LOCUS       NM_001077663            3571 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  Homo sapiens upregulator of cell proliferation (URGCP), transcript
            variant 3, mRNA.
ACCESSION   NM_001077663
VERSION     NM_001077663.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Tokay,E.
  TITLE     [Epidermal Growth Factor Mediates Up-regulation of URGCP Oncogene
            in Human Hepatoma Cancer Cells]
  JOURNAL   Mol Biol (Mosk) 55 (4), 676-682 (2021)
   PUBMED   34432785
  REMARK    GeneRIF: [Epidermal Growth Factor Mediates Up-regulation of URGCP
            Oncogene in Human Hepatoma Cancer Cells].
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Tokay,E., Sagkan,R.I. and Kockar,F.
  TITLE     TNF-alpha Induces URG-4/URGCP Gene Expression in Hepatoma Cells
            through Starvation Dependent Manner
  JOURNAL   Biochem Genet 59 (1), 300-314 (2021)
   PUBMED   33034821
  REMARK    GeneRIF: TNF-alpha Induces URG-4/URGCP Gene Expression in Hepatoma
            Cells through Starvation Dependent Manner.
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Aslan,F. and Avcikurt,A.S.
  TITLE     URG4 expression in invasive breast carcinoma and its relation to
            clinicopathological characteristics
  JOURNAL   Breast Cancer 26 (4), 485-491 (2019)
   PUBMED   30680688
  REMARK    GeneRIF: URG4 overexpression in breast ductal carcinomas is
            significantly associated with good prognostic parameters.
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Dodurga,Y., Secme,M. and Lale Satiroglu-Tufan,N.
  TITLE     A novel oncogene URG4/URGCP and its role in cancer
  JOURNAL   Gene 668, 12-17 (2018)
   PUBMED   29775749
  REMARK    GeneRIF: Relationship between URG4/URGCP expression and
            clinicopathologic characteristics were evaluated and significant
            results were in various cancer types (review).
            Review article
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Hong,L., Qing,O., Ji,Z., Chengqu,Z., Ying,C., Hao,C., Minhui,X. and
            Lunshan,X.
  TITLE     Downregulation of miR-16 via URGCP pathway contributes to glioma
            growth
  JOURNAL   Sci Rep 7 (1), 13470 (2017)
   PUBMED   29044221
  REMARK    GeneRIF: All these results suggested that URGCP accelerates glioma
            growth through the NF-kappaB/c-myc/miR-16/Cyclin D1/E1 pathway, and
            both URGCP and miR-16 function as a novel cell cycle regulators in
            glioma and could be considered as potential targets for glioma
            therapy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Huang,J., Zhu,B., Lu,L., Lian,Z., Wang,Y., Yang,X.,
            Satiroglu-Tufan,N.L., Liu,J. and Luo,Z.
  TITLE     The expression of novel gene URG4 in osteosarcoma: correlation with
            patients' prognosis
  JOURNAL   Pathology 41 (2), 149-154 (2009)
   PUBMED   18972316
  REMARK    GeneRIF: URG4 may play important roles in the development of
            osteosarcoma, and might be a useful molecular marker for predicting
            the prognosis of osteosarcoma.
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Song,J., Xie,H., Lian,Z., Yang,G., Du,R., Du,Y., Zou,X., Jin,H.,
            Gao,J., Liu,J. and Fan,D.
  TITLE     Enhanced cell survival of gastric cancer cells by a novel gene URG4
  JOURNAL   Neoplasia 8 (12), 995-1002 (2006)
   PUBMED   17217616
  REMARK    GeneRIF: URG4 plays an important role in the development of human
            gastric cancer by regulating the expression of cyclin D1.
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
            Clayton,M.M., Zhu,M. and Feitelson,M.A.
  TITLE     Hepatitis Bx antigen stimulates expression of a novel cellular
            gene, URG4, that promotes hepatocellular growth and survival
  JOURNAL   Neoplasia 4 (4), 355-368 (2002)
   PUBMED   12082552
  REMARK    GeneRIF: URG4 may be a natural effector of HBxAg that contributes
            importantly to multistep hepatocarcinogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648505.1, AB040940.1 and AK000661.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001077663.2.
            
            Summary: URG4 is upregulated in the presence of hepatitis B virus
            (HBV)-encoded X antigen (HBxAg) and may contribute to the
            development of hepatocellular carcinoma by promoting hepatocellular
            growth and survival (Tufan et al., 2002 [PubMed
            12082552]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) encodes the longest protein
            (isoform 3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640797.1, BX648505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000453200.6/
                                                  ENSP00000396918.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1290              BX648505.1         14-1303
            1291-1878           AB040940.1         2061-2648
            1879-3571           AK000661.1         59-1751
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3571
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="upregulator of cell proliferation"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:HGNC:30890"
                     /db_xref="MIM:610337"
     exon            1..35
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2817
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     up-regulated gene 4; HBxAg up-regulated gene 4 protein;
                     HBV X protein up-regulated gene 4 protein; up-regulator of
                     cell proliferation"
                     /codon_start=1
                     /product="up-regulator of cell proliferation isoform 3"
                     /protein_id="NP_001071131.1"
                     /db_xref="CCDS:CCDS47578.1"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:HGNC:30890"
                     /db_xref="MIM:610337"
                     /translation="MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREM
                     EGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDS
                     MKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDP
                     ADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLP
                     DSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKS
                     QLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAF
                     LNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRG
                     KRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVED
                     MAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVE
                     KEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYF
                     LRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFY
                     EAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKEL
                     HVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFS
                     QDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAA
                     ILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQG
                     DGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGL
                     SNQNKNIQQLIELVRRL"
     exon            36..62
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     exon            63..133
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     exon            134..184
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     exon            185..223
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     exon            224..3571
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="hexamer: AATAAA"
     polyA_site      3571
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="major polyA site"
ORIGIN      
        1 agcggagacc tcgctgcgct catggcgtcg cccgggatag aagtggaatt actgggcaaa
       61 gggcattcag atttgggaga agtagcccca gaaataaaag catcagagag acgaacagct
      121 gtggccattg cagatttgga atggagagaa atggaaggag atgattgcga gttccgttat
      181 ggagatggta caaatgaggc tcaggacaat gattttccaa cagtggagag aagcaggctt
      241 caagaaatgc tgtcactttt gggcctagag acgtaccagg tccagaaact cagcctccag
      301 gactctctgc agatcagttt tgacagtatg aagaactggg cccctcaggt tcccaaagac
      361 ttgccctgga atttcctcag gaagttgcag gccctcaatg ctgatgccag gaataccact
      421 atggtgctgg acgtgctccc agacgccagg cctgtggaga aggagagcca gatggaagag
      481 gagatcatct actgggaccc agctgatgac cttgctgccg acatttattc cttttctgag
      541 ctgcccaccc ctgatacgcc agtgaacccc ttagaccttc tctgtgccct gctgctctcc
      601 tcagacagtt tcctgcaaca agaaatagcg ttgaaaatgg ccctctgcca gtttgcactc
      661 ccactcgtgt tgcctgactc ggagaaccac taccatacat ttctgctgtg ggccatgcgg
      721 ggcattgtga ggacatggtg gtcccagccc ccaaggggca tggggagctt ccgggaagac
      781 agcgtggtct tgtccagggc gcccgccttc gccttcgtgc gcatggacgt cagtagcaac
      841 tccaagtccc agcttctcaa cgccgtcctc agcccgggcc acaggcagtg ggactgcttc
      901 tggcatcggg acctcaactt gggcaccaat gcccgggaga tttcggatgg gttggtagaa
      961 atttcctggt tttttcccag cggaagggag gacttggaca ttttcccaga acctgtggcc
     1021 tttctgaacc tgagaggtga catcgggtct cactggctgc agtttaagct cttgacagaa
     1081 atctcctccg ctgtgtttat attgactgac aatatcagta agaaggaata caaattgctg
     1141 tactccatga aggagtcaac cacaaaatac tacttcatcc tgagtcccta ccgtgggaag
     1201 cgcaacacaa acctgagatt tctgaataag ttaattcctg tgctgaaaat agaccactca
     1261 catgtcctgg taaaggtcag cagcactgac agcgacagct tcgtgaagag gatccgggcc
     1321 atcgttggga atgtgctgcg ggcaccctgc aggcgggtat ctgtggagga catggcgcac
     1381 gcagcccgca aactgggcct aaaggtcgac gaggactgtg aggagtgtca gaaagcgaaa
     1441 gaccggatgg agaggattac caggaaaatc aaagactcgg atgcctacag aagggacgag
     1501 ctgaggctgc agggggaccc ctggagaaag gcagcccaag tggagaagga gttctgccag
     1561 ctccagtggg ccgtggaccc ccctgagaag cacagggctg agctgaggcg gcggctgcta
     1621 gaacttcgaa tgcagcagaa cggccatgat ccctcctcgg gggtgcagga gttcatctcg
     1681 gggatcagca gcccctcctt gagtgagaag cagtacttcc tgaggtggat ggagtggggc
     1741 ctggcacggg tggcccagcc gcgactgaga cagcctccgg agacgcttct caccctgaga
     1801 ccaaagcatg ggggcaccac agacgtgggg gagccgctct ggcctgagcc cctaggggtg
     1861 gaacacttct tgcgggagat gggacagttt tatgaggctg agagctgtct tgtggaggca
     1921 gggaggctgc cggcaggcca gaggcgtttt gcccacttcc caggcttggc ctcggagctg
     1981 ctgctgacag ggctgcctct ggagctaatc gatgggagca cgctgagcat gcccgtccgc
     2041 tgggtcacag ggctcctgaa ggagctgcac gtccgactgg agagacggtc aaggctggtg
     2101 gttctgtcaa ccgtcggggt gccaggcacg ggcaagtcca cactcctcaa caccatgttt
     2161 gggctgcggt ttgccacagg gaagagctgc ggtcctcgag gggccttcat gcagctcatc
     2221 acagtggctg agggcttcag ccaggacctg ggctgtgacc acatcctggt gatagactcc
     2281 gggggcttga taggtggggc cttgacgtca gctggggaca gatttgagct ggaggcttcc
     2341 ttggccactc tgctcatggg actgagcaat gtcaccgtga tcagtctagc tgaaaccaag
     2401 gacattccag cagctattct gcatgcattt ctgaggttag aaaaaacggg gcacatgccc
     2461 aactaccagt ttgtatacca gaaccttcat gatgtatctg ttcccggccc taggcccaga
     2521 gacaagagac agctcctgga tccacctggt gacctgagca gggctgcagc ccagatggag
     2581 aaacagggcg acggcttccg ggcactggca ggcctggcct tctgcgaccc tgagaagcag
     2641 cacatctggc acatcccagg cctgtggcac ggagcacctc ccatggccgc agtgagcttg
     2701 gcctacagtg aagccatatt tgaattgaag agatgcctac tcgaaaacat caggaacggc
     2761 ttgtcgaacc aaaacaaaaa catccagcag ctcattgagc tggtgagacg gctgtgagtg
     2821 tgcagagaaa cccagttcag gtgtaggagg ctgctgtggg cagccctgtc tgatggggca
     2881 cccgtgtggg gctgtgctct ggtgcctgag aatggctggt gcccaatcga catgagaaga
     2941 cgaggaaaag acagggtttg gagtctcctc aacagtgtta aaagaggaag tgacctcaca
     3001 gaccagctca gagatgttac caagaatatc acagccccca gggtagggag acaagcagca
     3061 gtttgttctg tctcagctcc tgtcaaggat cctgcggggt gggccctctg tatagctgct
     3121 ctctgtcact ggcccctgga gtgggagcag cgtccttagt cactgcaggc ccaggcgggc
     3181 aggtggtccc aggacagagg tggggaagtt gtcctgagga agcagaagta ggccttgctc
     3241 ccgcccaacc caagggcctc cagtggacca gcattcaaga tgtgagtgcc cgtggtgtgc
     3301 aaggcactcc catggcaccg tatttattga ctgatctgtg aaggcttccc tgacccctgc
     3361 ccaggaagag ttcactggtc gctctgttgt gccccacagc actttgttat acctctgcca
     3421 cacacttcac gcagcgcgtt gtaactcatg tgtttacatg tctgtccccc cagactgtga
     3481 gctccttgag ggcagggact gtacattctc cagctctgtg tccccagggc ctggcacatt
     3541 gtagacgctt aataaatgtc tgttaaatga a
//
