LOCUS       NM_001085372            1927 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquinol-cytochrome c reductase complex assembly
            factor 3 (UQCC3), mRNA.
ACCESSION   NM_001085372
VERSION     NM_001085372.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Yang,Y., Zhang,G., Guo,F., Li,Q., Luo,H., Shu,Y., Shen,Y., Gan,J.,
            Xu,L. and Yang,H.
  TITLE     Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating
            OXPHOS and Glycolysis in Hepatocellular Carcinoma
  JOURNAL   Cell Rep 33 (5), 108340 (2020)
   PUBMED   33147459
  REMARK    GeneRIF: Mitochondrial UQCC3 Modulates Hypoxia Adaptation by
            Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Li,G.P., Ke,J.L., Lu,P.P., Zhu,X., Wang,C., Wang,J.Y., Shen,X.Y.
            and Xiong,S.Q.
  TITLE     [The Anti-virus Effect of AY358935 Gene on Vesicular Stomatitis
            Virus and the Mechanism Study]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 50 (4), 540-545 (2019)
   PUBMED   31642232
  REMARK    GeneRIF: AY358935 gene has an anti-VSV effect, and its anti-virus
            mechanism may involve the interferon-associated natural immune
            response.
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Yang,Y., Xiong,S., Cai,B., Luo,H., Dong,E., Li,Q., Ji,G., Zhao,C.,
            Wen,Y., Wei,Y. and Yang,H.
  TITLE     Mitochondrial C11orf83 is a potent Antiviral Protein Independent of
            interferon production
  JOURNAL   Sci Rep 7, 44303 (2017)
   PUBMED   28418037
  REMARK    GeneRIF: Mitochondrial C11orf83 is a potent antiviral protein
            independent of interferon production; and knockdown of either OAS3
            or RNase L impaired the antiviral capability of C11orf83.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Desmurs,M., Foti,M., Raemy,E., Vaz,F.M., Martinou,J.C., Bairoch,A.
            and Lane,L.
  TITLE     C11orf83, a mitochondrial cardiolipin-binding protein involved in
            bc1 complex assembly and supercomplex stabilization
  JOURNAL   Mol Cell Biol 35 (7), 1139-1156 (2015)
   PUBMED   25605331
  REMARK    GeneRIF: C11orf83 depletion in HeLa cells caused abnormal crista
            morphology, higher sensitivity to apoptosis, a decreased ATP level
            due to impaired respiration and subtle, but significant, changes in
            cardiolipin composition.
REFERENCE   6  (bases 1 to 1927)
  AUTHORS   Wanschers,B.F., Szklarczyk,R., van den Brand,M.A., Jonckheere,A.,
            Suijskens,J., Smeets,R., Rodenburg,R.J., Stephan,K., Helland,I.B.,
            Elkamil,A., Rootwelt,T., Ott,M., van den Heuvel,L., Nijtmans,L.G.
            and Huynen,M.A.
  TITLE     A mutation in the human CBP4 ortholog UQCC3 impairs complex III
            assembly, activity and cytochrome b stability
  JOURNAL   Hum Mol Genet 23 (23), 6356-6365 (2014)
   PUBMED   25008109
  REMARK    GeneRIF: UQCC3 functions in complex III assembly and that the
            c.59T>A mutation has a causal role in complex III deficiency.
REFERENCE   7  (bases 1 to 1927)
  AUTHORS   Xiong,S.Q., Yang,H.S. and Long,Q.D.
  TITLE     [Bioinformatics analysis and function prediction of the novel gene
            AY358935]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 30 (2), 232-235 (2010)
   PUBMED   20159687
  REMARK    GeneRIF: AY358935 is a predicted secretary protein with a small
            molecular weight that might have important functions in cellular
            proliferation and anti-viral innate immune regulation.
REFERENCE   8  (bases 1 to 1927)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358935.1, CA422425.1,
            AP001458.6, BC090057.1, BF055120.1 and AI972746.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001085372.2.
            
            Summary: Complex III is a mitochondrial inner membrane protein
            complex that transfers electrons from ubiquinol to cytochrome c.
            This gene encodes a protein that functions in complex III assembly.
            Mutations in this gene result in Mitochondrial complex III
            deficiency, nuclear type 9. [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses a downstream start codon,
            which is more consistent with the presence of an N-terminal signal
            peptide, and with experimental evidence for cleavage of this signal
            peptide in PMID:15340161. It should be noted that an alternative
            upstream start codon, which would result in a protein that is 38 aa
            longer at the N-terminus, also exists. However, the use of the
            upstream start codon would eliminate the signal peptide, and it has
            a weak Kozak signal, so it is likely that leaky scanning by
            ribosomes will allow the use of the downstream start codon.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA538472.1, SRR1803613.7345.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377953.4/ ENSP00000367189.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AY358935.1         20-356
            338-618             CA422425.1         18-298              c
            619-928             AP001458.6         79645-79954
            929-1814            BC090057.1         915-1800
            1815-1904           BF055120.1         3-92                c
            1905-1927           AI972746.1         14-36               c
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1927
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="ubiquinol-cytochrome c reductase complex assembly
                     factor 3"
                     /db_xref="GeneID:790955"
                     /db_xref="HGNC:HGNC:34399"
                     /db_xref="MIM:616097"
     exon            1..193
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..355
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="UPF0723 protein C11orf83; assembly factor CBP4
                     homolog"
                     /codon_start=1
                     /product="ubiquinol-cytochrome-c reductase complex
                     assembly factor 3"
                     /protein_id="NP_001078841.1"
                     /db_xref="CCDS:CCDS41658.1"
                     /db_xref="GeneID:790955"
                     /db_xref="HGNC:HGNC:34399"
                     /db_xref="MIM:616097"
                     /translation="MDSLRKMLISVAMLGAGAGVGYALLVIVTPGERRKQEMLKEMPL
                     QDPRSREEAARTQQLLLATLQEAATTQENVAWRKNWMVGGEGGAGGRSP"
     exon            194..1927
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /inference="alignment:Splign:2.1.0"
     regulatory      595..600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="hexamer: AATAAA"
     polyA_site      621
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="major polyA site"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="hexamer: AATAAG"
     polyA_site      1814
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
     regulatory      1885..1890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="hexamer: ATTAAA"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
                     /note="hexamer: AATAAA"
     polyA_site      1904
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
     polyA_site      1927
                     /gene="UQCC3"
                     /gene_synonym="C11orf83; CCDS41658.1; MC3DN9; UNQ655"
ORIGIN      
        1 agtgagaccg cgcggcaaca gcttgcggct gcggggagct cccgtgggcg ctccgctggc
       61 tgtgcaggcg gccatggatt ccttgcggaa aatgctgatc tcagtcgcaa tgctgggcgc
      121 aggggctggc gtgggctacg cgctcctcgt tatcgtgacc ccgggagagc ggcggaagca
      181 ggaaatgcta aaggagatgc cactgcagga cccaaggagc agggaggagg cggccaggac
      241 ccagcagcta ttgctggcca ctctgcagga ggcagcgacc acgcaggaga acgtggcctg
      301 gaggaagaac tggatggttg gcggcgaagg cggcgccggc gggaggtcac cgtgagaccg
      361 gacttgcctc cgtgggcgcc ggaccttggc ttgggcgcag gaatccgagg cagcctttct
      421 ccttcgtggg cccagcggag agtccggacc gagataccat gccaggactc tccggggtcc
      481 tgtgagctgc cgtcgggtga gcacgtttcc cccaaaccct ggactgactg ctttaaggtc
      541 cgcaaggcgg gccagggccg agacgcgagt cggatgtggt gaactgaaag aaccaataaa
      601 atcatgttcc tccacccaga atgagccctg cagtcgacac ctaccaatgc ttagagacgc
      661 gtggtcggtg ctgggggcgc ggcctggagc tgctgcctgt cccaccccac cagaagaggc
      721 tgatcccgat aggtatctga ccacattttt tttttttttt tttttttgag acggagtcaa
      781 tgtcacccag gctggagtgc agtggcacga tctcggctca ctgcaacctc cgcccctggg
      841 ttccagcaat tctcctgcct cagcttcccg agtagccggg atcacaagtg cgcgccacca
      901 agcccagcta acttttgtgt ttttagttga gacagggttc accatgttgg ctagactggt
      961 ctcgaactcc agacccaggt gatccgcccg cctcggcctc ccaaagggct gggattacag
     1021 gcgtgaacca cctcgccctg ccgcggccac attttttctt ttttttgaga tggagtcttg
     1081 ctcttgtcac ccaggcagga gtgcagtggc gcaatcttgg ctcactgcaa cctctgcctc
     1141 ctgggttcaa gctgttctcc ttactcagcc tcccatgtag ctgggattac aggcgtccgc
     1201 aaccacgccc ggctgatatt agtagtttta gtagaggcgg gtttcaccat gtggccaggc
     1261 tgatctcgaa ctcctgacct caggcagttc acccgtctca gcctcccaaa gtgctgggat
     1321 tagaggcgtg agccactgcg cccggccaac cacattttca aaacaggtca tgtggtgtca
     1381 ggttggagtg tacttccagg gataaccgtg ggacattctt gaaatctgaa ctatcctggg
     1441 aagtcttgaa gtaatggatg cctatagtgg acactcagga ctcctgtcct tggagcgaga
     1501 ttggaggggc atctagcact taacatatgc cacaatgctt tctgtggcca ttatttaacc
     1561 tctggttaaa caagcttagg aggctgactt actagtagta aaaggagtgt gctttgagtc
     1621 acagatcctg gttgaactcc agcatgttac aaacctcagc cctgttctat gaaaggtcat
     1681 aactacgagg attattgtaa aacattaatt tagaaatgta aagtggtccc caatctctgg
     1741 atctggtcag gatttattgg agctgccact gaggggatta aataagtggg gtcaaagccc
     1801 cacagcctag tcaaccaagt tgctcctctt ttgtctatcc tgtggttccc aagcaagact
     1861 gcaattgaaa aaaaggctgc tgttattaaa gtcagaacac caaataaagc tttttttttt
     1921 tttttga
//
