LOCUS       NM_001204871             802 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens URGCP-MRPS24 readthrough (URGCP-MRPS24), mRNA.
ACCESSION   NM_001204871
VERSION     NM_001204871.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA
            and Butte NF.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 802)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004985.2 and AI027170.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001204871.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring URGCP (upregulator of cell
            proliferation) and MRPS24 (mitochondrial ribosomal protein S24)
            genes on chromosome 7. The read-through transcript is predicted to
            encode a protein that shares sequence identity with the upstream
            gene product but its C-terminal region is distinct due to a
            frameshift relative to the downstream gene. [provided by RefSeq,
            Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AI027170.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 55665, 64951
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC004985.2         58804-58809
            7-21                AI027170.1         1-15
            22-35               AC004985.2         58825-58838
            36-229              AI027170.1         28-221
            230-240             AC004985.2         96057-96067
            241-286             AI027170.1         233-278
            287-297             AC004985.2         96347-96357
            298-356             AI027170.1         289-347
            357-377             AC004985.2         96417-96437
            378-802             AC004985.2         98418-98842
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..802
                     /gene="URGCP-MRPS24"
                     /note="URGCP-MRPS24 readthrough"
                     /db_xref="GeneID:100534592"
                     /db_xref="HGNC:HGNC:49188"
     exon            1..35
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..354
                     /gene="URGCP-MRPS24"
                     /codon_start=1
                     /product="uncharacterized protein LOC100534592"
                     /protein_id="NP_001191800.1"
                     /db_xref="GeneID:100534592"
                     /db_xref="HGNC:HGNC:49188"
                     /translation="MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRY
                     GDGTNEAQDNDFPTGAVLEPRAALRLARPAHLPGLRQEPGGPSTRKQGGQAGDLRGGT
                     RAALHRPP"
     exon            36..106
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            107..157
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            158..196
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            197..265
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            266..377
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            378..802
                     /gene="URGCP-MRPS24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URGCP-MRPS24"
                     /note="hexamer: AATAAA"
     polyA_site      802
                     /gene="URGCP-MRPS24"
                     /note="major polyA site"
ORIGIN      
        1 agcggagacc tcgctgcgct catggcgtcg cccgggcatt cagatttggg agaagtagcc
       61 ccagaaataa aagcatcaga gagacgaaca gctgtggcca ttgcagattt ggaatggaga
      121 gaaatggaag gagatgattg cgagttccgt tatggagatg gtacaaatga ggctcaggac
      181 aatgattttc caacaggtgc tgtcctggag ccgagagctg ccttgcgctt ggcgcgccct
      241 gcacacctcc ccggtctgcg ccaagaaccg ggcggcccga gtacgcgtaa gcaaggggga
      301 caagccggtg acctacgagg aggcacacgc gccgcactac atcgcccacc gtaaaggctg
      361 gctgtcgctg cacacaggta acctggatgg agaggaccat gccgcagagc gaacggtgga
      421 ggatgttttc cttcgcaagt tcatgtgggg taccttccca ggctgcctgg ctgaccagct
      481 ggttttaaag cgccggggta accagttgga gatctgtgcc gtggtcctga ggcagttgtc
      541 tccacacaag tactacttcc tcgtgggcta cagtgaaact ttgctgtcct acttttacaa
      601 atgtcctgtg cgactccacc tccaaactgt gccctcaaag gttgtgtata agtacctcta
      661 gaacaatccc cttttttcca tcaagctgta gcctgcagag aatggaaacg tgggaaagga
      721 atggtatgtg ggggaaatgc atcccctcag aggactgagg catagtctct catctgctat
      781 tgaataaaga ccttctatct tg
//
