LOCUS       NM_014777               5601 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens URB2 ribosome biogenesis homolog (URB2), transcript
            variant 2, mRNA.
ACCESSION   NM_014777 XM_375851
VERSION     NM_014777.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5601)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5601)
  AUTHORS   Reiner,A.P., Hartiala,J., Zeller,T., Bis,J.C., Dupuis,J.,
            Fornage,M., Baumert,J., Kleber,M.E., Wild,P.S., Baldus,S.,
            Bielinski,S.J., Fontes,J.D., Illig,T., Keating,B.J., Lange,L.A.,
            Ojeda,F., Muller-Nurasyid,M., Munzel,T.F., Psaty,B.M., Rice,K.,
            Rotter,J.I., Schnabel,R.B., Tang,W.H., Thorand,B., Erdmann,J.,
            Jacobs,D.R. Jr., Wilson,J.G., Koenig,W., Tracy,R.P.,
            Blankenberg,S., Marz,W., Gross,M.D., Benjamin,E.J., Hazen,S.L. and
            Allayee,H.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Genome-wide and gene-centric analyses of circulating
            myeloperoxidase levels in the charge and care consortia
  JOURNAL   Hum Mol Genet 22 (16), 3381-3393 (2013)
   PUBMED   23620142
REFERENCE   3  (bases 1 to 5601)
  AUTHORS   Chen,T.C., Lee,S.A., Hong,T.M., Shih,J.Y., Lai,J.M., Chiou,H.Y.,
            Yang,S.C., Chan,C.H., Kao,C.Y., Yang,P.C. and Huang,C.Y.
  TITLE     From midbody protein-protein interaction network construction to
            novel regulators in cytokinesis
  JOURNAL   J Proteome Res 8 (11), 4943-4953 (2009)
   PUBMED   19799413
REFERENCE   4  (bases 1 to 5601)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   5  (bases 1 to 5601)
  AUTHORS   Vlcek,S., Foisner,R. and Wilson,K.L.
  TITLE     Lco1 is a novel widely expressed lamin-binding protein in the
            nuclear interior
  JOURNAL   Exp Cell Res 298 (2), 499-511 (2004)
   PUBMED   15265697
REFERENCE   6  (bases 1 to 5601)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D50923.2 and AW611528.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014777.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50923.2, SRR1803613.189787.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258243.7/ ENSP00000258243.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5600              D50923.2           14-5613
            5601-5601           AW611528.1         10-10               c
FEATURES             Location/Qualifiers
     source          1..5601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..5601
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="URB2 ribosome biogenesis homolog"
                     /db_xref="GeneID:9816"
                     /db_xref="HGNC:HGNC:28967"
                     /db_xref="MIM:619372"
     exon            1..110
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..249
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4698
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="nucleolar preribosomal-associated protein 1;
                     nucleolar preribosomal-associated protein 2; URB2 ribosome
                     biogenesis 2 homolog"
                     /codon_start=1
                     /product="unhealthy ribosome biogenesis protein 2 homolog"
                     /protein_id="NP_055592.2"
                     /db_xref="CCDS:CCDS31052.1"
                     /db_xref="GeneID:9816"
                     /db_xref="HGNC:HGNC:28967"
                     /db_xref="MIM:619372"
                     /translation="MAAVYSGISLKLKSKTTSWEDKLKLAHFAWISHQCFLPNKEQVL
                     LDWARQSLVAFYKKKLELKEDIVERLWIYIDNILHSRKLQNLLKNGKTINLQISLVKI
                     INERVAEFSLSGSQRNICAVLRCCQGILSTPALAVIYTAKQELMVALLSQLCWSACRQ
                     PEGAVVAQLFEVIHLALGHYLLILQQQVNPRRAFGDVTAHLLQPCLVLRHLLSGGTWT
                     QAGQGQLRQVLSRDIRSQIEAMFRGGIFQPELLSSYKEGLLDQQQGDVKTGAMKNLLA
                     PMDTVLNRLVDAGYCAASLHTSVVANSVALLYKLFLDSYFKEGNQLLCFQVLPRLFGC
                     LKISHLQEEQSKALSTSDWTTELLVVEQLLNSVANNNIYNIAADRIRHEEAQFRFYRH
                     VAELLINHAQAPIPAWFRCLKTLISLNHLILEPDLDDLLASAWIDAEVTEFRTKKAQE
                     ALIRTVFQTYAKLRQVPRLFEEVLGVICRPAAEALRQPVLASGPSTVLSACLLELPPS
                     QILDTWSLVLEKFQSLVLPYLQSDADMALKSLSLSLLLHCIMFNMRSLDSSTPLPIVR
                     RTQCMMERMMRELVQPLLALLPDTPGPEPELWLQKVSDSVLLLSYTWAQVDAMFSLNC
                     SQYHSMSGPLIGVALEISNLPSLLPGVKTQHWKKIEKFTAQFSSLGTYCLEQLYLQKM
                     KRTLMQTSFRSEGAIQSLRCDAAFIIGSGRKSLNQRTTASWDGQVGMVSGLTYPVAHW
                     HLIVSNLTILISYLCPDDVGYLASVLLRTLPMGKAQEVSIDEEAYITLEKISKAFLHS
                     PLFPEMQSLHSAFLTCVTTSCSSILCSGAQRDSGLVSQQLPWLFEKDHMVVGHWENRF
                     AKAGPEGIEPRGEIAQNLLSLVKSDFPIQLEGEQLESILGLLEVISALQLDSLLPPYH
                     VHYFLVLLSMAVTKLGCSCSSSLALKFLTTCYQLLGYLQKGKSARSVFKIMYGSDIFE
                     VVLTSLFRASSRFLIEMDDPAWLEFLQVIGTFLEELMQMLIQMKLSLVLNFRKITAFL
                     SSSKPYTEAASSKQLENQNPQGRQLLLVSLTRLCHVLGPFLKEQKLGQEAPAALSELL
                     QQVVLQTGAVLQLCSVPGARGWRLPSVLISSVSTLLEADLGQHCRDGGADISQGSDRT
                     LLSHVALYQGVYSQILLELPALAGHDQSFQAALQFLTLFFLAPELHPKKDSVFTSMFH
                     SVRRVLADPEIPVQVTQDIEPHLGALFTQMLEVGTTEDLRLVMQCILQGLDVSNMWKA
                     DVQAVVSAVTLLRLLLNCPLSGEKASLLWRACPQIVTALTLLNREASQEQPVSLTVVG
                     PVLDVLAALLRQGEEAIGNPHHVSLAFSILLTVPLDHLKPLEYGSVFPRLHNVLFSIL
                     QCHPKVMLKAIPSFLNSFNRLVFSVMREGRQKDKGSIDDLPTVLKCARLVERMYSHIA
                     ARAEEFAVFSPFMVAQYVLEVQKVTLYPAVKSLLQEGIYLILDLCIEPDVQFLRASLQ
                     PGMRDIFKELYNDYLKYHKAKHEGEKRYTA"
     exon            250..426
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..3757
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3918
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4029
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4272
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4360
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4500
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..5601
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4952..4957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="hexamer: AATAGA"
     polyA_site      4977
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="major polyA site"
     regulatory      5432..5437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="hexamer: AATAAA"
     polyA_site      5457
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="major polyA site"
     regulatory      5578..5583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
                     /note="hexamer: CATAAA"
     polyA_site      5601
                     /gene="URB2"
                     /gene_synonym="KIAA0133; NET10; NPA2"
ORIGIN      
        1 gtacagcggc ctccgccgca ccgggacagc agccgccgcc gctgccgccg tcctcccctg
       61 tctacccgga gctgtctcga gctgagcccc ctaccgggcc ggatcccgag ataaagccta
      121 gccatggctg ctgtttattc tggcatttcc cttaagctta aaagcaagac aacttcctgg
      181 gaagataaac taaaactagc tcactttgct tggatttctc accagtgctt tcttccaaat
      241 aaagaacaag tgttacttga ttgggcaaga caatcattgg ttgcatttta taagaaaaag
      301 cttgaactga aggaagatat tgttgaaagg ctttggatct atatagataa cattttacat
      361 agcagaaaat tgcagaatct cctcaagaat ggaaagacca ttaatcttca gatttcccta
      421 gtcaagatca tcaatgagag agtagctgag ttctctcttt cgggatccca aagaaacatc
      481 tgtgctgtcc ttcgatgttg ccagggcatc ctgtcgacac ctgccctggc tgtcatctac
      541 acggccaaac aggagctgat ggtggccttg ctgagccagc tttgctggtc ggcctgcagg
      601 cagcccgaag gagctgtggt agcccagttg tttgaggtca ttcacctggc ccttggccat
      661 tatctcttga tcctgcagca gcaggtcaac ccaagacgtg cctttgggga tgtgactgct
      721 cacctgctcc agccgtgcct ggtcctgagg cacttactct ctgggggcac atggacgcag
      781 gctggccagg gccagctgag gcaggtgctg agccgggaca tcaggagtca gattgaggcc
      841 atgttccgag gagggatttt tcagcctgag ctactgtcat cctacaagga ggggctcttg
      901 gaccagcagc aaggggatgt gaagacggga gccatgaaga accttctggc tcccatggac
      961 accgtgctta acaggctggt tgatgctggc tactgtgcag catcccttca tacctctgtt
     1021 gtggccaact cagtggcctt gctgtataag ctctttctag attcttactt taaggaggga
     1081 aaccagcttc tctgcttcca ggttctcccc aggttgtttg gctgcttgaa gatttcacac
     1141 ctgcaggagg agcagagcaa agccctgtcc acatcagatt ggaccacaga gcttttggtt
     1201 gtggaacagc tactaaactc agtggccaac aacaatatct acaacatcgc tgccgacaga
     1261 attcggcacg aagaggctca gttccgcttt taccgccacg tggctgagct gctgataaac
     1321 catgcacaag cacccatacc ggcctggttc cgctgtctga agactttgat atctctgaat
     1381 catttgattt tggagccaga cctggatgac ctgctggctt cagcgtggat cgatgccgag
     1441 gtaacagagt ttcgaaccaa aaaagcccag gaggcgctta ttcgtactgt cttccagact
     1501 tatgccaaac tccgacaagt gccacggttg tttgaagagg ttttgggggt gatctgtcgt
     1561 ccagctgctg aggcactgag gcagcctgtg ctggcctcgg gcccctccac ggtactctct
     1621 gcatgcctcc tggagctgcc tccaagtcag atcctggaca cgtggtccct tgtgctggag
     1681 aagttccagt ctttagtctt gccctatttg cagagtgatg ccgacatggc cctgaaatca
     1741 ctgtcactga gcttgctgct gcactgcatc atgttcaaca tgaggagcct ggacagcagc
     1801 acgcctctgc ccattgtcag acggacacag tgcatgatgg agaggatgat gagggagctc
     1861 gtgcagcccc tgctggccct tctcccggac accccaggcc cagagccaga gctgtggctg
     1921 cagaaggtca gtgactctgt gctcctgctc tcttacactt gggcccaggt ggacgctatg
     1981 ttcagtttga actgtagcca gtatcactct atgtctgggc cccttatagg tgttgctctg
     2041 gagatctcga acctcccttc gttgctccca ggtgtaaaaa cacagcattg gaagaagata
     2101 gagaagttta cagctcagtt cagctctctt ggtacatatt gcttagaaca gctgtacctg
     2161 cagaaaatga aaaggacttt aatgcaaact agtttccggt ctgaaggagc catccaaagt
     2221 ttgaggtgcg atgctgcctt tattattggt tccggcagaa aaagcttgaa tcagagaacg
     2281 acggcttcct gggatggcca agttgggatg gtgagtggac tcacataccc tgtagcacac
     2341 tggcacttga ttgtgtcaaa tctcacaatt ttaatatcct atctgtgtcc agatgatgtg
     2401 ggatacctgg ccagtgtcct gctgagaact ttacccatgg gcaaagccca ggaagtctca
     2461 atagatgaag aggcatacat cacactggaa aaaatatcca aagccttcct tcatagccct
     2521 ctctttccag agatgcagtc ccttcattct gctttcttaa cgtgcgtaac cacaagttgc
     2581 tccagcattc tgtgttctgg tgcccagcgt gactcaggtc ttgtcagtca gcagcttccc
     2641 tggctttttg aaaaggacca catggttgtg ggtcattggg aaaacagatt tgcaaaagct
     2701 ggacccgaag gtatagaacc tagaggagaa attgcccaga acttactgtc cctggtcaag
     2761 agtgacttcc ctatccagct ggagggagag cagttggaaa gcatcctggg gcttttggaa
     2821 gtgatttctg ccttacagct ggacagcctc ttgccaccct atcatgtgca ttattttctt
     2881 gtgttactgt ccatggccgt caccaaacta ggatgctctt gctcctcctc actggctctc
     2941 aagttcttga cgacttgcta ccaacttctt ggttacttgc aaaaggggaa aagtgctcgc
     3001 tctgtgttca agatcatgta tggtagtgat atttttgagg ttgtactgac ctcattgttc
     3061 agagctagta gtaggttcct tattgagatg gatgatcccg cttggctgga attcctccaa
     3121 gtgataggga cgttcttaga ggagctaatg cagatgctca tccaaatgaa gctgagcttg
     3181 gtgctcaatt ttagaaaaat caccgcattc ctctctagtt ccaaaccata cacggaggca
     3241 gcttcaagca aacaattaga aaatcagaac ccccagggca ggcagctcct tctggtgtct
     3301 ttaaccaggt tgtgccatgt cctgggacct ttcctcaaag agcagaagct gggccaagag
     3361 gccccagcag cactgtctga gctgctgcag caggttgtgc tgcagacagg agctgtgctg
     3421 cagctctgct cagtgccggg ggcccggggc tggcgccttc cctcggtcct catctcatcc
     3481 gtcagcacgc tcttggaagc cgacctgggt cagcactgca gggatggagg ggccgacatt
     3541 tcccaaggaa gcgacaggac gctgctctcc catgttgccc tctaccaggg tgtttactct
     3601 cagatactgt tggagttgcc agctctcgcg ggacatgatc agtcttttca ggcagccttg
     3661 cagtttttga ctctgttctt tttggcccca gaactgcatc ccaaaaagga ctccgtgttt
     3721 acctccatgt ttcattctgt gagaagagtt cttgcagatc ctgaaattcc tgttcaggtc
     3781 actcaggata ttgagcctca tttgggagcc ttgttcaccc aaatgttaga ggttgggacg
     3841 acagaggact tgaggctggt gatgcagtgt attctccagg gactggatgt cagtaacatg
     3901 tggaaagcag atgtgcaggc tgttgtgtca gctgttacac tgctgaggct gctactgaac
     3961 tgcccactca gtggagagaa agcaagtctg ttgtggcgtg cgtgtcccca gatagtcaca
     4021 gctttaacac tcttaaaccg agaagcttct caggagcagc ctgtgtccct cacagtggtc
     4081 gggcctgtct tagatgtcct ggctgcactg ctgcggcagg gggaggaggc catcggcaac
     4141 ccccaccacg tcagcctggc cttcagcatc cttctcactg tccctttgga ccatctgaag
     4201 ccgctggagt atggaagcgt cttcccgagg ctgcacaacg tgctcttctc aatcctgcag
     4261 tgtcacccta aggtaatgct gaaagccatc ccttctttct tgaactcttt caatagattg
     4321 gtgttttcag ttatgcggga agggcggcag aaggacaaag gaagcataga tgacctgcct
     4381 acggtcctaa agtgtgcacg cctggttgaa agaatgtaca gccacatcgc cgcacgagct
     4441 gaggagtttg ctgtgttttc cccatttatg gtggcccagt acgtgttgga ggtacagaag
     4501 gtgaccttat atccagctgt gaaaagtctg ctgcaggagg gcatttacct catcctggac
     4561 ctctgcatcg agcctgacgt ccagttcctg cgggcctcgc tgcagccggg aatgagagac
     4621 atctttaagg agctctataa tgactatctc aagtaccaca aggccaaaca tgaaggagag
     4681 aaaagatata cggcctaagg ctatgggaca gaagtgccgc cagtgacact gtccagaggc
     4741 tttggctgca tggtctgaaa gagctggaga atgaaagact taagatgttc taattcgtag
     4801 tattggtata catagaaaat cctttggggt ttatgtagta tattttgatg tattttacat
     4861 cgtgtttttc ttactatttt ttaatacata gttttatgca gtaagtattg caatagaatc
     4921 ctgaaaattg accctgggat gagattaatt caatagaaaa attgctgact cttgggacct
     4981 ttctgtgttt ggttctcgtc ttggctcagt ggtttggtgt tccctcgtct gcactggaaa
     5041 ctacataaaa cttggctttt tactttgggt acatgggcgt ataattcagc cctgtttaaa
     5101 tatacttgcc tttcaaattc ttcaagtaac atgggaagta ttcttgaaat gtcacatttt
     5161 ctgccttccc tctaagtatg ctttctgaag aagtcaggga aagttagagt ctgtggcctg
     5221 aggtgtctgc tctgggtggc gatagtgggc acctcaggca ggtcggtgac gtttagcaca
     5281 ggtgccaggg ctcctgcctg ctcctcctgt gttagctctg tgaagttcat ttaggaattt
     5341 ttttttccta tgcagtttaa gaaataatcc taattgtttt ttcttattac ctaagcaata
     5401 tatttttatt atagcaacct cagaaaagaa aaataaaagg ataatttaaa aaactcattc
     5461 atagtctcag ttacccagat aacctcggtt gtcaccttgg agtatcttgt tgtagtccct
     5521 ttactatgtg tatgtatata gatgtgcata taaatatata tagtagctaa attggatcat
     5581 aaatgcattt ttttaaagtt a
//
