LOCUS       NM_007000               1265 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens uroplakin 1A (UPK1A), transcript variant 1, mRNA.
ACCESSION   NM_007000 NM_032896
VERSION     NM_007000.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1265)
  AUTHORS   Munipalli,S.B. and Yenugu,S.
  TITLE     Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta
            1
  JOURNAL   Reprod Sci 30 (12), 3520-3528 (2023)
   PUBMED   37468792
  REMARK    GeneRIF: Uroplakin 1a Interacts with Regucalcin and Proteasome
            Subunit Beta 1.
REFERENCE   2  (bases 1 to 1265)
  AUTHORS   Reiswich,V., Konemann,S., Lennartz,M., Hoflmayer,D., Menz,A.,
            Chirico,V., Hube-Magg,C., Fraune,C., Bernreuther,C., Simon,R.,
            Clauditz,T.S., Sauter,G., Hinsch,A., Kind,S., Jacobsen,F.,
            Steurer,S., Minner,S., Buscheck,F., Burandt,E., Marx,A.H., Lebok,P.
            and Krech,T.
  TITLE     Large-scale human tissue analysis identifies Uroplakin 1a as a
            putative diagnostic marker for urothelial cancer
  JOURNAL   Pathol Res Pract 237, 154028 (2022)
   PUBMED   35872365
  REMARK    GeneRIF: Large-scale human tissue analysis identifies Uroplakin 1a
            as a putative diagnostic marker for urothelial cancer.
REFERENCE   3  (bases 1 to 1265)
  AUTHORS   Byun,Y., Choi,Y.C., Jeong,Y., Yoon,J. and Baek,K.
  TITLE     Long Noncoding RNA Expression Profiling Reveals Upregulation of
            Uroplakin 1A and Uroplakin 1A Antisense RNA 1 under Hypoxic
            Conditions in Lung Cancer Cells
  JOURNAL   Mol Cells 43 (12), 975-988 (2020)
   PUBMED   33273139
  REMARK    GeneRIF: Long Noncoding RNA Expression Profiling Reveals
            Upregulation of Uroplakin 1A and Uroplakin 1A Antisense RNA 1 under
            Hypoxic Conditions in Lung Cancer Cells.
REFERENCE   4  (bases 1 to 1265)
  AUTHORS   Hashimoto,J., Takahashi,M., Saito,A., Murata,M., Kurimura,Y.,
            Nishitani,C., Takamiya,R., Uehara,Y., Hasegawa,Y., Hiyama,Y.,
            Sawada,N., Takahashi,S., Masumori,N., Kuroki,Y. and Ariki,S.
  TITLE     Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic
            Escherichia coli To Protect the Bladder from Infection
  JOURNAL   J Immunol 198 (7), 2898-2905 (2017)
   PUBMED   28228557
REFERENCE   5  (bases 1 to 1265)
  AUTHORS   Zhu,H., Tang,Y., Zhang,X., Jiang,X., Wang,Y., Gan,Y. and Yang,J.
  TITLE     Downregulation of UPK1A suppresses proliferation and enhances
            apoptosis of bladder transitional cell carcinoma cells
  JOURNAL   Med Oncol 32 (3), 84 (2015)
   PUBMED   25701463
  REMARK    GeneRIF: Down-regulation of UPK1A suppresses proliferation and
            enhances apoptosis of bladder transitional cell carcinoma cells.
REFERENCE   6  (bases 1 to 1265)
  AUTHORS   Hall,G.D., Weeks,R.J., Olsburgh,J., Southgate,J., Knowles,M.A.,
            Selby,P.J. and Chester,J.D.
  TITLE     Transcriptional control of the human urothelial-specific gene,
            uroplakin Ia
  JOURNAL   Biochim Biophys Acta 1729 (2), 126-134 (2005)
   PUBMED   15913809
  REMARK    GeneRIF: determined the genomic structure of the uroplakin Ia gene
            and defined the position of a transcriptional start site
REFERENCE   7  (bases 1 to 1265)
  AUTHORS   Ogawa,K., Johansson,S.L. and Cohen,S.M.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   8  (bases 1 to 1265)
  AUTHORS   Yuasa,T., Yoshiki,T., Isono,T., Tanaka,T., Hayashida,H. and
            Okada,Y.
  TITLE     Expression of transitional cell-specific genes, uroplakin Ia and
            II, in bladder cancer: detection of circulating cancer cells in the
            peripheral blood of metastatic patients
  JOURNAL   Int J Urol 6 (6), 286-292 (1999)
   PUBMED   10404304
REFERENCE   9  (bases 1 to 1265)
  AUTHORS   Lobban,E.D., Smith,B.A., Hall,G.D., Harnden,P., Roberts,P.,
            Selby,P.J., Trejdosiewicz,L.K. and Southgate,J.
  TITLE     Uroplakin gene expression by normal and neoplastic human urothelium
  JOURNAL   Am J Pathol 153 (6), 1957-1967 (1998)
   PUBMED   9846985
REFERENCE   10 (bases 1 to 1265)
  AUTHORS   Wu,X.R., Medina,J.J. and Sun,T.T.
  TITLE     Selective interactions of UPIa and UPIb, two members of the
            transmembrane 4 superfamily, with distinct single
            transmembrane-domained proteins in differentiated urothelial cells
  JOURNAL   J Biol Chem 270 (50), 29752-29759 (1995)
   PUBMED   8530366
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002115.1.
            
            On Jan 5, 2021 this sequence version replaced NM_007000.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is found in the asymmetrical unit membrane
            (AUM) where it can complex with other transmembrane 4 superfamily
            proteins. It may play a role in normal bladder epithelial
            physiology, possibly in regulating membrane permeability of
            superficial umbrella cells or in stabilizing the apical membrane
            through AUM/cytoskeletal interactions. The protein may also play a
            role in tumor suppression. Alternative splicing results in multiple
            transcript variants of this gene. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.804531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000222275.3/
                                                ENSP00000222275.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC002115.1         88566-88587
            23-110              AC002115.1         88858-88945
            111-311             AC002115.1         90503-90703
            312-386             AC002115.1         95281-95355
            387-494             AC002115.1         95487-95594
            495-674             AC002115.1         97889-98068
            675-758             AC002115.1         99861-99944
            759-1265            AC002115.1         100024-100530
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1265
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="uroplakin 1A"
                     /db_xref="GeneID:11045"
                     /db_xref="HGNC:HGNC:12577"
                     /db_xref="MIM:611557"
     exon            1..22
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            23..110
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..803
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uroplakin-1a; tspan-21; uroplakin Ia; tetraspanin-21"
                     /codon_start=1
                     /product="uroplakin-1a isoform 1"
                     /protein_id="NP_008931.1"
                     /db_xref="CCDS:CCDS12470.1"
                     /db_xref="GeneID:11045"
                     /db_xref="HGNC:HGNC:12577"
                     /db_xref="MIM:611557"
                     /translation="MASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTAD
                     QYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLI
                     VYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECC
                     GTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGC
                     FEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTML"
     exon            111..311
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            312..386
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            387..494
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            495..674
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            675..758
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1265
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1245..1250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="hexamer: AATAAA"
     regulatory      1249..1254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="hexamer: AATAAA"
     polyA_site      1261
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="major polyA site"
     polyA_site      1265
                     /gene="UPK1A"
                     /gene_synonym="TSPAN21; UP1A; UPIA; UPKA"
                     /note="major polyA site"
ORIGIN      
        1 agagaggctg cagacagaga aggatgatgg cgtctgcggc agcagcggag gccgagaagg
       61 gatctccagt tgtggtgggc ctgctagttg tgggcaatat cattattctg ctgtcaggcc
      121 tgtccctgtt tgctgagacc atatgggtga cagccgacca gtaccgtgta tacccactga
      181 tgggagtctc aggcaaggat gacgtcttcg ctggtgcctg gattgccatc ttctgcggct
      241 tctccttctt catggtagcc agttttggtg tgggtgccgc actctgccgc cgccggtcca
      301 tggtcctcac gtacctggtg ctcatgctca tcgtctacat cttcgagtgc gcctcctgca
      361 tcacgtccta cacccaccgt gactacatgg tgtccaaccc atccctgatc accaagcaga
      421 tgctgacctt ctacagcgcg gacaccgacc agggccagga gctgacccgc ctctgggacc
      481 gcgtcatgat tgagcaagaa tgctgtggca catctggtcc catggactgg gtgaacttca
      541 cgtcagcctt ccgggcggcc actccggagg tggtgttccc ctggccccca ctgtgctgtc
      601 gccggacggg aaacttcatc cccctcaacg aggagggctg ccgcctgggg cacatggact
      661 acctgttcac caagggctgc ttcgaacaca tcggccacgc catcgacagc tacacgtggg
      721 gtatctcgtg gtttgggttt gccatcctga tgtggacgct cccggtcatg ctgatagcca
      781 tgtatttcta caccatgctc tgagggacag gaggggaagg caacatacac accccggact
      841 cctccgcatc ctcctcctgc ttcctccgct gggcctggat ggctgcctca cctctcacct
      901 cccaacgtcc ctagccctta cgtccttcca cttccaagat ctttttccag gttcctgagc
      961 cctactgtgt ctcaggtgtg ccctgaaacc ccagggcttg tgtgcacata tccttagccc
     1021 atctttcaag ggacctctcc atgatcccac ctcccattca cagatacctc tcttgtagct
     1081 ctctgacctc ctccttcatg gcaggcatcg ccattcttgc tgaaccgttt gtgattgcca
     1141 tttgagctct ggaagcctct attgccatga gagttctgtc acggtcactt tactgtcccc
     1201 atcatcaccc agcacggggc taagcatata ctagatagtc aataaataaa taaataatga
     1261 atgaa
//
