LOCUS       NM_007122               1807 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens upstream transcription factor 1 (USF1), transcript
            variant 1, mRNA.
ACCESSION   NM_007122
VERSION     NM_007122.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Gao,L. and Li,J.
  TITLE     USF1 Silencing Reduces Ferroptosis Resistance in Prostate Cancer
            Cells
  JOURNAL   Arch Esp Urol 77 (8), 865-874 (2024)
   PUBMED   39385481
  REMARK    GeneRIF: USF1 Silencing Reduces Ferroptosis Resistance in Prostate
            Cancer Cells.
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Moss,C.E., Johnston,S.A., Kimble,J.V., Clements,M., Codd,V.,
            Hamby,S., Goodall,A.H., Deshmukh,S., Sudbery,I., Coca,D.,
            Wilson,H.L. and Kiss-Toth,E.
  TITLE     Aging-related defects in macrophage function are driven by MYC and
            USF1 transcriptional programs
  JOURNAL   Cell Rep 43 (4), 114073 (2024)
   PUBMED   38578825
  REMARK    GeneRIF: Aging-related defects in macrophage function are driven by
            MYC and USF1 transcriptional programs.
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Baidya,A., Khatun,M., Mondal,R.K., Ghosh,S., Chakraborty,B.C.,
            Mallik,S., Ahammed,S.K.M., Chowdhury,A., Banerjee,S. and Datta,S.
  TITLE     Hepatitis B virus suppresses complement C9 synthesis by limiting
            the availability of transcription factor USF-1 and inhibits
            formation of membrane attack complex: implications in disease
            pathogenesis
  JOURNAL   J Biomed Sci 29 (1), 97 (2022)
   PUBMED   36376872
  REMARK    GeneRIF: Hepatitis B virus suppresses complement C9 synthesis by
            limiting the availability of transcription factor USF-1 and
            inhibits formation of membrane attack complex: implications in
            disease pathogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Lee,J.C., Lusis,A.J. and Pajukanta,P.
  TITLE     Familial combined hyperlipidemia: upstream transcription factor 1
            and beyond
  JOURNAL   Curr Opin Lipidol 17 (2), 101-109 (2006)
   PUBMED   16531745
  REMARK    GeneRIF: upstream transcription factor 1 has a part in the etiology
            of familial combined hyperlipidemia and its component traits,
            although the mechanism of causality still remains largely unknown.
            Review article
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Saito,T., Oishi,T., Yanai,K., Shimamoto,Y. and Fukamizu,A.
  TITLE     Cloning and characterization of a novel splicing isoform of USF1
  JOURNAL   Int J Mol Med 12 (2), 161-167 (2003)
   PUBMED   12851711
  REMARK    GeneRIF: we report the molecular cloning and functional
            characterization of a novel alternative splicing variant of human
            USF1 (hUSF1), termed USF1/BD.
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Lefrancois-Martinez,A.M., Martinez,A., Antoine,B., Raymondjean,M.
            and Kahn,A.
  TITLE     Upstream stimulatory factor proteins are major components of the
            glucose response complex of the L-type pyruvate kinase gene
            promoter
  JOURNAL   J Biol Chem 270 (6), 2640-2643 (1995)
   PUBMED   7852331
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Henrion,A.A., Martinez,A., Mattei,M.G., Kahn,A. and Raymondjean,M.
  TITLE     Structure, sequence, and chromosomal location of the gene for USF2
            transcription factors in mouse
  JOURNAL   Genomics 25 (1), 36-43 (1995)
   PUBMED   7774954
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Shieh,B.H., Sparkes,R.S., Gaynor,R.B. and Lusis,A.J.
  TITLE     Localization of the gene-encoding upstream stimulatory factor (USF)
            to human chromosome 1q22-q23
  JOURNAL   Genomics 16 (1), 266-268 (1993)
   PUBMED   8486371
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Roy,A.L., Meisterernst,M., Pognonec,P. and Roeder,R.G.
  TITLE     Cooperative interaction of an initiator-binding transcription
            initiation factor and the helix-loop-helix activator USF
  JOURNAL   Nature 354 (6350), 245-248 (1991)
   PUBMED   1961251
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Gregor,P.D., Sawadogo,M. and Roeder,R.G.
  TITLE     The adenovirus major late transcription factor USF is a member of
            the helix-loop-helix group of regulatory proteins and binds to DNA
            as a dimer
  JOURNAL   Genes Dev 4 (10), 1730-1740 (1990)
   PUBMED   2249772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP280296.1, AL832119.1 and
            AL591806.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007122.4.
            
            Summary: This gene encodes a member of the basic helix-loop-helix
            leucine zipper family, and can function as a cellular transcription
            factor. The encoded protein can activate transcription through
            pyrimidine-rich initiator (Inr) elements and E-box motifs. This
            gene has been linked to familial combined hyperlipidemia (FCHL).
            Alternative splicing of this gene results in multiple transcript
            variants. A related pseudogene has been defined on chromosome 21.
            [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            3 encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832119.1, SRR1803617.171008.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368021.7/ ENSP00000357000.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BP280296.1         3-13
            12-1783             AL832119.1         51-1822
            1784-1788           AL591806.16        93272-93276         c
            1789-1807           AL832119.1         1826-1844
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1807
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /note="upstream transcription factor 1"
                     /db_xref="GeneID:7391"
                     /db_xref="HGNC:HGNC:12593"
                     /db_xref="MIM:191523"
     exon            1..120
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            121..213
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1138
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /note="isoform 1 is encoded by transcript variant 1; major
                     late transcription factor 1; upstream stimulatory factor
                     1; class B basic helix-loop-helix protein 11"
                     /codon_start=1
                     /product="upstream stimulatory factor 1 isoform 1"
                     /protein_id="NP_009053.1"
                     /db_xref="CCDS:CCDS1214.1"
                     /db_xref="GeneID:7391"
                     /db_xref="HGNC:HGNC:12593"
                     /db_xref="MIM:191523"
                     /translation="MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPD
                     PNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSD
                     DAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQF
                     FVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNW
                     IVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDND
                     VLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN"
     exon            214..263
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            264..379
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            380..481
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            482..677
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            678..765
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            766..824
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            825..919
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1048
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1807
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /note="hexamer: GATAAA"
     polyA_site      1807
                     /gene="USF1"
                     /gene_synonym="bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI;
                     UEF"
                     /note="major polyA site"
ORIGIN      
        1 gcccctcacc aacatggccg cgggctggaa gtgcgcatga gcagctgtct atggagatac
       61 ctaggccggg agagggagaa cacagttgga gaaaatcggc agctgagacg gccttggccg
      121 gacttagcac tcaggcctgt gaatcaggag atacaaagac ctccaaaaaa ggaccagttc
      181 ctcggatgtg ccccctcaca gagagatgaa ggggcagcag aaaacagctg aaacggaaga
      241 ggggacagtg cagattcagg aaggtgcagt ggctactggg gaagacccaa ccagtgtggc
      301 tattgccagc atccagtcag ctgccacctt ccctgacccc aacgtcaagt acgtcttccg
      361 aactgagaat gggggccagg tgatgtacag ggtgatccag gtgtctgagg ggcagctgga
      421 tggccaaact gagggaactg gcgccatcag tggctaccct gccactcaat ccatgaccca
      481 ggcggtgatc cagggtgctt tcaccagtga tgatgcagtt gacacggagg ggacagctgc
      541 tgagacgcac tatacttact tccccagcac ggcagtggga gatggggcag ggggtaccac
      601 atcggggagt acagctgctg ttgttactac ccagggctca gaggcactgc tggggcaggc
      661 gacccctcct ggcactggtc aattctttgt gatgatgtca ccacaagaag tactgcaggg
      721 aggaagccag cgctcaattg cccctaggac tcacccttat tccccgaagt cagaagctcc
      781 ccggacgact cgggatgaga aacgcagggc tcagcataat gaagtggagc gtcgccgccg
      841 agacaagatc aacaactgga tcgtgcagct ctccaagata atcccagact gctctatgga
      901 gagcaccaag tctggccaga gtaaaggtgg gattctatcc aaagcttgtg attatatcca
      961 ggagcttcgg cagagtaacc accgcttgtc tgaagaactg cagggacttg accaactgca
     1021 gctggacaat gacgtgcttc gacaacaggt ggaagatctt aaaaacaaga atctgctgct
     1081 tcgagctcag ttgcggcacc acggattaga ggtcgtcatc aagaatgaca gcaactaact
     1141 atggggattc aggggctttg ggcccaagaa ctgcagatag cccaggagca acagcctaat
     1201 cccgtgcccc tttccttcac tgccccactt ctggcatggg acagggggaa gttcagaagg
     1261 tgtgtccttg aactgaggcc ctgtgatatg gcggcctgca gtggtgtgaa acacacaatg
     1321 tggacgtgca ctgacagcct tgcccacccc caccatgcag cccctgggcc cttgtgctcc
     1381 tctcgcacaa tgcatgtgct gtctccatgc tggatactgg acacactaaa ctctggggct
     1441 tgtcctgtgc ttgcttagag tgcccagcag aggtttgctg acaggtgatg ctctggcttg
     1501 ccccaggact ctggcacttc cattggttct tcctttccct ggagctgagg tttagatgtg
     1561 caacctgtgg ctcaggggag caagcttaca caagaagtga gggaaggatg tttagcagtg
     1621 gctggtgccc atgaagagga gattggccag tgagaagctg aggcctatgc agacatctct
     1681 ggagccagag agaacaacag gcaggggccc acttggggcc ttcccccttg tgggggtcgt
     1741 tttttttttt tcttttcttt tttttttttt tttttttttt tttttaagat aaaattgttc
     1801 aaagcca
//
