LOCUS       NM_080872               9149 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens unc-5 netrin receptor D (UNC5D), transcript variant 1,
            mRNA.
ACCESSION   NM_080872
VERSION     NM_080872.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9149)
  AUTHORS   Shi,L.P., Zou,C., Mao,L.J., Chen,T.T. and Xie,T.
  TITLE     The expression of UNC5D is abnormal in the early stage of
            colorectal tumors associated with its proliferation and migration
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (1), 199-213 (2024)
   PUBMED   38235871
  REMARK    GeneRIF: The expression of UNC5D is abnormal in the early stage of
            colorectal tumors associated with its proliferation and migration.
REFERENCE   2  (bases 1 to 9149)
  AUTHORS   Uhan,S., Zidar,N., Tomazic,A. and Hauptman,N.
  TITLE     Hypermethylated promoters of genes UNC5D and KCNA1 as potential
            novel diagnostic biomarkers in colorectal cancer
  JOURNAL   Epigenomics 12 (19), 1677-1688 (2020)
   PUBMED   33078631
  REMARK    GeneRIF: Hypermethylated promoters of genes UNC5D and KCNA1 as
            potential novel diagnostic biomarkers in colorectal cancer.
REFERENCE   3  (bases 1 to 9149)
  AUTHORS   Dong,D., Zhang,L., Bai,C., Ma,N., Ji,W., Jia,L., Zhang,A.,
            Zhang,P., Ren,L. and Zhou,Y.
  TITLE     UNC5D, suppressed by promoter hypermethylation, inhibits cell
            metastasis by activating death-associated protein kinase 1 in
            prostate cancer
  JOURNAL   Cancer Sci 110 (4), 1244-1255 (2019)
   PUBMED   30632669
  REMARK    GeneRIF: these results suggested that UNC5D as a novel putative
            metastatic suppressor gene that is commonly down-regulated by
            hypermethylation in PCa.
REFERENCE   4  (bases 1 to 9149)
  AUTHORS   Wang,Z., Claus Henn,B., Wang,C., Wei,Y., Su,L., Sun,R., Chen,H.,
            Wagner,P.J., Lu,Q., Lin,X., Wright,R., Bellinger,D., Kile,M.,
            Mazumdar,M., Tellez-Rojo,M.M., Schnaas,L. and Christiani,D.C.
  TITLE     Genome-wide gene by lead exposure interaction analysis identifies
            UNC5D as a candidate gene for neurodevelopment
  JOURNAL   Environ Health 16 (1), 81 (2017)
   PUBMED   28754176
  REMARK    GeneRIF: The authors identified a locus on chromosome 8, containing
            UNC5D, and demonstrated evidence of its genome-wide significance
            with mental composite scores. Within this locus, the joint effects
            of two independent single nucleotide polymorphisms had a p-value of
            4.38 x 10(-9) for mental composite scores.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9149)
  AUTHORS   Lu,Y.C., Nazarko,O.V., Sando,R. 3rd, Salzman,G.S., Li,N.S.,
            Sudhof,T.C. and Arac,D.
  TITLE     Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell
            Adhesion
  JOURNAL   Structure 23 (9), 1678-1691 (2015)
   PUBMED   26235030
REFERENCE   6  (bases 1 to 9149)
  AUTHORS   Wang,H., Ozaki,T., Shamim Hossain,M., Nakamura,Y., Kamijo,T.,
            Xue,X. and Nakagawara,A.
  TITLE     A newly identified dependence receptor UNC5H4 is induced during DNA
            damage-mediated apoptosis and transcriptional target of tumor
            suppressor p53
  JOURNAL   Biochem Biophys Res Commun 370 (4), 594-598 (2008)
   PUBMED   18402767
  REMARK    GeneRIF: UNC5H4 amplifies p53-dependent apoptotic response.
REFERENCE   7  (bases 1 to 9149)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   8  (bases 1 to 9149)
  AUTHORS   Zhong,Y., Takemoto,M., Fukuda,T., Hattori,Y., Murakami,F.,
            Nakajima,D., Nakayama,M. and Yamamoto,N.
  TITLE     Identification of the genes that are expressed in the upper layers
            of the neocortex
  JOURNAL   Cereb Cortex 14 (10), 1144-1152 (2004)
   PUBMED   15142956
REFERENCE   9  (bases 1 to 9149)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 9149)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358147.1, BY798317.2, AB055056.1, AB073394.1, AK092313.1,
            CK904280.1, AI004193.1 and CN289823.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080872.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.201298.1, AY358147.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404895.7/ ENSP00000385143.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AY358147.1         19-399
            382-961             BY798317.2         20-599
            962-3234            AY358147.1         980-3252
            3235-4448           AB055056.1         2965-4178
            4449-4455           AB055056.1         4180-4186
            4456-6108           AB073394.1         1-1653
            6109-8478           AK092313.1         1-2370
            8479-8737           CK904280.1         319-577             c
            8738-9075           AI004193.1         95-432              c
            9076-9149           CN289823.1         135-208
FEATURES             Location/Qualifiers
     source          1..9149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..9149
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /note="unc-5 netrin receptor D"
                     /db_xref="GeneID:137970"
                     /db_xref="HGNC:HGNC:18634"
                     /db_xref="MIM:616466"
     exon            1..413
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..3172
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; netrin receptor UNC5D; netrin receptor Unc5h4;
                     unc-5 homolog 4; protein unc-5 homolog D; protein unc-5
                     homolog 4"
                     /codon_start=1
                     /product="netrin receptor UNC5D isoform 1 precursor"
                     /protein_id="NP_543148.2"
                     /db_xref="CCDS:CCDS6093.2"
                     /db_xref="GeneID:137970"
                     /db_xref="HGNC:HGNC:18634"
                     /db_xref="MIM:616466"
                     /translation="MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPE
                     SIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEET
                     LDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKN
                     FEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLII
                     RQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRS
                     RTCTNPAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTA
                     PPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVVA
                     VAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTV
                     SRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSR
                     TFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLI
                     PHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCA
                     DVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEP
                     ITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKL
                     LHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPT
                     TTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYS
                     IRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGD
                     LDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL"
     exon            414..632
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..776
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..880
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1061
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1229
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1394
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1427
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1613
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1991
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2076
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2245
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2473
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2623
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2788
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2967
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..9149
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8877..8882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /note="hexamer: AGTAAA"
     polyA_site      8899
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
     regulatory      9128..9133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /note="hexamer: AATAAA"
     polyA_site      9149
                     /gene="UNC5D"
                     /gene_synonym="PRO34692; Unc5h4"
                     /note="major polyA site"
ORIGIN      
        1 ccgtagttcg gggcccggca gcggcgcgag ggctgggaac tgcgcggcgg ggactgcggg
       61 cgactccggc atccgcgctg gcggcagcgg tcgccgcgcc gtgggaagct atggggacgc
      121 gccctttctc ggggtgccca ttcagcggcg gctcggagct ccctgccccg ctgctttagg
      181 aagcgatcgt ggagcagagt cactctctga agactcccga gacccattcg actcgggacc
      241 ctcatcgccg accctttccc gggctcccgg agcgtgaaga agagccgccc tccggaacgc
      301 ggcgaggagc atggggagag cggcggccac cgcaggcggc ggcggagggg cgcgccgctg
      361 gctcccgtgg ctggggctgt gcttctgggc ggcagggacc gcggctgccc gaggaactga
      421 caatggcgaa gcccttcccg aatccatccc atcagctcct gggacactgc ctcatttcat
      481 agaggagcca gatgatgctt atattatcaa gagcaaccct attgcactca ggtgcaaagc
      541 gaggccagcc atgcagatat tcttcaaatg caacggcgag tgggtccatc agaacgagca
      601 cgtctctgaa gagactctgg acgagagctc aggtttgaag gtccgcgaag tgttcatcaa
      661 tgttactagg caacaggtgg aggacttcca tgggcccgag gactattggt gccagtgtgt
      721 ggcgtggagc cacctgggta cctccaagag caggaaggcc tctgtgcgca tagcctattt
      781 acggaaaaac tttgaacaag acccacaagg aagggaagtt cccattgaag gcatgattgt
      841 actgcactgc cgcccaccag agggagtccc tgctgccgag gtggaatggc tgaaaaatga
      901 agagcccatt gactctgaac aagacgagaa cattgacacc agggctgacc ataacctgat
      961 catcaggcag gcacggctct cggactcagg aaattacacc tgcatggcag ccaacatcgt
     1021 ggctaagagg agaagcctgt cggccactgt tgtggtctac gtgaatggag gctggtcttc
     1081 ctggacagag tggtcagcct gcaatgttcg ctgtggtaga ggatggcaga aacgttcccg
     1141 gacctgcacc aacccagctc ctctcaatgg tggggccttt tgtgagggaa tgtcagtgca
     1201 gaaaataacc tgcacttctc tttgtcctgt ggatgggagc tgggaagtgt ggagcgaatg
     1261 gtccgtctgc agtccagagt gtgaacattt gcggatccgg gagtgcacag caccaccccc
     1321 gagaaatggg ggcaaattct gtgaaggtct aagccaggaa tctgaaaact gcacagatgg
     1381 tctttgcatc ctagataaaa aacctcttca tgaaataaaa ccccaaagca ttgagaatgc
     1441 cagcgacatt gctttgtact cgggcttggg tgctgccgtc gtggccgttg cagtcctggt
     1501 cattggtgtc accctttaca gacggagcca gagtgactat ggcgtggacg tcattgactc
     1561 ttctgcattg acaggtggct tccagacctt caacttcaaa acagtccgtc aaggtaactc
     1621 cctgctcctg aattctgcca tgcagccaga tctgacagtg agccggacat acagcggacc
     1681 catctgtctg caggaccctc tggacaagga gctcatgaca gagtcctcac tctttaaccc
     1741 tttgtcggac atcaaagtga aagtccagag ctcgttcatg gtttccctgg gagtgtctga
     1801 gagagctgag taccacggca agaatcattc caggactttt ccccatggaa acaaccacag
     1861 ctttagtaca atgcatccca gaaataaaat gccctacatc caaaatctgt catcactccc
     1921 cacaaggaca gaactgagga caactggtgt ctttggccat ttaggggggc gcttagtaat
     1981 gccaaataca ggggtgagct tactcatacc acacggtgcc atcccagagg agaattcttg
     2041 ggagatttat atgtccatca accaaggtga acccagcctc cagtcagatg gctctgaggt
     2101 gctcctgagt cctgaagtca cctgtggtcc tccagacatg atcgtcacca ctccctttgc
     2161 attgaccatc ccgcactgtg cagatgtcag ttctgagcat tggaatatcc atttaaagaa
     2221 gaggacacag cagggcaaat gggaggaagt gatgtcagtg gaagatgaat ctacatcctg
     2281 ttactgcctt ttggacccct ttgcgtgtca tgtgctcctg gacagctttg ggacctatgc
     2341 gctcactgga gagccaatca cagactgtgc cgtgaagcaa ctgaaggtgg cggtttttgg
     2401 ctgcatgtcc tgtaactccc tggattacaa cttgagagtt tactgtgtgg acaatacccc
     2461 ttgtgcattt caggaagtgg tttcagatga aaggcatcaa ggtggacagc tcctggaaga
     2521 accaaaattg ctgcatttca aagggaatac ctttagtctt cagatttctg tccttgatat
     2581 tcccccattc ctctggagaa ttaaaccatt cactgcctgc caggaagtcc cgttctcccg
     2641 cgtgtggtgc agtaaccggc agcccctgca ctgtgccttc tccctggagc gttatacgcc
     2701 cactaccacc cagctgtcct gcaaaatctg cattcggcag ctcaaaggcc atgaacagat
     2761 cctccaagtg cagacatcaa tcctagagag tgaacgagaa accatcactt tcttcgcaca
     2821 agaggacagc actttccctg cacagactgg ccccaaagcc ttcaaaattc cctactccat
     2881 cagacagcgg atttgtgcta catttgatac ccccaatgcc aaaggcaagg actggcagat
     2941 gttagcacag aaaaacagca tcaacaggaa tttatcttat ttcgctacac aaagtagccc
     3001 atctgctgtc attttgaacc tgtgggaagc tcgtcatcag catgatggtg atcttgactc
     3061 cctggcctgt gcccttgaag agattgggag gacacacacg aaactctcaa acatttcaga
     3121 atcccagctt gatgaagccg acttcaacta cagcaggcaa aatggactct agtccacttc
     3181 ctcccatgag acagagtgat ggccagcttg gggacatttg ctttaaatgg gaaagaggcc
     3241 gctttctgcc cagtggcgtt gggggaattc agccttcatt tataatcagt gagattcccc
     3301 tgttgaagaa actaaatttt atataggtaa aacatgttaa tagggaagag tacaagctct
     3361 cttacatata agagggctct actatctcct tggaatccac atttgggtta actcctcaga
     3421 tttggagtgg caaggataaa agtgagggca gaagtagctg tgggaaaaga tgagctatga
     3481 taatgctggg aaggcagaga ttgattaagt gcatgctttg aaataggttt ttaatgatgt
     3541 gccccaaagg gccagctgat tctggtacta gattgtcaga gttttctacc aactggcatc
     3601 tgtgatgtca gagatcattg taaaaatggc ttttagacgt gaaacagggt tgccaaccca
     3661 tttgtatgac ttcaacaacg tcaaggaggg catttagaat ttagaatctg agcacatcac
     3721 accagcacca gctccctgtc tcttctagcc acttaatgga gacacaatgg agaggtaaga
     3781 cagaccacaa actagttctt atagtgtact ccacctttta cttttttcct gagacaaatc
     3841 tacccttatt ctttcttcct cttccttacc ccttgcagta gggaggtatc aaggagcata
     3901 attaaacttg tcaatacgga aagttgtttt ttctaacaca acaaagtggg accatctcta
     3961 ttcccatcta agccactcaa attgctgagt gctattagaa cacagcttat tacatggata
     4021 tggggacagg agagattaaa gcaggttcaa aaacacatga actgcagatg ccataggcct
     4081 caaatcagct gtaattctag gagacacgtg ttgatctagt tatctaacat tgttgttata
     4141 agaaaatgag tttactgcat ttttcaatcc agattcttga aattgtctaa catgtgggta
     4201 ctgtgtcatc acaaaatctc tcagtaaggc tatatgtgat cctcattttg cctcttggga
     4261 aattagcaga tagtctttgc tctaaatgat atctgagtaa atagacttga ggaatcctct
     4321 accacagtgt ccctgaaacc acatgcatca ttcaggaagc cttcaccctg tgactattca
     4381 gcctccctga atatgctttc tctatagaac cactaacata tggctattgc tctatgattt
     4441 ttttttttac attaggaggc agtgatattg tggaagattg aaatccacag ataattcatg
     4501 accctcatct tatcacttta ctccatcttt ttatcctatt aaattatttt tgacaagatg
     4561 tcctggtaga ctaaaggtga acagatttgc tcttgctcat cttctggtgg atattttaac
     4621 ttgctattca caatcaggac aaccaaagtc aaggacccag atgaaccaca aggcagctag
     4681 tcagctactt agaggttggt tacattcgaa taaaaagtag tcagggaatg ggggaggtgg
     4741 ggagttgggg agtacttggc agttgggata tgatccattt ttttaaacaa gttttttgta
     4801 gatcccttgt aaaataataa taataatgtt gtgaatctcc atgccaagtg aaaaaggcct
     4861 aaagatgagt tgaatttgtg ataccatggg taaggcatgg aagaactctt gaatgtgttg
     4921 gccattttct ctaactaaca tgtggtatgt atggtcccct atattagata gaagtctttg
     4981 ctacatgtaa ttcaaaagca tctcgctttt ctcaggaacc aaaggcttat gatgtaggac
     5041 aaagaaatca tcttagaact gtcaagcata ttttcacaat accatgtcaa gatcaggaaa
     5101 acaccctttt gctagtgtgc ttaacttatt tatttcttct aggaaacaat agataaacag
     5161 catgaaaatg taaatcatct ggcatcactg atagaatttc tgaaagagaa agagaagtag
     5221 atggtcaacc agtcactagt tggttggcat gaggtggtgt gcagaggaaa gctgcattca
     5281 ctattgagta aaaacttgta gaaagcacat tatagagctt atgttggaat ccatcttgga
     5341 ggatttttgt tttaaactgt ctttagcatt ttccctcttc ccttctaatg ggcattataa
     5401 ttgtttcatc tactctgtga atctacatag gtcttttttt ttagatgttt gatacatttt
     5461 aagtattttt aaatagatga aaattctaaa tgattttccc tcaaatctat ctagattatt
     5521 ttaagatgag acaagattat tgtcaatccc tgaatgtctg gagttacctc ccatggattt
     5581 ttttttcctt tggcctgggt tttataaaca acttgaacat catatcatat aggataacaa
     5641 aggaggaagt taacttaatt cacctcagac ttcagcctaa gattcaatca aattcatcct
     5701 tcagcctgtc ttgtttcttc tttatgtttc ttttacttat tgctgctagg atcctacata
     5761 ggatttctat agaaatgtat gaaattctgt ggtcactgca tgtcaggatt gcacagtatg
     5821 ttacaataca atttcaaaga gaacccacat ttgtgagatt tacagaccaa ggtgtggtgg
     5881 aggaggtaga attgcagatc agataaaaag tgagcttaca cttgaactta gttattcact
     5941 gtgacctaaa tttagtccta ttgtaatatg tgcctgtcac aacacaaata cccctcttga
     6001 aagagattta ctcatctatc caagcactta atttggaaat tttattgtcc tattgcaaaa
     6061 tgaaacaaaa ttaaaagtgg cctcgagtac ttggtaagtt acttaaaatt tttacaaaaa
     6121 tatcccactc aatgccaaat ctttcagtcc tcaaaggcat ttaagtccaa tagtcatgct
     6181 ttaaatatgg ctttaaatta tgccaccaaa atggtgcact tcacagattc accagactgt
     6241 agcatcataa agttaattta cagtttttac aacattgctt ctacattctt actggtttac
     6301 attaaaatcc tttaagccaa aaggaagctt gctctatgga tttaaatgca aacttcattt
     6361 accagtgcag gaagtctcat aaaactcaga tgtactccca caaaaatttt attggccttt
     6421 ttgtaagaga tgaaaaagaa ttgacacagt tctctttaaa gagaagaact tttttattat
     6481 tatttttatc tccaactgca ggtggtgtct tttgccaagg tctctgtatt tttctttcag
     6541 ttgtctttgg gaggggatgt taagtcaaat cactaaaaca gggttctctt tggattaaaa
     6601 gttctggatt tattgcaact attttccttg agaaacattc tcagcatcag gattgataaa
     6661 caaatgtaga tgattaaaat aggataattg gttttagata atatcttcta ctgccaaact
     6721 tctggcaaat ttacctgtga atttcaaaat gttataaaat ctcttgatat gcttttgttt
     6781 ttccttttag ccattttctc ttcaatttct tagtccctct gccctctgta aatgtgttga
     6841 gtgatatagc tatcagatgt attgaaggca aagttctcgc agaggtctct gttccagctc
     6901 tgtaaaggtc acaggaatcg tgaaggagct gagaaatctt cctctccggc ccactgtctg
     6961 tggcccattg tcattgtttc ctcatgaaac attgcagagt ttgaatcctc agtaactctc
     7021 attgactgga ttagaggtga tggccacagc aaatgggaga gcaaaatgtt ggcctacaga
     7081 gaatgacaca attttattcg cctttggtgt tagttgccat agtgctgtat ttgaaaatcg
     7141 atgctttagc caaaagctga atgaccaccg tttccgtagt ttccactgtt ttgtctgcat
     7201 agaattttcc tgaactacaa gcaaaaatgt attttgtcca atgtcacaaa agtgaaaatg
     7261 ttactaatct tagatgtgtt gcatattttg tgtttttacg ttccaaactc tttcaaaagc
     7321 tgccgttaca aagctgtttg gctgtattga cagcatgtgg tgtttttaca aaagcaattc
     7381 taggagagcc agtgtctacc atgaactcct gacatcccca ctccagggtc attcatgaca
     7441 ttgaaatggc aacttgtaca ctgtaattct tcgaaaagta acaggggatg gaaatcagac
     7501 ctggccgtta gtcactagtg tgtagtaccg tgatctgaag taggaaattt aactgacata
     7561 gaataattgt ggtttttgaa gcagctactc attgcttttt ccttttgctg tgaagatcat
     7621 ggattgggaa tgtcctcgtg aggtggacct aaggcagtaa catttaaact tcatgtccta
     7681 gcacccgccc tccatctgac ccaaagataa aaaaggcatc aagcttcatg gttatgccta
     7741 agcttaaaaa ttcccttccc cactactaat attgagttca gcagggcccc atcttactta
     7801 tttttcaaaa aagttatagc tttgaattat agactatatt actaaatttg gtaaggtagt
     7861 tctttgcatg aatgggaatg tgtgtcaaaa tactttcaca aaaggcatga ttacaatgga
     7921 aatgcccctt tgcctccagt tttgctaacc ctaaaaagta tttcactaat ttcaagcact
     7981 gtttacactc aaatcccaaa attggccaaa ttatataatt ctcttaaatt ttcatttctg
     8041 taggtggaga tttaactatg gttctggtga atcatagaag ggagagacaa tatttgaggg
     8101 gagtttatca gcagaatatc atgccttatg accccattac tgaaacacag acattacaat
     8161 cagaaataga cctaataatt ccaatatccc tccattaact agttccagtg atgctgagag
     8221 acacagcacc ctgtgccagg tatcagaaat ataagcctca gcagagggta actgaaaact
     8281 ttcaatcaga aacactctcc aaggcttatg gctagattat gtaggtcact accattcaaa
     8341 acttttctat acaaaggtgg aaaagcactc agaatctggg aattttctgg ttggaagaac
     8401 aatgttctcc ttttccaaat tggaataaag actcagaatt acccattctt cataatcatg
     8461 tctgattggt acatacactc caggaagtct caacctagaa acatttccaa cctaagcatt
     8521 taaaggaaaa ctggctcatt cttctgaccc aaactcaaaa aatatgagta cttgcgtacc
     8581 tccatttctg catgaagatt ttaaaacaga tttcattttt ttctgtttat tttgggaagg
     8641 tgcgtggggg tgttctttca agtgattcac atctcaaacc cataccactc tcaactttta
     8701 tttgatgtgt tcaaagccaa aaaataaaat aaaataaagc agggctgaac acttaatttg
     8761 acatgaagct gaaggactga gcaagccaga ggagagaggt tgaatgaagc atagccttgg
     8821 cttcatacca cactttttgt gccttgtatt atcaatgtaa attctgaatg ttgtacagta
     8881 aacttggatg gacttcttag aaaaggctgc actggcttct ttttcagcac atgtacatat
     8941 ctataaatat atatacatat atatttggta atgccaaaca gctctgttat attgtattga
     9001 acaaaatgga cggtttggat gttttatgtc gagtttgcaa aaaaaaaaaa aaaaaaaaaa
     9061 actggatggt tgcagacttt tcaagataaa tgtacagacg taaattactg catatcagtt
     9121 atttatgaat aaagagtctt ttattgaca
//
