LOCUS       NM_030914               2595 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ubiquitin related modifier 1 (URM1), transcript
            variant 1, mRNA.
ACCESSION   NM_030914
VERSION     NM_030914.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Zhang,X. and Chen,X.L.
  TITLE     The emerging roles of ubiquitin-like protein Urm1 in eukaryotes
  JOURNAL   Cell Signal 81, 109946 (2021)
   PUBMED   33548388
  REMARK    GeneRIF: The emerging roles of ubiquitin-like protein Urm1 in
            eukaryotes.
            Review article
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   Pabis,M., Termathe,M., Ravichandran,K.E., Kienast,S.D.,
            Krutyholowa,R., Sokolowski,M., Jankowska,U., Grudnik,P.,
            Leidel,S.A. and Glatt,S.
  TITLE     Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system
            in tRNA thiolation and ubiquitin-like conjugation
  JOURNAL   EMBO J 39 (19), e105087 (2020)
   PUBMED   32901956
  REMARK    GeneRIF: Molecular basis for the bifunctional Uba4-Urm1
            sulfur-relay system in tRNA thiolation and ubiquitin-like
            conjugation.
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Judes,A., Ebert,F., Bar,C., Thuring,K.L., Harrer,A., Klassen,R.,
            Helm,M., Stark,M.J. and Schaffrath,R.
  TITLE     Urmylation and tRNA thiolation functions of ubiquitin-like
            Uba4.Urm1 systems are conserved from yeast to man
  JOURNAL   FEBS Lett 589 (8), 904-909 (2015)
   PUBMED   25747390
  REMARK    GeneRIF: ubiquitin-like Urm1.Uba4 systems are conserved and
            exchangeable between human and yeast cells
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Petroski,M.D., Salvesen,G.S. and Wolf,D.A.
  TITLE     Urm1 couples sulfur transfer to ubiquitin-like protein function in
            oxidative stress
  JOURNAL   Proc Natl Acad Sci U S A 108 (5), 1749-1750 (2011)
   PUBMED   21245332
  REMARK    GeneRIF: observations suggest that Urm1 activation is more similar
            to that of a prokaryotic sulfur carrier protein than that of a
            ubiquitin-like protein
REFERENCE   5  (bases 1 to 2595)
  AUTHORS   Van der Veen,A.G., Schorpp,K., Schlieker,C., Buti,L., Damon,J.R.,
            Spooner,E., Ploegh,H.L. and Jentsch,S.
  TITLE     Role of the ubiquitin-like protein Urm1 as a noncanonical
            lysine-directed protein modifier
  JOURNAL   Proc Natl Acad Sci U S A 108 (5), 1763-1770 (2011)
   PUBMED   21209336
  REMARK    GeneRIF: Urm1 has a conserved dual role by integrating the
            functions of prokaryotic sulfur carriers with those of eukaryotic
            protein modifiers of the Ub family
REFERENCE   6  (bases 1 to 2595)
  AUTHORS   Schlieker,C.D., Van der Veen,A.G., Damon,J.R., Spooner,E. and
            Ploegh,H.L.
  TITLE     A functional proteomics approach links the ubiquitin-related
            modifier Urm1 to a tRNA modification pathway
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18255-18260 (2008)
   PUBMED   19017811
  REMARK    GeneRIF: Urm1 is activated by an unusual mechanism to yield a
            thiocarboxylate intermediate that serves as sulfur donor in tRNA
            thiolation reactions
REFERENCE   7  (bases 1 to 2595)
  AUTHORS   Schmitz,J., Chowdhury,M.M., Hanzelmann,P., Nimtz,M., Lee,E.Y.,
            Schindelin,H. and Leimkuhler,S.
  TITLE     The sulfurtransferase activity of Uba4 presents a link between
            ubiquitin-like protein conjugation and activation of sulfur carrier
            proteins
  JOURNAL   Biochemistry 47 (24), 6479-6489 (2008)
   PUBMED   18491921
  REMARK    GeneRIF: The UBA4-URM1 system represents the evolutionary link
            between protein conjugation and protein modification by sulfur
            carrier proteins.
REFERENCE   8  (bases 1 to 2595)
  AUTHORS   Xu,J., Zhang,J., Wang,L., Zhou,J., Huang,H., Wu,J., Zhong,Y. and
            Shi,Y.
  TITLE     Solution structure of Urm1 and its implications for the origin of
            protein modifiers
  JOURNAL   Proc Natl Acad Sci U S A 103 (31), 11625-11630 (2006)
   PUBMED   16864801
REFERENCE   9  (bases 1 to 2595)
  AUTHORS   Singh,S., Tonelli,M., Tyler,R.C., Bahrami,A., Lee,M.S. and
            Markley,J.L.
  TITLE     Three-dimensional structure of the AAH26994.1 protein from Mus
            musculus, a putative eukaryotic Urm1
  JOURNAL   Protein Sci 14 (8), 2095-2102 (2005)
   PUBMED   16046629
REFERENCE   10 (bases 1 to 2595)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003581.1 and AL359091.10.
            
            On Jul 19, 2019 this sequence version replaced NM_030914.3.
            
            Transcript Variant: This variant (1) lacks a segment in the 3'
            coding region, compared to variant 2, which results in a protein
            (isoform 1) with a distinct C-terminus, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001880.1, BC003581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372853.9/ ENSP00000361944.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               BC003581.1         14-640
            628-2595            AL359091.10        89245-91212
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2595
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="ubiquitin related modifier 1"
                     /db_xref="GeneID:81605"
                     /db_xref="HGNC:HGNC:28378"
                     /db_xref="MIM:612693"
     exon            1..42
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..313
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="isoform a is encoded by transcript variant 1;
                     ubiquitin-related modifier 1 homolog"
                     /codon_start=1
                     /product="ubiquitin-related modifier 1 isoform a"
                     /protein_id="NP_112176.1"
                     /db_xref="CCDS:CCDS6900.1"
                     /db_xref="GeneID:81605"
                     /db_xref="HGNC:HGNC:28378"
                     /db_xref="MIM:612693"
                     /translation="MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPWDIRNLLIW
                     IKKNLLKERPELFIQGDSVRPGILVLINDADWELLGELDYQLQDQDSVLFISTLHGG"
     exon            43..113
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            114..195
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            196..244
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            245..2595
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1290..1295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="hexamer: AATAAA"
     polyA_site      1313
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="major polyA site"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="hexamer: AATAAA"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URM1"
                     /gene_synonym="C9orf74"
                     /note="hexamer: AATAAA"
     polyA_site      2587
                     /gene="URM1"
                     /gene_synonym="C9orf74"
     polyA_site      2595
                     /gene="URM1"
                     /gene_synonym="C9orf74"
ORIGIN      
        1 cctcaacatg gctgcgccct tgtcagtgga ggtggagttc ggaggtggtg cggagctcct
       61 gtttgacggt attaagaaac atcgagtcac tttgcctgga caggaggaac cctgggacat
      121 ccggaacctg ctcatctgga tcaagaagaa tttgctaaaa gagcggccag agttgttcat
      181 ccagggagac agcgtgcggc caggaattct ggtgctgatt aacgatgccg actgggagct
      241 actgggtgag ctggactacc agcttcagga ccaggacagc gtcctcttca tctccactct
      301 gcacggcggc tgagggccct tctctgggcc tgggcaccct tagaggggag aacgaagcaa
      361 tcagacatcc ccttgggccc tgcttccagg tctccctgtc ccccttgcct gccttcttcc
      421 ctgctctgtc ccctaagctc cctccaggca gggaaaagag gccaggtgct aaaaatgagc
      481 ctttctcaag cacgtgagca gcggaaggca gacaggcgcc agagcccagc actccctttt
      541 ccagcagctg tggtggggga gggttcccct ccagtttgtc aagagttgaa ggaggctctg
      601 tggccaggtg acctggctgc cttccactcc ttgtacctca gtctaaacat ggagtggccg
      661 ctgacaaggc gctccagccc cagagccagc gtcttcatgg ggaagatgaa tggacctgag
      721 tagctgaagg aaggcccctc cctacccaaa gactggaggc ttctcagcct caatttccct
      781 gtctgtacag ctgagggctc tgcctgtccc ccactgctat cagtatggaa ccccagctgg
      841 ggtcccctat tgagtgccga ctccccccac cgccagcagc tgctcctcca gccacacccc
      901 tcctgctccc cccaccccta gcccttgacc ctggctggcc tgccccgctc cacaggccac
      961 cagatgggct cctgagaccc tccccaggct gcttacagct cattctgctg ggggtagaga
     1021 tgaggggagg gagtaagtta aaccttggac tagcaagtag aagcctgggg ggatgcgtgt
     1081 gcctcagttt cctcctccac aactgaatat agtggctgaa aactggggag atacttgatg
     1141 gcgcgaatgt ccgttttctc tcccttccca cctcctgcag gaagcaggac ggggcaggca
     1201 gcacctggta ggcacagtgc tttgcccctc ctccccttcc cttctggaag tcttggggcc
     1261 tcagtgcttg caacagccgg ccttgggcaa ataaaagact aggttgttta ctagccttgc
     1321 ttggagcttc atccttggaa acgggtggca cctcatatcc ccccagccgt ggtctgtgat
     1381 acaacctctc catcctcagc ctagggcctc agagctaccc ttcacccaaa agaggggtgg
     1441 gggtgaacac tcagacaatc tgagaggggg tagtctaata gagccatctg gagaagggag
     1501 tggcagagcc agtctgtgct gaccagtctg tgtcccggga cgcatcccca cccgtctgtc
     1561 caaggctttg tcccaccagc tgcagccagc agcctcagaa cccaaaatga gggtagcata
     1621 gataagactg ctgagccccc tttctgtggt ctttcctttc catgacctag agaaaagagc
     1681 tttgctggag ggagaccccc aaaaagaatt agggtgctaa catcccacca aaagcatcat
     1741 cccacccaaa atgttgcttt tcattctatg tcaataattt aaggtggaat ttctctcacc
     1801 ctgtggagat gaaagtggca aaaggttgtc ccagcagtgt tgggggatgg ggtgtgcaca
     1861 tcattctttt gggggtagat gacctgctgg ctggtgggct tttctccagg actactgcag
     1921 gtagagaccc tctgggcttg tgtggagtgg gagcagccgt gttgggacta tggggaggag
     1981 ctggtctggg tgcaaattaa ggccagtgtt ggggtctgag tgctgtccag aaaggctgtg
     2041 tgaccaaccc tcactagttc ctgaggtcag ggtctccatg ttagggaaca gagcaagaga
     2101 cttggaacag ctccctacag ctgcacttct agaaggtcag cctgtccgat tcttgtaacc
     2161 tggaggtccc tccccatctg cagccccctg agctgcagga gcggccccat cagtgcacct
     2221 gattggaaca cactagattt caggtcctgg aaactgggcg ctaggatccg tttccctggc
     2281 tgcagagagt gggaggtgtg atgtggaata tcccttctcc cagcacaccc caattaatac
     2341 tgaagagtag ggcaggagga ggtgctggga aaaccgggtt tcttggcaca tgggggtgca
     2401 agcactgtgg ttgaaattgg ccatgtccaa ggcacaccag acgatttcag gtcattttta
     2461 gccctagact ggaaaggggt caggggacag gtgacctggg ctcagccccc agcagctccc
     2521 aactgcccct ctcccaagca actcctgatc cctgcttttg aggaaataaa caaataaaac
     2581 cccgctatct ccgaa
//
