LOCUS       NM_001080461            2091 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens UNC homeobox (UNCX), mRNA.
ACCESSION   NM_001080461 NM_001085389 XM_294209 XM_941336
VERSION     NM_001080461.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Daniele,G., Simonetti,G., Fusilli,C., Iacobucci,I., Lonoce,A.,
            Palazzo,A., Lomiento,M., Mammoli,F., Marsano,R.M., Marasco,E.,
            Mantovani,V., Quentmeier,H., Drexler,H.G., Ding,J., Palumbo,O.,
            Carella,M., Nadarajah,N., Perricone,M., Ottaviani,E., Baldazzi,C.,
            Testoni,N., Papayannidis,C., Ferrari,S., Mazza,T., Martinelli,G.
            and Storlazzi,C.T.
  TITLE     Epigenetically induced ectopic expression of UNCX impairs the
            proliferation and differentiation of myeloid cells
  JOURNAL   Haematologica 102 (7), 1204-1214 (2017)
   PUBMED   28411256
  REMARK    GeneRIF: our findings suggest a novel leukemogenic role of UNCX,
            associated with epigenetic modifications and with impaired cell
            proliferation and differentiation in AML.
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Garin-Muga,A., Odriozola,L., Martinez-Val,A., Del Toro,N.,
            Martinez,R., Molina,M., Cantero,L., Rivera,R., Garrido,N.,
            Dominguez,F., Sanchez Del Pino,M.M., Vizcaino,J.A., Corrales,F.J.
            and Segura,V.
  TITLE     Detection of Missing Proteins Using the PRIDE Database as a Source
            of Mass Spectrometry Evidence
  JOURNAL   J Proteome Res 15 (11), 4101-4115 (2016)
   PUBMED   27581094
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Irvin,M.R., Shrestha,S., Chen,Y.D., Wiener,H.W., Haritunians,T.,
            Vaughan,L.K., Tiwari,H.K., Taylor,K.D., Scherzer,R., Saag,M.S.,
            Grunfeld,C., Rotter,J.I. and Arnett,D.K.
  TITLE     Genes linked to energy metabolism and immunoregulatory mechanisms
            are associated with subcutaneous adipose tissue distribution in
            HIV-infected men
  JOURNAL   Pharmacogenet Genomics 21 (12), 798-807 (2011)
   PUBMED   21897333
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073094.11.
            
            On Nov 23, 2018 this sequence version replaced NM_001080461.2.
            
            Summary: This gene encodes a homeobox transcription factor that is
            involved in somitogenesis and neurogenesis and is required for the
            maintenance and differentiation of specific elements of the axial
            skeleton. This gene also plays a role in controlling the
            development of connections of hypothalamic neurons to pituitary
            elements, allowing central neurons to reach the peripheral blood
            circulation and deliver hormones that control peripheral functions.
            The expression of this gene is associated with an increased
            frequency of acute myeloid leukemia. [provided by RefSeq, Jul
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KM587717.1, HY145527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316333.9/ ENSP00000314480.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC073094.11        73414-73833
            421-596             AC073094.11        74062-74237
            597-2091            AC073094.11        76374-77868
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2091
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="UNC homeobox"
                     /db_xref="GeneID:340260"
                     /db_xref="HGNC:HGNC:33194"
     exon            1..420
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1742
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="Unc4.1 homeobox; homeobox protein Uncx4.1; UNC
                     homeobox protein"
                     /codon_start=1
                     /product="homeobox protein unc-4 homolog"
                     /protein_id="NP_001073930.1"
                     /db_xref="CCDS:CCDS34583.1"
                     /db_xref="GeneID:340260"
                     /db_xref="HGNC:HGNC:33194"
                     /translation="MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSA
                     AAAASVPFSIDGLLGGSCAAAASVVNPTPLLPAACGVGGDGQPFKLSDSGDPDKESPG
                     CKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKW
                     RKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQGRH
                     LHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPAAKGPGAHASGAAGTAPAPPGEPP
                     APGTCDPAFYPSQRSGAGPQPRPGRPADKDAASCGPGAAVAAVERGAAGLPKASPFSV
                     ESLLSDSPPRRKAASNAAAAAAAGLDFAPGLPCAPRTLIGKGHFLLYPITQPLGFLVP
                     QAALKGGAGLEPAPKDAPPAPAVPPAPPAQASFGAFSGPGGAPDSAFARRSPDAVASP
                     GAPAPAPAPFRDLASAAATEGGGGDCADAGTAGPAPPPPAPSPRPGPRPPSPAEEPAT
                     CGVPEPGAAAGPSPPEGEELDMD"
     exon            421..596
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..2091
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="hexamer: AATAAA"
     polyA_site      2091
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="major polyA site"
ORIGIN      
        1 aaagcgccgg agtgcgggcg aagcatgtgt ggggctccgg gtccctgtct ccgccgccgc
       61 cgcccgcgcc tcccgccgct ggcccgcccc ggccccggcc cgcgcccccg cgccccgcca
      121 ccggccccgc cggccccccg cgcgagatga tggacggccg cctcctggaa cacccgcatg
      181 cccagttcgg gggctcgctg ggcggcgtgg tgggcttccc ctacccgctg ggccaccacc
      241 acgtgtacga gctggccggg caccagctgc agtcggccgc cgccgccgcc tcggtgccct
      301 tctccatcga cggcctgctc gggggctcgt gcgccgccgc cgcctcggtg gtcaacccca
      361 cgccgctgct gccagccgcc tgcggggtcg gcggggacgg ccagcccttc aagctgtcag
      421 actcggggga cccggacaag gagagcccgg gctgcaagcg gcggcgcacc cgcaccaact
      481 tcaccggctg gcagctggag gagctggaga aggcgttcaa cgagagccac tatcccgacg
      541 tgttcatgcg cgaggcgctg gcgctgcgcc tagacctggt cgagtcccga gttcaggtct
      601 ggttccaaaa ccgccgggcc aagtggagga agaaggagaa cacgaaaaag ggcccggggc
      661 ggccggcgca caactcgcac ccgaccacgt gcagcggcga gcccatggac ccggaggaga
      721 tcgcgcgcaa ggagctggag aagatggaga agaagaagcg caagcacgag aagaagctgc
      781 tgaagagcca gggccgccac ttgcactcgc ccggcggcct gtccctgcac agcgcgccca
      841 gctccgacag cgacagcggc ggcggcggcc tgtctccgga gccgcccgag ccgccgccgc
      901 ccgccgccaa gggccccgga gcgcacgcct cgggcgccgc ggggaccgcg cccgcccctc
      961 ccggcgagcc gcctgcaccc ggcacctgcg accccgcctt ctacccgagc caaagaagcg
     1021 gcgccggccc acagccgcgc ccaggtcgcc ctgcggacaa ggacgcggcc tcgtgcgggc
     1081 caggggccgc tgtggcggcg gtggagcgcg gcgccgcggg gctgcccaag gccagcccat
     1141 tcagcgtgga gagcctcctg tccgactcgc cgccgcgccg gaaagccgct tccaacgccg
     1201 ccgccgccgc cgccgcgggg ctggacttcg cgcccgggct gccgtgcgcg ccgcggaccc
     1261 tgatcggcaa gggccacttc ctcctctacc ccatcacgca gccgctcggc ttcctggtgc
     1321 cgcaggccgc gctcaagggc ggcgcgggcc tggagccggc gcccaaggac gcgccgcccg
     1381 cgcccgccgt gccgcccgcg ccgcctgccc aggccagttt cggggccttc tcggggcccg
     1441 gcggcgcccc ggactcggcc ttcgcgcgtc gcagccccga cgccgtcgcc tccccggggg
     1501 ccccagcccc ggccccggcg cctttccggg acctcgcctc ggcagcggct accgagggcg
     1561 gcggcgggga ctgcgcggac gcggggaccg ccggccccgc gcccccgccg cccgcgccgt
     1621 cgcccaggcc cggccctcgg cctcccagcc ccgccgagga gccggccacc tgcggggttc
     1681 ccgagcctgg cgcggcggcc ggacccagcc cgccggaggg cgaggagctg gacatggact
     1741 gaggccgcgg cggccgggag aggcgcgtag ccggcccgcg gccgctcgct caggctccga
     1801 ctcacgcaac gaatcaggtg atcggctcta gaaacactgc tttcccttct tttcttttgt
     1861 tttctttctt ttattatttt ttttaagagt aaacgaaagt gctgtatgaa ttcggaccca
     1921 ggcagcaacc acaggactgg gggtgagacc ctcctcctcc caagagagca aaaaggaccc
     1981 atggccccca aaaaacccca caacgagaat cctcagcctt gtaaaatgca aaaatgtcta
     2041 agaatattta tatatgtacc atttttgata aataaagctg gtcaaacgca a
//
