LOCUS       NM_003728               9642 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens unc-5 netrin receptor C (UNC5C), mRNA.
ACCESSION   NM_003728
VERSION     NM_003728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9642)
  AUTHORS   Treccarichi,S., Failla,P., Vinci,M., Musumeci,A., Gloria,A.,
            Vasta,A., Calabrese,G., Papa,C., Federico,C., Saccone,S. and
            Cali,F.
  TITLE     UNC5C: Novel Gene Associated with Psychiatric Disorders Impacts
            Dysregulation of Axon Guidance Pathways
  JOURNAL   Genes (Basel) 15 (3), 306 (2024)
   PUBMED   38540364
  REMARK    GeneRIF: UNC5C: Novel Gene Associated with Psychiatric Disorders
            Impacts Dysregulation of Axon Guidance Pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9642)
  AUTHORS   Wang,H., Zhou,Z., Liu,Y., Wang,P., Chen,L., Qi,S., Xie,J. and
            Tang,J.
  TITLE     Identification and validation of HOXD3 and UNC5C as molecular
            signatures in keloid based on weighted gene co-expression network
            analysis
  JOURNAL   Genomics 114 (4), 110403 (2022)
   PUBMED   35709926
  REMARK    GeneRIF: Identification and validation of HOXD3 and UNC5C as
            molecular signatures in keloid based on weighted gene co-expression
            network analysis.
REFERENCE   3  (bases 1 to 9642)
  AUTHORS   Xing,H., Wang,P., Liu,S., Jing,S., Lin,J., Yang,J., Zhu,Y. and
            Yu,M.
  TITLE     A global integrated analysis of UNC5C down-regulation in cancers:
            insights from mechanism and combined treatment strategy
  JOURNAL   Biomed Pharmacother 138, 111355 (2021)
   PUBMED   33706130
  REMARK    GeneRIF: A global integrated analysis of UNC5C down-regulation in
            cancers: insights from mechanism and combined treatment strategy.
REFERENCE   4  (bases 1 to 9642)
  AUTHORS   Yuan,M., Xie,F., Xia,X., Zhong,K., Lian,L., Zhang,S., Yuan,L. and
            Ye,J.
  TITLE     UNC5C-knockdown enhances the growth and metastasis of breast cancer
            cells by potentiating the integrin alpha6/beta4 signaling pathway
  JOURNAL   Int J Oncol 56 (1), 139-150 (2020)
   PUBMED   31789389
  REMARK    GeneRIF: UNC5Cknockdown enhances the growth and metastasis of
            breast cancer cells by potentiating the integrin alpha6/beta4
            signaling pathway.
REFERENCE   5  (bases 1 to 9642)
  AUTHORS   Yang,H.S., Chhatwal,J.P., Xu,J., White,C.C., Hanseeuw,B.,
            Rabin,J.S., Papp,K.V., Buckley,R.F., Schultz,A.P., Properzi,M.J.,
            Gatchel,J.R., Amariglio,R.E., Donovan,N.J., Mormino,E.C.,
            Hedden,T., Marshall,G.A., Rentz,D.M., Johnson,K.A., De Jager,P.L.
            and Sperling,R.A.
  TITLE     An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy
            in Clinically Normal Older Adults
  JOURNAL   J Alzheimers Dis 68 (3), 1161-1170 (2019)
   PUBMED   30883345
  REMARK    GeneRIF: An UNC5C Allele Predicts Cognitive Decline and Hippocampal
            Atrophy in Clinically Normal Older Adults.
REFERENCE   6  (bases 1 to 9642)
  AUTHORS   Geisbrecht,B.V., Dowd,K.A., Barfield,R.W., Longo,P.A. and
            Leahy,D.J.
  TITLE     Netrin binds discrete subdomains of DCC and UNC5 and mediates
            interactions between DCC and heparin
  JOURNAL   J Biol Chem 278 (35), 32561-32568 (2003)
   PUBMED   12810718
REFERENCE   7  (bases 1 to 9642)
  AUTHORS   Thiebault,K., Mazelin,L., Pays,L., Llambi,F., Joly,M.O.,
            Scoazec,J.Y., Saurin,J.C., Romeo,G. and Mehlen,P.
  TITLE     The netrin-1 receptors UNC5H are putative tumor suppressors
            controlling cell death commitment
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4173-4178 (2003)
   PUBMED   12655055
  REMARK    GeneRIF: may represent tumor suppressor that inhibit tumor
            extension outside the region of netrin-1 availability by inducing
            apoptosis
REFERENCE   8  (bases 1 to 9642)
  AUTHORS   Kennedy,T.E.
  TITLE     Cellular mechanisms of netrin function: long-range and short-range
            actions
  JOURNAL   Biochem Cell Biol 78 (5), 569-575 (2000)
   PUBMED   11103947
  REMARK    Review article
REFERENCE   9  (bases 1 to 9642)
  AUTHORS   Livesey,F.J.
  TITLE     Netrins and netrin receptors
  JOURNAL   Cell Mol Life Sci 56 (1-2), 62-68 (1999)
   PUBMED   11213262
  REMARK    Review article
REFERENCE   10 (bases 1 to 9642)
  AUTHORS   Ackerman,S.L. and Knowles,B.B.
  TITLE     Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
  JOURNAL   Genomics 52 (2), 205-208 (1998)
   PUBMED   9782087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106881.9, AC098584.2 and
            AC105395.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003728.3.
            
            Summary: This gene product belongs to the UNC-5 family of netrin
            receptors. Netrins are secreted proteins that direct axon extension
            and cell migration during neural development. They are bifunctional
            proteins that act as attractants for some cell types and as
            repellents for others, and these opposite actions are thought to be
            mediated by two classes of receptors. The UNC-5 family of receptors
            mediate the repellent response to netrin; they are transmembrane
            proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I
            thrombospondin motifs in the extracellular region. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.228788.1,
                                           SRR1660803.132071.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453304.6/ ENSP00000406022.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC106881.9         93564-93803         c
            241-462             AC098584.2         116880-117101       c
            463-606             AC098584.2         83076-83219         c
            607-710             AC098584.2         59729-59832         c
            711-891             AC098584.2         31957-32137         c
            892-1059            AC098584.2         26447-26614         c
            1060-1224           AC098584.2         23899-24063         c
            1225-1416           AC098584.2         1455-1646           c
            1417-1761           AC098584.2         439-783             c
            1762-1849           AC105395.1         157875-157962       c
            1850-2018           AC105395.1         148379-148547       c
            2019-2252           AC105395.1         144482-144715       c
            2253-2402           AC105395.1         126798-126947       c
            2403-2567           AC105395.1         124648-124812       c
            2568-2746           AC105395.1         111905-112083       c
            2747-9642           AC105395.1         104255-111150       c
FEATURES             Location/Qualifiers
     source          1..9642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.3"
     gene            1..9642
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /note="unc-5 netrin receptor C"
                     /db_xref="GeneID:8633"
                     /db_xref="HGNC:HGNC:12569"
                     /db_xref="MIM:603610"
     exon            1..240
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2912
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /note="unc5 (C.elegans homolog) c; unc-5 homolog 3;
                     protein unc-5 homolog C; protein unc-5 homolog 3"
                     /codon_start=1
                     /product="netrin receptor UNC5C precursor"
                     /protein_id="NP_003719.3"
                     /db_xref="CCDS:CCDS3643.1"
                     /db_xref="GeneID:8633"
                     /db_xref="HGNC:HGNC:12569"
                     /db_xref="MIM:603610"
                     /translation="MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDD
                     FFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQ
                     KDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYV
                     RIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYI
                     TIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRC
                     GRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTH
                     WRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLA
                     ISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYR
                     GPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQS
                     LLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYE
                     MYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILL
                     KNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRL
                     KLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHN
                     LRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLC
                     VRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSL
                     DAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLE
                     EMGRHETVVSLAAEGQY"
     exon            241..462
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..606
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..710
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..891
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1059
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1224
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1416
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1761
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1849
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2018
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2252
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2402
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2567
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2746
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..9642
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9622..9627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /note="hexamer: ATTATA"
     polyA_site      9642
                     /gene="UNC5C"
                     /gene_synonym="UNC5H3"
                     /note="major polyA site"
ORIGIN      
        1 gttatttctt cggactgctt cgcggtgcac ggattcagct tctgcccagt ggggctttca
       61 gctgtttgcg cgtctctctg tccccctccc ctccccccgg cacacctctg tctacgatga
      121 ggaaaggtct gcgggcgaca gcggcccgct gcggactggg actgggatac ttgctgcaaa
      181 tgctcgtgct acctgccctg gccctgctca gcgccagcgg cactggctcc gccgcccaag
      241 atgatgactt ttttcatgaa ctcccagaaa cttttccttc tgatccacct gagcctctgc
      301 cacatttcct tattgagcct gaagaagctt atattgtgaa gaataagccc gtgaacctgt
      361 actgtaaagc aagccctgcc acccagatct atttcaagtg taatagtgaa tgggttcatc
      421 agaaggacca catagtagat gaaagagtag atgaaacttc cggtctcatt gtccgggaag
      481 tgagcattga gatttcgcgc cagcaagtgg aagaactctt tggacctgaa gattactggt
      541 gccagtgtgt ggcctggagc tccgcgggta ccacaaagag ccggaaggcg tatgtgcgca
      601 ttgcatatct acggaagaca tttgagcagg aacccctagg aaaggaagtg tctttggaac
      661 aggaagtctt actccagtgt cgaccacctg aagggatccc agtggctgag gtggaatggt
      721 tgaaaaatga agacataatt gatcccgttg aagatcggaa tttttatatt actattgatc
      781 acaacctcat cataaagcag gcccgactct ctgatactgc aaattacacc tgtgttgcca
      841 aaaacattgt tgccaagagg aaaagtacaa ctgccactgt catagtctat gtcaacggtg
      901 gctggtccac ctggacggag tggtctgtgt gtaacagccg ctgtggacga gggtatcaga
      961 aacgtacaag gacttgtacc aacccggcac cactcaatgg gggtgccttc tgtgaagggc
     1021 agagtgtgca gaaaatagcc tgtactacgt tatgcccagt ggatggcagg tggacgccat
     1081 ggagcaagtg gtctacttgt ggaactgagt gcacccactg gcgcaggagg gagtgcacgg
     1141 cgccagcccc caagaatgga ggcaaggact gcgacggcct cgtcttgcaa tccaagaact
     1201 gcactgatgg gctttgcatg cagactgctc ctgattcaga tgatgttgct ctctatgttg
     1261 ggattgtgat agcagtgatc gtttgcctgg cgatctctgt agttgtggcc ttgtttgtgt
     1321 atcggaagaa tcatcgtgac tttgagtcag atattattga ctcttcggca ctcaatgggg
     1381 gctttcagcc tgtgaacatc aaggcagcaa gacaagatct gctggctgta cccccagacc
     1441 tcacgtcagc tgcagccatg tacagaggac ctgtctatgc cctgcatgac gtctcagaca
     1501 aaatcccaat gaccaactct ccaattctgg atccactgcc caacctgaaa atcaaagtgt
     1561 acaacacctc aggtgctgtc accccccaag atgacctctc tgagtttacg tccaagctgt
     1621 cccctcagat gacccagtcg ttgttggaga atgaagccct cagcctgaag aaccagagtc
     1681 tagcaaggca gactgatcca tcctgtaccg catttggcag cttcaactcg ctgggaggtc
     1741 accttattgt tcccaattca ggagtcagct tgctgattcc cgctggggcc attccccaag
     1801 ggagagtcta cgaaatgtat gtgactgtac acaggaaaga aactatgagg ccacccatgg
     1861 atgactctca gacacttttg acccctgtgg tgagctgtgg gcccccagga gctctgctca
     1921 cccgcccagt cgtcctcact atgcatcact gcgcagaccc caataccgag gactggaaaa
     1981 tactgctcaa gaaccaggca gcacagggac agtgggagga tgtggtggtg gtcggggagg
     2041 aaaacttcac caccccctgc tacattcagc tggatgcaga ggcctgccac atcctcacag
     2101 agaacctcag cacctacgcc ctggtaggac attccaccac caaagcggct gcgaagcgcc
     2161 tcaagctggc catctttggg cccctgtgct gctcctcgct ggagtacagc atccgagtct
     2221 actgtctgga tgacacccag gatgccctga aggaaatttt acatcttgag agacagatgg
     2281 gaggacagct cctagaagaa cctaaggctc ttcattttaa aggcagcacc cacaacctgc
     2341 gcctgtcaat tcacgatatc gcccattccc tctggaagag caaattgctg gctaaatatc
     2401 aggaaattcc attttaccat gtttggagtg gatctcaaag aaacctgcac tgcaccttca
     2461 ctctggaaag atttagcctg aacacagtgg agctggtttg caaactctgt gtgcggcagg
     2521 tggaaggaga agggcagatc ttccagctca actgcaccgt gtcagaggaa cctactggca
     2581 tcgatttgcc gctgctggat cctgcgaaca ccatcaccac ggtcacgggg cccagtgctt
     2641 tcagcatccc tctccctatc cggcagaagc tctgtagcag cctggatgcc ccccagacga
     2701 gaggccatga ctggaggatg ctggcccata agctgaacct ggacaggtac ttgaattact
     2761 ttgccaccaa atccagccca actggcgtaa tcctggatct ttgggaagca cagaacttcc
     2821 cagatggaaa cctgagcatg ctggcagctg tcttggaaga aatgggaaga catgaaacgg
     2881 tggtgtcctt agcagcagaa gggcagtatt aaccaccatg ctggaagggg aaatgaagga
     2941 caaaaatgca cagggagtct gtggccgtcc aggtgaatca cagctgagga ggaaatccag
     3001 atgagaccaa tgcacttcac aggcaagact gcagcaggag ccagaaggaa aacagataca
     3061 actgcccatg tacatgccca ctttactcgg acatcatcac gggagttaag aaaaattgtg
     3121 taaatttgta ccttgaattt agctatcaac ctaattttcc tcttagttgg gctgtatgct
     3181 gtgtggtaca ggatcttaca gtttcctagg aaacgctttt tattgctatc cagatatatg
     3241 gataaacttt cttaacaaac ccaatttcta caaatgttgt ttacatcaaa ttggacaggg
     3301 atgcagacac tgtccatggc tcgttctatt tttgttcaaa tcatttgaag ttgaagctgt
     3361 ggacggtttg ttgtgtctat ttcagattag taatttacag agaaatcaca gacttttgct
     3421 acaaatcgtg tgcatcaagt gtctcagata atcctcccat cagtgttctg tttctagaac
     3481 ttgtagaacc agtgttactg tttgtatcag ggaagtggag aatctaagtg taaaaaagaa
     3541 ataactaaga ctcctattcc ttggagggac ccttctggtg ccctttggga ataaagctgt
     3601 agcactgcag ggaagacagt gattcatgtt caaccccaca aacaagcatt tttttcacaa
     3661 catgtgtgtt tgtttgtaat atgcaatatg aagtgttttt ttttaaaggt attattatta
     3721 tttacaggta ttctggtaaa atgatttttt taaatttcta tttttgttag cagtgctgtt
     3781 tgttagtatt tggttattga ctagacctgt cccacctttt cacctatcaa ggtgggtgtg
     3841 gtcatcagtt taattcaaca tgcatcactt ccttgacctt ttacctttcc cttattccac
     3901 cccagaaagg tgattgataa atgctgaatg gctttgtcag tctgttcctt cagcttgctc
     3961 aggcagggtc tttctttctc ctctgaggag tcttaaggag acgtgttctc tattaagttc
     4021 acttaatatt gccgttgtgt ggccccacgt cgactcccta tggtgctcta ctctagaggc
     4081 agtgtggttg gaggaatgga ctctaaactg gagatcaaga aaccagttct cattgtgggt
     4141 ctgtcactgt cttgttgcgc caccttgaga aagtcattta accacacgac ctcagtgtcc
     4201 tcactagaaa gtgaaagggt gggattagat catctccaag ttctgaaatg ctcaacttcc
     4261 accgtgatgc ctccagtctc attcatcagt ctgaagacca caatggactc tgacctggat
     4321 catcatttaa aaatcatcag ctggtctttt gcccaggcta tgttacgcct ttcaagtagt
     4381 tctgacaagg aagatgatta ttctaaccag cattatgatg ttgtttgttt ggcctgagtc
     4441 gctctgcatc attgcattat gctgttcact gagagatgac atccctttat tatcattttc
     4501 ttagcctctc ttgggatgcc cctgccccca gccttcctga ctggttgcaa attctgtttt
     4561 ttattattgt cttggcatct tgatatctag accactccta caagtttatc tggcagtagg
     4621 aacttggtgc atttttttct acgctacacc cccccaccct taatctttct ttgctgtcat
     4681 aatattcagt agcatttata aaagctgtct agttagctct ttaaaaactt ttgtcctgca
     4741 aaatgtttgt tagtcaacac actactttgt gtaaacaact attatgtttc cttgggacca
     4801 tcacaagctc tttaacaaac acaaggactc aattcattca gcaggtgggg attaaagaat
     4861 caaagcccag tagcaaaacc aaaactgaag aacaagcaga catgtgtatg aatcggaacc
     4921 tttagaacat gactgtggtt tacttttagg ctggaggcac acaagttgct gaacagactt
     4981 gaattataca tgtgcttcca tctttccatg tttccgctcc tattttggta gcatcttgag
     5041 attccttgat gcctccgcca tcctcatccc tgaggaactg ctgatacctt gctatggaac
     5101 ctcttctttc tttcatgctt tttattccgt atcttctgtt ttggacatac atacatatat
     5161 tctataaaat ctctctcagc ccaccccctg cattaggatt tccatattta aaatatttgt
     5221 acactgactg gggaagggag agattgcact ataaacaagt tcagtggatg tttgtagcaa
     5281 tgagtaaaac tgtattctaa attaaaaatc aaatatatat acacgcagtt atacacacac
     5341 attttttaaa aggaggagga ggaaagagag ctattgtcca ttcctacatt ttgaaataaa
     5401 cttgtcaaga ttacgcatca gtaccagggt tgtggaatca tctatggaaa tcaagaacta
     5461 gaatctgaac tgaatggtca aagaaacttc tatgcctagt gaaaactaga ggggagcaac
     5521 tatgtagcta tgaacatgaa tcaattccat aactgttact aaaaacttat tttgactaaa
     5581 aagtcaccaa cacagaacta ttgaacacaa acaggaattg tttgtcttac tgaagtcact
     5641 gagaaccctt ggggttcact tcagatgctt ttttggttca acttcccacc accagaaaag
     5701 ggaaaagtga ttgatttcgt gtgtgaggta ctcatctgtc agaaccctta atgtttccta
     5761 ttaagtgaat gacaacttcc atacatacac tatttatacc aaataatttt cactacaaat
     5821 tctgatttcc ttctcctttg gagtaaagta atagctgtta gattgctttc aaacttagaa
     5881 ggtccagata taacagttca tttcatagga agccacttca tcaaccattc tatgtgatac
     5941 atcctgcttc tttctacacc gctggagagg cagtttggct ggtttcattt ggatagaaaa
     6001 aactatcatt tgtgcatgct gccatctagt ggtgtacaac acaatctaac ctgagtttaa
     6061 tattcactag aatgtgtttg acgaagggaa tgaaaacctg tagagttcaa ggacctttat
     6121 gacaaacaga tgtagggaaa ttttcacttc aaatttataa ttttcttatt ctcacttttt
     6181 tttcatttgc atcactcatc tcaatattag gtcactgtga gcccagtaca tcaactcatt
     6241 catacacaac atatcttcag ttgcttcttg taacagaact atgtaaaatc tatataaaac
     6301 agtctttgaa gagttgtcat ttttaacact tatggttttc attggggttt gtatacttta
     6361 aatctccttt tagttcctta atatttatct ttggaaatgt aagaagtatc tgcttagaaa
     6421 gaaataagtc ttatatatgc gaatggaata ctatgtctag ggaagagaaa attggggttg
     6481 ttaatcaaag ggaagaaagc agcttctttt ctgctgaatt tgggaatcca aaggcagagg
     6541 tttcatcctg tttttatttt cttcttatca cactctttca agtttcctta atgtatctgg
     6601 aaggaataga agttggattc agaattgata actggcatgg tgatgacaaa cctgtgtaac
     6661 accaaggttc tcacagctaa cagctgtttc acaaacggca tcttccaaat gaacagtcac
     6721 ctctgctatg cagaaaaccc ccatcctgct gtgagcaagt taggctcttc aagaactgga
     6781 caacttttgg gtgaggtgtt caatatcaaa ctgcataatc attagccatt ttcatatata
     6841 ctattttata gatttaagtc tctcaactat caaaaagtag agcgattttc aggagaaaaa
     6901 agtcgtgggg actgagttca ggacaccctg aaactatgcg accagtaatt tttttaaggt
     6961 attttttcct acaagtaagg tatctgaaaa gtcaacgttt tgagggtgga atcaagactt
     7021 ttcacttctc ctggcaaaga gcaacaaggc tcttgtctcg tgtccttctg tgtgtctctg
     7081 tcaggatcac agcagctgtg ctcttggtct gcttactcct ctgtaatcca cgtatgcaga
     7141 agggagttaa taaggtgatc accatctccc cagaattcaa aggtctttgc ctctataagg
     7201 tctgccccta tggggccagg aaaatataaa cctatataag gacttgcaag agagcataaa
     7261 gaaggtagaa aaggtttact tgttgggttt tcaagccttc aagttgaatg agtcttagct
     7321 tttgctgggc agttgttctg gacaagtcat cagtttcatg tggagaactc agtgtaagcc
     7381 caaggctaat gaatgagagg ggtcccatgg aaacacagct gaaatgaaat gggactttat
     7441 ccatcttctt tgagaatgga agagcttttg tgaagcagta catcattgct caagataatg
     7501 gttgataagc attagatttt atagatctaa taaggaaaat attttattat ctcaagttaa
     7561 caaaacattt ttttacctct cgagtgcctc ataggaccaa ctattactct ttggctttta
     7621 tttttctttt tgtattattt ttatatattc tttaaccttg ctgagctagt attgactgaa
     7681 atctttagaa ctttgcctct gggcaatgaa gtaatgtttc tctaccctaa gatatctatt
     7741 tgtataatct ctggctgtaa tgatcacttt ggaagatttc ctttgcatct ctaattattt
     7801 ctttttaatg gaataaggca taagggggaa taaatatatt gtaaccaatg ttatgtaaac
     7861 ccatatccat acaggccagg aaagccaaat gaagtcattt ccagaattct agtgtgaaaa
     7921 acctattttt gaaaagtggg gagatggctt tgtgtagaac tgggtgggtt ttctctgcag
     7981 actaagtcta gccatgagct tccagatcct ttagttttat cagccttgtg cttaccccat
     8041 tttcataaat gctactttaa cagccagtct tcataagtca tggttcctag gttttcctgt
     8101 cacctcattg tattcatctg tggtaggata ttaacgggct cattcaacca aatgtaatgt
     8161 gtgcctcaga cctatttagc atggttgggg ggcatcagca ggacaaacca acaggtactc
     8221 cgcaagtgta ctggcacagc aagcccacca attattagca gctcttcatc agcctgctgt
     8281 ctactcagac gcttgcctac tgaagggacc tgtccagaga tcttctggaa tcccaggttg
     8341 ggaatctctg cagaatgtcg tgacagttgt ggcccaacta gcttctgagt agaaacaagg
     8401 aagctaccct gagatatagt cagctgccca cctgccatag tatttgctac tgaatgccag
     8461 ccttttaaca taccatttca gatttgtcct tcaacaaaaa tataaattgc aagtcatacc
     8521 atttaagggt cttttacaaa tatgtctaaa ttgtgtgtca tttttaagtt ccaaaggtct
     8581 actggactaa gtactatcag accagctgta gaacctgatg gcgctgatcc ggggtggaat
     8641 aaccctcagt actggtgtgt agaagatgaa ttgtaggcag gttttgctga tcagcagcct
     8701 aaggattgat gggctctctt ttggcctctg atcctgagca ctatggaggc agcatcagag
     8761 aatggggacc tgagctacat aggttctcaa tgttaaaaca actctgttcg gagtgacata
     8821 taagagcaag aaatctacag ctggtgtaaa atacctttgc cttttctatc ccgaaagtaa
     8881 caaatggcat ctgtacatgt aggggtaaaa actcagatgt ctactcctcc aggccatgga
     8941 caagaaaaag tacagcagtc agaacagtgg aacaagtgat ttgcattctc ttcttcacgc
     9001 tttcctagat ctgccattgg tagcgcagcc ctcgccctcc agacataatg catcgagccc
     9061 agttgcaggg aacatcactg tgtgtgtgtg atgtcatggt gttatatgtg ttgagtttaa
     9121 tgttgagctg aagcaagttg gtgaccttcc tctttgctct ttgtaaagaa gacaccaatg
     9181 tttgtcagag aaaaatcccc agcagtcgtg ttgaagaggc agtgtcatcc acctactgtc
     9241 ccctttggaa cagttcaact gcagaaaggt cggattgagg ttttgtgctt tgtcgttttt
     9301 cttttttaaa caaaacatga caaccttggc ttttccgata tggaacactt ttgttgttgt
     9361 ggagttccct cttgctgtat cttctatgca attccttttc taaaaaaacc ccccggcaga
     9421 ggcagagtgc cctccggata tctgtccggc gccttgctga gtggtggagg tgagggatac
     9481 cagctccggg tgtgcctctt ttctctccct ggctgccaat cctgattttc cctgcagtcc
     9541 ccttggtttg taaattgcct gcatttattc tgtcagccaa catgtacaaa atgtaagaaa
     9601 gaatttttaa acaggtaata aattatattt ataagcaaca aa
//
