LOCUS       NM_001321150            1353 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens upstream transcription factor 2, c-fos interacting
            (USF2), transcript variant 3, mRNA.
ACCESSION   NM_001321150
VERSION     NM_001321150.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Xu,K., Li,Y.D., Ren,L.Y., Song,H.L., Yang,Q.Y. and Xu,D.L.
  TITLE     Long non-coding RNA X-Inactive Specific Transcript (XIST)
            interacting with USF2 promotes osteogenic differentiation of
            periodontal ligament stem cells through regulation of WDR72
            transcription
  JOURNAL   J Periodontal Res 58 (6), 1235-1247 (2023)
   PUBMED   37712743
  REMARK    GeneRIF: Long non-coding RNA X-Inactive Specific Transcript (XIST)
            interacting with USF2 promotes osteogenic differentiation of
            periodontal ligament stem cells through regulation of WDR72
            transcription.
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Liu,W., Xie,A., Xiong,J., Li,S., Yang,L. and Liu,W.
  TITLE     WDR3 promotes stem cell-like properties in prostate cancer by
            inhibiting USF2-mediated transcription of RASSF1A
  JOURNAL   J Gene Med 25 (7), e3498 (2023)
   PUBMED   36905106
  REMARK    GeneRIF: WDR3 promotes stem cell-like properties in prostate cancer
            by inhibiting USF2-mediated transcription of RASSF1A.
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Huang,W.Y., Liao,Z.B., Zhang,J.C., Zhang,X., Zhang,H.W.,
            Liang,H.F., Zhang,Z.Y., Yang,T., Yu,J. and Dong,K.S.
  TITLE     USF2-mediated upregulation of TXNRD1 contributes to hepatocellular
            carcinoma progression by activating Akt/mTOR signaling
  JOURNAL   Cell Death Dis 13 (11), 917 (2022)
   PUBMED   36319631
  REMARK    GeneRIF: USF2-mediated upregulation of TXNRD1 contributes to
            hepatocellular carcinoma progression by activating Akt/mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Chen,M., Li,X., Du,B., Chen,S. and Li,Y.
  TITLE     Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis
            in pancreatic cancer through transcriptional regulation of pyruvate
            kinase M2
  JOURNAL   Biochem Pharmacol 205, 115255 (2022)
   PUBMED   36210578
  REMARK    GeneRIF: Upstream stimulatory factor 2 inhibits erastin-induced
            ferroptosis in pancreatic cancer through transcriptional regulation
            of pyruvate kinase M2.
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Ghosh,A.K., Datta,P.K. and Jacob,S.T.
  TITLE     The dual role of helix-loop--helix-zipper protein USF in ribosomal
            RNA gene transcription in vivo
  JOURNAL   Oncogene 14 (5), 589-594 (1997)
   PUBMED   9053857
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Groenen,P.M., Garcia,E., Debeer,P., Devriendt,K., Fryns,J.P. and
            Van de Ven,W.J.
  TITLE     Structure, sequence, and chromosome 19 localization of human USF2
            and its rearrangement in a patient with multicystic renal dysplasia
  JOURNAL   Genomics 38 (2), 141-148 (1996)
   PUBMED   8954795
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Viollet,B., Lefrancois-Martinez,A.M., Henrion,A., Kahn,A.,
            Raymondjean,M. and Martinez,A.
  TITLE     Immunochemical characterization and transacting properties of
            upstream stimulatory factor isoforms
  JOURNAL   J Biol Chem 271 (3), 1405-1415 (1996)
   PUBMED   8576131
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Lefrancois-Martinez,A.M., Martinez,A., Antoine,B., Raymondjean,M.
            and Kahn,A.
  TITLE     Upstream stimulatory factor proteins are major components of the
            glucose response complex of the L-type pyruvate kinase gene
            promoter
  JOURNAL   J Biol Chem 270 (6), 2640-2643 (1995)
   PUBMED   7852331
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Blanar,M.A. and Rutter,W.J.
  TITLE     Interaction cloning: identification of a helix-loop-helix zipper
            protein that interacts with c-Fos
  JOURNAL   Science 256 (5059), 1014-1018 (1992)
   PUBMED   1589769
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Sirito,M., Walker,S., Lin,Q., Kozlowski,M.T., Klein,W.H. and
            Sawadogo,M.
  TITLE     Members of the USF family of helix-loop-helix proteins bind DNA as
            homo- as well as heterodimers
  JOURNAL   Gene Expr 2 (3), 231-240 (1992)
   PUBMED   1450663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AD000684.1, AY147880.1 and
            AI240594.1.
            
            On May 31, 2019 this sequence version replaced NM_001321150.1.
            
            Summary: This gene encodes a member of the basic helix-loop-helix
            leucine zipper family of transcription factors. The encoded protein
            can activate transcription through pyrimidine-rich initiator (Inr)
            elements and E-box motifs and is involved in regulating multiple
            cellular processes. [provided by RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.122985.1, AY147880.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AD000684.1         17927-18066
            141-788             AY147880.1         1-648
            789-1223            AD000684.1         28222-28656
            1224-1353           AI240594.1         21-150              c
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1353
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /note="upstream transcription factor 2, c-fos interacting"
                     /db_xref="GeneID:7392"
                     /db_xref="HGNC:HGNC:12594"
                     /db_xref="MIM:600390"
     exon            1..202
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..788
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /note="isoform 3 is encoded by transcript variant 3; c-fos
                     interacting protein; upstream stimulatory factor 2; major
                     late transcription factor 2; class B basic
                     helix-loop-helix protein 12"
                     /codon_start=1
                     /product="upstream stimulatory factor 2 isoform 3"
                     /protein_id="NP_001308079.1"
                     /db_xref="CCDS:CCDS82329.1"
                     /db_xref="GeneID:7392"
                     /db_xref="HGNC:HGNC:12594"
                     /db_xref="MIM:600390"
                     /translation="MDMLDPGLDPAASATAAAAASHDKGPEAEEGVELQEGGDGPGAE
                     EQTAVAITSVQQAAFGDHNIQYQFRTETNGGQTGTQRTIAPRTHPYSPKIDGTRTPRD
                     ERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELR
                     QTNQRMQETFKEAERLQMDNELLRQQIEELKNENALLRAQLQQHNLEMVGEGTRQ"
     exon            203..249
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            250..368
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            369..415
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            416..474
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            475..569
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            570..698
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1353
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="USF2"
                     /gene_synonym="bHLHb12; FIP"
                     /note="major polyA site"
ORIGIN      
        1 gtatctcctc cgtcccctcc tgccgcgcgg cgtgagcgcc gggctcgggg cccccccggc
       61 cgcccgcccc ctcccctccc tccctcccct cccctcccct cccccccggg ccccgcgccc
      121 cccccgcccc cgcccccccc atggacatgc tggacccggg tctggatccc gctgcctcgg
      181 ccaccgctgc tgccgccgcc agccacgaca agggacccga ggcggaggag ggcgtcgagc
      241 tgcaggaagg cggggacggc ccaggagcgg aggagcagac agcggtggcc atcaccagcg
      301 tccagcaggc ggcgttcggc gaccacaaca tccagtacca gttccgcaca gagacaaatg
      361 gaggacagac aggaacacag aggacgatcg ccccccggac acacccttac tctccaaaaa
      421 ttgatggaac cagaacaccc cgagatgaga ggagaagagc ccagcacaac gaagtggagc
      481 ggaggcggag ggacaagatc aacaactgga tcgtccagct ttcgaaaatc attccagact
      541 gtaacgcaga caacagcaag acgggagcga gtaaaggagg gatcctgtcc aaggcctgcg
      601 attacatccg ggagttgcgc cagaccaacc agcgcatgca ggagaccttc aaagaggccg
      661 agcggctgca gatggacaac gagctcctga ggcagcagat cgaggagctg aagaatgaga
      721 acgccctgct tcgagcccag ctgcagcagc acaacctgga gatggtgggc gagggcaccc
      781 ggcagtgacg cccgccacca ccacgcagcc gccgccgccc acgccggcct ctgctgcccc
      841 cttccccagc ccttagcaca gagagggaca catgcccctc ccccagctgc gtttttttat
      901 agtagatttt taacaaaaaa cggggagaaa taatgcattt ctgtggatac agtgcccacc
      961 gccctcctcc acttggaaac ggtatcctcc ctgcccatcc gtctgtctgt cgcccttctc
     1021 ccggccctca ctaagccccg gcacttctag tggtctcacc tggaggcaag agggagggga
     1081 cagaggccct gccacgtccc gctgcctcct gctctctgga ggtactgaga cagggtgctg
     1141 atgggaagga ggggagcctt tggggggcca cccggggcct ggacctatgc agggaggcca
     1201 cgtcccaccc cacctcttgt ttctgggtcc ctgctcccct ttgggggtgt gtgtgtgtgt
     1261 tttaattttc tttatggaaa aattgacaaa aaaaaaatag agagagaggt atttaactgc
     1321 aataaactgg ccccatgtgg cccccgcctt gtc
//
