LOCUS       NM_018974               2111 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens unc-93 homolog A (UNC93A), transcript variant 1, mRNA.
ACCESSION   NM_018974
VERSION     NM_018974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Liu,Y., Dodds,P., Emilion,G., Mungall,A.J., Dunham,I., Beck,S.,
            Wells,R.S., Charnock,F.M. and Ganesan,T.S.
  TITLE     The human homologue of unc-93 maps to chromosome 6q27 -
            characterisation and analysis in sporadic epithelial ovarian cancer
  JOURNAL   BMC Genet 3, 20 (2002)
   PUBMED   12381271
  REMARK    GeneRIF: Results suggest that no evidence for UNC93A as a tumour
            suppressor gene in sporadic ovarian cancer has been identified and
            further research is required to evaluate its normal function and
            role in the pathogenesis of ovarian cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091987.1 and AJ422141.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018974.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091987.1, AJ508812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230256.8/ ENSP00000230256.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1692              AK091987.1         1-1692
            1693-2111           AJ422141.1         1621-2039
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..2111
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /note="unc-93 homolog A"
                     /db_xref="GeneID:54346"
                     /db_xref="HGNC:HGNC:12570"
                     /db_xref="MIM:607995"
     exon            1..262
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1549
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /note="isoform 1 is encoded by transcript variant 1; unc93
                     homolog A; protein unc-93 homolog A; dJ366N23.1 (putative
                     C. elegans UNC-93 (protein 1, C46F11.1) LIKE); dJ366N23.2
                     (putative C. elegans UNC-93 (protein 1, C46F11.1)
                     C-terminal LIKE)"
                     /codon_start=1
                     /product="protein unc-93 homolog A isoform 1"
                     /protein_id="NP_061847.2"
                     /db_xref="CCDS:CCDS5300.1"
                     /db_xref="GeneID:54346"
                     /db_xref="HGNC:HGNC:12570"
                     /db_xref="MIM:607995"
                     /translation="MDRSLRNVLVVSFGFLLLFTAYGGLQSLQSSLYSEEGLGVTALS
                     TLYGGMLLSSMFLPPLLIERLGCKGTIILSMCGYVAFSVGNFFASWYTLIPTSILLGL
                     GAAPLWSAQCTYLTITGNTHAEKAGKRGKDMVNQYFGIFFLIFQSSGVWGNLISSLVF
                     GQTPSQETLPEEQLTSCGASDCLMATTTTNSTQRPSQQLVYTLLGIYTGSGVLAVLMI
                     AAFLQPIRDVQRESEGEKKSVPFWSTLLSTFKLYRDKRLCLLILLPLYSGLQQGFLSS
                     EYTRSYVTCTLGIQFVGYVMICFSATDALCSVLYGKVSQYTGRAVLYVLGAVTHVSCM
                     IALLLWRPRADHLAVFFVFSGLWGVADAVWQTQNNALYGVLFEKSKEAAFANYRLWEA
                     LGFVIAFGYSMFLCVHVKLYILLGVLSLTMVAYGLVECVESKNPIRPHAPGQVNQAED
                     EEIQTKM"
     exon            263..444
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            445..674
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            675..800
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1015
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1151
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1283
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2111
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="UNC93A"
                     /gene_synonym="dJ366N23.1; dJ366N23.2; Unc-93A"
                     /note="major polyA site"
ORIGIN      
        1 attaacgagt gacagtctta atgactaaca cacctctaac atttcacctc tagctcagat
       61 gagagagaga atgggacttc ttggtactga ttgtttttcc catgcctcaa ttggtttctt
      121 ttagggagct acaaatttac gtgttcactg gtgattgatc ttttcatcca gcacaatgga
      181 cagaagtcta aggaacgtcc ttgtggtttc ctttgggttc ctgcttctct ttacagccta
      241 tggaggtctg cagagcctgc agagcagcct gtacagcgag gagggcctgg gtgtcacagc
      301 gctcagcacc ctctatggag gcatgctcct gtcctccatg ttcctcccac cgctcctcat
      361 cgagaggctg ggctgcaagg ggaccatcat cctctccatg tgtggctacg tggccttctc
      421 cgtgggcaac ttcttcgcca gctggtacac tttgatcccc acctccatac tgctgggact
      481 cggggccgcc ccgctgtggt ctgcacagtg cacatacctc acgatcacgg gaaacacaca
      541 tgcagagaag gcgggaaagc gtggcaaaga catggtgaac cagtattttg gcatcttctt
      601 cctcatattc cagtcatccg gtgtgtgggg caacttgatc tcatcgctgg tatttggcca
      661 gactcccagc caagagaccc ttccagaaga gcagctcacg tcctgtgggg ccagtgactg
      721 cctgatggcc accacaacca ccaacagcac ccagaggccc tcccagcagc tggtctacac
      781 cctcctgggc atctacactg ggagtggtgt cctggctgtc ctgatgatag ctgcgttcct
      841 ccaacccata cgagatgttc agcgggaaag tgaaggagag aagaaatcag tacctttctg
      901 gtccacttta ctgtcgactt tcaagctata tagagataaa cgtctgtgcc tcttaattct
      961 gctgccgctg tacagtggat tgcagcaagg attcctctcc agcgaataca caaggtccta
     1021 tgtcacctgc accctgggca tccagttcgt cggctacgtg atgatctgct tctcggccac
     1081 tgacgcgctg tgctccgtgt tgtatggaaa ggtctcgcag tacacgggca gggctgtgct
     1141 gtacgtgctg ggcgcggtga cccacgtgtc ctgcatgatt gccctactgc tgtggagacc
     1201 tcgtgctgac catctggcag tgttcttcgt attctctggc ctgtggggcg tggcagatgc
     1261 cgtctggcag acacaaaaca atgctctcta cggcgttctg tttgagaaga gcaaggaagc
     1321 tgccttcgcc aattaccgcc tgtgggaggc cctgggcttc gtcattgcct tcgggtacag
     1381 catgtttttg tgcgtgcacg tcaagctcta cattctgctg ggggtcctga gcctgaccat
     1441 ggtggcgtat gggcttgtgg agtgcgtgga gtccaagaac ccgatcagac cccacgctcc
     1501 aggacaggtc aaccaggcag aggatgaaga aatacaaaca aaaatgtgag agcagtgagg
     1561 tccgaggagg atgaactcag aaagcaccag ccagagaatt ttcttagaag atgcctcagg
     1621 acatagagcg gctcctcatc accatctcag cacaatttgg ccattctgaa gagatcatgt
     1681 tatttcactc ttcatgtatt ttttttctat tctaacaaat ttttcgtcca ccatcttaac
     1741 agagatcaag tgtatacatg aaggtatcag ttcatttaat tttagatgca aaagaaaaag
     1801 gtctaacgta caatcagcca attagaattt gcctgaaatc atagactcac cctagtttta
     1861 ttgctgtagt tgtttttaag aattggaagc ctgcttaaaa aatgtagttg agccccataa
     1921 ttttacaaat gggcgaactt ttaaacttct aactctactt ggatcaaaac ctcatacatt
     1981 ttacaaaggg gtcctgacaa gtcagctgac tcaacctcac agagtcaggg ggtgacaaag
     2041 ccagactggg gctcaggatt cctgaaacgt gtggggtctg cgtttctaaa taaagacggt
     2101 tatttaatgg a
//
