LOCUS       NM_018467                845 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens unconventional SNARE in the ER 1 (USE1), mRNA.
ACCESSION   NM_018467
VERSION     NM_018467.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 845)
  AUTHORS   Schnell,L., Zubrod,A., Catone,N., Bialas,J. and Aichem,A.
  TITLE     Tumor necrosis factor mediates USE1-independent FAT10ylation under
            inflammatory conditions
  JOURNAL   Life Sci Alliance 6 (11), e202301985 (2023)
   PUBMED   37604583
  REMARK    GeneRIF: Tumor necrosis factor mediates USE1-independent
            FAT10ylation under inflammatory conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 845)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 845)
  AUTHORS   Palagano,E., Zuccarini,G., Prontera,P., Borgatti,R., Stangoni,G.,
            Elisei,S., Mantero,S., Menale,C., Forlino,A., Uva,P., Oppo,M.,
            Vezzoni,P., Villa,A., Merlo,G.R. and Sobacchi,C.
  TITLE     Mutations in the Neuroblastoma Amplified Sequence gene in a family
            affected by Acrofrontofacionasal Dysostosis type 1
  JOURNAL   Bone 114, 125-136 (2018)
   PUBMED   29929043
REFERENCE   6  (bases 1 to 845)
  AUTHORS   Aoki,T., Ichimura,S., Itoh,A., Kuramoto,M., Shinkawa,T., Isobe,T.
            and Tagaya,M.
  TITLE     Identification of the neuroblastoma-amplified gene product as a
            component of the syntaxin 18 complex implicated in
            Golgi-to-endoplasmic reticulum retrograde transport
  JOURNAL   Mol Biol Cell 20 (11), 2639-2649 (2009)
   PUBMED   19369418
  REMARK    GeneRIF: Results together suggest that NAG links between p31 and
            ZW10-RINT-1 and is involved in Golgi-to-ER transport.
REFERENCE   7  (bases 1 to 845)
  AUTHORS   Okumura,A.J., Hatsuzawa,K., Tamura,T., Nagaya,H., Saeki,K.,
            Okumura,F., Nagao,K., Nishikawa,M., Yoshimura,A. and Wada,I.
  TITLE     Involvement of a novel Q-SNARE, D12, in quality control of the
            endomembrane system
  JOURNAL   J Biol Chem 281 (7), 4495-4506 (2006)
   PUBMED   16354670
REFERENCE   8  (bases 1 to 845)
  AUTHORS   Nakajima,K., Hirose,H., Taniguchi,M., Kurashina,H., Arasaki,K.,
            Nagahama,M., Tani,K., Yamamoto,A. and Tagaya,M.
  TITLE     Involvement of BNIP1 in apoptosis and endoplasmic reticulum
            membrane fusion
  JOURNAL   EMBO J 23 (16), 3216-3226 (2004)
   PUBMED   15272311
REFERENCE   9  (bases 1 to 845)
  AUTHORS   Hirose,H., Arasaki,K., Dohmae,N., Takio,K., Hatsuzawa,K.,
            Nagahama,M., Tani,K., Yamamoto,A., Tohyama,M. and Tagaya,M.
  TITLE     Implication of ZW10 in membrane trafficking between the endoplasmic
            reticulum and Golgi
  JOURNAL   EMBO J 23 (6), 1267-1278 (2004)
   PUBMED   15029241
REFERENCE   10 (bases 1 to 845)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020913.9.
            
            On Nov 23, 2018 this sequence version replaced NM_018467.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.251445.1,
                                           SRR5189667.84173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263897.10/ ENSP00000263897.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC020913.9         112348-112498
            152-201             AC020913.9         112793-112842
            202-280             AC020913.9         112983-113061
            281-433             AC020913.9         113160-113312
            434-443             AC020913.9         114444-114453
            444-471             AC020913.9         115355-115382
            472-646             AC020913.9         116204-116378
            647-845             AC020913.9         116622-116820
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..845
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /note="unconventional SNARE in the ER 1"
                     /db_xref="GeneID:55850"
                     /db_xref="HGNC:HGNC:30882"
                     /db_xref="MIM:610675"
     exon            1..151
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..829
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /note="Q-SNARE; SNARE-like tail-anchored protein 1
                     homolog; putative MAPK activating protein PM26; protein
                     p31; USE1-like protein; unconventional SNARE in the ER 1
                     homolog"
                     /codon_start=1
                     /product="vesicle transport protein USE1"
                     /protein_id="NP_060937.2"
                     /db_xref="CCDS:CCDS46011.1"
                     /db_xref="GeneID:55850"
                     /db_xref="HGNC:HGNC:30882"
                     /db_xref="MIM:610675"
                     /translation="MAASRLELNLVRLLSRCEAMAAEKRDPDEWRLEKYVGALEDMLQ
                     ALKVHASKPASEVINEYSWKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARER
                     VPATKTVHLQSRARYTSEMRSELLGTDSAEPEMDVRKRTGVAGSQPVSEKQLAAELDL
                     VLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTE
                     SERLEQHTQKSVNWLLWAMLIIVCFIFISMILFIRIMPKLK"
     exon            152..201
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..280
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..433
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..443
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..471
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..646
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..845
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      825..830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /note="hexamer: AATAAA"
     polyA_site      845
                     /gene="USE1"
                     /gene_synonym="D12; MDS032; P31; SLT1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttaac atggagccgg cggaaggggt ggtgtagggc cgggcgataa tggcggcgtc
       61 gaggctggag ctaaacctgg tgcggctgct atcccgctgc gaggcgatgg cagcggagaa
      121 acgggacccg gacgagtggc gcctggagaa gtacgtggga gccctagagg acatgttgca
      181 ggccctgaag gtccacgcga gcaaaccggc ctctgaggtg atcaatgaat attcctggaa
      241 ggtggatttt ctgaagggga tgctgcaagc cgagaagctg acctcctcct cagagaaagc
      301 actggccaac cagttcctgg cccctggccg tgtgccaacc acagccagag agcgagtgcc
      361 cgccacaaag acggtgcatc tgcagtcacg ggcgcggtac accagcgaga tgcggagtga
      421 gctactaggc acggactctg cagagcctga gatggacgta aggaagagaa ctggagtggc
      481 agggtcccag ccagtgagtg agaagcagtt ggcagctgag ctagacctcg tcctgcagcg
      541 acatcagaac ctccaggaaa agctggcgga agagatgcta ggactggccc ggagcctcaa
      601 gaccaatacc ctggccgccc agagtgtcat caagaaggac aaccagaccc tgtcacactc
      661 actgaaaatg gcggaccaga acctggagaa actgaagacg gagtcagagc gtctggagca
      721 gcacacgcag aagtcagtca actggctgct ctgggccatg ctcattatcg tctgcttcat
      781 cttcattagc atgatcctct tcattcgaat catgcctaaa ctcaaataaa gacccccgcc
      841 cacct
//
