LOCUS       NM_006760                934 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens uroplakin 2 (UPK2), mRNA.
ACCESSION   NM_006760
VERSION     NM_006760.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   van Pel,D.M., Pors,J., Yuen,E., Chan,R., Kos,Z., Hayes,M.M. and
            Wang,G.
  TITLE     Distinct Uroplakin II Staining Pattern in Apocrine Breast Carcinoma
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (10), 681-686 (2022)
   PUBMED   36227121
  REMARK    GeneRIF: Distinct Uroplakin II Staining Pattern in Apocrine Breast
            Carcinoma.
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Pryma,C., Villamil,C., Gibb,E.A., Oo,H.Z., Seiler,R.,
            Contreras-Sanz,A., Douglas,J., Black,P.C. and Wang,G.
  TITLE     Uroplakin II as a single marker for luminal versus basal molecular
            subtypes in muscle invasive urothelial carcinoma
  JOURNAL   Virchows Arch 481 (3), 397-403 (2022)
   PUBMED   35612672
  REMARK    GeneRIF: Uroplakin II as a single marker for luminal versus basal
            molecular subtypes in muscle invasive urothelial carcinoma.
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Leivo,M.Z., Tacha,D.E. and Hansel,D.E.
  TITLE     Expression of uroplakin II and GATA-3 in bladder cancer mimickers:
            caveats in the use of a limited panel to determine cell of origin
            in bladder lesions
  JOURNAL   Hum Pathol 113, 28-33 (2021)
   PUBMED   33887302
  REMARK    GeneRIF: Expression of uroplakin II and GATA-3 in bladder cancer
            mimickers: caveats in the use of a limited panel to determine cell
            of origin in bladder lesions.
REFERENCE   4  (bases 1 to 934)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Mochizuki,K., Kawai,M., Odate,T., Tahara,I., Inoue,T., Kasai,K.,
            Nakazawa,T., Katoh,R. and Kondo,T.
  TITLE     Diagnostic Utility of Prostein, Uroplakin II and SATB2 for
            Diagnosing Carcinoma of Unknown Primary Origin: A Systematic
            Immunohistochemical Profiling
  JOURNAL   Anticancer Res 38 (8), 4759-4766 (2018)
   PUBMED   30061246
  REMARK    GeneRIF: Uroplakin II was immunopositive in 53% and 60% of
            urothelial carcinomas (UC) of the bladder and the ureter,
            respectively.
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Yuasa,T., Yoshiki,T., Isono,T., Tanaka,T., Hayashida,H. and
            Okada,Y.
  TITLE     Expression of transitional cell-specific genes, uroplakin Ia and
            II, in bladder cancer: detection of circulating cancer cells in the
            peripheral blood of metastatic patients
  JOURNAL   Int J Urol 6 (6), 286-292 (1999)
   PUBMED   10404304
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Lobban,E.D., Smith,B.A., Hall,G.D., Harnden,P., Roberts,P.,
            Selby,P.J., Trejdosiewicz,L.K. and Southgate,J.
  TITLE     Uroplakin gene expression by normal and neoplastic human urothelium
  JOURNAL   Am J Pathol 153 (6), 1957-1967 (1998)
   PUBMED   9846985
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Wu,R.L., Osman,I., Wu,X.R., Lu,M.L., Zhang,Z.F., Liang,F.X.,
            Hamza,R., Scher,H., Cordon-Cardo,C. and Sun,T.T.
  TITLE     Uroplakin II gene is expressed in transitional cell carcinoma but
            not in bilharzial bladder squamous cell carcinoma: alternative
            pathways of bladder epithelial differentiation and tumor formation
  JOURNAL   Cancer Res 58 (6), 1291-1297 (1998)
   PUBMED   9515818
  REMARK    Erratum:[Cancer Res 1998 Jul 1;58(13):2904]
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Lin,J.H., Wu,X.R., Kreibich,G. and Sun,T.T.
  TITLE     Precursor sequence, processing, and urothelium-specific expression
            of a major 15-kDa protein subunit of asymmetric unit membrane
  JOURNAL   J Biol Chem 269 (3), 1775-1784 (1994)
   PUBMED   7507484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD556028.1 and Y13645.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006760.3.
            
            Summary: This gene encodes one of the proteins of the highly
            conserved urothelium-specific integral membrane proteins of the
            asymmetric unit membrane which forms urothelium apical plaques in
            mammals. The asymmetric unit membrane is believed to strengthen the
            urothelium by preventing cell rupture during bladder distention.
            The encoded protein is expressed in the peripheral blood of bladder
            cancer patients with transitional cell carcinomas.[provided by
            RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13645.1, ERR279850.3032.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264031.3/ ENSP00000264031.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CD556028.1         16-33
            19-934              Y13645.1           4-919
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..934
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /note="uroplakin 2"
                     /db_xref="GeneID:7379"
                     /db_xref="HGNC:HGNC:12579"
                     /db_xref="MIM:611558"
     exon            1..129
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..608
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /note="uroplakin II"
                     /codon_start=1
                     /product="uroplakin-2 precursor"
                     /protein_id="NP_006751.1"
                     /db_xref="CCDS:CCDS8404.1"
                     /db_xref="GeneID:7379"
                     /db_xref="HGNC:HGNC:12579"
                     /db_xref="MIM:611558"
                     /translation="MAPLLPIRTLPLILILLALLSPGAADFNISSLSGLLSPALTESL
                     LVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTRLS
                     AYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVIT
                     VLLSVAMFLLVLGFIIALALGSRK"
     exon            130..261
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            262..400
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            401..471
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            472..934
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      909..914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /note="hexamer: AATAAA"
     polyA_site      934
                     /gene="UPK2"
                     /gene_synonym="UP2; UPII"
                     /note="major polyA site"
ORIGIN      
        1 acttgcctca ggaaccccag cctgccagca cctattccac ctcccagccc agcatggcac
       61 ccctgctgcc catccggacc ttgcccttga tcctgattct gctggctctg ctgtccccag
      121 gggctgcaga cttcaacatc tcaagcctct ctggtctgct gtccccggcg ctaacggaga
      181 gcctgctggt tgccttgccc ccctgtcacc tcacaggagg caatgccaca ctgatggtcc
      241 ggagagccaa tgacagcaaa gtggtgacgt ccagctttgt ggtgcctccg tgccgtgggc
      301 gcagggaact ggtgagtgtg gtggacagtg gtgctggctt cacagtcact cggctcagtg
      361 cataccaggt gacaaacctc gtgccaggaa ccaaattcta catttcctac ctagtgaaga
      421 aggggacagc cactgagtcc agcagagaga tcccaatgtc cacactccct cgaaggaaca
      481 tggaatccat tgggctgggt atggcccgca cagggggcat ggtggtcatc acggtgctgc
      541 tctctgtcgc catgttcctg ctggtgctgg gcttcatcat tgccctggca ctgggctccc
      601 gcaagtaagg aggtctgccc ggagcagcag cttctccagg aagcccaggg caccatccag
      661 ctccccagcc cacctgctcc caggccccag gcctgtggct cccttggtgc cctcgcctcc
      721 tcctcctgcc ctcctctccc ctagagccct ctcctccctc tgtccctctc cttgccccca
      781 gtgcctcacc ttccaacact ccattattcc tctcacccca ctcctgtcag agttgacttt
      841 cctcccattt taccacttta aacaccccca taacaattcc cccatccttc agtgaactaa
      901 gtccctataa taaaggctga ggctgcatct gcca
//
