LOCUS       NM_170744               6841 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens unc-5 netrin receptor B (UNC5B), transcript variant 1,
            mRNA.
ACCESSION   NM_170744
VERSION     NM_170744.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6841)
  AUTHORS   Vennela,J., Pottakkat,B., Vairappan,B.S., Verma,S.K. and
            Mukherjee,V.
  TITLE     Hepatic Expression of NTN4 and Its Receptors in Patients with
            Hepatocellular Carcinoma
  JOURNAL   Asian Pac J Cancer Prev 24 (12), 4285-4292 (2023)
   PUBMED   38156865
  REMARK    GeneRIF: Hepatic Expression of NTN4 and Its Receptors in Patients
            with Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6841)
  AUTHORS   Huang,L., An,X., Zhu,Y., Zhang,K., Xiao,L., Yao,X., Zeng,X.,
            Liang,S. and Yu,J.
  TITLE     Netrin-1 induces the anti-apoptotic and pro-survival effects of
            B-ALL cells through the Unc5b-MAPK axis
  JOURNAL   Cell Commun Signal 20 (1), 122 (2022)
   PUBMED   35974411
  REMARK    GeneRIF: Netrin-1 induces the anti-apoptotic and pro-survival
            effects of B-ALL cells through the Unc5b-MAPK axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6841)
  AUTHORS   Sun,Y., Manceau,A., Frydman,L., Cappuccio,L., Neves,D., Basso,V.,
            Wang,H., Fombonne,J., Maisse,C., Mehlen,P. and Paradisi,A.
  TITLE     Delta40p53 isoform up-regulates netrin-1/UNC5B expression and
            potentiates netrin-1 pro-oncogenic activity
  JOURNAL   Proc Natl Acad Sci U S A 118 (36) (2021)
   PUBMED   34470826
  REMARK    GeneRIF: Delta40p53 isoform up-regulates netrin-1/UNC5B expression
            and potentiates netrin-1 pro-oncogenic activity.
REFERENCE   4  (bases 1 to 6841)
  AUTHORS   Pradella,D., Deflorian,G., Pezzotta,A., Di Matteo,A., Belloni,E.,
            Campolungo,D., Paradisi,A., Bugatti,M., Vermi,W., Campioni,M.,
            Chiapparino,A., Scietti,L., Forneris,F., Giampietro,C., Volf,N.,
            Rehman,M., Zacchigna,S., Paronetto,M.P., Pistocchi,A., Eichmann,A.,
            Mehlen,P. and Ghigna,C.
  TITLE     A ligand-insensitive UNC5B splicing isoform regulates angiogenesis
            by promoting apoptosis
  JOURNAL   Nat Commun 12 (1), 4872 (2021)
   PUBMED   34381052
  REMARK    GeneRIF: A ligand-insensitive UNC5B splicing isoform regulates
            angiogenesis by promoting apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6841)
  AUTHORS   Yang,Z., Li,H., Luo,P., Yan,D., Yang,N., Zhang,Y., Huang,Y.,
            Liu,Y., Zhang,L., Yan,J. and Zhang,C.
  TITLE     UNC5B Promotes Vascular Endothelial Cell Senescence via the
            ROS-Mediated P53 Pathway
  JOURNAL   Oxid Med Cell Longev 2021, 5546711 (2021)
   PUBMED   34239689
  REMARK    GeneRIF: UNC5B Promotes Vascular Endothelial Cell Senescence via
            the ROS-Mediated P53 Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6841)
  AUTHORS   Llambi,F., Lourenco,F.C., Gozuacik,D., Guix,C., Pays,L., Del
            Rio,G., Kimchi,A. and Mehlen,P.
  TITLE     The dependence receptor UNC5H2 mediates apoptosis through
            DAP-kinase
  JOURNAL   EMBO J 24 (6), 1192-1201 (2005)
   PUBMED   15729359
REFERENCE   7  (bases 1 to 6841)
  AUTHORS   Thiebault,K., Mazelin,L., Pays,L., Llambi,F., Joly,M.O.,
            Scoazec,J.Y., Saurin,J.C., Romeo,G. and Mehlen,P.
  TITLE     The netrin-1 receptors UNC5H are putative tumor suppressors
            controlling cell death commitment
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4173-4178 (2003)
   PUBMED   12655055
  REMARK    GeneRIF: may represent tumor suppressor that inhibit tumor
            extension outside the region of netrin-1 availability by inducing
            apoptosis
REFERENCE   8  (bases 1 to 6841)
  AUTHORS   Tanikawa,C., Matsuda,K., Fukuda,S., Nakamura,Y. and Arakawa,H.
  TITLE     p53RDL1 regulates p53-dependent apoptosis
  JOURNAL   Nat Cell Biol 5 (3), 216-223 (2003)
   PUBMED   12598906
REFERENCE   9  (bases 1 to 6841)
  AUTHORS   Komatsuzaki,K., Dalvin,S. and Kinane,T.B.
  TITLE     Modulation of G(ialpha(2)) signaling by the axonal guidance
            molecule UNC5H2
  JOURNAL   Biochem Biophys Res Commun 297 (4), 898-905 (2002)
   PUBMED   12359238
  REMARK    GeneRIF: Modulation of G(ialpha(2)) signaling by the axonal
            guidance of this protein
REFERENCE   10 (bases 1 to 6841)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128132.1, AY358351.1, DA810535.1 and AL049370.1.
            
            On Nov 23, 2018 this sequence version replaced NM_170744.4.
            
            Summary: This gene encodes a member of the netrin family of
            receptors. This particular protein mediates the repulsive effect of
            netrin-1 and is a vascular netrin receptor. This encoded protein is
            also in a group of proteins called dependence receptors (DpRs)
            which are involved in pro- and anti-apoptotic processes. Many DpRs
            are involved in embryogenesis and in cancer progression. Two
            alternatively spliced transcript variants have been described for
            this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB096256.1, AK128132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335350.10/ ENSP00000334329.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1909              AK128132.1         36-1944
            1910-3608           AY358351.1         1891-3589
            3609-3898           AK128132.1         3644-3933
            3899-3910           DA810535.1         200-211
            3911-4150           DA810535.1         213-452
            4151-6841           AL049370.1         1-2691
FEATURES             Location/Qualifiers
     source          1..6841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..6841
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /note="unc-5 netrin receptor B"
                     /db_xref="GeneID:219699"
                     /db_xref="HGNC:HGNC:12568"
                     /db_xref="MIM:607870"
     exon            1..495
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..3254
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane receptor Unc5H2; netrin receptor
                     UNC5B; unc-5 homolog 2; protein unc-5 homolog B;
                     p53-regulated receptor for death and life protein 1;
                     protein unc-5 homolog 2"
                     /codon_start=1
                     /product="netrin receptor UNC5B isoform 1 precursor"
                     /protein_id="NP_734465.2"
                     /db_xref="CCDS:CCDS7309.1"
                     /db_xref="GeneID:219699"
                     /db_xref="HGNC:HGNC:12568"
                     /db_xref="MIM:607870"
                     /translation="MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPA
                     EPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATG
                     LRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPL
                     GKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLS
                     DTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNP
                     APLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNG
                     GRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILM
                     AVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAG
                     IYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPP
                     GTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLL
                     VPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPH
                     CAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVF
                     TGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVE
                     EPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLER
                     HSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAF
                     KIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQ
                     QDDGDLNSLASALEEMGKSEMLVAVATDGDC"
     exon            496..720
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..864
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..968
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1149
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1317
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1482
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1515
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1710
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2100
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2188
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2357
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2591
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2741
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2906
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3088
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..6841
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6818..6823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /note="hexamer: ATTATA"
     polyA_site      6841
                     /gene="UNC5B"
                     /gene_synonym="p53RDL1; UNC5H2"
                     /note="major polyA site"
ORIGIN      
        1 attgtggcag gcggctgggg ccggctaggg cgccggagcc gcacgcagcc gcggggctcc
       61 gagaggcgcg cactggggct gggactgcgc ggcgccgccg ctgcgagcgc cactgagcgg
      121 tcgcgcaact tcggaggcac agcgccggag ccaggcgagc gctcagagac ccggagccag
      181 aggggcgcgc cggagcctcg ttcgagagcc ggcgccaggc acccaccgcg ctccgagtgc
      241 caggcggccc tccgcgcagc gtggcttccg ctgcccccac ggaaggcacg ggctggcgct
      301 gccgggcgcc ggggaggacg gcgaggagga ggcggcggcg gcggagacgg cggcggcgag
      361 actggggcca gggagacagc cctgggggag aggcgcccga accaggccgc gggagcatgg
      421 gggcccggag cggagctcgg ggcgcgctgc tgctggcact gctgctctgc tgggacccga
      481 ggctgagcca agcaggcact gattctggca gcgaggtgct ccctgactcc ttcccgtcag
      541 cgccagcaga gccgctgccc tacttcctgc aggagccaca ggacgcctac attgtgaaga
      601 acaagcctgt ggagctccgc tgccgcgcct tccccgccac acagatctac ttcaagtgca
      661 acggcgagtg ggtcagccag aacgaccacg tcacacagga aggcctggat gaggccaccg
      721 gcctgcgggt gcgcgaggtg cagatcgagg tgtcgcggca gcaggtggag gagctctttg
      781 ggctggagga ttactggtgc cagtgcgtgg cctggagctc cgcgggcacc accaagagtc
      841 gccgagccta cgtccgcatc gcctacctgc gcaagaactt cgatcaggag cctctgggca
      901 aggaggtgcc cctggaccat gaggttctcc tgcagtgccg cccgccggag ggggtgcctg
      961 tggccgaggt ggaatggctc aagaatgagg atgtcatcga ccccacccag gacaccaact
     1021 tcctgctcac catcgaccac aacctcatca tccgccaggc ccgcctgtcg gacactgcca
     1081 actatacctg cgtggccaag aacatcgtgg ccaaacgccg gagcaccact gccaccgtca
     1141 tcgtctacgt gaatggcggc tggtccagct gggcagagtg gtcaccctgc tccaaccgct
     1201 gtggccgagg ctggcagaag cgcacccgga cctgcaccaa ccccgctcca ctcaacggag
     1261 gggccttctg cgagggccag gcattccaga agaccgcctg caccaccatc tgcccagtcg
     1321 atggggcgtg gacggagtgg agcaagtggt cagcctgcag cactgagtgt gcccactggc
     1381 gtagccgcga gtgcatggcg cccccacccc agaacggagg ccgtgactgc agcgggacgc
     1441 tgctcgactc taagaactgc acagatgggc tgtgcatgca aaataagaaa actctaagcg
     1501 accccaacag ccacctgctg gaggcctcag gggatgcggc gctgtatgcg gggctcgtgg
     1561 tggccatctt cgtggtcgtg gcaatcctca tggcggtggg ggtggtggtg taccgccgca
     1621 actgccgtga cttcgacaca gacatcactg actcatctgc tgccctgact ggtggtttcc
     1681 accccgtcaa ctttaagacg gcaaggccca gcaacccgca gctcctacac ccctctgtgc
     1741 ctcctgacct gacagccagc gccggcatct accgcggacc cgtgtatgcc ctgcaggact
     1801 ccaccgacaa aatccccatg accaactctc ctctgctgga ccccttaccc agccttaagg
     1861 tcaaggtcta cagctccagc accacgggct ctgggccagg cctggcagat ggggctgacc
     1921 tgctgggggt cttgccgcct ggcacatacc ctagcgattt cgcccgggac acccacttcc
     1981 tgcacctgcg cagcgccagc ctcggttccc agcagctctt gggcctgccc cgagacccag
     2041 ggagcagcgt cagcggcacc tttggctgcc tgggtgggag gctcagcatc cccggcacag
     2101 gggtcagctt gctggtgccc aatggagcca ttccccaggg caagttctac gagatgtatc
     2161 tactcatcaa caaggcagaa agtaccctcc cgctttcaga agggacccag acagtattga
     2221 gcccctcggt gacctgtgga cccacaggcc tcctgctgtg ccgccccgtc atcctcacca
     2281 tgccccactg tgccgaagtc agtgcccgtg actggatctt tcagctcaag acccaggccc
     2341 accagggcca ctgggaggag gtggtgaccc tggatgagga gaccctgaac acaccctgct
     2401 actgccagct ggagcccagg gcctgtcaca tcctgctgga ccagctgggc acctacgtgt
     2461 tcacgggcga gtcctattcc cgctcagcag tcaagcggct ccagctggcc gtcttcgccc
     2521 ccgccctctg cacctccctg gagtacagcc tccgggtcta ctgcctggag gacacgcctg
     2581 tagcactgaa ggaggtgctg gagctggagc ggactctggg cggatacttg gtggaggagc
     2641 cgaaaccgct aatgttcaag gacagttacc acaacctgcg cctctccctc catgacctcc
     2701 cccatgccca ttggaggagc aagctgctgg ccaaatacca ggagatcccc ttctatcaca
     2761 tttggagtgg cagccagaag gccctccact gcactttcac cctggagagg cacagcttgg
     2821 cctccacaga gctcacctgc aagatctgcg tgcggcaagt ggaaggggag ggccagatat
     2881 tccagctgca taccactctg gcagagacac ctgctggctc cctggacact ctctgctctg
     2941 cccctggcag cactgtcacc acccagctgg gaccttatgc cttcaagatc ccactgtcca
     3001 tccgccagaa gatatgcaac agcctagatg cccccaactc acggggcaat gactggcgga
     3061 tgttagcaca gaagctctct atggaccggt acctgaatta ctttgccacc aaagcgagcc
     3121 ccacgggtgt gatcctggac ctctgggaag ctctgcagca ggacgatggg gacctcaaca
     3181 gcctggcgag tgccttggag gagatgggca agagtgagat gctggtggct gtggccaccg
     3241 acggggactg ctgagcctcc tgggacagcg ggctggcagg gactggcagg aggcaggtgc
     3301 agggaggcct ggggcagcct cctgatgggg atgtttggcc tctgcttcct cccagttcac
     3361 agccagagtt gcctctcctc ctcctcttcc ccaaccccca gaccatgacc agccttagaa
     3421 aatccatgta ctctgttgtt agagggccca gagttccttc tccacccccg ctctctctct
     3481 cttggcctga gatctctgtg caggaaccaa gatggggctg aagcctctgg aggcagttgg
     3541 ttgggggcgg gcaggcagga ggccctccct ccaccccccc accctcagcc cggcaacttc
     3601 tgggttccat gggttttagt tccgttctcg ttttcttcct ccgttattga tttctccttt
     3661 ctccctaagc ccccttctgc ttccacgccc ttttcctctt tgaagagtca agtacaattc
     3721 agacaaactg ctttctcctg tccaaaagca aaaaggcaaa ggaaagaaag aaagcttcag
     3781 accgctagta aggctcaaag aagaagaaaa acaccaaaac cacaagggaa aagaaaaacc
     3841 cagtttctta ggaaacgcaa acgatttatt atccagatta tttggataag tcctttttaa
     3901 gaaaaaaaaa gaaaatgaaa aacaacacaa aaaaaataga aaactctttt cttgagtgtg
     3961 gatgagaatg ggcacgctca cacttctggc caggagtgaa tgtgcctgtg tgtgtgtgtg
     4021 tgtgtgtgtg tgtgtgtgta catgtacgcg tgtgcattga ggagagagag actgaacaga
     4081 gagtactttg ctgctaacga atccatcttg gactaaattc tgacaaggcc tcagtttccc
     4141 cagttgtgca gggagtaggt cagacagggt tttcactgtc tagatttagc tggttagatt
     4201 ttcctctaaa atcttaagca gatgctgaat ccataaagcc aaggagtgct gagggctgga
     4261 gtgggtgggc cctccctccc acagccccag ggagatacat ctggactcct gggaatctgg
     4321 attaagaaag ttgggatgaa agaggaggac tgctcaggcc agttgtgagc cagggagaat
     4381 gttccagtct ggttttggtc tggtggctcc tagaaaggga tgtggcccag aagtgggact
     4441 caaacagaga gatgaagtag gggaggggag tcctccacgg gcatctctct cctggcggct
     4501 ggatagcttt accctagggt ggggccagcc ctgacaccct catcccctcc tcagcccagc
     4561 agcctctaga gcagcgtggt gctctcttga tggccaggaa tccagaatct gcccttcccc
     4621 aaccttggtt tctccttctg taaagcagag tgatggctga gaagtcctct ctagctgcag
     4681 aagcctgagc ttcccggtgt cagtcagctc tgcaacgtgg gagccttgga ggcgggtggc
     4741 ctggctgtgc ttcatatgcc caggagtgga gaaggaggct gagaagctgg tttcccagct
     4801 ctgatctcca caggcacctc ctataaccct cctctcaccc accccgctac ggtctgagag
     4861 atctgaaata acctttccca gtgggcaggg ttgccagggt tgaggggaca gcacatacca
     4921 cccccaccca acctgttcga ggggccctgc atggcacggg atgagtccct gccctgtgca
     4981 gctgcctggc agtggctggg acaaggatct tgcagccagc acagaggcct cttcaaaggc
     5041 ctctccctct tggcactcca ggcaaggcag gtgcccgctt ccccaacacc tccaggcagt
     5101 gaccctaggg catgccccag caggtctccg agcagccact gggacccgtc tcagcacatc
     5161 ctggcctttg aaagtctgat atcctgagag gagggcaggt tttagggccg cagttccagc
     5221 cagcgtcccc agcctggctt ccctgccatg gactcagtag ctcgtggggc ttcttaccac
     5281 ccaccagccc cgctggggtg cggcctggct gtgggcaaag gaggacttgc ctggagattt
     5341 gagagaagat tccttctacc agggctgctg aggggccagg cctgcatcag gggctaggct
     5401 ctggctgggc ccggaggctg agactaaggc tttcgaccct ggtgcctcca tgtggatgct
     5461 gcctcagaca aaggcagtga gccttccctg ccaaagtgcc catcccatgg gctcggcctc
     5521 actggtcact gttagcccat gaacacgtgt gggcctcggt cacgtggctt tgagggcagt
     5581 ctgaccaggc tagaccacac gtgccgtgac agggggtgcc attcccctcg caggctctaa
     5641 tgtgcccaca tgtagcctgg cagtccaaag accaagaatc aacttgcaaa tctgccatta
     5701 aactgctgtg cgacttcagg catatcactg ccttctctgg gcttcagtgt ccttttcata
     5761 cctagaagtc tgcggtctga ggctctttgg gttcagacac actgttctag gcttctgtag
     5821 gggaccttgt gatctgccgt gcccctcctc cctgttcttt tctgtcctcc ccaccccacc
     5881 ctcagaagct gcttgctctg cccccaggac aggagcttga cggatgaagt gcagccagcc
     5941 acccaggtgc catttccagt ctgacttcca gaaatgtgca ccatgtccta gagcacagac
     6001 ccattggctg gagcctcctg ggagggttca aaccatcagc tctatgagaa atgcccagaa
     6061 aggctttgcc gactccatcc gtctgtggag gctgcctgcc tccggggtgg gatgggtggt
     6121 ttctcctcca attcagaccc aagaggtagc ccccgagggc atgtacctgg tgggaagcag
     6181 ctcaggtacc cttgggggtt gcagggccct tacgcaggta tttctctctc tctcctctct
     6241 ggggtgcgtg tgtgcgtgcg cgtgtgcgtg cctatgcttt tctctgtggg cacatcagga
     6301 tgcccctcgg agagcatgtg cacgtgtccc cacctgagcg agcgtgtgtg tgtgctcctc
     6361 tgcgtcccag gtttggacgt ctagggtttg gtgtgcctgt cttctgccct ccctgagccc
     6421 acagggtcag tcaatgtatc ttctacgtgc ctctccctct gccttctctc acagtgcccc
     6481 cggctccaga gctcaggggt aggggttctc ctgagggtgc aggggatcct tctcatctcc
     6541 tggaccctcc agggcactct ggtccctatt ccccagctcc taggcagctg agccgggtcc
     6601 cttaggggag gtgaccagga gctttggtgc agggagctct tggtggggca aagggctgga
     6661 cccctgccag gtctgtggac atggttatat gcccgggaga ggggggtgca gggccccagg
     6721 gatggccccc aatcccacct ctgtttattc tgtaaactgc aacctataaa taacctttag
     6781 cattcctatt gtaacaaaat taatttttat gaaataaatt atatttccta gtctaataaa
     6841 a
//
