LOCUS       NM_001105577             967 bp    mRNA    linear   PRI 19-JUL-2024
DEFINITION  Homo sapiens ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-)
            decarboxylase (URAD), transcript variant 1, mRNA.
ACCESSION   NM_001105577 XM_929568 XM_940733
VERSION     NM_001105577.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Ramazzina,I., Folli,C., Secchi,A., Berni,R. and Percudani,R.
  TITLE     Completing the uric acid degradation pathway through phylogenetic
            comparison of whole genomes
  JOURNAL   Nat Chem Biol 2 (3), 144-148 (2006)
   PUBMED   16462750
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AL591024.14.
            
            On Sep 2, 2019 this sequence version replaced NM_001105577.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no human transcripts were available to represent this
            gene. The genomic coordinates used for the transcript record were
            based on orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142680,
                              SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332715.6/ ENSP00000333490.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AL591024.14        46439-46669         c
            232-967             AL591024.14        35693-36428         c
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..967
                     /gene="URAD"
                     /gene_synonym="PRHOXNB"
                     /note="ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-)
                     decarboxylase"
                     /db_xref="GeneID:646625"
                     /db_xref="HGNC:HGNC:17785"
                     /db_xref="MIM:615804"
     exon            1..231
                     /gene="URAD"
                     /gene_synonym="PRHOXNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..578
                     /gene="URAD"
                     /gene_synonym="PRHOXNB"
                     /EC_number="4.1.1.97"
                     /note="OHCU decarboxylase; parahox cluster neighbor"
                     /codon_start=1
                     /product="putative
                     2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
                     decarboxylase"
                     /protein_id="NP_001099047.1"
                     /db_xref="CCDS:CCDS45020.1"
                     /db_xref="GeneID:646625"
                     /db_xref="HGNC:HGNC:17785"
                     /db_xref="MIM:615804"
                     /translation="MDIEKVNSMDLGEFVDVFGNATERCPLIAAAVWSQRPFSDLEDL
                     EKHFFAFIDALAQSGQEGILRCHPDLAGSELQRGTLTAESQREQSGAGLRSLGADERL
                     RLAELNAQYRARFGFPFVLAARFSDRTAVPRELARRLLCPSAQELRTALGEVKKIGSL
                     RLADLLRADPAKL"
     exon            232..967
                     /gene="URAD"
                     /gene_synonym="PRHOXNB"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      967
                     /gene="URAD"
                     /gene_synonym="PRHOXNB"
                     /note="major polyA site"
ORIGIN      
        1 actcactcac cgagagggga gctggacgtc ccgctgtctc cagtggaata caaggaatgg
       61 acattgagaa ggtcaactcc atggaccttg gagaattcgt ggatgtgttt gggaatgcca
      121 ctgagagatg tcctctgatt gcagctgctg tttggtccca gcggccattc tctgatttgg
      181 aagatttaga gaagcacttt tttgccttta ttgatgccct tgcacagtca ggccaggagg
      241 gcatcctgcg ctgccacccg gacctggcgg gcagcgagct gcagcggggc acgctcacgg
      301 ccgagtcgca gcgggaacag agcggcgcag gcctgaggag cctgggcgcg gacgagcggc
      361 tgcggctggc cgagctcaac gcgcagtacc gcgcgcgctt cggtttcccc ttcgtgctcg
      421 ccgcgcgctt cagcgaccgg acggcggtgc cgcgcgagct ggcgcgccgg ctgctctgcc
      481 cgtccgcgca ggagctgcgc actgctctgg gcgaggtgaa gaagatcggc agcctgcgcc
      541 tggccgacct cctccgcgca gaccccgcca agctgtagct gccgcgcggg ccagggaccc
      601 gggacgcaca accggacgcg cgggggccac ggcccggagc tgtgcgtcct gggcgggagg
      661 cggactcggg cctggaacag cgtccacaca cgtgcacaaa ggaagtggag aattgaggca
      721 atcatacgag taatgagtcc ttttgtccgc ccacccacac gcgcacgcgt tgccaaaata
      781 tccatattgt ttagtgcttt gccccggatt tatccagctc actgcttcaa ttcttcactc
      841 cctttgcggc ccccgacacc accggccttt gtggattcca aagcgtttat ccagttctcc
      901 ccaaccctct cctgctaagc ccgaactgca aagcaaaacg gacggaaaag gaatctttta
      961 tgccaca
//
