LOCUS       NM_006830               1299 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit
            XI (UQCR11), mRNA.
ACCESSION   NM_006830
VERSION     NM_006830.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Ma,W., Tian,Y., Shi,L., Liang,J., Ouyang,Q., Li,J., Chen,H.,
            Sun,H., Ji,H., Liu,X., Huang,W., Gao,X., Jin,X., Wang,X., Liu,Y.,
            Yu,Y., Guo,X., Tian,Y., Yang,F., Li,F., Wang,N. and Cai,B.
  TITLE     N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of
            ac4C modification to promote heart regeneration
  JOURNAL   Nat Commun 15 (1), 2137 (2024)
   PUBMED   38459019
  REMARK    GeneRIF: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb
            independently of ac4C modification to promote heart regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Valnot,I., Kassis,J., Chretien,D., de Lonlay,P., Parfait,B.,
            Munnich,A., Kachaner,J., Rustin,P. and Rotig,A.
  TITLE     A mitochondrial cytochrome b mutation but no mutations of nuclearly
            encoded subunits in ubiquinol cytochrome c reductase (complex III)
            deficiency
  JOURNAL   Hum Genet 104 (6), 460-466 (1999)
   PUBMED   10453733
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Islam,M.M., Suzuki,H., Yoneda,M. and Tanaka,M.
  TITLE     Primary structure of the smallest (6.4-kDa) subunit of human and
            bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences
  JOURNAL   Biochem Mol Biol Int 41 (6), 1109-1116 (1997)
   PUBMED   9161705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DW465790.1, BC003594.1 and
            AA807820.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006830.3.
            
            Summary: This gene encodes the smallest known component of the
            ubiquinol-cytochrome c reductase complex, which forms part of the
            mitochondrial respiratory chain. The encoded protein may function
            as a binding factor for the iron-sulfur protein in this complex.
            [provided by RefSeq, Oct 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.136473.1,
                                           SRR3476690.203981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 10453733; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000591899.8/
                                                  ENSP00000467262.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DW465790.1         28-57
            31-1296             BC003594.1         1-1266
            1297-1299           AA807820.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1299
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="ubiquinol-cytochrome c reductase, complex III
                     subunit XI"
                     /db_xref="GeneID:10975"
                     /db_xref="HGNC:HGNC:30862"
                     /db_xref="MIM:609711"
     exon            1..103
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..224
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="ubiquinol-cytochrome c reductase, 6.4kDa subunit;
                     complex III subunit XI; complex III subunit 10;
                     ubiquinol-cytochrome c reductase complex 6.4 kDa protein"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 10"
                     /protein_id="NP_006821.1"
                     /db_xref="CCDS:CCDS12073.1"
                     /db_xref="GeneID:10975"
                     /db_xref="HGNC:HGNC:30862"
                     /db_xref="MIM:609711"
                     /translation="MVTRFLGPRYRELVKNWVPTAYTWGAVGAVGLVWATDWRLILDW
                     VPYINGKFKKDN"
     exon            104..252
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /inference="alignment:Splign:2.1.0"
     exon            253..1299
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      399..404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="hexamer: ATTAAA"
     polyA_site      419
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="major polyA site"
     regulatory      613..618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="hexamer: AACAAG"
     polyA_site      655
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
                     /note="hexamer: AATGAA"
     polyA_site      1299
                     /gene="UQCR11"
                     /gene_synonym="0710008D09Rik; QCR10; UQCR"
ORIGIN      
        1 agtgtagccg ggtcagctgg acagggtcat cctgagggtg cgactccgcc gcgatggtga
       61 cccggttcct gggcccacgc taccgggagc tggtcaagaa ctgggtcccg acggcctaca
      121 catggggcgc tgtgggcgcc gtggggctgg tgtgggccac cgattggcgg ctgatcctgg
      181 actgggtacc ttacatcaat ggcaagttta agaaggataa ttaattacac aaacccttca
      241 cagactgctc tggtgcctgg tggtgctagc tcctcccacc tcagcacctg ctgcatctgg
      301 agcagcccaa gcctcaggat ggacaagagg aaacccacag ctcagcttca ggcttcttat
      361 gtttctgaaa acagcttgga tattttaatg cacgttgcat taaacctcac tgaaacctgc
      421 tccgtgcccg gatgttgatc atgctggtgg cttggttact gtgactgtag ctggagtggc
      481 acaggtgacc caggcgtcct ttcagctcca gaatgttgca agtctaggag agtgttccaa
      541 tggctgacag aaactgccta tttgaaatgg ctcataagta gtatctgcag tgtgttcatc
      601 cgttgctgcc ttaacaagtc acccacacgt agtggcttaa agcaacgaac attcactctc
      661 tcacagtctg tgtcagtcgg ggatttggga gtgatgtatc tgggtggttg tggcccagag
      721 tctctcatga ggttgcagtt aagacatcag ccaaggccac ttcgtctgag gaaggctcaa
      781 ctggggctgg agccacttcc aagccagtgc cctcacgtgg ctgtcggtga cagccacagt
      841 tccttcccat gggggcccct acacgaagct gcttgagcat cctcacggca tggcctctgc
      901 cttccccaga gcaggtgaac caagggagag gaaggagcaa gccacagtgc ttctatgagc
      961 caccctgaga agtctcacgt gatcacttcc gccacagcct gtttatcaaa agcaagcccc
     1021 ccaggcccag cccacgtgca gagggaggag aatgaggttc tgtgttttga agggaagaat
     1081 atcagaattg gtagacattt caaactgtca cattagggat acaaaaatga acaggctggg
     1141 agtggtggct cagcctacaa tcccaacact ttgggaggct gaggaagggg catcacttga
     1201 accaggagtt cagtactaac ctgggcaaca aagaggcccc tgtctctgat aaaaagaaaa
     1261 aaaatgaaaa aataaaaatg aacaggtata aaaagagaa
//
