LOCUS       NM_001124767            1769 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquinol-cytochrome c reductase complex assembly
            factor 5 (UQCC5), mRNA.
ACCESSION   NM_001124767 XM_001716881 XM_001717970 XM_001718706
VERSION     NM_001124767.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Liang,C., Zhang,S., Robinson,D., Ploeg,M.V., Wilson,R., Nah,J.,
            Taylor,D., Beh,S., Lim,R., Sun,L., Muoio,D.M., Stroud,D.A. and
            Ho,L.
  TITLE     Mitochondrial microproteins link metabolic cues to respiratory
            chain biogenesis
  JOURNAL   Cell Rep 40 (7), 111204 (2022)
   PUBMED   35977508
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Dennerlein,S., Poerschke,S., Oeljeklaus,S., Wang,C.,
            Richter-Dennerlein,R., Sattmann,J., Bauermeister,D., Hanitsch,E.,
            Stoldt,S., Langer,T., Jakobs,S., Warscheid,B. and Rehling,P.
  TITLE     Defining the interactome of the human mitochondrial ribosome
            identifies SMIM4 and TMEM223 as respiratory chain assembly factors
  JOURNAL   Elife 10, e68213 (2021)
   PUBMED   34969438
  REMARK    GeneRIF: Defining the interactome of the human mitochondrial
            ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly
            factors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1769)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095910.1, BG031013.1, BM674004.1 and AC112215.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001124767.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017996.1, BX480229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000477703.6/ ENSP00000417806.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK095910.1         1-15
            16-405              BG031013.1         6-395
            406-449             BM674004.1         19-62               c
            450-1769            AC112215.3         90487-91806
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1769
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="ubiquinol-cytochrome c reductase complex assembly
                     factor 5"
                     /db_xref="GeneID:440957"
                     /db_xref="HGNC:HGNC:37257"
                     /db_xref="MIM:620435"
     exon            1..302
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..364
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="UPF0640 protein C3orf78; small integral membrane
                     protein 4"
                     /codon_start=1
                     /product="ubiquinol-cytochrome c reductase complex
                     assembly factor 5"
                     /protein_id="NP_001118239.1"
                     /db_xref="CCDS:CCDS46844.1"
                     /db_xref="GeneID:440957"
                     /db_xref="HGNC:HGNC:37257"
                     /db_xref="MIM:620435"
                     /translation="MFTRAQVRRILQRVPGKQRFGIYRFLPFFFVLGGTMEWIMIKVR
                     VGQETFYDVYRRKASERQYQRRLEDE"
     exon            303..1769
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      383..388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="hexamer: AATAAA"
     polyA_site      405
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="major polyA site"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="hexamer: AATATA"
     polyA_site      456
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
     polyA_site      511
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="UQCC5"
                     /gene_synonym="C3orf78; SMIM4"
ORIGIN      
        1 actcgtgcgc ctaccagaca gtggcggagg acggcgctcg ctagtctccc aggtcgcggt
       61 acacggcgag aacgggcggg gcggtctcgg ctgcgtccgg gcgatccagt gcttagttcc
      121 gtcatatccc tctccacgac ctcggtcgag catgttcacc agggcccagg tgagacggat
      181 tctgcagcgg gtgcccggga agcagcgatt tggcatctac cggttcctgc ccttcttttt
      241 tgtcctggga ggaacgatgg agtggatcat gattaaagtg cgcgtgggcc aggagacctt
      301 ctatgatgtc taccgtagaa aagcctcaga aagacagtat cagagaaggc tggaagatga
      361 atgagactga acttcagcag tcaataaagt caatatgaat ttttactatt ggtttcagtg
      421 ccttttaaaa tatacttttc agatctcttg ttctgacaca gcttgtcctt tatcagctgc
      481 acaatattcc aataactgtt tttgcaaaga atttttatag ttctgtctct gcttgagtac
      541 ttcccaagtc actgctggac agcacttgtg ggaaaattat ttcctcctaa aacactcact
      601 cgatgaatct agtccatgaa atatttctta aacaattcaa ggatcaatca ggatgctttt
      661 cagtgaagcc cgaattgttt tcggcaatct ttgtttttag gcaactaatt ataaccttat
      721 ttactttttt gcagaattca aattaaatta tggacacatt ctctattgcc agatcattta
      781 aaccaggata attatgcagg ttgtatttct gccagctact agactataaa ctttttgcta
      841 gggtggtgga aattcttgat tgactacgca tttctcatgc tagtgttctt gtgaacagaa
      901 atatgctcct cccttgcttg gctcccctaa actgcaaggg ctggatcttc atgaggactg
      961 tgggcaacag gtttcacact actctaggat gaagatgttg ctgttcgatt cagctgctag
     1021 aaacagttgc tccttccatg agaaagtgaa cctacacagt ataaagcatc ccagacttga
     1081 gctaaatcag aggctcagtc tattgagtga tttggcaatc tgacccagtg taagtttgga
     1141 tcagcctggt agaaaaagca gatacctttc catgcttgca tagccacatc taacatcgtt
     1201 tcaagcaaaa aaaaatctac atactaaaga ctaagtttca gaatagtttc taactattgc
     1261 atgagaataa agctgatgct taaggccata gggtatcctc aagttaatga tctctgccac
     1321 aaacatgtct cctaattttt tctagatttt tcttctaatt ttagtccact tatcttagaa
     1381 ccaattcagt aaagaaccat taactaacta ctcccatctc cttaaagcac tacctacact
     1441 acagtgcagc aagcccagag tcacagctgg gagatggctt gaatgtgaaa ggccagtaat
     1501 gacctctgcc atcagggaga ggacggtggt tcatcgtatt ctcatgccca gttgtgtcat
     1561 ctaggattcc tggtaaacct aacctgataa accattttta gtgacttgac tgctgtataa
     1621 aaactatagt atgattctca attatatggc catactccat gtttgcccta acccaccttg
     1681 ttttaggagt ttagtatttg atacatatag aaaatacgtc atacctttta caaagaataa
     1741 tagtaaacac taataaaacc attggctaa
//
