LOCUS       NM_006294               8459 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ubiquinol-cytochrome c reductase binding protein
            (UQCRB), transcript variant 1, mRNA.
ACCESSION   NM_006294
VERSION     NM_006294.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8459)
  AUTHORS   Ma,W., Tian,Y., Shi,L., Liang,J., Ouyang,Q., Li,J., Chen,H.,
            Sun,H., Ji,H., Liu,X., Huang,W., Gao,X., Jin,X., Wang,X., Liu,Y.,
            Yu,Y., Guo,X., Tian,Y., Yang,F., Li,F., Wang,N. and Cai,B.
  TITLE     N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of
            ac4C modification to promote heart regeneration
  JOURNAL   Nat Commun 15 (1), 2137 (2024)
   PUBMED   38459019
  REMARK    GeneRIF: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb
            independently of ac4C modification to promote heart regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8459)
  AUTHORS   Guan,N., Kobayashi,H., Ishii,K., Davidoff,O., Sha,F., Ikizler,T.A.,
            Hao,C.M., Chandel,N.S. and Haase,V.H.
  TITLE     Disruption of mitochondrial complex III in cap mesenchyme but not
            in ureteric progenitors results in defective nephrogenesis
            associated with amino acid deficiency
  JOURNAL   Kidney Int 102 (1), 108-120 (2022)
   PUBMED   35341793
  REMARK    GeneRIF: Disruption of mitochondrial complex III in cap mesenchyme
            but not in ureteric progenitors results in defective nephrogenesis
            associated with amino acid deficiency.
REFERENCE   3  (bases 1 to 8459)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 8459)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8459)
  AUTHORS   Haut,S., Brivet,M., Touati,G., Rustin,P., Lebon,S.,
            Garcia-Cazorla,A., Saudubray,J.M., Boutron,A., Legrand,A. and
            Slama,A.
  TITLE     A deletion in the human QP-C gene causes a complex III deficiency
            resulting in hypoglycaemia and lactic acidosis
  JOURNAL   Hum Genet 113 (2), 118-122 (2003)
   PUBMED   12709789
REFERENCE   6  (bases 1 to 8459)
  AUTHORS   Malaney,S., Heng,H.H., Tsui,L.C., Shi,X.M. and Robinson,B.H.
  TITLE     Localization of the human gene encoding the 13.3-kDa subunit of
            mitochondrial complex III (UQCRB) to 8q22 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 73 (4), 297-299 (1996)
   PUBMED   8751380
REFERENCE   7  (bases 1 to 8459)
  AUTHORS   Hosokawa,Y., Suzuki,H., Nishikimi,M., Matsukage,A., Yoshida,M.C.
            and Ozawa,T.
  TITLE     Chromosomal assignment of the gene for the ubiquinone-binding
            protein of human mitochondrial cytochrome bc1 complex
  JOURNAL   Biochem Int 21 (1), 41-44 (1990)
   PUBMED   2167087
REFERENCE   8  (bases 1 to 8459)
  AUTHORS   Suzuki,H., Hosokawa,Y., Toda,H., Nishikimi,M. and Ozawa,T.
  TITLE     Isolation of a single nuclear gene encoding human
            ubiquinone-binding protein in complex III of mitochondrial
            respiratory chain
  JOURNAL   Biochem Biophys Res Commun 161 (1), 371-378 (1989)
   PUBMED   2543413
REFERENCE   9  (bases 1 to 8459)
  AUTHORS   Suzuki,H., Hosokawa,Y., Toda,H., Nishikimi,M. and Ozawa,T.
  TITLE     Cloning and sequencing of a cDNA for human mitochondrial
            ubiquinone-binding protein of complex III
  JOURNAL   Biochem Biophys Res Commun 156 (2), 987-994 (1988)
   PUBMED   3056408
REFERENCE   10 (bases 1 to 8459)
  AUTHORS   Wakabayashi,S., Takao,T., Shimonishi,Y., Kuramitsu,S.,
            Matsubara,H., Wang,T., Zhang,Z. and King,T.E.
  TITLE     Complete amino acid sequence of the ubiquinone binding protein
            (QP-C), a protein similar to the 14,000-dalton subunit of the yeast
            ubiquinol-cytochrome c reductase complex
  JOURNAL   J Biol Chem 260 (1), 337-343 (1985)
   PUBMED   2981208
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003465.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2019 this sequence version replaced NM_006294.4.
            
            Summary: This gene encodes a subunit of the ubiquinol-cytochrome c
            oxidoreductase complex, which consists of one mitochondrial-encoded
            and 10 nuclear-encoded subunits. The protein encoded by this gene
            binds ubiquinone and participates in the transfer of electrons when
            ubiquinone is bound. This protein plays an important role in
            hypoxia-induced angiogenesis through mitochondrial reactive oxygen
            species-mediated signaling. Mutations in this gene are associated
            with mitochondrial complex III deficiency. Alternatively spliced
            transcript variants have been found for this gene. Related
            pseudogenes have been identified on chromosomes 1, 5 and X.
            [provided by RefSeq, Dec 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.201728.1,
                                           SRR1803613.161699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000287022.10/
                                                  ENSP00000287022.5
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AP003465.2         120757-120790       c
            35-106              AP003465.2         118401-118472       c
            107-273             AP003465.2         117019-117185       c
            274-8459            AP003465.2         108192-116377       c
FEATURES             Location/Qualifiers
     source          1..8459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..8459
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="ubiquinol-cytochrome c reductase binding protein"
                     /db_xref="GeneID:7381"
                     /db_xref="HGNC:HGNC:12582"
                     /db_xref="MIM:191330"
     exon            1..34
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..351
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /EC_number="7.1.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquinol-cytochrome c reductase, complex III subunit VI;
                     cytochrome b-c1 complex subunit 7; ubiquinol-cytochrome c
                     reductase complex 14 kDa protein; complex III subunit 7;
                     complex III subunit VII; mitochondrial ubiquinone-binding
                     protein"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 7 isoform 1"
                     /protein_id="NP_006285.1"
                     /db_xref="CCDS:CCDS6269.1"
                     /db_xref="GeneID:7381"
                     /db_xref="HGNC:HGNC:12582"
                     /db_xref="MIM:191330"
                     /translation="MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDV
                     KEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRER
                     KEREEWAKK"
     exon            35..106
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /inference="alignment:Splign:2.1.0"
     exon            107..273
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /inference="alignment:Splign:2.1.0"
     exon            274..8459
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      450..455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: AATAAA"
     polyA_site      475
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="major polyA site"
     polyA_site      503
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     regulatory      683..688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: AATAAA"
     polyA_site      725
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     regulatory      4306..4311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: AATAAA"
     polyA_site      4330
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     regulatory      4700..4705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: AATAAA"
     polyA_site      4730
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     polyA_site      4842
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     regulatory      6103..6108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: ATTAAA"
     polyA_site      6123
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
     regulatory      8443..8448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
                     /note="hexamer: AATAAG"
     polyA_site      8459
                     /gene="UQCRB"
                     /gene_synonym="MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6;
                     UQPC"
ORIGIN      
        1 ctctttctgg tcaaaatggc tggtaagcag gccgtttcag catcaggcaa gtggctggat
       61 ggtattcgaa aatggtatta caatgctgca ggattcaata aactggggtt aatgcgagat
      121 gatacaatat acgaggatga agatgtaaaa gaagccataa gaagacttcc tgagaacctt
      181 tataatgaca ggatgtttcg cattaagagg gcactggacc tgaacttgaa gcatcagatc
      241 ttgcctaaag agcagtggac caaatatgaa gaggaaaatt tctaccttga accgtatctg
      301 aaagaggtta ttcgggaaag aaaagaaaga gaagaatggg caaagaagta atcatgtagt
      361 tgaagtctgt ggatgcagct gttatgaaga tggttaaact tgaaacaaac aattttaaga
      421 attatttggt ctgaagatgt tttactttaa ataaatgtct attgtaatgg ctggagtttt
      481 tgaattccaa accttatact gaataactac tgaatccctt tactgttaaa tttttttcca
      541 aactttcaag atatatttag ttgtgtttaa ctgctacttg gagctcagaa gccactttat
      601 cagttttcct cactggttgg atagcctatc agtttatgga aggatataac ttccgtaagt
      661 tacatcctta tggaagctac tgaataaaag aagggggtat gcacccccta gtttgccaag
      721 attgagaaat agcctcttca ctggtatgca aacagatttg attttgcatc ctatcattta
      781 aaaagaaatt atgtctgcac cccaacatag gcatacttaa gtaatataca tactcctgtg
      841 ctaacatgta tactagaaaa caaaaagatg ttagaaaaat aaaagtataa agacaaatca
      901 tactgtcccc atatcccagt gacttttcca ctttggaaat gattgttatg aagtttaagg
      961 gttggatact agtcagttaa aagttttaag attatagggt aatttttaaa aatataaatt
     1021 agaatcattg gcaaggcatg gtggctcatg cctgtaatcc cagcactttg ggaggccgag
     1081 gcgggcgggt cacctgaagt caggaatttg agaccagcct ggccaacatg gtgaaaccct
     1141 gtctctacta aaaatacaaa aaattagcta ggcgtgatgg taggcacctg taatcccagc
     1201 tactcgggag gctgagggag gagaattgct tgaccccagg aggtggaggt tgcagtgagc
     1261 ctagatcaca ccactgcact tcagcctgag cgacattgac tgtctcaaaa aaaaaattag
     1321 gattattcaa tgttgtcatc atttccactc ctaaattctg aaatgctttc tttggtagag
     1381 gtgagagtgt ggagccacag ctagtagaga aggaacagta ggacctgcag cctccctggt
     1441 tttccaggac aagtcattgc tgtgtgtggc aggaatgcct tacctcaaat aacaaaacag
     1501 tgtgaaaaac gaatttgtgt tacatttaaa gtttgtaaag caatgagaaa tgtgtgtatc
     1561 ataaagagca tctttaaatt tttgctaaaa tattagcctc ttaaattctc taggaacccc
     1621 ctcccccgct tttttttttc ctttcgctgg tcgttatttt tctaaaccta tcctgaaatc
     1681 atgtcaattt tcttttgtat ggttgaagac aactagatca cttgataatg gttttgctca
     1741 ggtcacattg tgacaaggtt ttaatgtagt cctactttgc agaaggaggc caagaagatg
     1801 ggctgtctag aacccccttt aaaagcattt gtctattcag aaaattttcc tgagtagatc
     1861 tctgcaaagg ctcttttaat agtgatttca agatcacgtt tgcaggactc tggtctattc
     1921 gttcagacgt ctactgtgca caattacaag gagactacaa ctgaggcatc tcaaagagca
     1981 ctgtcaaggt gtgtagggag ccgggtgggt ggagggaggc tgggctctga ccctagaaac
     2041 catgcttatg aatgctgtta atgtttaaag caagcctaag ggcactgctg aaggacaggg
     2101 gaacaaatag aactgaccaa gactgaggta taacaggaac ccccaggcta tccacctgct
     2161 caaggtaaag tgtggtatta cataaggcaa cctctgattt tgtaagagtt cttcctaaag
     2221 ccaaagtgta tgcctattct atgtttccag attacttcat tcttctaaat gagaacaagt
     2281 gtgcaaaagt tctttgaaca ctagatcaat gttttgtgtt cattataaat tatggttatc
     2341 gtcctgcttg ttatgaagac taagaaagta gatctagtat ttggctcaca caggtgaatg
     2401 ggtgagaatt tgttaatcca tcagtgaagt cctttcattt gaaagagagg gcctttctat
     2461 tatcaaaagc cgtcctgtgt ggaaaatcac catgagagtg cctgaaacac aggcactctg
     2521 cattgtcctg tagaccaaat ctacattgtc ctgtagtctg gtctacattg tcctgtagac
     2581 cgaatggtag agtgattcag agctaattct gggttagact gcacaggtct gaatctattt
     2641 gctcactgtg tagtgcttta ggaatacaat ttaacctctc cgtgcttcag tttgtttgtc
     2701 cctaagatag agctaatgat agaaacctac ttcacccagt tgtgaaaatt aactgactgc
     2761 atgtcaagca ctaacagttt ctggcatata gtatgcataa tgtaaattat gtgctgagaa
     2821 gcgagaaaga ataacttggg aaaacgctga atatcatcaa tgtcgaatag ctaaccagta
     2881 gctaaggtcc aaggtctcct ctcttccttc tatgtggcac tcttgtttct ggttcatcta
     2941 ctccccttgg gtgtcacctc cttgagtgaa gtacctgctg gagatgagaa gagtggaact
     3001 ggatctgcat gacagctttg attaggatgg agctaagact tggctatctc cctgttttgt
     3061 gttttggatg ggtgacattt taaaactgcc aatattcaaa tcctgctaat ttgctttgta
     3121 cagtttaaaa tgtttgatat cttttgttgt ttaaagtttg agattggttt tgaatataca
     3181 gttttcctac atcttgaaga aagttatgtt tgtttactct gaagtggtct atgttctgtt
     3241 tgtttgtttt actatacttt gcaaaaaaac agatggctgg cttatgttca ctgttgtagt
     3301 gcactaccta gtatcacttg gccttcctgt tgtcaagatg taggaagcag cgtaagggat
     3361 gtcgggcctt cagaccccca attgccagct gtggtcctag ttccagattg catggaaata
     3421 tttgataaca ttcctgcact gagttatcat ggtctgaata tttatgtgac gctctacgag
     3481 tggtaccaaa atgttagtga tggagttttt actaatggca ccttttcctg tttttaaatt
     3541 ctagaatctt aataaatcca aagtgtacat tttggtagtg atttcattta gttatttact
     3601 ttaaggactc ccttttcaag cattaactct gcactaattt tgacttatga aaagattcag
     3661 cagtaagaat aaaaactggg ccaaagccca aagtaataat ccttcacaaa taggatggag
     3721 ttttaaaaat atgggcatcc tgtgtgtagc tttgaaaata accaaactac ttggaattaa
     3781 aaagttaggt gaacatgaag attgtcataa ccaaatcctt gacagcttga tggatgaaga
     3841 gcagatgggt ttatggtgta tgggaggaag catggatttt aggagggaca gtatcagaga
     3901 gggatggtta gaaagtgagt aagacaggtt gctctttgga aaacaaggaa aatcccttta
     3961 ttagaacaag gcatgaaatt ctgccactag gtggcgatgc cctataactt tacaacttag
     4021 tgtacatcac acgagcacta tggaagattt ctccattctg cgccccacca actccctccc
     4081 ctccttcatt tttcaggatg acaacacctt agaggtttat ggccatcagg agaatttact
     4141 actaagctat atactgatgt aatgaaatct aatatatgtt gtgcaatgaa ttatgagatg
     4201 ttatttagtt tcaggatttt attacttcaa tcagttatga ccatatttcc ttttatatga
     4261 ttgctcactc tttaaacata ccagatgact gtataaggaa cacctaataa agtctataga
     4321 tgttaaaata ttttaaatgt tttaatttat atgccataat ttgtttacat tctggttata
     4381 ctggcgttca tattaaaagc cataacatgt tagaatctga gatctcaggt cggatagtgc
     4441 ctctaagtta tattttgcta agaaatttta ttgtattagc aattgagcaa gaaagaagaa
     4501 ctgaatcatt atacggtggt taatttttag catagatgtc agaaagcctg ttaatattcc
     4561 agaggcttat gataaactat ttaaattgtc attctggatt ctgattatat ctcctacaaa
     4621 gaaagagtgt attatttatt gaactttttg tttgaataca tgtgcctatt tttgcataaa
     4681 tgtaaaaatg taattttaaa ataaacccct gaaaacttct ggtaacatta tccagttgaa
     4741 taattgttct gttagtattc taaatatttt aagaaaattg tatacatatc tgtgacaatt
     4801 gtattcacaa gccaaaccaa aaaaagataa ttatttgttt tacaaaggag tcagcttaca
     4861 atttttctct tatgcatgca tttaaaatgt ggtttgccat taaactggaa acactgatct
     4921 gaggccaatg atttaggcaa gtcattagtc taaagattgg cttcctcagc tagaaaatga
     4981 agggctttga ctaaaaagtc tttttcattt cagtaccaaa acattctggg tctgtgattt
     5041 aacttacgct ctttattgtt gggatgaact aatactgatg gaatactagc tttgtactag
     5101 gcactgttcg tatgttgtct cttttaatcc tccctgcaac cttctggcat ggctattata
     5161 atgcccattg tatggaagaa gaaattaggc ttcgaaagtc cattttatgc ttgttcatta
     5221 cataattttc tggatttttt aaattgatgt atgtgtttat gttccaggct aggcagaagc
     5281 taggaagaat atagcagcct cgtcactgtt gaaatctggg gctagataat tctttgttgt
     5341 gggggcctcc tctgtgtgtt acaggatatt tagcagcatc ctggcttcta cacgataggt
     5401 accagtagcg cctcctgcct ccaactgtaa caaccaaaaa tgttttgaga cattgtctgg
     5461 aaatgttccc ctgggggagc agaattgctc ccagctaaaa accaccagtg tagggaatac
     5521 agagaaaaac caagatggta gagacaggta tgtaatcaga tgcatgaata tgtaaacata
     5581 gatgtacata ctgtgtgaat tgtccacaaa aaatatgtac tgggtactat ggaaacatgg
     5641 agaaggtaaa ctaactaaac ctggatggga atcagggcct ctgataatgt ggctgattcc
     5701 agaacagtaa gcaaagttag ctaagccaag aagatggtga agggctttcc aagcagaaga
     5761 aaatgagcag gaaatgctca aaggcatgga agtgcaggat gtatgtctag ggaaggacag
     5821 gcagttttgc actgatggag tggcaaatat cagctggaga gacatgggag atgcaacctg
     5881 aaaggtgtac gccatattga gatgcctgga cttcatcctg tgagcagcag agtgtttgga
     5941 tagattctgg gaagtgaaaa tgttggggca aaggggatga atatttgaag tttttcaata
     6001 ctggacttcc aatttgcttt tcaaaagttt ataataattt atattcatct aagcaatcac
     6061 gagggtccct ttattgcatt cctgcctgca ctgagtgctc tcattaaaag caatctttgt
     6121 gaatttggtt ggagagtttc ttgtttaaac ttgcatttct tggattgagt agctagacgt
     6181 ttttccatat gctattatca agttgttatt tctctttcat caatcttgtt catgtccttc
     6241 acctatgggc ctatttttaa ttttcacagc cttttcctta tttgtttagt tttcctctta
     6301 gctccctctt cccccttccc aaacctgggt cagttcttat ctatttgtat gagaccttta
     6361 tatgtttaga tagtacccct tttacttaca tttgctgaaa tgatattttt atttcatcgt
     6421 ttgaatttta tttgaggttt tttggatgcc ttttcaactt tgttcatggt gggttttgtc
     6481 aaatggaagt ttctgatttt tatgtagtac aaactctcag tcctctcctc tgtggttttg
     6541 cctctgaggt catgctttga gaagtcctct ctttactcca agttttcata aatatccagc
     6601 aaggtttcat ccagtacttt taggtataag aaacaaaacc ataaatcttc aatccctctg
     6661 gagtttaggg atatggtgtg agcagagtat atttttgaga gatactaaga agtccagttg
     6721 gcctgactgg atatcagtta gatgtgtaag aggtggatgt gaggaagggt aaaagagaga
     6781 ggtccggagg ggctccacaa acacgggtct gttgagggtg atgcagcctg gtaatcagcc
     6841 ccttctgtgg cttctcattc tgtgagacgt tggctgtgct gcatattcta aatctactct
     6901 tgtcccttct ggattcagct ctgtacccca ggagagataa attgatgtaa agactgcaca
     6961 aatagacact tttgccttct ggcttctggc ttgggcttgg ccagccagtg tggggagggt
     7021 ggccacctgc aagagagggc agatgagaga gacagagata tttattcccc agcccacgtt
     7081 cctctgaaga aagctacagc tcctgtcagg cagcccctct caagattcct acagctctcc
     7141 cttccatccc tccccactct gctatctcta tcaaagttgg ttctccttga ccttgcctgc
     7201 cgtttgttaa ttgtcccttc attggacatt ctttggtttg cctgattggg tgtgccacac
     7261 tttcctgcca ggactctgac tcacacagaa ctgggctgcc cttgagaatg gctaggttgc
     7321 cccatgagag caccaagtgc tgctacttgg aactggtttg tggtcagttc ctggaaaacc
     7381 aaagcttgct tctttgaggt aagctaactc atgccccaga gtcagactcc aggagaccac
     7441 actagttcca gttgaaggga gtggccttcc aaagcctggc ttctaccacc cccacctgtc
     7501 tgcctctacc catgatagat ctgcttccaa tcagagactt actcttctac acaatttaat
     7561 gcaggtaaat gccagtgcta aaaagatgcc atatgataga aaacagaagg tttgtccatt
     7621 ctgaaaacat tgtgttctct ttcctcctgt tttaactccc tcttccccaa acacattctg
     7681 caaaattcta cctctaacct tttttccttc tattctcagt cccctgcaat ggcacttgca
     7741 atcctcacca tactctgtct aaattctagc tttactttaa gacaaaaatt aaattctgcc
     7801 tactgagaga agctctttgt caaccccagg cacttgacat ttctattttc tttgactttg
     7861 taaagcactt actacttcaa ccaatcattt actatttaac aataataaat actatttacc
     7921 tagtgttcac tgtgggccat ttcaggtttc atttattcct tgaaaatttt tccaaggtga
     7981 gcacaattat cctcttttca tagaggctca gacatgttag gtaacgggta caagatcaca
     8041 ctttgcaagt gagcaaatgg aaagttaaat tctgtcttcc ttgaaattgc tatgttgtct
     8101 tttctttttt atttaaggtg tacagcatga tgttttgata caaatataca tagtgaaatg
     8161 attactacag gcaagcaaat taaaatatcc attaccacga tagtactttg tgtatgtgtg
     8221 tctggtgagc acctaaaatc tacactttca gcaaattttt agtgtacaat ataattatag
     8281 tcaccatgct gtacatgaaa tctctagacc tgttcatctt gtataattgc aagtttgtgt
     8341 atcctttgac ctacctctcc ccatttcctg atccttccca ctctggaaac caccattctt
     8401 ctctgtttct atgtatttga catgttttag attgcacaaa taaataagat catgcagta
//
