LOCUS       NM_001267052            5668 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens unc-45 myosin chaperone B (UNC45B), transcript variant
            3, mRNA.
ACCESSION   NM_001267052
VERSION     NM_001267052.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5668)
  AUTHORS   Lu,S.H., Wu,Y.H., Su,L.Y., Hsu,Z.T., Weng,T.H., Wang,H.Y., Yu,C.,
            Hsu,P.W. and Tsai,S.Y.
  TITLE     Cardiac myofibrillogenesis is spatiotemporally modulated by the
            molecular chaperone UNC45B
  JOURNAL   Stem Cell Reports 18 (7), 1405-1420 (2023)
   PUBMED   37295424
  REMARK    GeneRIF: Cardiac myofibrillogenesis is spatiotemporally modulated
            by the molecular chaperone UNC45B.
REFERENCE   2  (bases 1 to 5668)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5668)
  AUTHORS   Donkervoort,S., Kutzner,C.E., Hu,Y., Lornage,X., Rendu,J.,
            Stojkovic,T., Baets,J., Neuhaus,S.B., Tanboon,J., Maroofian,R.,
            Bolduc,V., Mroczek,M., Conijn,S., Kuntz,N.L., Topf,A., Monges,S.,
            Lubieniecki,F., McCarty,R.M., Chao,K.R., Governali,S., Bohm,J.,
            Boonyapisit,K., Malfatti,E., Sangruchi,T., Horkayne-Szakaly,I.,
            Hedberg-Oldfors,C., Efthymiou,S., Noguchi,S., Djeddi,S., Iida,A.,
            di Rosa,G., Fiorillo,C., Salpietro,V., Darin,N., Faure,J.,
            Houlden,H., Oldfors,A., Nishino,I., de Ridder,W., Straub,V.,
            Pokrzywa,W., Laporte,J., Foley,A.R., Romero,N.B., Ottenheijm,C.,
            Hoppe,T. and Bonnemann,C.G.
  TITLE     Pathogenic Variants in the Myosin Chaperone UNC-45B Cause
            Progressive Myopathy with Eccentric Cores
  JOURNAL   Am J Hum Genet 107 (6), 1078-1095 (2020)
   PUBMED   33217308
  REMARK    GeneRIF: Pathogenic Variants in the Myosin Chaperone UNC-45B Cause
            Progressive Myopathy with Eccentric Cores.
REFERENCE   4  (bases 1 to 5668)
  AUTHORS   Bujalowski,P.J., Nicholls,P., Barral,J.M. and Oberhauser,A.F.
  TITLE     Thermally-induced structural changes in an armadillo repeat protein
            suggest a novel thermosensor mechanism in a molecular chaperone
  JOURNAL   FEBS Lett 589 (1), 123-130 (2015)
   PUBMED   25436418
  REMARK    GeneRIF: temperature-dependent structural changes in the UCS
            chaperone domain of UNC-45B that occur within a physiologically
            relevant heat-shock range.
REFERENCE   5  (bases 1 to 5668)
  AUTHORS   Ni,W. and Odunuga,O.O.
  TITLE     UCS proteins: chaperones for myosin and co-chaperones for Hsp90
  JOURNAL   Subcell Biochem 78, 133-152 (2015)
   PUBMED   25487020
  REMARK    Review article
REFERENCE   6  (bases 1 to 5668)
  AUTHORS   Hansen,L., Comyn,S., Mang,Y., Lind-Thomsen,A., Myhre,L., Jean,F.,
            Eiberg,H., Tommerup,N., Rosenberg,T. and Pilgrim,D.
  TITLE     The myosin chaperone UNC45B is involved in lens development and
            autosomal dominant juvenile cataract
  JOURNAL   Eur J Hum Genet 22 (11), 1290-1297 (2014)
   PUBMED   24549050
  REMARK    GeneRIF: We have characterized a human UNC45B mutation in a Danish
            family with autosomal dominant cataract developing in early
            childhood.
REFERENCE   7  (bases 1 to 5668)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   8  (bases 1 to 5668)
  AUTHORS   Fratev,F., Osk Jonsdottir,S. and Pajeva,I.
  TITLE     Structural insight into the UNC-45-myosin complex
  JOURNAL   Proteins 81 (7), 1212-1221 (2013)
   PUBMED   23408646
REFERENCE   9  (bases 1 to 5668)
  AUTHORS   Price,M.G., Landsverk,M.L., Barral,J.M. and Epstein,H.F.
  TITLE     Two mammalian UNC-45 isoforms are related to distinct cytoskeletal
            and muscle-specific functions
  JOURNAL   J Cell Sci 115 (Pt 21), 4013-4023 (2002)
   PUBMED   12356907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647642.1, AL833281.1 and
            AL832355.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001267052.1.
            
            Summary: This gene encodes a co-chaperone required for folding and
            accumulation of type II myosins. The protein consists of three
            tetratricopeptide repeat motifs at the N-terminus that form a
            complex with heat shock protein 90, a central region of unknown
            function that is conserved in all Unc-45 proteins, and a C-terminal
            Unc-45/Cro1/She4 domain. The protein is expressed at high levels in
            striated muscle, where its muscle myosin chaperone activity is
            dependent on heat shock protein 90 acting as a co-chaperone. A
            missense mutation in this gene has been associated with cataract
            development. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site compared to variant 1. It encodes
            isoform 2, which is shorter than isoform 1. Variants 2 and 3 encode
            the same isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833281.1, SRR1803614.155878.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394570.7/ ENSP00000378071.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BX647642.1         1-24
            25-1881             AL833281.1         1-1857
            1882-2070           AL832355.1         1879-2067
            2071-2708           BX647642.1         2074-2711
            2709-4811           AL832355.1         2706-4808
            4812-5668           AL832355.1         4811-5667
FEATURES             Location/Qualifiers
     source          1..5668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..5668
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="unc-45 myosin chaperone B"
                     /db_xref="GeneID:146862"
                     /db_xref="HGNC:HGNC:14304"
                     /db_xref="MIM:611220"
     exon            1..94
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2884
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="isoform 2 is encoded by transcript variant 3;
                     protein unc-45 homolog B; striated muscle UNC45;
                     cardiomyopathy associated 4"
                     /codon_start=1
                     /product="protein unc-45 homolog B isoform 2"
                     /protein_id="NP_001253981.1"
                     /db_xref="CCDS:CCDS45648.1"
                     /db_xref="GeneID:146862"
                     /db_xref="HGNC:HGNC:14304"
                     /db_xref="MIM:611220"
                     /translation="MAEVEAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLAT
                     LYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQR
                     CATLEPRNQNFQEMLRRLNTSIQEKLRVQFSTDSRVQKMFEILLDENSEADKREKAAN
                     NLIVLGREEAGAEKIFQNNGVALLLQLLDTKKPELVLAAVRTLSGMCSGHQARATVIL
                     HAVRIDRICSLMAVENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLK
                     QITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKV
                     VGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITGKFDPQDM
                     DKNLNAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHAST
                     KLSRATFIITNGVSLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGTDYGLRQFAEGSTE
                     KLAKQCRKWLCNMSIDTRTRRWAVEGLAYLTLDADVKDDFVQDVPALQAMFELAKTSD
                     KTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLL
                     KAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLAL
                     EGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
                     LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLA
                     DGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCL
                     HDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARE
                     CLIKCMDYGFIKPVS"
     exon            95..262
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            263..299
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            300..475
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            476..565
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            566..733
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            734..902
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1073
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1245
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1546
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1641
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1783
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1924
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2052
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2119
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2233
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2349
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2467
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2623
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..5668
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="hexamer: TATAAA"
     polyA_site      3288
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="major polyA site"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="hexamer: AATAAA"
     polyA_site      4616
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="major polyA site"
     regulatory      5644..5649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
                     /note="hexamer: AATAAA"
     polyA_site      5668
                     /gene="UNC45B"
                     /gene_synonym="CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B;
                     UNC45"
ORIGIN      
        1 agactgaggc tggctggctg gaggttgaca caggagtgct caggggagca gcatcacaag
       61 agggcagatc gaaagcatcg tccttgctga aaaaatggca gaggtggaag cggtacagct
      121 gaaggaggaa ggaaaccggc atttccagct ccaggactac aaggccgcca caaatagcta
      181 cagccaggcc ctgaagctga ccaaggacaa ggccctgctg gccacgcttt atcggaaccg
      241 ggcagcctgt ggcctgaaaa cggagagcta cgtccaggca gcttcagatg cctccagagc
      301 catcgacatc aactcctcgg acatcaaggc tctgtatcgg cgatgccagg cactggagca
      361 cctggggaag ctggaccagg ccttcaaaga cgtgcagcgt tgtgccaccc tcgagccacg
      421 gaaccagaac ttccaggaga tgctgaggag actcaacacc agcattcagg agaagctccg
      481 agtgcagttc tccacagact cgagggtaca gaagatgttt gagatcctct tggatgaaaa
      541 cagtgaggct gataagcggg aaaaggctgc caacaatctc attgtcctag gccgtgagga
      601 agcaggggct gagaagatct tccagaacaa tggagtagcc ttgctactgc agcttctgga
      661 cactaagaag cctgagctgg tgctggctgc agtgcggacc ctgtcgggca tgtgcagcgg
      721 ccaccaagcc agagccacag tgattctgca tgcagtgcgg atagaccgaa tctgtagcct
      781 catggccgtg gagaatgagg agatgtctct ggctgtctgc aacctgctcc aagccatcat
      841 tgactccttg tctggggagg acaagcggga gcatcgaggg aaggaggagg ccctggttct
      901 agacaccaag aaggacctga agcagatcac cagccacctg ctggacatgc tagtcagcaa
      961 gaaggtgtct ggccagggca gggatcaggc gctgaacctg ctcaataaga atgttcccag
     1021 gaaggacctt gccattcatg acaactcacg taccatctat gtggtggata atggtctgag
     1081 gaagatcctg aaggttgtgg ggcaggttcc agatctgcca tcctgcctgc ccctgactga
     1141 caacacccgc atgctggcct ctatcctcat caacaagctc tatgatgacc tgcgctgtga
     1201 cccggagcgc gatcacttcc gcaagatctg tgaggaatat atcacgggca agtttgaccc
     1261 ccaggacatg gacaagaact tgaatgccat ccagacagtg tcagggatcc tgcagggccc
     1321 ctttgacctg ggcaaccagc tgctgggact gaaaggtgtg atggagatga tggtggcact
     1381 atgtggctca gagcgcgaga cggaccagct ggtggccgtg gaggccctca tccatgcctc
     1441 cacgaagctc agccgcgcca ccttcatcat caccaatgga gtgtcactgc tcaaacagat
     1501 ctacaagacc accaaaaatg agaagatcaa gatccgcaca ctggtgggac tctgtaagct
     1561 cggctctgca ggtggcacag actacggtct caggcagttt gcggaagggt cgacagaaaa
     1621 actggccaaa cagtgtcgca agtggctgtg caatatgtcc atagacactc ggacccgacg
     1681 ctgggcagtg gagggcctgg cctacctcac gctggacgct gatgtgaagg acgactttgt
     1741 ccaggacgtc cctgccctgc aggccatgtt tgagctggcc aagaccagtg acaagaccat
     1801 cctgtactcg gtggccacca ccctggtgaa ctgcaccaac agctacgatg tcaaggaggt
     1861 catcccagag cttgtccagc tcgccaagtt ctccaagcag catgtgcccg aggaacaccc
     1921 caaggacaag aaggacttta tagacatgcg ggtgaagcgg cttctgaagg cgggtgtcat
     1981 ctctgccctg gcttgcatgg tgaaagcaga tagtgccatc ctcactgacc agaccaagga
     2041 gctgctggcc agggtattcc tggcactgtg tgacaaccca aaggaccgag gcaccattgt
     2101 ggctcaaggt ggtggcaagg ccctgattcc cctggctttg gagggcacag atgtgggcaa
     2161 ggtgaaggca gcccacgctc tagcaaagat cgctgctgtc tccaatccgg acattgcttt
     2221 tcctggggag cgggtgtatg aggtggtgcg gccccttgta agactcttgg acacacagag
     2281 ggatgggctt cagaactatg aggctctcct aggcctcacc aacctgtctg ggcggagtga
     2341 caaactccgg cagaagatct ttaaggagag ggccttgcca gacatcgaga actacatgtt
     2401 tgagaatcat gatcagctgc ggcaggcggc caccgagtgc atgtgcaaca tggtgctcca
     2461 caaggaggta caggaaaggt tcttggctga cgggaatgac cggctgaagc tggtggtgct
     2521 gctctgcggg gaggatgatg ataaggtgca gaatgcggct gcaggggctc tggccatgct
     2581 gacagcagca cacaagaaac tgtgcctcaa gatgactcaa gtgacaaccc agtggttgga
     2641 gatcctccag cggctttgcc tgcacgacca gctgtctgtc caacaccggg gcctggtcat
     2701 tgcctacaac ctactggcag ccgatgctga gctggccaag aagctggtgg agagtgagct
     2761 gctggagatc ctgactgtgg tgggcaaaca ggagccagat gagaagaagg cagaagtggt
     2821 tcagacagcc cgagaatgtc tcatcaagtg catggattat ggtttcatta aaccagtgtc
     2881 ttagacagcg accctcaggg atgctgggag tggtcctgta ctgtgcagag tcctgggttg
     2941 gttgggttct cctgaagagt caggtcatct agggatcata gcagtgacaa tgaagtctca
     3001 atataaagga aagacttgat tgttctctga gttgtgagtc ttctcctttg tcctgacaga
     3061 gtttggatgt ttcactctct ctcttgcttc ctgtctcctt atatttgtca tgtttcagaa
     3121 attcccagaa taattttcac ccatgattag aaataggttg gatcattctt tctgtaccca
     3181 ttctgaaggc caggataata ggttgaagtt ctttatattt tggaaaatgg attttgtggt
     3241 aaggtaggaa ctaacgggtg tgtgcatata aaggttaatg ctgttgtatt tggatgctga
     3301 tctgtgctgt tttcatgacc tctctcccac actatttgaa tcagtctgtt cagaactgtg
     3361 tgtttcacct gcagtgctct gtcccagtcc catgcccatt cccatcactt cactgtgatg
     3421 gaaatagagt ttatgttcaa cagtggggca tgacctctgc aatttgcttg ggaaagtctt
     3481 ccaagcaaga tggacatgat gaatacaaat aagatctact caaagtactt caaacaaaaa
     3541 ataaataatt cattggctca tgtatcttgg ccacccaggg aaggtctgac attgttagtt
     3601 agatccagag tttcaaatgt catcaccatg gatgtgtctt tttctctctc tcatttcccc
     3661 tccccatatc ttgtctttta tttattatag gtttgtctca ttccctggca ggctctctcc
     3721 ctgtgatagg aaagagagtc cccagcagcc ccagggtgac atagttgtta tagttcatta
     3781 tggaatagaa gagagaagag cattctcaat aacccggcaa agttcccagg gatgactctg
     3841 atatgtctat gtctcaggtc acatttccat ctatgaacca atcatattca gaggtggaat
     3901 gctaattggc caggcctggg tcatatatac aagtctaggg aagaaatgag cttcatccct
     3961 gtccaattga catggactga ttaggggtat taatggaaga ggtgtgccac cacaaaagaa
     4021 tgtaccctgg gcagatcaaa gaacatattc tgtatgtcag gcttggccac aaaagaatga
     4081 cacaagtaat atgctgtaga tcagaacctc tctgctaata ttgccttttt agcatggtta
     4141 agatagctaa gatctagtac tgtcactcca gtatgtccca attctaccta cgtttattga
     4201 agggtcaaca gttctgatct cagcattggg taaagggtgg gacattcaga tttacggtcc
     4261 ttgataaaaa caatttacaa cgttccgttg tgtaataaat gtaagtgtac atatgcctgg
     4321 gacatcagct ggaaaaggga cagactatca gagagttgca ctgttgcggt atgggccaaa
     4381 tccaacataa tacccgctgt acctctagag aactaaaacc ttaatttctc agatcttttc
     4441 tgcactaatg gtctttacat acagcctaca ttttaactaa ctcttgcatg ggcttgtttc
     4501 acagcaggaa actatattca tcatatcctt attatgatag agaatgacaa cattcaaaag
     4561 ggtgtggtgc ttctgaaaat atacacaata aatggcatga tttgacctct gtcaaattct
     4621 tctttcctgc tttcctcata tgtgggcttg agtgggtgta tttagctcct ttaaaggaaa
     4681 ctctttcaca ggcagggcca cactcttact cgttttgatc tcatgaggtt acatctgcca
     4741 gtggcgttca gggccagtta gataaagttc atcttgtttg gattggagag actttttttt
     4801 tttttttttt tgagacaggg tcttgctctg taacctaggc tcaagtgcag tgcagtggtg
     4861 cagtcatggc tcaccgcagc cttggtctcc tgggctcaag tgatctttct acttcagcct
     4921 cctcaatagc tgggactaca ggcacacacc accaccccca ggtaattaaa aaattttttt
     4981 ttgtagagac agggtctcac tatgttgccc agtctgggag accacattct ttaacatgaa
     5041 tattttgtaa atagtccaag aagatctaga ggaaagctga attccttcat ctgatttttg
     5101 ccactgggct gcctcccatt gtctggctaa gtcttcatgg gaggccttta agaaaagctg
     5161 tgacaaatac ctttgtttcc cactgcctag gttacataag tagttggctt ttccagccta
     5221 gactcttata ttgttgcttg taagagggcc cttctttgca gatttctttt ttttttcatc
     5281 tatgctttca aataggcaga tgctagcctg agatcatctc tttattgagg tagtttgccc
     5341 aaaaacagca aggaacagcc aatacctgcc aactttctag gtttttccaa ccaattctct
     5401 tacagaaaat ctataaatat cttagaggta tgtttcttag tttcccaaca tataatggga
     5461 aaattcatca tttatattat tacttttaac tgaagtatgt tgttatcaga gaacttggtc
     5521 tgtgtcatat taatcctttg ccatttgaga agcatacagt tttaaagttt atatctccaa
     5581 aaggatattt tgtaaaaatt taaccccttt gactcttagt cttctcattt gtgaaaggta
     5641 aataataaag aatttctgtt cctagtaa
//
