LOCUS       NM_001080419            3890 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens unk zinc finger (UNK), transcript variant 1, mRNA.
ACCESSION   NM_001080419 XM_036115
VERSION     NM_001080419.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3890)
  AUTHORS   Murn,J., Teplova,M., Zarnack,K., Shi,Y. and Patel,D.J.
  TITLE     Recognition of distinct RNA motifs by the clustered CCCH zinc
            fingers of neuronal protein Unkempt
  JOURNAL   Nat Struct Mol Biol 23 (1), 16-23 (2016)
   PUBMED   26641712
REFERENCE   2  (bases 1 to 3890)
  AUTHORS   Murn,J., Zarnack,K., Yang,Y.J., Durak,O., Murphy,E.A., Cheloufi,S.,
            Gonzalez,D.M., Teplova,M., Curk,T., Zuber,J., Patel,D.J., Ule,J.,
            Luscombe,N.M., Tsai,L.H., Walsh,C.A. and Shi,Y.
  TITLE     Control of a neuronal morphology program by an RNA-binding zinc
            finger protein, Unkempt
  JOURNAL   Genes Dev 29 (5), 501-512 (2015)
   PUBMED   25737280
REFERENCE   3  (bases 1 to 3890)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3890)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3890)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087289.9, AK307289.1 and BC053362.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080419.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053362.1, AB051540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589666.6/ ENSP00000464893.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC087289.9         168549-168581       c
            34-50               AK307289.1         1-17
            51-1094             BC053362.1         1-1044
            1095-1095           AC087289.9         136559-136559       c
            1096-1748           BC053362.1         1046-1698
            1749-1749           AC087289.9         133442-133442       c
            1750-3890           BC053362.1         1700-3840
FEATURES             Location/Qualifiers
     source          1..3890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3890
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /note="unk zinc finger"
                     /db_xref="GeneID:85451"
                     /db_xref="HGNC:HGNC:29369"
                     /db_xref="MIM:616375"
     exon            1..179
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2508
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /note="zinc finger CCCH-type containing 5; unkempt
                     homolog; zinc finger CCCH-type domain containing 5; zinc
                     finger CCCH domain-containing protein 5; unkempt family
                     zinc finger; unk family zinc finger"
                     /codon_start=1
                     /product="RING finger protein unkempt homolog"
                     /protein_id="NP_001073888.2"
                     /db_xref="CCDS:CCDS45778.2"
                     /db_xref="GeneID:85451"
                     /db_xref="HGNC:HGNC:29369"
                     /db_xref="MIM:616375"
                     /translation="MSKGPGPGGSAASSAPPAATAQVLQAQPEKPQHYTYLKEFRTEQ
                     CPLFVQHKCTQHRPYTCFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLCPE
                     GDECPFLHRTTGDTERRYHLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPV
                     YDIRELQAMEALQNGQTTVEGSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKT
                     EPCKKPPRLCRQGYACPYYHNSKDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGD
                     ACQYCHTRTEQQFHPEIYKSTKCNDMQQSGSCPRGPFCAFAHVEQPPLSDDLQPSSAV
                     SSPTQPGPVLYMPSAAGDSVPVSPSSPHAPDLSALLCRNSSLGSPSNLCGSPPGSIRK
                     PPNLEGIVFPGESGLAPGSYKKAPGFEREDQVGAEYLKNFKCQAKLKPHSLEPRSQEQ
                     PLLQPKQDMLGILPAGSPLTSSISSSITSSLAATPPSPVGTSSVPGMNANALPFYPTS
                     DTVESVIESALDDLDLNEFGVAALEKTFDNSTVPHPGSITIGGSLLQSSAPVNIPGSL
                     GSSASFHSASPSPPVSLSSHFLQQPQGHLSQSENTFLGTSASHGSLGLNGMNSSIWEH
                     FASGSFSPGTSPAFLSGPGAAELARLRQELDEANSTIKQWEESWKQAKQACDAWKKEA
                     EEAGERASAAGAECELAREQRDALEVQVKKLQEELERLHAGPEPQALPAFSDLEALSL
                     STLYSLQKQLRAHLEQVDKAVFHMQSVKCLKCQEQKRAVLPCQHAALCELCAEGSECP
                     ICQPGRAHTLQS"
     exon            180..389
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            390..566
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..697
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            698..833
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            834..951
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1036
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1179
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1380
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1446
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1621
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1723
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1912
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2094
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2352
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..3890
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3872..3877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /note="hexamer: AATAAA"
     polyA_site      3890
                     /gene="UNK"
                     /gene_synonym="UNKEMPT; ZC3H5; ZC3HDC5"
                     /note="major polyA site"
ORIGIN      
        1 gcactgggtc ctcggcgcgg accgcgcaga ctgaataata aaaggggagc ggcgaagagg
       61 caggaagaca agaccatgtc gaagggcccc gggcccggcg gctccgcagc ttcctcggcg
      121 cccccggccg ctaccgctca ggtgctgcag gcacagcccg agaaaccgca gcactacacg
      181 tacctgaaag aattccgcac agagcagtgc ccactctttg tgcaacacaa atgcacgcag
      241 catcggccct acacctgctt ccactggcac ttcgtgaacc agcggcgccg ccggtccatc
      301 cgccgtcggg acggcacctt caattacagc cctgacgtct actgcaccaa gtacgacgag
      361 gctacaggcc tctgcccgga gggcgacgag tgcccattcc tgcacagaac cacaggggac
      421 actgagcgca ggtaccacct tcgttactac aaaactggaa tctgcatcca cgagacagac
      481 tcgaaaggca actgcaccaa aaacggcctg cactgcgctt ttgcccacgg gccccatgac
      541 ctccgctccc ctgtctacga catcagggag cttcaggcca tggaggcctt gcagaatggc
      601 cagaccacgg tagaggggag catagagggc cagtcggctg gggctgcgag ccatgccatg
      661 atagaaaaga tcctcagcga ggagcctcgg tggcaagaga ctgcttatgt gctggggaac
      721 tataagacgg agccttgcaa gaagcccccg cggctgtgcc gccaaggcta tgcctgtccc
      781 tactaccaca acagcaagga ccggcggcgg agcccccgga agcacaaata caggtcgtct
      841 ccatgtccaa acgtcaagca cggggatgag tggggagacc ctggcaagtg tgagaacgga
      901 gacgcctgcc agtactgcca cacccgcacc gagcagcagt tccaccccga gatctacaag
      961 tccaccaagt gcaacgacat gcagcagtcg ggcagctgtc cccgaggacc cttctgcgcc
     1021 tttgcccacg tagaacagcc acccctgagt gacgacctgc agccttcctc agctgtgtcc
     1081 agccccaccc agccaggtcc tgtcctgtac atgccatctg ccgccggaga ctcggtgcct
     1141 gtgagcccct ccagcccgca tgcccctgac ctcagtgccc tcctctgtag aaacagcagc
     1201 ctaggcagcc cgtctaacct ctgcggctcc ccaccgggct ccatcaggaa gcccccaaac
     1261 ctggagggca tcgtcttccc tggggagtct ggcctggccc ctggcagcta taagaaggct
     1321 cccggcttcg agagggaaga ccaggtggga gccgagtacc tgaaaaattt caaatgccag
     1381 gccaaattaa aaccccactc attagagccc aggagtcaag agcagcctct gcttcagccc
     1441 aaacaggaca tgctgggcat cctccccgca ggcagccccc tgacctcaag catctcttct
     1501 agtatcacct ccagcctggc agctaccccc cctagcccag tgggcaccag cagcgtcccc
     1561 ggcatgaatg caaacgctct gcccttctac cccaccagcg acacggtaga gtcagtcata
     1621 gagtctgctt tggatgacct ggacctgaat gagtttggcg tggccgccct ggagaagact
     1681 ttcgataaca gcacagtgcc ccacccagga agcatcacca tcggcggcag cttgctgcag
     1741 agctctgcac ccgtgaacat ccccggctcc ttgggcagct ctgcctcctt ccactcagca
     1801 tccccgtccc ctcccgtcag cctctcctcg catttcctgc agcagcccca gggccacctg
     1861 agtcagtcgg aaaacacatt tttgggaacc tcagcatcac atggatcttt gggtctgaac
     1921 gggatgaaca gcagcatctg ggagcatttt gcctctggaa gcttctcccc gggcacttcc
     1981 cccgctttcc tatcagggcc aggggctgcc gagctggccc gacttcggca agagctggat
     2041 gaagccaaca gcaccatcaa gcagtgggag gagtcctgga agcaggccaa gcaggcttgt
     2101 gatgcctgga agaaagaggc ggaggaggct ggtgagcggg ccagtgcggc gggcgccgag
     2161 tgcgagctgg cccgggagca gcgggatgca ctggaggtgc aggtgaagaa gctccaggag
     2221 gagctggagc ggctacacgc ggggcctgag ccccaggccc tgcccgcctt ctccgacctg
     2281 gaggcgctct cactctccac cctctactcc ctccagaaac aactgcgggc ccacctggaa
     2341 caagtggaca aggccgtgtt ccacatgcag tcggtgaaat gccttaagtg tcaggaacag
     2401 aagcgggcag tgctgccgtg ccaacacgct gcgctgtgtg agctctgcgc tgagggcagc
     2461 gagtgcccca tctgccagcc tggccgggcc cacaccctcc agtcgtgacc ctgcaggcct
     2521 ggcccagcct ggcccagatc ttctcaccta ggacttttta aagtatatat atatatatga
     2581 atatatatat atatgtgtat gtatgtatgt atatgtatat gattatgtat atgtatacat
     2641 ttccgtatgt atgtatatgt atacatttcc gtatgtgtgc aggtatgcgt ggtggtgtgg
     2701 acagtgtctg tgtgtatatc tgtacataga tatagacaca cactttaaaa gacttaccaa
     2761 gcacttttta aaagaagaaa ctattttgca gtcctcccct acccactccc tgcccttccc
     2821 actgcagaga tgacatcccc tcttctccca ctggcctttt ggcagagaat ctggttctgt
     2881 ctctttttta atgtaggaac taactatttt taacttcttc ctggggcctg agcagggaag
     2941 ggtgggactg gaaggcacta aggggaaggg agaagccctc agggcaggcc ctgctccccc
     3001 tacctccttg ccagggcaag ggtggagtgt ggaagacgtg ggtcccccag agcaggcctg
     3061 gcccccagct gtgagggcct cagggaggcc cgagggggag tgctgggggt ctcagctggc
     3121 ttagctccta agtttaccaa atgttaattt agtcttgggg agaacagcaa gggctggagg
     3181 ccagtgctgc agggccagcc ccactcctga cacctgggcc cttgaagctc cttgaggggc
     3241 aaggcccagg agttccagcc ctcaggttcc tgagggtcca ccctcagtcc ttccccccgc
     3301 cgcccctccc cggactcccc acaagagcct ccctggcccc agggccgcct accaggctgg
     3361 tactcattct atgaccaccg cccccaacca gctgccccca gctctccctg ccccctcccc
     3421 tctctggcag ctagcagggc aattggcggg gaggagtgcg gactgaggac tgaggaccaa
     3481 gggggcccag gccctgccct cctacccgga ggggctccgt ttgcattcct tggtgctctc
     3541 tgagtgcagc tggtgtcccg ccctgttctg ggcggacgcc tgtgtgcgtg tgtgtgtgcc
     3601 tgtccagtgt atattgtgtc ttagcttcca ttttaaaaat tgttctgtac agagagagat
     3661 gcagcagggg cgggagggca gagtgggcgg aggggagcag ccgcaccccc agcaccgggt
     3721 gtctgcggta ggaacaagag ggctgagagg gtctggtcct ggcccaggct cccccttggg
     3781 ctcagcacga aagggctttc aatgaattaa gtgaaaactt tttccttttt tacaaaaatg
     3841 caaaaatcaa caaagctcca aacctattgg aaataaaata tgaacttgca
//
