LOCUS       NM_003796               3460 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens URI1 prefoldin like chaperone (URI1), transcript
            variant 1, mRNA.
ACCESSION   NM_003796
VERSION     NM_003796.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3460)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3460)
  AUTHORS   Xu,Y., Ji,Y., Li,X., Ding,J., Chen,L., Huang,Y. and Wei,W.
  TITLE     URI1 suppresses irradiation-induced reactive oxygen species (ROS)
            by activating autophagy in hepatocellular carcinoma cells
  JOURNAL   Int J Biol Sci 17 (12), 3091-3103 (2021)
   PUBMED   34421352
  REMARK    GeneRIF: URI1 suppresses irradiation-induced reactive oxygen
            species (ROS) by activating autophagy in hepatocellular carcinoma
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3460)
  AUTHORS   Tsuchiya,H., Amisaki,M., Takenaga,A., Honjo,S., Fujiwara,Y. and
            Shiota,G.
  TITLE     HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related
            Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 20 (22), 5714 (2019)
   PUBMED   31739577
  REMARK    GeneRIF: HBx and c-MYC are involved in URI1 expression in HCC-B.
            URI1 expression may play important roles in the development and
            progression of HCC-B because HBx and c-MYC are well-known oncogenic
            factors in the virus and host
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3460)
  AUTHORS   Yang,H., Gu,J., Zheng,Q., Li,M., Lian,X., Miao,J., Jiang,J. and
            Wei,W.
  TITLE     RPB5-mediating protein is required for the proliferation of
            hepatocellular carcinoma cells
  JOURNAL   J Biol Chem 286 (13), 11865-11874 (2011)
   PUBMED   21310960
REFERENCE   6  (bases 1 to 3460)
  AUTHORS   Theurillat,J.P., Metzler,S.C., Henzi,N., Djouder,N., Helbling,M.,
            Zimmermann,A.K., Jacob,F., Soltermann,A., Caduff,R.,
            Heinzelmann-Schwarz,V., Moch,H. and Krek,W.
  TITLE     URI is an oncogene amplified in ovarian cancer cells and is
            required for their survival
  JOURNAL   Cancer Cell 19 (3), 317-332 (2011)
   PUBMED   21397856
  REMARK    GeneRIF: Data show that URI is an 'addicting' oncogene selectively
            required for the survival of ovarian cancer cells with increased
            URI copy number.
REFERENCE   7  (bases 1 to 3460)
  AUTHORS   Wei,W., Gu,J.X., Zhu,C.Q., Sun,F.Y., Dorjsuren,D., Lin,Y. and
            Murakami,S.
  TITLE     Interaction with general transcription factor IIF (TFIIF) is
            required for the suppression of activated transcription by
            RPB5-mediating protein (RMP)
  JOURNAL   Cell Res 13 (2), 111-120 (2003)
   PUBMED   12737519
REFERENCE   8  (bases 1 to 3460)
  AUTHORS   Liu,L. and McKeehan,W.L.
  TITLE     Sequence analysis of LRPPRC and its SEC1 domain interaction
            partners suggests roles in cytoskeletal organization, vesicular
            trafficking, nucleocytosolic shuttling, and chromosome activity
  JOURNAL   Genomics 79 (1), 124-136 (2002)
   PUBMED   11827465
REFERENCE   9  (bases 1 to 3460)
  AUTHORS   Van Leuven,F., Torrekens,S., Moechars,D., Hilliker,C., Buellens,M.,
            Bollen,M. and Delabie,J.
  TITLE     Molecular cloning of a gene on chromosome 19q12 coding for a novel
            intracellular protein: analysis of expression in human and mouse
            tissues and in human tumor cells, particularly Reed-Sternberg cells
            in Hodgkin disease
  JOURNAL   Genomics 54 (3), 511-520 (1998)
   PUBMED   9878255
REFERENCE   10 (bases 1 to 3460)
  AUTHORS   Dorjsuren,D., Lin,Y., Wei,W., Yamashita,T., Nomura,T., Hayashi,N.
            and Murakami,S.
  TITLE     RMP, a novel RNA polymerase II subunit 5-interacting protein,
            counteracts transactivation by hepatitis B virus X protein
  JOURNAL   Mol Cell Biol 18 (12), 7546-7555 (1998)
   PUBMED   9819440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461036.1, AK292170.1,
            AW954529.1, BG742069.1, AW003989.1 and AA678820.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2011 this sequence version replaced NM_003796.2.
            
            Summary: This gene encodes member of the prefoldin family of
            molecular chaperones. The encoded protein functions as a
            scaffolding protein and plays roles in ubiquitination and
            transcription, in part though interactions with the RNA polymerase
            II subunit RPB5. This gene may play a role in multiple malignancies
            including ovarian cancer and hepatocellular carcinoma.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene, and a pseudogene of this
            gene is located on the long arm of chromosome 22. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.99664.1,
                                           SRR1660803.199958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392271.6/ ENSP00000376097.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               DB461036.1         13-341
            330-1226            AK292170.1         66-962
            1227-1254           AW954529.1         349-376
            1255-2447           AK292170.1         988-2180
            2448-2889           BG742069.1         223-664
            2890-3443           AW003989.1         17-570              c
            3444-3460           AA678820.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3460
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /note="URI1 prefoldin like chaperone"
                     /db_xref="GeneID:8725"
                     /db_xref="HGNC:HGNC:13236"
                     /db_xref="MIM:603494"
     exon            1..426
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1917
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /note="isoform a is encoded by transcript variant 1;
                     RPB5-mediating protein; RNA polymerase II subunit
                     5-mediating protein; protein phosphatase 1, regulatory
                     subunit 19; unconventional prefoldin RPB5 interactor 1"
                     /codon_start=1
                     /product="unconventional prefoldin RPB5 interactor 1
                     isoform a"
                     /protein_id="NP_003787.2"
                     /db_xref="CCDS:CCDS12420.1"
                     /db_xref="GeneID:8725"
                     /db_xref="HGNC:HGNC:13236"
                     /db_xref="MIM:603494"
                     /translation="MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNC
                     QERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
                     NWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVD
                     IREEIKCDFEFKAKHRIAHKPHSKPKTSDIFEADIANDVKSKDLLADKELWARLEELE
                     RQEELLGELDSKPDTVIANGEDTTSSEEEKEDRNTNVNAMHQVTDSHTPCHKDVASSE
                     PFSGQVNSQLNCSVNGSSSYHSDDDDDDDDDDDDDNIDDDDGDNDHEALGVGDNSIPT
                     IYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSTGSGHSAQELPTIRTPADIY
                     RAFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAAEFDDRRGVLRSISCEEATCSD
                     TSESILEEEPQENQKKLLPLSVTPEAFSGTVIEKEFVSPSLTPPPAIAHPALPTIPER
                     KEVLLEASEETGKRVSKFKAARLQQKD"
     exon            427..461
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            462..540
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            541..676
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            677..768
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            827..995
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1344
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1487
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1734
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..3460
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /note="hexamer: AGTAAA"
     polyA_site      2557
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /note="major polyA site"
     regulatory      3435..3440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
                     /note="hexamer: ATTAAA"
     polyA_site      3460
                     /gene="URI1"
                     /gene_synonym="C19orf2; NNX3; PPP1R19; RMP; URI"
ORIGIN      
        1 gtgtggggag gcgcggccgc cacgcgacgc ctggctgggc ccgcaccgga gaggcgtctc
       61 ggtacctggc aggcggcctg ctactcggag cccgctgcgg ggcggcggcg gcggggacat
      121 gcacgtgtga gatgcggcag cgggcggcgc ggacgcgaac agcagcggcg gcggcgggcg
      181 cggcctcctg ggcgcggggc gcgcggtgcc tgagggcggg cgcgcgggcg ctgggcaact
      241 gccggccgcg ccgcctgcgc aggcgctggt tcaggactca cacgccgcgc tgaggcccgc
      301 gggcccgtca tggaggcgcc caccgtggag acgccccccg acccctcgcc cccttcggcc
      361 ccggcccctg ccctggttcc gttgcgcgcc ccggatgtgg cgcggctgcg cgaggagcag
      421 gaaaaggtgg tcactaactg ccaagagaga atccagcatt ggaagaaggt agataatgac
      481 tataatgccc ttcgagaaag actcagcacc ttgcctgata aattgtctta taatataatg
      541 gtaccatttg gcccttttgc cttcatgcca ggaaaacttg tccatactaa tgaagtcact
      601 gttttactgg gggacaactg gtttgcaaag tgctcagcaa agcaggctgt aggtttagtt
      661 gagcaccgga aagaacatgt aagaaaaaca atagatgact taaaaaaagt gatgaaaaat
      721 tttgaatcca gagttgaatt cacagaagat ttgcagaaaa tgagcgatgc tgcaggtgat
      781 attgttgaca tacgagaaga aattaaatgt gacttcgaat ttaaagcaaa acaccgaatt
      841 gctcataaac cgcattccaa accaaaaact tcagatattt ttgaagcaga tattgcaaat
      901 gatgtgaaat ccaaggattt gctagctgat aaagaactgt gggctcgact tgaagaacta
      961 gagagacagg aagaattgct gggtgaactt gatagtaagc ctgatactgt gattgcaaat
     1021 ggagaagata cgacatcttc tgaagaggaa aaggaagatc gtaacacaaa tgtgaatgcg
     1081 atgcatcaag taacagactc tcatactcct tgtcataagg atgttgcaag ttcagaacca
     1141 ttcagtggtc aagtgaatag tcagttgaac tgttcagtga atggttccag ttcttaccac
     1201 agtgatgatg atgatgatga tgatgatgac gacgacgacg acaacattga cgacgatgat
     1261 ggtgataacg accatgaggc tttaggggtt ggagataatt ctataccaac aatatatttt
     1321 tcacatactg ttgagcctaa gagggtccga ataaatactg gaaagaatac cactttaaaa
     1381 ttcagtgaaa agaaagaaga agccaaacgt aaacgaaaga acagcactgg cagtggccac
     1441 tctgcccagg agctgccgac catcaggacg cctgcagaca tttacagagc ctttgttgat
     1501 gttgtgaatg gagaatatgt ccctcgcaaa tccatcctga agtctcgaag tagagagaat
     1561 agtgtgtgta gcgacactag tgaaagcagt gctgctgaat ttgatgatag gcggggagtt
     1621 ttgaggagta tcagctgcga agaagccact tgcagtgaca ccagtgagag cattttggaa
     1681 gaggaaccac aagaaaatca aaagaaactt ttgcccttat cagtaacacc tgaggctttt
     1741 tctggaactg ttatagaaaa agaatttgta tcaccttcct taacaccacc cccagccatt
     1801 gctcatcccg cactacccac tattccagaa cgaaaggaag ttctgttgga agcatctgaa
     1861 gaaactggaa agagggtttc aaagtttaaa gctgccagat tgcaacagaa agactaggcc
     1921 ctgtctagga aatgggaatt tacatcctaa aacctagttg ttcatttgtt tagagtatct
     1981 atagcaaaat aggttacatg tagtttgaaa taaggtatcc tgagttactt tggcaacaag
     2041 ttcttttacc cttacccgtg gtatttgaaa aaaatcaagg taactgtctg aatactttaa
     2101 tatcagcttg ttttgtgaat tctctgaata ctgtcaacac tcttatctaa gtttgccttt
     2161 atgatgcagt ggcagcattt tgaattactt ttcaaagaat actgttcata tgcattgttt
     2221 ttgtgtttca aactaaatac aggcagtttt gtgccagctg tgatattgtg cataccatat
     2281 ggaccatttt aaagaaaatt ttaaaatttc aaatagattc aacaattaca ttacttgctt
     2341 tcacatttta aaggcacttt aaaaaaatct acttctcttg taggttttgc ggctagttgg
     2401 ctattcaaga aacctcgccc ctctgaatgt catactgtaa tctttaagga agaaagctac
     2461 atgaattaat tgtactctat gggaaaattt ctttggaaag atattttgta aaactttttt
     2521 ttccaagtaa aaactttatg aaacttggtc tcaaaaatgt tgtgaacttt atgattcaaa
     2581 attgagtaca gatatgtcct tgattcatat gtatgctaca tgtatcacac aacagatctg
     2641 gaattctttc agttcctcag atacttctcc cttagttttt gcagtttcac tgggattatg
     2701 ttttgggaaa caaggaaagg tctagatgct taaacatttt aaataaaaat tccttacagt
     2761 ttcatcttcc caacattttc attctttaag gctactttcc tactaactga aataacacat
     2821 ttacttttac cacaattcct caaaataaat ttattctaac attgaaaata acattacaag
     2881 ttaatcatta gcttgatgca tgctaaaatg tagcttttaa aaagcattct gcattagtac
     2941 taaaataagc catcaatgcc agtccaccct ctctattcat ggctaaatat ttaaaggtta
     3001 tttatagctt ctttaatgaa ttcttcttaa acaaagtgaa attatgtcct agaaaagtag
     3061 aagctattcg taactagagc agtgcaactt taaagtttta tgaatatgta ttttaatgac
     3121 aagggggcga gcttgcatcc ccactagtta atggataatt caaaccgagg actgattttg
     3181 aaagatcacc taaaaatgta gatttgttct ttagtaaatt tagatcaact atgcatatat
     3241 tttgtaggta aatctttcag tccatgcccc aaccctcacc aaaaccaaag cagaaattac
     3301 acacacaaag atgctcccgt taggaattgc tattcacatg aggctttctg tgctagattt
     3361 ttttctcaga aacaaacttt actgtaggac tattgtggtg ttcttaacag atttgtaatt
     3421 tcaagatgcg tgtcattaaa taatttttca tgttcacaga
//
