LOCUS       NM_003364               1664 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens uridine phosphorylase 1 (UPP1), transcript variant 1,
            mRNA.
ACCESSION   NM_003364
VERSION     NM_003364.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Xiao,X., Qiu,T., Cheng,Q., Wang,W., Fan,C. and Zuo,F.
  TITLE     Uridine phosphorylase-1 promotes cell viability and cell-cycle
            progression in human epidermal keratinocytes via the glycolytic
            pathway
  JOURNAL   Clin Exp Pharmacol Physiol 51 (7), e13874 (2024)
   PUBMED   38797519
  REMARK    GeneRIF: Uridine phosphorylase-1 promotes cell viability and
            cell-cycle progression in human epidermal keratinocytes via the
            glycolytic pathway.
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Li,Y., Jiang,M., Aye,L., Luo,L., Zhang,Y., Xu,F., Wei,Y., Peng,D.,
            He,X., Gu,J., Yu,X., Li,G., Ge,D. and Lu,C.
  TITLE     UPP1 promotes lung adenocarcinoma progression through the induction
            of an immunosuppressive microenvironment
  JOURNAL   Nat Commun 15 (1), 1200 (2024)
   PUBMED   38331898
  REMARK    GeneRIF: UPP1 promotes lung adenocarcinoma progression through the
            induction of an immunosuppressive microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Huang,Y.T., Yeh,P.C., Lan,S.C. and Liu,P.F.
  TITLE     Metabolites modulate the functional state of human uridine
            phosphorylase I
  JOURNAL   Protein Sci 29 (11), 2189-2200 (2020)
   PUBMED   32864839
  REMARK    GeneRIF: Metabolites modulate the functional state of human uridine
            phosphorylase I.
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Wang,J., Xu,S., Lv,W., Shi,F., Mei,S., Shan,A., Xu,J. and Yang,Y.
  TITLE     Uridine phosphorylase 1 is a novel immune-related target and
            predicts worse survival in brain glioma
  JOURNAL   Cancer Med 9 (16), 5940-5947 (2020)
   PUBMED   32583596
  REMARK    GeneRIF: Uridine phosphorylase 1 is a novel immune-related target
            and predicts worse survival in brain glioma.
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Pizzorno,G., Cao,D., Leffert,J.J., Russell,R.L., Zhang,D. and
            Handschumacher,R.E.
  TITLE     Homeostatic control of uridine and the role of uridine
            phosphorylase: a biological and clinical update
  JOURNAL   Biochim Biophys Acta 1587 (2-3), 133-144 (2002)
   PUBMED   12084455
  REMARK    GeneRIF: Characterization of the promoter region of UPase has
            indicated a direct regulation of its expression by the tumor
            suppressor gene p53. Review.
            Review article
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Miyashita,H., Takebayashi,Y., Eliason,J.F., Fujimori,F., Nitta,Y.,
            Sato,A., Morikawa,H., Ohashi,A., Motegi,K., Fukumoto,M., Mori,S.
            and Uchida,T.
  TITLE     Uridine phosphorylase is a potential prognostic factor in patients
            with oral squamous cell carcinoma
  JOURNAL   Cancer 94 (11), 2959-2966 (2002)
   PUBMED   12115385
  REMARK    GeneRIF: Uridine phosphorylase overexpression is associated with
            lymph node metastasis in oral neoplasms
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Kanzaki,A., Takebayashi,Y., Bando,H., Eliason,J.F., Watanabe Si,S.,
            Miyashita,H., Fukumoto,M., Toi,M. and Uchida,T.
  TITLE     Expression of uridine and thymidine phosphorylase genes in human
            breast carcinoma
  JOURNAL   Int J Cancer 97 (5), 631-635 (2002)
   PUBMED   11807789
  REMARK    GeneRIF: The expression level of UPase gene may be an independent
            prognostic marker in human breast carcinoma
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Russell,R.L., Cao,D., Zhang,D., Handschumacher,R.E. and Pizzorno,G.
  TITLE     Uridine phosphorylase association with vimentin. Intracellular
            distribution and localization
  JOURNAL   J Biol Chem 276 (16), 13302-13307 (2001)
   PUBMED   11278417
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Watanabe,S. and Uchida,T.
  TITLE     Cloning and expression of human uridine phosphorylase
  JOURNAL   Biochem Biophys Res Commun 216 (1), 265-272 (1995)
   PUBMED   7488099
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Denney,R.M., Nichols,E.A. and Ruddle,F.H.
  TITLE     Assignment of a gene for uridine phosphorylase to chromosome 7
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 195-199 (1978)
   PUBMED   752472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297863.1, BC001405.1,
            X90858.1, BC007348.2 and AC122132.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003364.3.
            
            Summary: This gene encodes a uridine phosphorylase, an enzyme that
            catalyzes the reversible phosphorylation of uridine (or 2'-
            deoxyuridine) to uracil and ribose-1-phosphate (or
            deoxyribose-1-phosphate). The encoded enzyme functions in the
            degradation and salvage of pyrimidine ribonucleosides. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 8. Variants 1, 3 and 8 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X90858.1, SRR1163655.103679.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395564.9/ ENSP00000378931.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK297863.1         39-78
            41-308              BC001405.1         69-336
            309-1346            X90858.1           309-1346
            1347-1661           BC007348.2         1618-1932
            1662-1664           AC122132.5         19985-19987
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..1664
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /note="uridine phosphorylase 1"
                     /db_xref="GeneID:7378"
                     /db_xref="HGNC:HGNC:12576"
                     /db_xref="MIM:191730"
     exon            1..154
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            155..331
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            332..396
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1285
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /EC_number="2.4.2.3"
                     /note="isoform a is encoded by transcript variant 1; UPase
                     1; urdPase 1"
                     /codon_start=1
                     /product="uridine phosphorylase 1 isoform a"
                     /protein_id="NP_003355.1"
                     /db_xref="CCDS:CCDS5507.1"
                     /db_xref="GeneID:7378"
                     /db_xref="HGNC:HGNC:12576"
                     /db_xref="MIM:191730"
                     /translation="MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRH
                     NFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGP
                     VLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVD
                     TCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQG
                     RLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRL
                     EGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA"
     exon            397..514
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            515..673
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            674..788
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            789..998
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1145
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1664
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /note="hexamer: ATTAAA"
     polyA_site      1347
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /note="major polyA site"
     regulatory      1643..1648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
                     /note="hexamer: ATTAAA"
     polyA_site      1664
                     /gene="UPP1"
                     /gene_synonym="UDRPASE; UP; UPASE; UPP"
ORIGIN      
        1 attcgagtgc tccggcgcac agacccgcgc cccgccgtct gcgagcctcc cgagagccgt
       61 cccttcgtcc ggccctggag cattgcgttt gtcgccggtg tcgcagtgcg aggatggcgc
      121 cgcgggtgta gcggctctct gcgcaggccg agtgggccca gagaagcgag gaactccgca
      181 gctcgtcgac acgtctcgtc tcctgtccca attcagggct tggtgaggtg actcgcggtc
      241 gcgggtgact cgccggcagg acactgcctg gaacgcctgg agcgcctccc actgcagacg
      301 tctgtccgcc tccagccgct ctcctctgac gggtcctgcc tcagttggcg gaatggcggc
      361 cacgggagcc aatgcagaga aagctgaaag tcacaatgat tgccccgtca gacttttaaa
      421 tccaaacata gcaaaaatga aagaagatat tctctatcat ttcaatctca ccactagcag
      481 acacaatttc ccagccttgt ttggagatgt gaagtttgtg tgtgttggtg gaagcccctc
      541 ccggatgaaa gccttcatca ggtgcgttgg tgcagagctg ggccttgact gcccaggtag
      601 agactatccc aacatctgtg cgggaactga ccgctatgcc atgtataaag taggaccggt
      661 gctgtctgtc agtcatggta tgggcattcc ttctatctca atcatgttgc atgagctcat
      721 aaagctgctg tactatgccc ggtgctccaa cgtcactatc atccgcattg gcacttctgg
      781 tgggataggt ctggagcccg gcactgtggt cataacagag caggcagtgg atacctgctt
      841 caaggcagag tttgagcaga ttgtcctggg gaagcgggtc atccggaaaa cggaccttaa
      901 caagaagctg gtgcaggagc tgttgctgtg ttctgcagag ctgagcgagt tcaccacagt
      961 ggtggggaac accatgtgca ccttggactt ctatgaaggg caaggccgtc tggatggggc
     1021 tctctgctcc tacacggaga aggacaagca ggcgtatctg gaggcagcct atgcagccgg
     1081 cgtccgcaat atcgagatgg agtcctcggt gtttgccgcc atgtgcagcg cctgcggcct
     1141 ccaagcggcc gtggtgtgtg tcaccctcct gaaccgcctg gaaggggacc agatcagcag
     1201 ccctcgcaat gtgctcagcg agtaccagca gaggccgcag cggctggtga gctacttcat
     1261 caagaagaaa ctgagcaagg cctgagcgct gccctgcacc tccgcagacc tgctgtgatg
     1321 acttgccatt aaaagcattg tccaaaatcc cctgttgtgt ggactttgag cacactttac
     1381 acaagaatct agaaaatcag atcgcgatta agagacagag aatcttggat taaccgcatg
     1441 ggagatgttc ttccttttga agtttcattg gagcattttc aatgatgtta gcctgatttg
     1501 gggtttcttc aagaacattc taccaaattt ttgtactatt tctagggaaa tttttcagac
     1561 tttaaaattc taatggtagt cagatttcat gtcactaaac aagaaatctg acaatagtgc
     1621 caggaaacta atttcctgat acattaaaaa aattccatgc acca
//
