LOCUS       NM_133369               3733 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens unc-5 netrin receptor A (UNC5A), mRNA.
ACCESSION   NM_133369 XM_030300
VERSION     NM_133369.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3733)
  AUTHORS   Padua,M.B., Bhat-Nakshatri,P., Anjanappa,M., Prasad,M.S., Hao,Y.,
            Rao,X., Liu,S., Wan,J., Liu,Y., McElyea,K., Jacobsen,M.,
            Sandusky,G., Althouse,S., Perkins,S. and Nakshatri,H.
  TITLE     Dependence receptor UNC5A restricts luminal to basal breast cancer
            plasticity and metastasis
  JOURNAL   Breast Cancer Res 20 (1), 35 (2018)
   PUBMED   29720215
  REMARK    GeneRIF: These studies reveal an unexpected role of the axon
            guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling
            and the luminal progenitor status of hormone-sensitive breast
            cancers. Furthermore, UNC5A knockdown cells provide an ideal model
            system to investigate metastasis of ERalpha(+) breast cancers
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3733)
  AUTHORS   Barnault,R., Lahlali,T., Plissonnier,M.L., Romero-Lopez,C.,
            Laverdure,N., Ducarouge,B., Rivoire,M., Mehlen,P., Zoulim,F. and
            Parent,R.
  TITLE     Hepatocellular carcinoma-associated depletion of the netrin-1
            receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic
            unfolded protein response towards prosurvival outcomes
  JOURNAL   Biochem Biophys Res Commun 495 (4), 2425-2431 (2018)
   PUBMED   29277614
  REMARK    GeneRIF: Such data indicate that cooperation between the UPR and
            UNC5A depletion as previously observed by ourselves in HCC patients
            samples may foster liver cancer development and growth.
REFERENCE   3  (bases 1 to 3733)
  AUTHORS   Plissonnier,M.L., Lahlali,T., Raab,M., Michelet,M.,
            Romero-Lopez,C., Rivoire,M., Strebhardt,K., Durantel,D.,
            Levrero,M., Mehlen,P., Zoulim,F. and Parent,R.
  TITLE     Reciprocal antagonism between the netrin-1 receptor
            uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus
  JOURNAL   Oncogene 36 (48), 6712-6724 (2017)
   PUBMED   28783179
  REMARK    GeneRIF: UNC5A is capable of impeding autophagy and promoting HCV
            restriction through specific impact on virion infectivity, in a
            cell death-independent and DAPK-related manner.
REFERENCE   4  (bases 1 to 3733)
  AUTHORS   Chen,J.Y., He,X.X., Ma,C., Wu,X.M., Wan,X.L., Xing,Z.K., Pei,Q.Q.,
            Dong,X.P., Liu,D.X., Xiong,W.C. and Zhu,X.J.
  TITLE     Netrin-1 promotes glioma growth by activating NF-kappaB via UNC5A
  JOURNAL   Sci Rep 7 (1), 5454 (2017)
   PUBMED   28710382
  REMARK    GeneRIF: The results suggest that netrin-1 promotes glioma cell
            proliferation by activating NF-kappaB signaling via UNC5A.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3733)
  AUTHORS   Zhu,Y., Yu,M., Chen,Y., Wang,Y., Wang,J., Yang,C. and Bi,J.
  TITLE     DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor
            in bladder cancer
  JOURNAL   Tumour Biol 35 (7), 6887-6891 (2014)
   PUBMED   24737586
  REMARK    GeneRIF: these data suggest an important role for UNC5A, a
            candidate tumor suppressor, in predicting response to DNA damage
            induced by chemotherapeutic drug and regulating cell death in
            bladder cancer
REFERENCE   6  (bases 1 to 3733)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3733)
  AUTHORS   Qin,S., Yu,L., Gao,Y., Zhou,R. and Zhang,C.
  TITLE     Characterization of the receptors for axon guidance factor netrin-4
            and identification of the binding domains
  JOURNAL   Mol Cell Neurosci 34 (2), 243-250 (2007)
   PUBMED   17174565
REFERENCE   8  (bases 1 to 3733)
  AUTHORS   Arakawa,H.
  TITLE     Netrin-1 and its receptors in tumorigenesis
  JOURNAL   Nat Rev Cancer 4 (12), 978-987 (2004)
   PUBMED   15573119
  REMARK    GeneRIF: UNC5 orthologues define a new mechanism for both the
            positive (induction) and negative (suppression) regulation of
            apoptosis in cancer cells (review)
            Review article
REFERENCE   9  (bases 1 to 3733)
  AUTHORS   Thiebault,K., Mazelin,L., Pays,L., Llambi,F., Joly,M.O.,
            Scoazec,J.Y., Saurin,J.C., Romeo,G. and Mehlen,P.
  TITLE     The netrin-1 receptors UNC5H are putative tumor suppressors
            controlling cell death commitment
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4173-4178 (2003)
   PUBMED   12655055
  REMARK    GeneRIF: may represent tumor suppressor that inhibit tumor
            extension outside the region of netrin-1 availability by inducing
            apoptosis
REFERENCE   10 (bases 1 to 3733)
  AUTHORS   Tanikawa,C., Matsuda,K., Fukuda,S., Nakamura,Y. and Arakawa,H.
  TITLE     p53RDL1 regulates p53-dependent apoptosis
  JOURNAL   Nat Cell Biol 5 (3), 216-223 (2003)
   PUBMED   12598906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091902.2, BI818609.1, BC033727.1, BC009333.2 and BM712478.1.
            
            On Nov 23, 2018 this sequence version replaced NM_133369.2.
            
            Summary: UNC5A belongs to a family of netrin-1 (MIM 601614)
            receptors thought to mediate the chemorepulsive effect of netrin-1
            on specific axons. For more information on UNC5 proteins, see UNC5C
            (MIM 603610).[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157824.1, ERR3218376.108601.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329542.9/ ENSP00000332737.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC091902.2         145356-145544
            190-880             BI818609.1         1-691
            881-1404            BC033727.1         1009-1532
            1405-3337           BC009333.2         311-2243
            3338-3733           BM712478.1         34-429
FEATURES             Location/Qualifiers
     source          1..3733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..3733
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /note="unc-5 netrin receptor A"
                     /db_xref="GeneID:90249"
                     /db_xref="HGNC:HGNC:12567"
                     /db_xref="MIM:607869"
     exon            1..262
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2721
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /note="unc5 (C.elegans homolog) a; netrin receptor UNC5A;
                     netrin receptor Unc5h1; unc-5 homolog 1; protein unc-5
                     homolog A; protein unc-5 homolog 1"
                     /codon_start=1
                     /product="netrin receptor UNC5A precursor"
                     /protein_id="NP_588610.2"
                     /db_xref="CCDS:CCDS34299.1"
                     /db_xref="GeneID:90249"
                     /db_xref="HGNC:HGNC:12567"
                     /db_xref="MIM:607869"
                     /translation="MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLP
                     HFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM
                     EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEV
                     SLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN
                     YTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGE
                     ECQGTDLDTRNCTSDLCVHTASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGL
                     DSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKF
                     QLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFL
                     GGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPP
                     GVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEAS
                     ACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKE
                     VVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWN
                     GTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALES
                     EAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPS
                     PTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC"
     exon            263..484
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..628
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..732
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..913
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1078
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1267
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1570
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1658
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1827
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2061
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2211
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2376
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2555
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..3733
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /note="hexamer: ATTATA"
     polyA_site      3733
                     /gene="UNC5A"
                     /gene_synonym="UNC5H1"
                     /note="major polyA site"
ORIGIN      
        1 gcattgctgc gctcccgtgc ccaagggagc cacgcgccgc gtgcgcccgg cagccggccg
       61 cccggaggca gcgcagtccg ctggcatggg ccccgggggc gccccgagct ggggctccgg
      121 gctgaggcgc taaagccgcc ctcccgcccg cggggccccg cgcccggccc gcccgcctgc
      181 ccgcccgcgg ccatggccgt ccggcccggc ctgtggccag cgctcctggg catagtcctc
      241 gccgcttggc tccgcggctc gggtgcccag cagagtgcca ccgtggccaa cccagtgcct
      301 ggtgccaacc cggacctgct tccccacttc ctggtggagc ccgaggatgt gtacatcgtc
      361 aagaacaagc cagtgctgct tgtgtgcaag gccgtgcccg ccacgcagat cttcttcaag
      421 tgcaacgggg agtgggtgcg ccaggtggac cacgtgatcg agcgcagcac agacgggagc
      481 agtgggctgc ccaccatgga ggtccgcatt aatgtctcaa ggcagcaggt cgagaaggtg
      541 ttcgggctgg aggaatactg gtgccagtgc gtggcatgga gctcctcggg caccaccaag
      601 agtcagaagg cctacatccg catagcctat ttgcgcaaga acttcgagca ggagccgctg
      661 gccaaggagg tgtccctgga gcagggcatc gtgctgccct gccgtccacc ggagggcatc
      721 cctccagccg aggtggagtg gctccggaac gaggacctgg tggacccgtc cctggacccc
      781 aatgtataca tcacgcggga gcacagcctg gtggtgcgac aggcccgcct tgctgacacg
      841 gccaactaca cctgcgtggc caagaacatc gtggcacgtc gccgcagcgc ctccgctgct
      901 gtcatcgtct acgtggacgg cagctggagc ccgtggagca agtggtcggc ctgtgggctg
      961 gactgcaccc actggcggag ccgtgagtgc tctgacccag caccccgcaa cggaggggag
     1021 gagtgccagg gcactgacct ggacacccgc aactgtacca gtgacctctg tgtacacact
     1081 gcttctggcc ctgaggacgt ggccctctat gtgggcctca tcgccgtggc cgtctgcctg
     1141 gtcctgctgc tgcttgtcct catcctcgtt tattgccgga agaaggaggg gctggactca
     1201 gatgtggctg actcgtccat tctcacctca ggcttccagc ccgtcagcat caagcccagc
     1261 aaagcagaca acccccatct gctcaccatc cagccggacc tcagcaccac caccaccacc
     1321 taccagggca gtctctgtcc ccggcaggat gggcccagcc ccaagttcca gctcaccaat
     1381 gggcacctgc tcagccccct gggtggcggc cgccacacac tgcaccacag ctctcccacc
     1441 tctgaggccg aggagttcgt ctcccgcctc tccacccaga actacttccg ctccctgccc
     1501 cgaggcacca gcaacatgac ctatgggacc ttcaacttcc tcgggggccg gctgatgatc
     1561 cctaatacag gaatcagcct cctcatcccc ccagatgcca taccccgagg gaagatctat
     1621 gagatctacc tcacgctgca caagccggaa gacgtgaggt tgcccctagc tggctgtcag
     1681 accctgctga gtcccatcgt tagctgtgga ccccctggcg tcctgctcac ccggccagtc
     1741 atcctggcta tggaccactg tggggagccc agccctgaca gctggagcct gcgcctcaaa
     1801 aagcagtcgt gcgagggcag ctgggaggat gtgctgcacc tgggcgagga ggcgccctcc
     1861 cacctctact actgccagct ggaggccagt gcctgctacg tcttcaccga gcagctgggc
     1921 cgctttgccc tggtgggaga ggccctcagc gtggctgccg ccaagcgcct caagctgctt
     1981 ctgtttgcgc cggtggcctg cacctccctc gagtacaaca tccgggtcta ctgcctgcat
     2041 gacacccacg atgcactcaa ggaggtggtg cagctggaga agcagctggg gggacagctg
     2101 atccaggagc cacgggtcct gcacttcaag gacagttacc acaacctgcg cctatccatc
     2161 cacgatgtgc ccagctccct gtggaagagt aagctccttg tcagctacca ggagatcccc
     2221 ttttatcaca tctggaatgg cacgcagcgg tacttgcact gcaccttcac cctggagcgt
     2281 gtcagcccca gcactagtga cctggcctgc aagctgtggg tgtggcaggt ggagggcgac
     2341 gggcagagct tcagcatcaa cttcaacatc accaaggaca caaggtttgc tgagctgctg
     2401 gctctggaga gtgaagcggg ggtcccagcc ctggtgggcc ccagtgcctt caagatcccc
     2461 ttcctcattc ggcagaagat aatttccagc ctggacccac cctgtaggcg gggtgccgac
     2521 tggcggactc tggcccagaa actccacctg gacagccatc tcagcttctt tgcctccaag
     2581 cccagcccca cagccatgat cctcaacctg tgggaggcgc ggcacttccc caacggcaac
     2641 ctcagccagc tggctgcagc agtggctgga ctgggccagc cagacgctgg cctcttcaca
     2701 gtgtcggagg ctgagtgctg aggccggcca ggcccgacac ctacactctc accagctttg
     2761 gcacccacca aggacaggca gaagccggac aggggccctt ccccacaccg gggagagctg
     2821 ctcggacagg ccccctcccg gccgaagctg tcccttaatg ctggtccttc agaccctgcc
     2881 cgaactccca cctctccatg gcctgcctag ccaggctggc actgccactc acactcggcc
     2941 ccagggccca ggagggacag tgcctggagc ctgggccagg cccagcccat ctgtgtgtgt
     3001 gtatgtgcgt gtgatgctac ctctcctccc gtccctctcc aggggccccg catacacacg
     3061 gccatgcacg cacacactgg gcctgggcca gggccccaga gctcctgcct gagctggacc
     3121 ttatgcaaac atttctgtgc ctgctgggta ggggcacgtc tgaggggccc tgctccaagc
     3181 ctgcaggacc gagggccaca gccggacagg gggtagcccc tggattcagg cacacgacca
     3241 ccacacgagc acgtgccacg catgcctcgt gtgctcatct cacacacacc cccctcccgg
     3301 gtcacgcaga caccccccaa ccacacacat ctcatgctgt acacctgagg ctgctcacgt
     3361 ctcacgccca gtgttggtgc acatttgcct ctcacatgct gccctctcca cccacccagg
     3421 gacaccccac ggctcctccc tgcccctgcc cctcccccag ccttgaggtg ccctgcccgg
     3481 cggggcctgt gaatatgcaa tgggagtccc aggctgtaca gtggtgagtg tgtgtgtggc
     3541 gtggcgtgcc cgtccccagg gctggctggt gccccacgcg gggcctgtca tgtgaagctc
     3601 gtgtcctgac tttgtcttaa gtgcattcac gcacttactc ttggccttat gtacacagcc
     3661 ttgcccggcc gccggggcac ataggggttt tatcgggcgt gaatgtaaat aaattatata
     3721 tatatattgc taa
//
