LOCUS       NM_173561               3156 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens unc-5 family C-terminal like (UNC5CL), mRNA.
ACCESSION   NM_173561
VERSION     NM_173561.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3156)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3156)
  AUTHORS   Hu,N., Wang,Z., Song,X., Wei,L., Kim,B.S., Freedman,N.D., Baek,J.,
            Burdette,L., Chang,J., Chung,C., Dawsey,S.M., Ding,T., Gao,Y.T.,
            Giffen,C., Han,Y., Hong,M., Huang,J., Kim,H.S., Koh,W.P.,
            Liao,L.M., Mao,Y.M., Qiao,Y.L., Shu,X.O., Tan,W., Wang,C., Wu,C.,
            Wu,M.J., Xiang,Y.B., Yeager,M., Yook,J.H., Yuan,J.M., Zhang,P.,
            Zhao,X.K., Zheng,W., Song,K., Wang,L.D., Lin,D., Chanock,S.J.,
            Goldstein,A.M., Taylor,P.R. and Abnet,C.C.
  TITLE     Genome-wide association study of gastric adenocarcinoma in Asia: a
            comparison of associations between cardia and non-cardia tumours
  JOURNAL   Gut 65 (10), 1611-1618 (2016)
   PUBMED   26129866
  REMARK    GeneRIF: rs2294693 near UNC5CL was significantly associated with
            Gastric non-cardia cancer risk (p=2.50x10(-8)), with OR (95% CI) of
            1.18 (1.12 to 1.26), but there was only a nominal association for
            cardia cancer (p=1.47x10(-2).
REFERENCE   3  (bases 1 to 3156)
  AUTHORS   Heinz,L.X., Rebsamen,M., Rossi,D.C., Staehli,F., Schroder,K.,
            Quadroni,M., Gross,O., Schneider,P. and Tschopp,J.
  TITLE     The death domain-containing protein Unc5CL is a novel
            MyD88-independent activator of the pro-inflammatory IRAK signaling
            cascade
  JOURNAL   Cell Death Differ 19 (4), 722-731 (2012)
   PUBMED   22158417
  REMARK    GeneRIF: The death domain-containing protein Unc5CL is a novel
            MyD88-independent activator of the pro-inflammatory IRAK signaling
            cascade.
REFERENCE   4  (bases 1 to 3156)
  AUTHORS   Wu,C., Hu,Z., He,Z., Jia,W., Wang,F., Zhou,Y., Liu,Z., Zhan,Q.,
            Liu,Y., Yu,D., Zhai,K., Chang,J., Qiao,Y., Jin,G., Liu,Z., Shen,Y.,
            Guo,C., Fu,J., Miao,X., Tan,W., Shen,H., Ke,Y., Zeng,Y., Wu,T. and
            Lin,D.
  TITLE     Genome-wide association study identifies three new susceptibility
            loci for esophageal squamous-cell carcinoma in Chinese populations
  JOURNAL   Nat Genet 43 (7), 679-684 (2011)
   PUBMED   21642993
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3156)
  AUTHORS   Zhang,J., Xu,L.G., Han,K.J. and Shu,H.B.
  TITLE     Identification of a ZU5 and death domain-containing inhibitor of
            NF-kappaB
  JOURNAL   J Biol Chem 279 (17), 17819-17825 (2004)
   PUBMED   14769797
  REMARK    GeneRIF: ZUD is an inhibitor of NF-kappaB activation and may
            provide an alternative regulatory mechanism for NF-kappaB-mediated
            transcription
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031778.1, AI791395.1, BC035284.1 and BM312066.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173561.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF681947.1, BC035284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244565.8/ ENSP00000244565.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL031778.1         84808-84829         c
            23-506              AI791395.1         1-484
            507-1414            BC035284.1         475-1382
            1415-1491           BM312066.1         435-511
            1492-3019           BC035284.1         1460-2987
            3020-3156           AL031778.1         72503-72639         c
FEATURES             Location/Qualifiers
     source          1..3156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3156
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="unc-5 family C-terminal like"
                     /db_xref="GeneID:222643"
                     /db_xref="HGNC:HGNC:21203"
                     /db_xref="MIM:617464"
     exon            1..60
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            61..506
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1678
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="ZU5 and death domain containing; protein unc-5
                     homolog C-like"
                     /codon_start=1
                     /product="UNC5C-like protein"
                     /protein_id="NP_775832.2"
                     /db_xref="CCDS:CCDS4847.1"
                     /db_xref="GeneID:222643"
                     /db_xref="HGNC:HGNC:21203"
                     /db_xref="MIM:617464"
                     /translation="MCPQESSFQPSQFLLLVGVPVASVLLLAQCLRWHCPRRLLGACW
                     TLNGQEEPVSQPTPQLENEVSRQHLPATLPEMVAFYQELHTPTQGQTMVRQLMHKLLV
                     FSAREVDHRGGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLV
                     SPVVACGPHGASFLKPCTLTFKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAHASR
                     DECRIHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCA
                     LQWALTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEGWENVDDSSCQLVPHLHI
                     WHGKCPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRFQASEEES
                     WAAPPPVSQPPPCNRLPPELFEQLRMLLEPNSITGNDWRRLASHLGLCGMKIRFLSCQ
                     RSPAAAILELFEEQNGSLQELHYLMTVMERLDCASAIQNYLSGTHGGSPGPERGGARD
                     NQGLELDEKL"
     exon            507..807
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1070
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1172
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1240
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1341
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1455
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..3156
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="hexamer: AATAAA"
     polyA_site      3019
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="major polyA site"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="hexamer: ATTAAA"
     polyA_site      3156
                     /gene="UNC5CL"
                     /gene_synonym="MUXA; ZUD"
                     /note="major polyA site"
ORIGIN      
        1 gacccttgtt tctcggagaa ggaactggac cagccagcag cctctaagag ctcctagacg
       61 gcctttggct ttggctggca caggggtgaa ggagagccag cggcattgag taaccaggcg
      121 aatgtgcccc caggagagtt cattccaacc ctcccagttc ctactgctgg tgggggtccc
      181 agtggcaagt gtcctccttc tggcccaatg ccttcgatgg cactgcccta gaaggctgct
      241 gggggcctgc tggacactga atggtcaaga ggaaccagtg tcccagccta ccccccaact
      301 agaaaatgag gtctcaaggc agcacctgcc agccacactg ccagagatgg ttgccttcta
      361 ccaggagcta cacacaccca ctcaaggcca gaccatggtc cgccagttga tgcacaaact
      421 gttggtgttt tcggctcgag aggtggatca ccgcggcggt tgcctgatgc tccaggatac
      481 aggcatctcc ttgctcatcc caccaggtgc tgtggctgtg ggccgccagg agcgggtgtc
      541 tttgatcctg gtgtgggacc tgtcggacgc cccatcgctg tcccaagccc aggggctggt
      601 aagccctgtg gtggcatgtg gcccccatgg ggcctccttc ctgaagcctt gcactctcac
      661 gttcaaacac tgtgccgagc agcccagcca tgctcgcacc tacagcagca acactaccct
      721 gctggatgcc aaggtatgga ggcccctggg gcggccgggg gcccacgcct cccgggatga
      781 gtgtcgcatc cacctctccc acttcagcct ctacacctgt gtgctggagg cacctgtggg
      841 gcgcgaagcc cgcaaatggc tgcagctggc cgtattctgc tcaccgctgg tgccaggaca
      901 gtcccatctg caactgcgta tctacttcct caacaacacg ccctgcgccc tgcagtgggc
      961 actgaccaac gagcagcccc atggtgggcg cctgcgtggg ccctgccagc tcttcgactt
     1021 caatggggct aggggcgacc agtgcctgaa gctcacgtac atctcagagg gttgggagaa
     1081 tgtggatgac agcagttgcc agctggttcc ccatctccac atctggcatg gaaagtgccc
     1141 cttccgctcc ttctgcttcc ggagaaaagc agccgatgag aatgaggact gttcagcact
     1201 aaccaatgag atcattgtca ccatgcacac cttccaggat ggcttggaga ccaagtatat
     1261 ggaaatcctc agattccagg catcagagga ggaatcctgg gcagcgccac cacctgtttc
     1321 ccagccgccc ccatgcaata ggctgccccc agagctcttt gagcagctgc ggatgttatt
     1381 ggagccaaac agcatcaccg gcaatgactg gcgcagactg gcctcccacc tggggctttg
     1441 cggcatgaag atccggttcc tgtcctgcca gcgcagcccc gcagcggcca tcctggagtt
     1501 gtttgaggag cagaacggca gcctgcagga gctgcactac ctcatgaccg tcatggagcg
     1561 gctagactgc gcctccgcca tccagaacta cctgagtggg acacacggcg gcagcccagg
     1621 ccccgagcgc gggggcgccc gggataacca gggcctggag ctggacgaga agctctgagc
     1681 gcccagcggg cagggccgga ggaggtgtag gggcgagagg ggttgttctc ctacgcctaa
     1741 gaggaacaca gcagctgttc ctggctgtgc ccaccaccct tcccagaacc ctcggacggt
     1801 gccagggccg cccgcgtcct cgccagcctc ccagcagcag gcgcgccctt ccggccgcga
     1861 gctgtcccgc gtgcgggtcc cctcctggcc ggcagagggc gcaggagccc aggagatggc
     1921 ctcagcgtgg ccagcctgcc aaactgacca ggggacggcc acggtccccg cgtgcacttt
     1981 agggccggtc aggccctaaa gtattcactg agcacttagg aagaccgggc attgggctgg
     2041 tgtcatgaag aatactggaa tataggaggt agggtctgga gccctgacaa gcacacagtt
     2101 cttttgcagg agtcaagatg tgctcatagg agccaagggc aaactcgaaa acagccctgc
     2161 cctgtggtta ggggaggtgg gtgtggcttt aggagttgag aggggaagag ctgagtgcgg
     2221 gctggagcag cgagaatgct tcacggagga tgttggggag agaggatttg atttgccgag
     2281 tggtttggag atctttaggg gcgggtaggg gaagagggtg gctggactta aggtaggagc
     2341 cgaaagtggg catgggagcc catccccgtg ggtgtgaggc cggggtagga ccaggcttcc
     2401 cggctaggca cgcctggctg gctgcctctg cctctactaa cttcctttgt ctctttatcc
     2461 tcctgcttag gccgtgtctt cctctctctc tgccattttc tctatcagaa aacattaaag
     2521 ctgagtagaa acttcaagat gatcattctg gcccagccct tttatctctt tatctccaat
     2581 ggtgtgcgtt ttaagtttct ctgacttggt ttttctgtcc ctgtctccca cagttgttcc
     2641 cgctctgcac ctgtgtttca gttactctct ctctctgtct tagatctttt tgtttctgcc
     2701 tagtctctgt gccctgtctt tgtgtgtttc tttctctgcc tgaaaccctc cctcttttcc
     2761 cttcaggcat atgtctctaa accaatgtta tgtatcaaag actgttgaaa gagacagggc
     2821 tactctagga atggatgggt ggggatattt tccccatgga tcaagatcca gtttagggtt
     2881 gggaaataaa ggatagggat aaaagaggca ccccattcag tcagcagata cttattcagc
     2941 acctactatg tgtttgatac tgtatacaaa agacatgaat gggctgggtc ctgaacagag
     3001 aataaagggt ttgactccat tctggaaatt cttttgtttg caaacaggtg ttgttaattt
     3061 gttcaaaggc aggcaaacaa tctctctggc aacacaattt tcttctgtat ttaattaaaa
     3121 aatattaaag ctttttttct atgatgaatg ataaaa
//
