LOCUS       NM_014825              10818 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens URB1 ribosome biogenesis homolog (URB1), mRNA.
ACCESSION   NM_014825
VERSION     NM_014825.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10818)
  AUTHORS   Wang,T., Li,L.Y., Chen,Y.F., Fu,S.W., Wu,Z.W., Du,B.B., Yang,X.F.,
            Zhang,W.S., Hao,X.Y. and Guo,T.K.
  TITLE     Ribosome assembly factor URB1 contributes to colorectal cancer
            proliferation through transcriptional activation of ATF4
  JOURNAL   Cancer Sci 112 (1), 101-116 (2021)
   PUBMED   32888357
  REMARK    GeneRIF: Ribosome assembly factor URB1 contributes to colorectal
            cancer proliferation through transcriptional activation of ATF4.
REFERENCE   2  (bases 1 to 10818)
  AUTHORS   Wang,T., Zhang,W.S., Wang,Z.X., Wu,Z.W., Du,B.B., Li,L.Y.,
            Chen,Y.F., Yang,X.F., Hao,X.Y. and Guo,T.K.
  TITLE     RAPTOR promotes colorectal cancer proliferation by inducing mTORC1
            and upregulating ribosome assembly factor URB1
  JOURNAL   Cancer Med 9 (4), 1529-1543 (2020)
   PUBMED   31886628
  REMARK    GeneRIF: RAPTOR promotes colorectal cancer proliferation by
            inducing mTORC1 and upregulating ribosome assembly factor URB1.
            Erratum:[Cancer Med. 2021 Oct;10(20):7442-7443. doi:
            10.1002/cam4.4337.. PMID: 34608772]
REFERENCE   3  (bases 1 to 10818)
  AUTHORS   He,J., Yang,Y., Zhang,J., Chen,J., Wei,X., He,J. and Luo,L.
  TITLE     Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1
            to modulate digestive organ development in zebrafish
  JOURNAL   J Genet Genomics 44 (12), 567-576 (2017)
   PUBMED   29246861
REFERENCE   4  (bases 1 to 10818)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 10818)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 10818)
  AUTHORS   Sekiguchi,T., Hayano,T., Yanagida,M., Takahashi,N. and Nishimoto,T.
  TITLE     NOP132 is required for proper nucleolus localization of DEAD-box
            RNA helicase DDX47
  JOURNAL   Nucleic Acids Res 34 (16), 4593-4608 (2006)
   PUBMED   16963496
REFERENCE   7  (bases 1 to 10818)
  AUTHORS   Dez,C., Froment,C., Noaillac-Depeyre,J., Monsarrat,B.,
            Caizergues-Ferrer,M. and Henry,Y.
  TITLE     Npa1p, a component of very early pre-60S ribosomal particles,
            associates with a subset of small nucleolar RNPs required for
            peptidyl transferase center modification
  JOURNAL   Mol Cell Biol 24 (14), 6324-6337 (2004)
   PUBMED   15226434
REFERENCE   8  (bases 1 to 10818)
  AUTHORS   Casadei,R., Strippoli,P., D'Addabbo,P., Canaider,S., Lenzi,L.,
            Vitale,L., Giannone,S., Frabetti,F., Facchin,F., Carinci,P. and
            Zannotti,M.
  TITLE     mRNA 5' region sequence incompleteness: a potential source of
            systematic errors in translation initiation codon assignment in
            human mRNAs
  JOURNAL   Gene 321, 185-193 (2003)
   PUBMED   14637006
REFERENCE   9  (bases 1 to 10818)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 10818)
  AUTHORS   Slavov,D., Hattori,M., Sakaki,Y., Rosenthal,A., Shimizu,N.,
            Minoshima,S., Kudoh,J., Yaspo,M.L., Ramser,J., Reinhardt,R.,
            Reimer,C., Clancy,K., Rynditch,A. and Gardiner,K.
  TITLE     Criteria for gene identification and features of genome
            organization: analysis of 6.5 Mb of DNA sequence from human
            chromosome 21
  JOURNAL   Gene 247 (1-2), 215-232 (2000)
   PUBMED   10773462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000269.2, AP000268.1, AP000267.1 and AP000266.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014825.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF231919.1, SRR1660807.160316.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382751.4/ ENSP00000372199.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AP000269.2         4541-4549           c
            10-244              AP000269.2         4306-4540           c
            245-384             AP000268.1         49082-49221         c
            385-536             AP000268.1         47850-48001         c
            537-669             AP000268.1         46959-47091         c
            670-766             AP000268.1         41982-42078         c
            767-852             AP000268.1         38935-39020         c
            853-978             AP000268.1         37184-37309         c
            979-1103            AP000268.1         36044-36168         c
            1104-1299           AP000268.1         31940-32135         c
            1300-1437           AP000268.1         30155-30292         c
            1438-1611           AP000268.1         26693-26866         c
            1612-1741           AP000268.1         25429-25558         c
            1742-1858           AP000268.1         24544-24660         c
            1859-1971           AP000268.1         23333-23445         c
            1972-2091           AP000268.1         21074-21193         c
            2092-2208           AP000268.1         18986-19102         c
            2209-2347           AP000268.1         18396-18534         c
            2348-2518           AP000268.1         17470-17640         c
            2519-2715           AP000268.1         16247-16443         c
            2716-2934           AP000268.1         14241-14459         c
            2935-3114           AP000268.1         12841-13020         c
            3115-3970           AP000268.1         10493-11348         c
            3971-4172           AP000268.1         8911-9112           c
            4173-4359           AP000268.1         8107-8293           c
            4360-4418           AP000268.1         5003-5061           c
            4419-4612           AP000268.1         2244-2437           c
            4613-4723           AP000268.1         941-1051            c
            4724-4787           AP000268.1         631-694             c
            4788-4959           AP000267.1         7781-7952           c
            4960-5062           AP000267.1         6935-7037           c
            5063-5223           AP000266.1         63276-63436         c
            5224-5335           AP000266.1         62538-62649         c
            5336-5442           AP000266.1         60525-60631         c
            5443-5586           AP000266.1         59848-59991         c
            5587-5696           AP000266.1         58578-58687         c
            5697-5894           AP000266.1         57264-57461         c
            5895-6136           AP000266.1         55724-55965         c
            6137-6736           AP000266.1         54514-55113         c
            6737-10817          AP000266.1         49067-53147         c
            10818-10818         AP000266.1         49066-49066         c
FEATURES             Location/Qualifiers
     source          1..10818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..10818
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="URB1 ribosome biogenesis homolog"
                     /db_xref="GeneID:9875"
                     /db_xref="HGNC:HGNC:17344"
                     /db_xref="MIM:608865"
     exon            1..244
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..6918
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="nucleolar preribosomal-associated protein 1;
                     nucleolar protein 254 kDa; URB1 ribosome biogenesis 1
                     homolog"
                     /codon_start=1
                     /product="nucleolar pre-ribosomal-associated protein 1"
                     /protein_id="NP_055640.2"
                     /db_xref="CCDS:CCDS46645.1"
                     /db_xref="GeneID:9875"
                     /db_xref="HGNC:HGNC:17344"
                     /db_xref="MIM:608865"
                     /translation="MGVPKRKASGGQDGAASSAGAAKRARKEELTGVRFKAQLKDPQG
                     PGPGLEAFVSAAKKLPREDVYDVVEGYIKISVECVEIFQLLSGEKRPESETMLIFQVF
                     EAILLRTASDLSHFHVVGTNIVKKLMNNHMKLICESLYASGYRLARACLSLMTAMVTQ
                     GPEAARDVCSHFDLNKKTLYTLVTKRDSKGVYDVRQAYVQFALSFLIAGDDSTIVQVL
                     EVKEFIPCIFSSGIKEDRISTINILLSTLKTKVVHNKNITKTQKVRFFTGQLLNHIAS
                     LYNWNGITDVNPENVKVSAEEAGKTMVRELVHNFLMDLCCSLKHGINFYDASLGTFGR
                     GGNLTLLHFLLGLKTAADDDLVADLVVNILKVCPDLLNKYFKEVTFSFIPRAKSTWLN
                     NIKLLNKIYEAQPEISRAFQTREFIPLPRLLAMVMVTTVPLVCNKSMFTQALNLDSTS
                     VRHTALSLISVILKRALKTVDHCLNKEVWQESGVYTAVMMEEFVQLFREALSKILPDL
                     NTVVWVWQSLKKQETKQDDKKGQKRSDGPPAACDAHQCDDAETILLKAVLLQVICLYQ
                     KVVPHVVMQYNFDFSKLLKGVISEQGLREEVPPILQHHMLKVALELPASKFLWLKAQE
                     GPDAEIIGGERSVFYLLMKMFVTSSHLQLKSLTKLLIMKILRDTGVFEHTWKELELWL
                     EHLENTMEEDKETVIQFLERILLTLVANPYSYTDKASDFVQEASMLQATMTKQEADDM
                     SIPISHIDDVLDMVDVLVEGSEGLDEEIGFTLSEDMILLTFPFSAVVPAALEARNKLL
                     LGTGNEAAENVVTYLTAVLTDLLHTQRDPLALCLLLQAYDKLEPPCLVPCCQQLSRFN
                     RYYSLWIPEQAREAWLLQAQGSPSPPALPLASSFTALLQAAYESQALRDEHIQVQLQA
                     TMPHLSMQQVLLAAKQVLLYLRSTVENFGQLGRSVGPPLLQLFLDLLRRLVVHCEQLD
                     AQNQQRCEAARAEADLFLDMESVASLELANDQTLEEVLVAILRHPTLEGWFLALEQQA
                     LPPHTLSPVLVKLLATHFSAGVLQLLAASAPILQNIGQLGLLARYSEAITQSVLKELQ
                     NRRAGPATSPPKTPPQLEALQELHPYMEGAQLREVTLALLSLPETHLVTQQPTKSPGK
                     ERHLNALGKTLVQLLTCSPQDQLQSGELLWSSEYVRGLGALLPTLAVDELDTVLLHTL
                     QRDPVLAPAVGADLLDYCLARRTQAALSIAALLLQESCTHLLWFEQWCLQAGPGLGLQ
                     GDLDDFLPLIHVYLQCRTRSHFTRPAGVSSAVIPVLRKTLWRQLQSRLLSTDSPPASG
                     LYQEILAQLVPFARAKDLSVLMDRLPSLLHTPSSHKRWIVADSISAALEGSAEELCAW
                     RRTLLESCVKWLIVSFSGGQQDDDNTQNQEKEMLLRLNALLHALNEVDPGDWQKFVKK
                     GLKFRYQDHTFLKMLLTAVQLLYSPESSVRTKLIQLPVVYVMLMQHSLFLPTLLTSDG
                     EESPDSQVKEALVDLMLTVVEMCPSVCESSHFAVLLGAYGATLSVLDQKILLLLRAYE
                     QNKLSLINFRVLLWGPAAVEHHKTCRSLGRSLWQQPSVGDILRLLDRDRMMQTILHFP
                     QNRRLLPPEDTQELIFKDKSRVDLDGLYDPCFLLQLFSELTRPEFVVDCRKFLDSNAL
                     GLTVTALSSYDPQMRAIAYHVLAAYYSHLEGARFQEQSQLLYLLDVVRNGIRTQDMRL
                     TFTLALFIAKAALQILKPEEHMYLKVSNFLLSHEYLNMDKVPGFYQFFYSSDFEQKTE
                     QKWVFGVLRQGIRDKQCYELCARRGIFHIILSFFHSPLCDEAAQNWILEILQNAAQVA
                     RSAYEIIRDYSLLTWILHILESKFLETPLLSNVISLLHTLWVTNLGDKAVEWESQRLC
                     QPSSQEPAKRLALHLVNEFLYVLIVLMKHLRPTLAPVQLTNFFGTLDSVLRYRATVIQ
                     AFRDMNRFTVNETVLSTKDVLVLLHKWSLIERDLKLQEDLRAAIEKAQARELMKMLKD
                     KNKPVMPARAKGPRGRKRRPGEAEEMADPELMASTLETCKGLLRSILTYWRPVIPGPD
                     PTQEPVDSASPESDAPGPVYAAASLAVSWVLRSVAEHPLSRAEAAGLIGWLKSHILPH
                     PVVVADLLKDSAVRSSIFRLYSRLCGAEGLAGPVQEVACLFNTVMLQLVAAQGRAGSP
                     FHPAMEALSLSSLSEKDEATQASAAFLVSLYIKDIWLGAQRPDTLLTHVRMVCEAADD
                     APSSEEEAIVVLCKDAASAASDA"
     exon            245..384
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..536
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..669
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..766
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..852
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..978
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1103
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1299
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1437
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1611
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1741
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1858
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1971
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2091
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2208
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2347
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2518
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2715
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2934
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3114
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3970
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4172
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4359
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4418
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4612
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4613..4723
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4787
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4959
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..5062
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5063..5223
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5335
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5442
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5443..5586
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5587..5696
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5697..5894
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..6136
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6137..6736
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6737..10818
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7771..7776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="hexamer: AATAAA"
     polyA_site      7798
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="major polyA site"
     regulatory      8352..8357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="hexamer: AATAAA"
     polyA_site      8370
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="major polyA site"
     regulatory      10793..10798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="hexamer: ATTAAA"
     polyA_site      10818
                     /gene="URB1"
                     /gene_synonym="C21orf108; NPA1"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgccatg tgggcctgaa gcgcgtgtct gctgtctgtg ccagtgctcc tgccgggtcc
       61 cctcaggtgt gtcgtttccg tcgcgcttcc gccctctcgg ccatgggggt ccccaagagg
      121 aaggcctcgg gcggccagga cggcgcggct tcctccgcgg gtgcagccaa gcgcgcccgc
      181 aaagaagagc tcacgggcgt gcggttcaag gctcagctga aggacccgca gggccccggg
      241 ccaggcttgg aagcgtttgt gtctgctgcc aagaagctac cacgagaaga tgtgtatgat
      301 gttgtggaag ggtatataaa gatttctgtt gagtgtgtcg aaattttcca gctcctaagt
      361 ggagagaaac gacctgaaag tgaaacgatg ttaatatttc aagttttcga ggccatatta
      421 ttgcggacag caagtgatct ttcacatttc catgttgtgg gaaccaacat tgtgaaaaag
      481 ctgatgaaca accacatgaa gctcatctgt gagtccctgt atgcctcagg ttacaggttg
      541 gctcgcgcct gcctgagcct gatgaccgcc atggtgaccc agggtccgga agctgccagg
      601 gacgtctgca gccattttga tttgaataaa aagaccctgt acaccctggt gaccaagagg
      661 gattcaaagg gagtgtacga cgttcggcag gcctacgttc agtttgctct ctccttttta
      721 attgcgggtg atgacagcac tatagtgcag gtgttggaag tgaaagaatt tattccttgc
      781 atttttagct cagggataaa ggaagatagg atctctacca tcaatatttt attatccaca
      841 ctgaaaacaa aggtagttca caataaaaat atcacaaaaa cccagaaggt gcgtttcttt
      901 acggggcagt tattgaacca catagcatcg ctgtacaact ggaatgggat taccgatgtg
      961 aacccagaaa atgtcaaggt ttctgccgaa gaagcaggga aaaccatggt gcgggagctt
     1021 gttcataact tcctgatgga tctttgctgt tcactcaagc atggaattaa tttttacgat
     1081 gcatctttgg gtacctttgg cagaggcgga aacctgacac tcttgcactt cttgctgggt
     1141 ttgaaaactg cagctgatga tgatctggtg gctgaccttg tggtaaacat cctcaaagtg
     1201 tgcccggact tactgaacaa atacttcaag gaagtaacgt tttcctttat cccacgagcg
     1261 aagtctactt ggttaaataa tatcaaacta ctaaacaaga tctatgaggc tcagccggag
     1321 atttcccggg catttcagac cagagagttt atacccttgc ctcggctcct ggcaatggtg
     1381 atggtgacca ccgtgcccct ggtgtgcaat aagagcatgt tcacccaagc attaaacttg
     1441 gacagcacct cagtgaggca cacagcctta tcccttattt ctgtcatttt gaagagggca
     1501 ttaaaaactg ttgaccactg cctgaataaa gaggtgtggc aggaatcagg cgtgtacaca
     1561 gctgtgatga tggaagaatt cgtgcagctc ttcagagaag ccctgagcaa gattttgcca
     1621 gacctgaaca ctgtcgtgtg ggtctggcag tcacttaaaa agcaagagac caaacaggat
     1681 gacaagaaag ggcagaaaag gagcgatggg cccccggctg cctgcgatgc tcaccagtgc
     1741 gatgatgcag aaaccattct tttgaaagct gttttgctcc aggtcatatg cctctaccag
     1801 aaggtggtcc cccacgtggt catgcagtac aactttgact tcagcaagct cctgaaaggt
     1861 gtcatctctg agcagggcct tcgagaggag gtgcctccca ttctgcagca ccacatgctg
     1921 aaggtggccc tggagctgcc ggccagcaag tttctgtggt taaaggcaca ggaaggccca
     1981 gatgcagaaa ttattggagg tgaacgatca gtattttact tactaatgaa aatgtttgtg
     2041 accagtagcc atttacaact gaagtcattg accaaacttc tgatcatgaa gattctgcgg
     2101 gacacggggg tgtttgagca cacctggaag gagctggagc tctggctgga gcatttagag
     2161 aacaccatgg aagaggacaa agagactgtg attcagtttc tggaacgcat tttattgaca
     2221 ttggtggcga atccctattc atacacagac aaagcatctg actttgtcca agaagcaagc
     2281 atgctgcagg ccactatgac gaagcaagaa gccgatgaca tgagcattcc catctcccac
     2341 attgacgatg ttctcgacat ggtggatgtc ctggtggagg gcagtgaagg cttggatgag
     2401 gaaatagggt tcacgttgag tgaagacatg atcctgctca cgttcccatt cagtgcggta
     2461 gtccctgcgg ccctggaagc caggaataag ttgctccttg ggacaggcaa tgaagcagcg
     2521 gaaaacgttg tgacatatct gacggcagtg ctgactgacc tcctccacac ccagagggac
     2581 cccctggctc tgtgtctcct gctccaggca tatgataagc ttgagcctcc atgcctggtg
     2641 ccttgctgcc agcagctctc acggtttaac agatactaca gcctctggat cccggagcaa
     2701 gcccgagagg cctggctgct gcaggcacag ggcagcccct cgccccctgc ccttcccttg
     2761 gcctcgtcct tcacagccct gctgcaggca gcctacgaga gccaagcgct tcgggacgag
     2821 cacatccagg tgcagctgca ggccaccatg ccacacctgt ccatgcagca ggtcctgctc
     2881 gcggccaagc aggtgttgct ctacctgcgg agcactgtgg agaacttcgg ccagctgggc
     2941 agaagtgtgg gcccgcccct cctgcagctc ttcctggatc tcctcaggcg cctggttgtc
     3001 cactgtgagc agctggatgc ccagaaccag cagagatgcg aggccgcccg ggccgaagcc
     3061 gacctcttcc tggacatgga gtccgtggcc tcgctggagt tggccaatga tcagacgctg
     3121 gaggaggtgc ttgtggccat cctcaggcac cccaccctgg agggctggtt cctggccctg
     3181 gagcagcagg ccctcccgcc gcacacgctc agccctgtcc tcgtgaagct cctggccacc
     3241 cactttagtg caggggtcct tcagctgctg gcagcaagtg ccccgatcct ccagaacatt
     3301 gggcagctgg gccttctggc caggtactca gaggccatca cccagagtgt gctgaaggaa
     3361 cttcagaaca ggagggcggg cccggccaca tcaccaccaa agaccccgcc gcagctggag
     3421 gccctgcagg agctgcatcc atacatggag ggtgcccagc tccgtgaggt caccctggcc
     3481 ttgctgagcc tgcctgagac acacctggtg acccagcaac ccacgaaatc ccccgggaag
     3541 gaaagacacc tgaatgctct tggaaagacc ctggtgcagc tgctgacctg cagcccccag
     3601 gatcagctgc agagtggtga gctcctgtgg tcctccgagt atgtgagagg cctgggggct
     3661 ctgctgccca cgctagcagt ggacgagctg gacacagtgc tcctccacac tctgcagaga
     3721 gaccctgtgc tggcccccgc agtcggggct gatctgcttg actactgcct ggcccggcgc
     3781 acacaggcgg ccctcagcat cgctgccctg ctcctccagg agagctgcac ccacttgctg
     3841 tggttcgagc agtggtgcct gcaggctggc ccagggctcg gcctccaggg ggacctggac
     3901 gacttccttc ccctcatcca tgtgtacctc cagtgcagga cacggagcca cttcacacgc
     3961 ccagcaggag tgtcttccgc tgtcattcct gtcttgagga agaccctgtg gaggcagcta
     4021 cagagcaggc ttcttagcac tgacagtccc ccagcatctg ggctgtacca ggagatcctg
     4081 gcacagctgg tcccgtttgc acgagccaag gatctcagtg tactcatgga ccgcctgccc
     4141 agcttgcttc acaccccaag cagtcacaag aggtggatcg tggccgactc catttcagca
     4201 gctctggaag ggtcagcaga agagctgtgt gcctggagaa ggaccctttt ggagtcctgt
     4261 gtgaagtggc tgatcgtgtc tttcagtggt ggacagcaag atgatgataa tactcagaat
     4321 caggagaagg aaatgctgct tagattaaat gcgttgttgc atgcacttaa tgaagttgat
     4381 cctggtgact ggcagaaatt cgtgaagaag ggactcaaat ttcggtacca ggaccacaca
     4441 tttttaaaga tgctcctcac cgccgtacag ctcctgtaca gcccagaaag ctccgtgcgc
     4501 acgaagctca tccagctccc ggtggtctac gtgatgctca tgcagcactc gctgtttctg
     4561 ccgactctac tgacgtctga cggagaggag agcccggaca gccaagtaaa agaagcgctg
     4621 gtggacctga tgctgacggt ggtggagatg tgcccctctg tctgtgagag cagccacttt
     4681 gcagtgcttc tcggggccta tggcgccact ctcagcgtcc tagatcagaa gattttactt
     4741 ctgcttcgag cgtatgagca gaacaagctc agcctcatca acttcagggt gctgctgtgg
     4801 ggcccagcgg ccgtggagca tcacaagacg tgccggagcc tgggcaggtc actgtggcag
     4861 cagccgagtg tcggggacat ccttcgcctg ctggaccggg accggatgat gcagaccatc
     4921 ctgcacttcc cccagaaccg gaggctgctg ccccccgagg acacacagga gctgatattc
     4981 aaagacaaaa gcagggtgga tcttgatggc ctctatgacc cctgctttct ccttcagctc
     5041 ttcagtgagc tgaccaggcc agagtttgtg gtggattgtc gaaaattttt ggattcaaat
     5101 gctctgggcc taactgtcac agccctcagc agctatgacc cccagatgcg agccatagcc
     5161 taccatgtcc tggcggccta ctactcgcac ttggagggcg cacggttcca agagcagtcc
     5221 cagctacttt acctgttgga tgtagtccgg aatgggattc gaactcagga catgagactt
     5281 acttttacct tggctctctt cattgccaaa gcagccctgc agattttgaa accagaggag
     5341 cacatgtacc tgaaggtcag caacttcctg ctgtcgcatg agtacttgaa catggacaaa
     5401 gtgccaggct tctaccagtt cttctacagc tccgactttg agcaaaaaac agagcagaag
     5461 tgggtgtttg gcgttctgcg gcaggggatc cgtgacaagc agtgctacga actgtgtgcc
     5521 cggcgtggca tcttccacat catcctgtcc ttcttccaca gcccgctgtg tgacgaggca
     5581 gcacagaatt ggattctgga aattctacag aatgctgccc aggttgccag atctgcgtat
     5641 gaaatcatac gagactatag ccttttaaca tggattttac acatccttga aagcaagttt
     5701 ctggagactc cgctgctgtc taatgtgatc tccttgctac acacactgtg ggtgaccaac
     5761 ctgggggaca aggcagtgga gtgggagagc cagcgccttt gccagcctag ctcccaggag
     5821 cctgccaagc ggcttgccct gcacctggtc aatgagttcc tttatgttct catcgtgctc
     5881 atgaagcacc tgaggcccac cttggccccc gtccagctga ccaacttctt cgggacactt
     5941 gactccgtgc tgaggtaccg ggccactgtc atacaggcct ttagggacat gaacagattc
     6001 accgtaaatg agacagtgct ttccaccaag gacgtccttg tcctcttgca caagtggagc
     6061 ctcattgaaa gagacctcaa gctccaggaa gacctgagag cagccattga gaaggcccaa
     6121 gcccgggagc tcatgaaaat gctcaaggat aagaacaagc ctgtcatgcc agcccgagcc
     6181 aaaggcccac ggggccgaaa gaggaggcct ggggaggcag aggagatggc tgaccctgag
     6241 ctgatggcat ctaccttgga gacatgcaag ggcctcctga ggtccatctt gacttactgg
     6301 agaccagtga tccctggtcc tgaccccact caggagcctg tggactcagc cagccccgag
     6361 agcgatgcgc caggccccgt atatgctgcc gcttccctgg cagtcagttg ggtgctgcgg
     6421 tcggtggccg agcacccgct cagcagggca gaggctgcag gactcattgg ctggcttaag
     6481 agccatattt tgccacaccc tgtggtcgtg gctgacctcc ttaaggacag tgccgtgagg
     6541 agcagcatat tcaggctgta tagccggctc tgtggggctg aggggctggc agggcctgtg
     6601 caggaggtgg cctgcctgtt caatacggtc atgctgcagc tggtggctgc ccagggccgg
     6661 gcagggagcc ccttccaccc ggccatggaa gccctctccc tgtcttctct gagtgagaag
     6721 gatgaagcca cacaagcctc cgcagcattc ctagtgtctc tctacataaa ggacatctgg
     6781 ctgggggctc agcggccgga caccctctta acccacgtcc ggatggtgtg tgaggccgca
     6841 gatgatgccc cgagcagtga agaggaggcc atcgtggtgc tctgcaagga cgccgccagc
     6901 gcagcctcag atgcttgact cctgccggcc agcaccttgc accctgatga ccagagcctc
     6961 gagcacagca ccagcttcta gaagtttggt tgagtcaagg gtttccagag aaggcatggg
     7021 aaacaacagg ttcagtacat tggctcagtt ctttgacaag aaaagttgag aggactttat
     7081 tgaactgccc agtaaatgat aaactcgggc ctgtaggtgc ccagcatcag agttgcaagg
     7141 aatgtgggga cttctaggcc atgaggccca tccagtgcct cgtcaggccg ccccttcctc
     7201 tctaggggct tggagctcat cacaggaaat agctcgagtt tgaggcagca cttctgaatg
     7261 cagaagagat tcatctgtgt taaagctgaa atgtcaaaag gtatcagatt ttttttatga
     7321 aaacgaagag agatgtttaa agtttatttt tcagcaggtg aggtggctca cgcctataat
     7381 cccagcactt tgggaggcca aggcgggtga atcacctgag gtcaggagtt cgaaaccagc
     7441 cttcccaaca tggtgaaacc ccatctctac taaaaataca aaaattagcc aggcatggta
     7501 gcgcacacct gtaattccag ctactcggga ggctaaggca ggggaatcgc ttgaacctgg
     7561 gaggtggagg ctacagtgag ctgagatcgt gccattgcgc tccagcctag gtgacagagc
     7621 aagactccat ctcaaaaaaa taaaaaaata aagtttgttt ttctataaaa agtcataaca
     7681 aagtattagt atgacttttt gaataagtta atttctgcca gtgtttaatt attttattaa
     7741 agaaaaggat gttacactga atccttaaag aataaaagtg atttgacctc tgctttgaga
     7801 agacagcctg taatttttaa agctatactt caaagagggg attttgaatt ttataaatgc
     7861 ttgttaatgt ctatttttgt aaggtttttg tgttttcctt tcattgttgt caagaggcta
     7921 tttttgctcc acataggcct gcatttattt taaaggtcag aattttactc ttaatggtca
     7981 tatattagtt ggggttgtag ctgacaaaag tcatgaaatt tcgtggtttt cacagttaaa
     8041 atttccgtct gttcctttaa aactctcctg catgcctggg gctcttggga tctgctctgt
     8101 ggcctaggat gtggctgttt tatctgccgt ataatgtaca tcgtgctgac aatgccttgg
     8161 ttttgtctga aacatttaca cttctatttt ccaccagtgt tctttagaat tgtttctgtt
     8221 ttaggtgact taaagtttta actaaagcat gagtaacgtt tgttggcata cagtcccttc
     8281 accacaaata attgtcttgc actgtctaca aagcaaggat cagttacctc acttgtcccc
     8341 ttccctaccc aaataaacct tacaacgcta ttctttgaga ctatcctgaa cttgaaatcc
     8401 cacgtttaga tccaagctgg actcaggcaa gcgctgctcc aacaaagcgt tctcttcctg
     8461 gttcccctta atctttatcc acctctccaa ggcctatctt tggggattcc tttggttata
     8521 ggcacctctg cttgtttatg cagggggcat tggccggaag gacattggtc tggggaatat
     8581 ccctgaaccc catgcctctg ggggcacagg gaggggcagc gagcaggtgg ggtggatttc
     8641 cacggcttca tccctggctc caggcctaag ctgcctccca ggttcttagg gcccagcaag
     8701 tcaatacata ctacgtcagg tggcgacaaa tgctccaaag ccgagttcca gctcagtcaa
     8761 gtgaggacac attttcagca cctcaccttc ttttctgcat ctctggagct catcagtctt
     8821 gcttttcttt gttctccctt ttaaatccac tgccctgacc ttgttcgtgt attttccagt
     8881 cacttagtgt ggaggaaggg aatctcatcc catggagaat agatcgaaca tggtcttcac
     8941 ctgacttaaa atataaaatg ctaaattaga aatatcttaa gtggggcggg gggcacagtt
     9001 attttaaaaa taaaacctat caactccctc cttgcctgaa agctgtaggg gacatatggg
     9061 tcttctgaga tttgctgtgt gatgctgtct cctctccagg gacaaggctg ctgggcacta
     9121 gaggactaga tctttcaagg gtcccagatc cactgtcaca taaagtcaca tccagaagac
     9181 ctttcctgcc agcttccagg gctctttgtg ttctgtgaca gcatttgggc atagatcctg
     9241 cttacccggc ctggctgctg acaggcgttg gctgcctgcc ctccagggga gacactttct
     9301 tgggctctgt ctttgaaagg ctgtggggag gttgaaggtg caactcaggt ccccagactg
     9361 cagtgagctg acctggcagg gcagatgcca tcacatctgg gggagccggc gggtgttagt
     9421 ggagcttgga tgggaactta cccagcatcc taacaaaggt acagaaggac caggtgaact
     9481 cagggctgat aacgcattac acagtaatgg taaagtggca tagtaaagat tagtaagcaa
     9541 acagcttttc ctcttgattt gcatatattt tattttccta ctcttccctg agcaaatata
     9601 agcagtaagc aagcaggcta ggtgtgctca ataaactcag caacacctgg gatgacctct
     9661 gcactcgagg ggccactgca atctttgtca aaggcatagg atgctcctgc tctagttgca
     9721 cttgacctag gtgccctttc tgctacatgc aaatggcctc taagaagaac gaggaacgta
     9781 tgtgtccagg ttggcttgat ttcaccagtt cactcagcta tggccacgat ttactgacat
     9841 cagctctgca attgagaggt cctgtctcca gggggaggct cgctgggctt gctcctgacg
     9901 aggggacccc cattgagggt cagttcccag aggagagtgg ggtgggtctg gaaacccccg
     9961 aggggcaagg tggaggagct ctcctgtcgt agcggctggt cagggccagt tctgctccct
    10021 ggctccactg agctcgcctg agcctgtgag gttgccaggg gttccctgtg gcacggcagg
    10081 cacttctgga tgcagaggtg gaggttgagg ccgtgactcc aggggcatgt ttggtggtgc
    10141 ttggggctgt tcctgtgaac agagcagagt gggaggcagg catcatagtt gctgcagaac
    10201 agtccatact gtggggctgg ggggtttcct gccacacctg ccatctgccc ggaccccata
    10261 gggaaggcca cacaggcaaa ttcctgagaa gggtcagcca gctcacaaag gtggccattc
    10321 tagagaaatc tcagaggaga ggaagtgctt tgtcaggaac taggcctcag gtctttccct
    10381 ggaggccact tcttcctaca ttgatttagg atgggggggg tggggggtgg aggggagcag
    10441 gttgacctcc catccagcgc tgtatctgag tgtagttcat tttatatcca tagcccaagc
    10501 caacttgtat cttggtgata tggtttggct gcgtcacgac acaaatctca ccttgaattg
    10561 taataatccc cacgtgtcgt gggaaggacc cagtgggagg taattgaatc atgggggcgg
    10621 gtcttcccat gctgttctcg tgatagtaag tctcatgaga tctgatggtt ttataaaggg
    10681 gagtttccct gcacatgccc ttttgcctgt gtcatgtaag atgtggcttt gctcttcctt
    10741 tgccttctgc catgactgtg aagcctcccc cgccatgtga aactgtgagt ccattaaacc
    10801 tctttccttt ataaatta
//
