LOCUS       NM_006953               1084 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens uroplakin 3A (UPK3A), transcript variant 1, mRNA.
ACCESSION   NM_006953
VERSION     NM_006953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1084)
  AUTHORS   Xu,D., Guo,J. and Xu,H.
  TITLE     High Expression of UPK3A Promotes the Progression of Gastric Cancer
            Cells by Inactivating p53 Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2022, 6897561 (2022)
   PUBMED   35774082
  REMARK    GeneRIF: High Expression of UPK3A Promotes the Progression of
            Gastric Cancer Cells by Inactivating p53 Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1084)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1084)
  AUTHORS   Szymanska,B., Matuszewski,M., Dembowski,J., Zdrojowy,R. and
            Dlugosz,A.
  TITLE     Uroplakin IIIa Is a Marker in Bladder Cancer but Seems Not to
            Reflect Chemical Carcinogenesis
  JOURNAL   Biomed Res Int 2018, 8315410 (2018)
   PUBMED   30069482
  REMARK    GeneRIF: UPIIIa is a biomarker for bladder cancer that is unrelated
            to chemical carcinogenesis
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1084)
  AUTHORS   Tsumura,H., Matsumoto,K., Ikeda,M., Yanagita,K., Hirano,S.,
            Hagiwara,M., Nagashio,R., Fujita,T., Sato,Y. and Iwamura,M.
  TITLE     High expression level of preoperative serum Uroplakin III is
            associated with biologically aggressive bladder cancer
  JOURNAL   Asian Pac J Cancer Prev 16 (4), 1539-1543 (2015)
   PUBMED   25743828
  REMARK    GeneRIF: High expression level of preoperative serum Uroplakin III
            is associated with biologically aggressive bladder cancer.
REFERENCE   5  (bases 1 to 1084)
  AUTHORS   Zeng,Y., Wu,X.X., Homma,Y., Yoshimura,N., Iwaki,H., Kageyama,S.,
            Yoshiki,T. and Kakehi,Y.
  TITLE     Uroplakin III-delta4 messenger RNA as a promising marker to
            identify nonulcerative interstitial cystitis
  JOURNAL   J Urol 178 (4 Pt 1), 1322-7 (2007)
   PUBMED   17698128
  REMARK    GeneRIF: uroplakin III and III-delta4 genes were significantly
            up-regulated only in patients with nonulcerative interstitial
            cystitis
REFERENCE   6  (bases 1 to 1084)
  AUTHORS   Schonfelder,E.M., Knuppel,T., Tasic,V., Miljkovic,P., Konrad,M.,
            Wuhl,E., Antignac,C., Bakkaloglu,A., Schaefer,F. and Weber,S.
  CONSRTM   ESCAPE Trial Group
  TITLE     Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia
            in humans
  JOURNAL   Am J Kidney Dis 47 (6), 1004-1012 (2006)
   PUBMED   16731295
  REMARK    GeneRIF: Our results indicate that de novo mutations in UPIIIA can
            be involved in defective early kidney development, but probably
            constitute only a rare cause of human renal hypodysplasia in a
            minor subset of individuals [UPIIIA].
REFERENCE   7  (bases 1 to 1084)
  AUTHORS   Olsburgh,J., Harnden,P., Weeks,R., Smith,B., Joyce,A., Hall,G.,
            Poulsom,R., Selby,P. and Southgate,J.
  TITLE     Uroplakin gene expression in normal human tissues and locally
            advanced bladder cancer
  JOURNAL   J Pathol 199 (1), 41-49 (2003)
   PUBMED   12474225
REFERENCE   8  (bases 1 to 1084)
  AUTHORS   Ogawa,K., Johansson,S.L. and Cohen,S.M.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   9  (bases 1 to 1084)
  AUTHORS   Lobban,E.D., Smith,B.A., Hall,G.D., Harnden,P., Roberts,P.,
            Selby,P.J., Trejdosiewicz,L.K. and Southgate,J.
  TITLE     Uroplakin gene expression by normal and neoplastic human urothelium
  JOURNAL   Am J Pathol 153 (6), 1957-1967 (1998)
   PUBMED   9846985
REFERENCE   10 (bases 1 to 1084)
  AUTHORS   Yuasa,T., Yoshiki,T., Tanaka,T., Kim,C.J., Isono,T. and Okada,Y.
  TITLE     Expression of uroplakin Ib and uroplakin III genes in tissues and
            peripheral blood of patients with transitional cell carcinoma
  JOURNAL   Jpn J Cancer Res 89 (9), 879-882 (1998)
   PUBMED   9818021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008718.23, BC069544.1,
            AB010637.1 and BM681088.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006953.3.
            
            Summary: This gene encodes a member of the uroplakin family, a
            group of transmembrane proteins that form complexes on the apical
            surface of the bladder epithelium. Mutations in this gene may be
            associated with renal adysplasia. Alternatively spliced transcript
            variants have been described.[provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085808.1, CR456608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216211.9/ ENSP00000216211.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL008718.23        106607-106644
            39-613              BC069544.1         6-580
            614-614             AB010637.1         549-549
            615-922             BC069544.1         582-889
            923-1084            BM681088.1         18-179              c
FEATURES             Location/Qualifiers
     source          1..1084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..1084
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /note="uroplakin 3A"
                     /db_xref="GeneID:7380"
                     /db_xref="HGNC:HGNC:12580"
                     /db_xref="MIM:611559"
     exon            1..117
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            118..273
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..553
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            554..636
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..769
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1084
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1061..1066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /note="hexamer: AATAAA"
     polyA_site      1084
                     /gene="UPK3A"
                     /gene_synonym="UP3A; UPIII; UPIIIA; UPK3"
                     /note="major polyA site"
ORIGIN      
        1 aggtctggtg cccgcgcctg ctcgctggac cgcccgcccc gcgctctggc ggctcctccc
       61 gggcgatgcc tccgctctgg gccctgctgg ccctcggctg cctgcggttc ggctcggctg
      121 tgaacctgca gccccaactg gccagtgtga ctttcgccac caacaacccc acacttacca
      181 ctgtggcctt ggaaaagcct ctctgcatgt ttgacagcaa agaggccctc actggcaccc
      241 acgaggtcta cctgtatgtc ctggtcgact cagccatttc caggaatgcc tcagtgcaag
      301 acagcaccaa caccccactg ggctcaacgt tcctacaaac agagggtggg aggacaggtc
      361 cctacaaagc tgtggccttt gacctgatcc cctgcagtga cctgcccagc ctggatgcca
      421 ttggggatgt gtccaaggcc tcacagatcc tgaatgccta cctggtcagg gtgggtgcca
      481 acgggacctg cctgtgggat cccaacttcc agggcctctg taacgcaccc ctgtcggcag
      541 ccacggagta caggttcaag tatgtcctgg tcaatatgtc cacgggcttg gtagaggacc
      601 agaccctgtg gtcagacccc atccgcacca accagctcac cccatactcg acgatcgaca
      661 cgtggccagg ccggcggagc ggaggcatga tcgtcatcac ttccatcctg ggctccctgc
      721 ccttctttct acttgtgggt tttgctggcg ccattgccct cagcctcgtg gacatgggga
      781 gttctgatgg ggaaacgact cacgactccc aaatcactca ggaggctgtt cccaagtcgc
      841 tgggggcctc ggagtcttcc tacacgtccg tgaaccgggg gccgccactg gacagggctg
      901 aggtgtattc cagcaagctc caagactgag cccagcacca cccctgggca gcagcatcct
      961 cctctctggc cttgccccag gccctgcagc ggtggttgtc acaccctgac ttcagggaag
     1021 gtgaaacagg gcttgtccct ccaactgcag gaaaaccctt aataaaatct tctgatgagt
     1081 tcta
//
