LOCUS       NM_001372107            5250 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens unk like zinc finger (UNKL), transcript variant 11,
            mRNA.
ACCESSION   NM_001372107 XM_005255505
VERSION     NM_001372107.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5250)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5250)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5250)
  AUTHORS   Lores,P., Visvikis,O., Luna,R., Lemichez,E. and Gacon,G.
  TITLE     The SWI/SNF protein BAF60b is ubiquitinated through a signalling
            process involving Rac GTPase and the RING finger protein Unkempt
  JOURNAL   FEBS J 277 (6), 1453-1464 (2010)
   PUBMED   20148946
REFERENCE   4  (bases 1 to 5250)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   5  (bases 1 to 5250)
  AUTHORS   Mohler,J., Weiss,N., Murli,S., Mohammadi,S., Vani,K., Vasilakis,G.,
            Song,C.H., Epstein,A., Kuang,T., English,J. et al.
  TITLE     The embryonically active gene, unkempt, of Drosophila encodes a
            Cys3His finger protein
  JOURNAL   Genetics 131 (2), 377-388 (1992)
   PUBMED   1339381
  REMARK    GeneRIF: Characterizes the related Drosophila gene and protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL032819.32, AL031721.1 and
            AL031709.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2019 this sequence version replaced XM_005255505.1.
            
            Summary: This gene encodes a RING finger protein that may function
            in Rac signaling. It can bind to Brg/Brm-associated factor 60b and
            can promote its ubiquitination. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Jun
            2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2469936.1,
                                           SRR18074967.181912.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389221.9/ ENSP00000373873.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL032819.32        8755-8844           c
            91-300              AL032819.32        7986-8195           c
            301-477             AL031721.1         33863-34039         c
            478-611             AL031721.1         32263-32396         c
            612-747             AL031721.1         30069-30204         c
            748-865             AL031721.1         27873-27990         c
            866-950             AL031721.1         24826-24910         c
            951-1036            AL031721.1         23586-23671         c
            1037-1099           AL031721.1         21327-21389         c
            1100-1277           AL031721.1         15903-16080         c
            1278-1370           AL031721.1         2214-2306           c
            1371-1598           AL031721.1         825-1052            c
            1599-1801           AL031709.12        35727-35929         c
            1802-2059           AL031709.12        35163-35420         c
            2060-5250           AL031709.12        31276-34466         c
FEATURES             Location/Qualifiers
     source          1..5250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5250
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /note="unk like zinc finger"
                     /db_xref="GeneID:64718"
                     /db_xref="HGNC:HGNC:14184"
                     /db_xref="MIM:617463"
     exon            1..90
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2215
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /note="isoform 7 is encoded by transcript variant 11; RING
                     finger protein unkempt-like; putative E3 ubiquitin-protein
                     ligase UNKL; zinc finger CCCH domain-containing protein
                     5-like; unkempt homolog-like; unkempt family zinc
                     finger-like"
                     /codon_start=1
                     /product="putative E3 ubiquitin-protein ligase UNKL
                     isoform 7"
                     /protein_id="NP_001359036.1"
                     /db_xref="CCDS:CCDS92080.1"
                     /db_xref="GeneID:64718"
                     /db_xref="HGNC:HGNC:14184"
                     /db_xref="MIM:617463"
                     /translation="MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKC
                     AQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHR
                     TTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQ
                     EALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPR
                     LCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSR
                     TEQQFHPEIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSST
                     GSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGS
                     GSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLG
                     AAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQP
                     PPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPN
                     GAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQ
                     KKEEVEAQVKQLQEELEGLGVASTLPGLRGCGDIGTIPLPKLHSLQSQLRLDLEAVDG
                     VIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW"
     exon            91..300
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            301..477
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            478..611
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            612..747
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            748..865
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            866..950
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1036
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1099
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1277
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1370
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1598
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1801
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2059
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..5250
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5232..5237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /note="hexamer: ATTAAA"
     polyA_site      5250
                     /gene="UNKL"
                     /gene_synonym="C16orf28; ZC3H5L; ZC3HDC5L"
                     /note="major polyA site"
ORIGIN      
        1 gttttgactg aaaatgccgt cggtttcgaa agcggcggca gcggcgctga gcgggtcccc
       61 cccgcagact gagaagccga cccactacag gtacctgaag gagttcagga cggagcagtg
      121 ccccctgttt tcacagcaca agtgcgcgca gcaccggccg ttcacctgct tccactggca
      181 cttcctcaac cagcggcgcc gcaggcccct ccgcaggcgc gacggcacct tcaactacag
      241 ccccgacgtg tactgctcca agtacaacga agccaccggc gtgtgccccg acggcgacga
      301 gtgtccctac ctgcaccgga cgacggggga cacagaacgc aagtaccacc tgcgttacta
      361 caaaacagga acctgcatcc acgagacaga cgcacgtggc cactgcgtga agaatgggct
      421 gcactgtgcc ttcgcgcacg gccccctgga cctgcggccg cccgtgtgtg acgtcaggga
      481 gctgcaggcc caggaagcct tgcagaacgg ccagctgggc ggcggggaag gggtcccgga
      541 tctgcagcct ggggtcttgg ccagccaggc catgattgag aagatcctga gcgaggaccc
      601 ccggtggcaa gatgccaact tcgtgctggg cagctacaag acggagcagt gcccgaagcc
      661 gccacgcctg tgccgccagg gctatgcgtg cccacactac cacaatagcc gggacaggcg
      721 gcgcaacccc cggcggttcc agtacaggtc cacgccctgc cccagtgtga agcacgggga
      781 tgagtggggg gaaccctcac gctgcgatgg cggcgacggc tgccagtatt gccactcccg
      841 cacggagcag cagttccatc ccgagatcta caaatctaca aaatgcaacg acatgcgcca
      901 aaccgggtac tgcccgcgcg gccccttctg tgcctttgca cacgttgaga agagcctggg
      961 gatggtgaat gaatggggct gtcacgacct ccacctcacg agtccttcct ccacgggcag
     1021 cggccagccg ggaaatgcca agcggagaga ctcgccggcc gagggtggcc ctaggggcag
     1081 cgagcaagac agcaagcaga accacctggc cgtgtttgca gcggtccacc cgccggcccc
     1141 cagcgtgagc tccagcgtgg cgtccagcct ggcgtccagc gccggctccg gcagctcctc
     1201 ccccactgcg ctgcccgcgc cccccgcccg tgccctcccg ctcggccccg ccagcagcac
     1261 tgtggaggcc gtcctcggtt ctgcgttaga cctgcatctt agcaatgtga atattgcatc
     1321 cctagagaag gacctggaag agcaagacgg ccacgacctg ggagcagcag gtcccaggtc
     1381 gctggccggc tctgcacctg tcgccatccc cggctccctg cccagagcac catcgctaca
     1441 ctcgccatcc tctgcgtcca cctcgccgct cggttcgctg tcccagcccc tcccagggcc
     1501 ggtgggctcc tcagccatga cgcctcccca gcagccgcca cccctgcgtt cagagccggg
     1561 cacactgggc tctgcagcct catcctacag ccccctaggt ttgaacggtg tccccgggag
     1621 catctgggac tttgtttccg gcagcttctc ccccagcccc tcccccatcc tgagtgccgg
     1681 ccccccatcc tcttcgagtg caagtccaaa cggagctgag ctggcccggg tcaggcggca
     1741 gctggacgag gccaagagga agatccggca gtgggaggag tcctggcagc aggtgaagca
     1801 ggtctgcgat gcctggcagc gagaggcgca ggaggccaag gagcgtgccc gtgtggccga
     1861 tagcgaccgg cagctggcgc tgcagaagaa ggaggaggtg gaggcacagg tgaagcagct
     1921 gcaggaggag ctggagggcc tgggcgtagc ctccacactg ccggggctgc ggggctgtgg
     1981 ggacatcggc accattcccc tgccgaagct gcactcgctg cagagtcagc tgcgcctgga
     2041 cctggaggcg gtggacggcg tgatcttcca gctccgcgcc aagcagtgtg tggcctgccg
     2101 ggagcgggcc cacggtgctg tcctgcggcc ctgtcagcac cacatcctct gtgagccgtg
     2161 tgcggccacc gcacctgagt gcccctactg caagggccag cccctgcagt ggtgacctca
     2221 gcggggacag ccacctcctg ctgggcaccc tggctccagc gctcctcctg accacggaca
     2281 tgtcgtcact cgcttctggt gccaccgacg tgaggaccga ggctgggagc ccttcctgtt
     2341 acacgttatc atgaggctgg gagccccgcc tgcgcttggc ctgacagcct ttcctgtcac
     2401 acgttgtcac ctatctagtc ctaccgacgg tttcaaggta ttttcctcaa aaaccttaaa
     2461 tgcaaaccca cagaacccgc ctgcctgtcc ctgaggggcc tggtgcctcc gggatccacg
     2521 cggcgctgtg atcacagcag tttgtggtcc tgacactact gtgactaggc cactgggagc
     2581 tggggtcttt caaagcactt tgtaaaccga ggaatttagt tagaggttat aaattgctct
     2641 aagctgcttt ctgttttttt ttaatatgcg ataatatgaa gctttatatg tgtactgtga
     2701 acttaaatat ttcatatcag tttattgtca attcatagta tgctaaatat attagatttc
     2761 atattctgaa actagtactt atgaaatgag tgtttatcta gtagtaagac ctaggatttt
     2821 tacattttcc aattaagtgc aaatagtatt tataagcaga gtgattatgg attgagatgt
     2881 ttttaacttg atggaaggag ctagttttcc tgagcctgtg tgtgcaccag gcactggggc
     2941 tgatgttcca gcctcgtggc gtgggagcag gagagctccg tcctgcattt ctgtggtccg
     3001 tggccgctgt ttctgtgcgc ctgcgcctcg gagagcaagt gaaggagcat catgggtttt
     3061 gttttctccc ttaaccctct gaaagacagt ttgatactaa caaaaaacgc agcagagggg
     3121 atccgacgtc agagctttta gaattacttt tttaagcagc tgtcttctgg ctgggtgcgg
     3181 tggctcatgc ctgtgatccc agcactttgg gaggcgggtg gatcacctaa ggtcaggagt
     3241 tcaagaccag cctggccaac atggtgcaac cccgtcttag taaaaataca aaaattggcc
     3301 tggcgtgaga gcgggcacct gtagtcccag ctactcggga ggctgaggca ggagaatcgc
     3361 ttgaacctgg gaggcagagg ttgcagtgag ccgagatcgc gccaccgcac tccagcccgg
     3421 gtgacagagc gagactctgg ctcaaaaaaa aaaaaaaaaa gctgttttct gattactcag
     3481 agctgtccta ggcaatggtg ctttgtagct ccttggagat gtcgctgggc gtcctggcag
     3541 gggtcaggca gtgaactggg agagtggttg cctccccagc acccgtgacc accctggtcc
     3601 tgctcgtgtg ggagatgctc gggccgtgtg tgcgccaggg tccggggtgc cgggtgtatg
     3661 tggcagtcac ctgacccgcg ctgccagtta tcatcggagc tcatccatgt ggccagtgag
     3721 gtcacaggag aggacccggc cacagcctct cagtggcctg gagcacacgg gggaagcgac
     3781 cccccccagg tcccggctct gctgtggtcc cctgtcccgt ctgcccctgg agcgacagtg
     3841 tggtttcggc cgcagcagaa acgtgactga gaacgcatcc ccgcgatgac ctgacccttc
     3901 tgctcagggc tgggactgtc cctaggagtt gagcaggaac aggcatctgt ggtttacggc
     3961 gacctggctc tccgcgggcc acgtgggtgg tgagggcaca cgagtgggaa gcggcaccga
     4021 cgtgtttctc cccgaccgtg gctttgccaa agacttttaa tagcattttt taagtgcaaa
     4081 acgtctaggt aaaaatcttt atcatcagtg accaaattag aatgtattta atatagtagg
     4141 tggtttaaga actgttttaa cgtaagacaa actgatagca acattctgtt gttttaaagg
     4201 aagtgggtcc gtgacattct gcagctagtc cactactcca aggtaactat cgacttggtt
     4261 tcagtgaatc tattttgttt ttaactacag tgatttatta gctcagtatc tagaaattac
     4321 gtatattttg tgctactgtc atcgatgtgt aaactctgtt tttatttgta tttatgcact
     4381 tggttcccat ttggagcctc tggtcttttc tgggataagt ggtgtctgcc gagacatctc
     4441 ccggttgtca gtggtcagga gcagctgagc tctagtctgc cagctgctct gctctttctg
     4501 ggaaggaggt ggcgcccgcc cctcagggtg tctccagggc tcagcttccg gggtggtaga
     4561 gctggggagc cccaggggtg gggggacagc tgggagatgg aggtggcacc tgctccccta
     4621 gatcagtact ggctctgagg acaggtgagc agtgggaaga ccaaagaatg gctggcagcg
     4681 ctgccagggt tggaaatggg ggcaagatcc tggggctgtg tgccctgggg cctccctcac
     4741 ctgtcttggt ggccatggcc tcagggatgg ctcctaggtg gctgaggcac agcagtggct
     4801 ggaaggtgcc ccgtggaggc tgaggtggag gcgcgcccag cagctccccc ctgtggccat
     4861 ggcgggcacg gggcgtagga gctggctggc ggccggctct gcatgttctt gttgcctgtc
     4921 gtctgtaact ctagtgttcg acattcgccg tgatacagtg gtgtcacgac gtgtgtaact
     4981 gtggtcagca gaccttgttc cgcgtggacg cctcaagtgg attaatttct ggaagcctca
     5041 atctgtatgt ttgagtattt acatgagaat gttatttgaa tggaattttc ttaacccaga
     5101 aggtagtatt tataatcatt tacttgtagc gaactgttta aagttaacac ttgtttaaat
     5161 ttttttacac tatagcattt atgcaatggt ttacagaatt catggagtta tttttatcag
     5221 tatgggaatt aattaaaacc ttgaatcttt
//
