attactcctt tgccttgaaa catttattgg gcccaccatg
    10681 tatggatcag catgtggtgg taagtcatac tcccaaatca gtgattccca agtcttggct
    10741 ttgggaacca gtatgcctcg tattctctta aagagcaaca agaatttctt gaaacaaaat
    10801 tagttcagaa ttgatttaaa ttttttaact tctggaaata cacgaagtta tgtctgagtc
    10861 atgagtgaca gtcattgatt aaatcatttc tctgtctctt ttttagcatt attgatcaca
    10921 gagtccgtta taaaaagtgg ttgattcctt tcaacattta acaataactt ctaatgaagg
    10981 gtaaaattcc agattctctt catgcgtaaa catttaatgt gtcaatcata gatgaaagga
    11041 atctagtttg atgttgtttc tttctttctt ttttttggaa aacacaagtt gctctgggat
    11101 ggcttatatg ttgttttata ccggttcagg aaatttattt ttgtttttat tgtaagacct
    11161 tttgcggtac cagagatggc accttttttc taggtaaggt gtaggaattc ctcaatggtc
    11221 ttgcttcgta aaatttaaca tatcagaact ggggaaagag aaaggagggg gttatttttt
    11281 tgcagcattt tccagtcaca tatcagggtt atactgaact gcaacaaaga tcaactttta
    11341 aaaattagcc ttcttaaaat acaaaatgat ttaagtattt taaagataat ttatttgcct
    11401 tgctcttgcc ttctaacatt agccatttca tggagaggct aaaacttata ctccaaaaaa
    11461 tgtggaagca cattttaatg ggagtaaaat taaaaaattt tgagaaaggg taaaatctta
    11521 tgaatatgca tcttcttagc tttatcttcc ctttgatagg taggcactta tgctcttcca
    11581 tctgctccat gtcaaatagg gctcagggaa gccagtcatt tccttagcga gatgattact
    11641 cctttgcctt gaaacattta ttgggcccac catgtatgga tcagtgtgtg gtagtgagtc
    11701 atactcccaa atcagtgatt cccaagtctt ggctttggga accagtatgc cttgtattct
    11761 cttaaaaagc aacaataatt tcttgaaaca aaattagttc agaattgatt taaaatattt
    11821 cagtgtgcca tatagctctg tcccttggtt tggttggcct tgttttttcc tgtgaagaat
    11881 gaaagggcaa aggtgatacc aaaatgaaac agctttggag tgatatcttt aggagcctgg
    11941 aagccatttt tgtaattttg ttgtctatat aaatgctacc tttgcctgga ggtagtgcgc
    12001 ctgtggctgt gtacatccag agggcaacag taatagccaa caaccagaca aactagtgaa
    12061 gttaatctgt gagtgatgat tttatgatac ttatatgcaa attaaaggca gaagttagtt
    12121 tcttctcaag atgccttttt ggctgaacat taccattttt ctttccccag ggtttgaaag
    12181 aaaagggcct tttttggatt taactatatt ctgtctgcat tctattcttc atgcgtaggt
    12241 ttctactaga acctgtggag gggggacacc aaatttagat tgagtcagtc catgctgata
    12301 agaagcgtga ggaccttgtt ggacacagag cttctagatc tttccacctg tagcctctac
    12361 cctgttcctg cactttacct gaaactgtgc ctctggtctt tagaccagct gttggaacat
    12421 atcactcacc cactcctctg ttatagcaaa gggccagctg ggatggtaca cgctgtgtaa
    12481 tcagacacct tctcgacaag tacagctgat gtttctcact gttgccttac cattctctga
    12541 gccatctttg atgttgattt gtaaaaaaaa acaaaaaaca aaaaaaaaac ctagtagcaa
    12601 aactcctgtt aaactcagag cttgtatgtg gtggtcattc aacatcctta tttctagatt
    12661 tacacaaact gtaccaactg taatcttttt ctggcacgcg tatgtggtca gatgcttcat
    12721 aaacgtgagc caacttgggt tgtaaacatt ggacataata tacaaattgg ggaattttgg
    12781 atgactgcat aatcctgtca ttagagattt cataagacag aagataactg tttatttgta
    12841 atttaacaca tttttagaaa agatgatctt taatttcttt ccctcagttg tgtatacagc
    12901 tatacaccat actaacaccg tactatgtca taggaactta aagttagatg tatctaaatc
    12961 ccttcacttt tctaagactt ctctgtgctc ccacccctga agtcttcaaa tcatttttca
    13021 tctgtgaagt cactgaggta ctgggcttga ctatagtggt aacagttaag gggagttgaa
    13081 ctattgatct tccaagaaga aagggaccag atagtgttaa gatgctgcag ttgtgttact
    13141 gtgaagaaaa gattcgcttc cactttcagc aggctatata aatatatata catatatata
    13201 tatattttca ctttggtaaa aaaaagttga aaaatctgag gagaacataa ttaccttcac
    13261 aaattattta tagatacact gggtgagaag cttactgtag ggcagtcacc caaaaaaaac
    13321 taattttagt gctttcaata gtgtaatatt tgtatctatt accatggcag cagtgtctgc
    13381 tgcacactgt gtcctattac tgtaaatctc ctggtttata attcttatgg aaactaattt
    13441 gttttgtaat ggaatccaga gcagatatgt ataatatgat caggattgtc ctacagttgt
    13501 aaataagaat aggtcctgtt tattttgaca tctttttaca aatgcattgt attagggtgt
    13561 gaatattctg aaccatcctc ttgtttaaag tttggaaatt tttattgtta aatgtaacat
    13621 tttaatggtt gtaataatta tttgtataga tatgaatata gtattttatt taagaaaata
    13681 aactttgcat ttttgcattg taaa
//
