LOCUS       NM_006952               2028 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens uroplakin 1B (UPK1B), mRNA.
ACCESSION   NM_006952
VERSION     NM_006952.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Goda,H., Nakashiro,K.I., Sano,Y., Adachi,T., Tokuzen,N.,
            Kuribayashi,N., Hino,S. and Uchida,D.
  TITLE     KRT13 and UPK1B for differential diagnosis between metastatic lung
            carcinoma from oral squamous cell carcinoma and lung squamous cell
            carcinoma
  JOURNAL   Sci Rep 13 (1), 22626 (2023)
   PUBMED   38114532
  REMARK    GeneRIF: KRT13 and UPK1B for differential diagnosis between
            metastatic lung carcinoma from oral squamous cell carcinoma and
            lung squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Zhang,Z.Y., Zhang,J.L., Zhao,L.X., Yang,Y., Guo,R., Zhou,N.,
            Liu,Y.R. and Zheng,G.P.
  TITLE     NAA10 promotes proliferation of renal cell carcinoma by
            upregulating UPK1B
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11553-11560 (2020)
   PUBMED   33275221
  REMARK    GeneRIF: NAA10 promotes proliferation of renal cell carcinoma by
            upregulating UPK1B.
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Wang,F.H., Ma,X.J., Xu,D. and Luo,J.
  TITLE     UPK1B promotes the invasion and metastasis of bladder cancer via
            regulating the Wnt/beta-catenin pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (17), 5471-5480 (2018)
   PUBMED   30229818
  REMARK    GeneRIF: UPK1B is up-regulated in bladder cancer and is
            significantly correlated with tumor stage, lymph node metastasis
            and poor prognosis.
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Bulut,I.K., Mir,S., Berdeli,A. and Sozeri,B.
  TITLE     The predictive value of urinary UPIb mRNA levels in VUR and
            recurrent urinary tract infections
  JOURNAL   Clin Nephrol 81 (3), 152-158 (2014)
   PUBMED   24559587
  REMARK    GeneRIF: Urine UPIb levels may be useful for predicting the risk of
            recurrent urinary tract infections in patients diagnosed with their
            first UTI and may also be considered as a noninvasive screening
            test for vesicoureteral reflux.
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Finch,J.L., Miller,J., Aspinall,J.O. and Cowled,P.A.
  TITLE     Cloning of the human uroplakin 1B cDNA and analysis of its
            expression in urothelial-tumor cell lines and bladder-carcinoma
            tissue
  JOURNAL   Int J Cancer 80 (4), 533-538 (1999)
   PUBMED   9935153
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Lobban,E.D., Smith,B.A., Hall,G.D., Harnden,P., Roberts,P.,
            Selby,P.J., Trejdosiewicz,L.K. and Southgate,J.
  TITLE     Uroplakin gene expression by normal and neoplastic human urothelium
  JOURNAL   Am J Pathol 153 (6), 1957-1967 (1998)
   PUBMED   9846985
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Yuasa,T., Yoshiki,T., Tanaka,T., Kim,C.J., Isono,T. and Okada,Y.
  TITLE     Expression of uroplakin Ib and uroplakin III genes in tissues and
            peripheral blood of patients with transitional cell carcinoma
  JOURNAL   Jpn J Cancer Res 89 (9), 879-882 (1998)
   PUBMED   9818021
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Finch,J.L., Webb,G.C., Evdokiou,A. and Cowled,P.A.
  TITLE     Chromosomal localization of the human urothelial 'tetraspan' gene,
            UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism
  JOURNAL   Genomics 40 (3), 501-503 (1997)
   PUBMED   9073521
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Wu,X.R., Medina,J.J. and Sun,T.T.
  TITLE     Selective interactions of UPIa and UPIb, two members of the
            transmembrane 4 superfamily, with distinct single
            transmembrane-domained proteins in differentiated urothelial cells
  JOURNAL   J Biol Chem 270 (50), 29752-29759 (1995)
   PUBMED   8530366
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL709739.1 and AB002155.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006952.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is found in the asymmetrical unit membrane
            (AUM) where it can form a complex with other transmembrane 4
            superfamily proteins. It may play a role in normal bladder
            epithelial physiology, possibly in regulating membrane permeability
            of superficial umbrella cells or in stabilizing the apical membrane
            through AUM/cytoskeletal interactions. The use of alternate
            polyadenylation sites has been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002155.1, SRR1803612.7527.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264234.8/ ENSP00000264234.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL709739.1         22-43
            23-2028             AB002155.1         1-2006
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.32"
     gene            1..2028
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="uroplakin 1B"
                     /db_xref="GeneID:7348"
                     /db_xref="HGNC:HGNC:12578"
                     /db_xref="MIM:602380"
     exon            1..41
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..138
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..852
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="tetraspan; UP1b; tspan-20; uroplakin Ib;
                     tetraspanin-20"
                     /codon_start=1
                     /product="uroplakin-1b"
                     /protein_id="NP_008883.2"
                     /db_xref="CCDS:CCDS2985.1"
                     /db_xref="GeneID:7348"
                     /db_xref="HGNC:HGNC:12578"
                     /db_xref="MIM:602380"
                     /translation="MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLY
                     PLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFE
                     VASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCC
                     GVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGC
                     YELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY"
     exon            139..339
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..414
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..537
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..717
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..801
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..2028
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="hexamer: AATAAA"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="hexamer: AATACA"
     polyA_site      1159
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="major polyA site"
     polyA_site      1177
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
                     /note="hexamer: AGTAAA"
     polyA_site      2028
                     /gene="UPK1B"
                     /gene_synonym="TSPAN20; UPIB; UPK1"
ORIGIN      
        1 gcggagcggg ccctaccgtg tgcgcagaaa gaggaggcgc ttgccttcag cttgtgggaa
       61 atcccgaaga tggccaaaga caactcaact gttcgttgct tccagggcct gctgattttt
      121 ggaaatgtga ttattggttg ttgcggcatt gccctgactg cggagtgcat cttctttgta
      181 tctgaccaac acagcctcta cccactgctt gaagccaccg acaacgatga catctatggg
      241 gctgcctgga tcggcatatt tgtgggcatc tgcctcttct gcctgtctgt tctaggcatt
      301 gtaggcatca tgaagtccag caggaaaatt cttctggcgt atttcattct gatgtttata
      361 gtatatgcct ttgaagtggc atcttgtatc acagcagcaa cacaacaaga ctttttcaca
      421 cccaacctct tcctgaagca gatgctagag aggtaccaaa acaacagccc tccaaacaat
      481 gatgaccagt ggaaaaacaa tggagtcacc aaaacctggg acaggctcat gctccaggac
      541 aattgctgtg gcgtaaatgg tccatcagac tggcaaaaat acacatctgc cttccggact
      601 gagaataatg atgctgacta tccctggcct cgtcaatgct gtgttatgaa caatcttaaa
      661 gaacctctca acctggaggc ttgtaaacta ggcgtgcctg gtttttatca caatcagggc
      721 tgctatgaac tgatctctgg tccaatgaac cgacacgcct ggggggttgc ctggtttgga
      781 tttgccattc tctgctggac tttttgggtt ctcctgggta ccatgttcta ctggagcaga
      841 attgaatatt aagcataaag tgttgccacc atacctcctt ccccgagtga ctctggattt
      901 ggtgctggaa ccagctctct cctaatattc cacgtttgtg ccccacacta acgtgtgtgt
      961 cttacattgc caagtcagat ggtacggact tcctttagga tctcaggctt ctgcagttct
     1021 catgactcct acttttcatc ctagtctagc attctgcaac atttatatag actgttgaaa
     1081 ggagaatttg aaaaatgcat aataactact tccatccctg cttattttta atttgggaaa
     1141 ataaatacat tcgaaggaac ctgtgttatc acagtaaccc agagctgtat ttggctagca
     1201 atctgcctgt atctctcact attatctaaa agaaaccttc caatgcttct gttgatctca
     1261 gtattgtcag gggaacagag aagttgggaa aagattactg aaatatacct tttgcatttc
     1321 tttctagagt agctcccata tatggagatg ggtgattctc ttgatgccac cttcagatcc
     1381 ttttattctc cagaataatt cttaacagtg gttcaaattt cctttcatac cttgaagtat
     1441 gtgtttagta gcctcaattc tccattaatt aaaagtgtgg gctgggcgtg ggggctcatg
     1501 cctgtaatcc cagcactttg ggaggccgag gtgggcagat cacctgaggt caggagttca
     1561 agaccagcct ggccaacatg gtgaaacccc gtctctacaa aaatacaaaa attagccagg
     1621 cgtgatggca ggtgcctgta atcctagcta cttggcaggc taacgcagga gaatcacttg
     1681 accgggagac agaggttgca gtgagctgag atcgtaccta ttgcactcca tcctggatga
     1741 aagagccaga ctctgtctca aaacaaacaa aaaagcgtgg ggacttctgg ggacagacaa
     1801 ggtgcctgtt atatatttac tcagtctttg ccctgaatgg tctcagcttg agaccatttc
     1861 aaactggaga gaagcaagcc agccaataga atggggtgat ttacagggat ttctgtttac
     1921 tgtcaaaata tttctcatct gcactatgtt tccatttgtg gtcctgaagg aaattcttat
     1981 aactcaacat ttgtctggtc ttataagtaa agacagcttt aaaatctg
//
