LOCUS       NM_199242               4080 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens unc-13 homolog D (UNC13D), mRNA.
ACCESSION   NM_199242 XM_113950
VERSION     NM_199242.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4080)
  AUTHORS   Duong,V.T., Lee,D., Kim,Y.H. and Oh,S.O.
  TITLE     Functional role of UNC13D in immune diseases and its therapeutic
            applications
  JOURNAL   Front Immunol 15, 1460882 (2024)
   PUBMED   39469717
  REMARK    GeneRIF: Functional role of UNC13D in immune diseases and its
            therapeutic applications.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4080)
  AUTHORS   Bahadir,A., Kader,S., Cebi,A.H., Erduran,E., Mutlu,M. and Aslan,Y.
  TITLE     Familial Hemophagocytic Lymphohistiocytosis With Heterozygous STX11
            and Homozygous UNC13D Mutations Diagnosed in the Neonatal Period
  JOURNAL   J Pediatr Hematol Oncol 44 (4), e866-e868 (2022)
   PUBMED   35293882
  REMARK    GeneRIF: Familial Hemophagocytic Lymphohistiocytosis With
            Heterozygous STX11 and Homozygous UNC13D Mutations Diagnosed in the
            Neonatal Period.
REFERENCE   3  (bases 1 to 4080)
  AUTHORS   Xinh,P.T., Chuong,H.Q., Diem,T.P.H., Nguyen,T.M., Van,N.D., Mai
            Anh,N.H., Nghia,H. and Vu,H.A.
  TITLE     Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2 genes in
            Vietnamese patients with hemophagocytic lymphohistiocytosis
  JOURNAL   Int J Lab Hematol 43 (6), 1524-1530 (2021)
   PUBMED   34339548
  REMARK    GeneRIF: Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2
            genes in Vietnamese patients with hemophagocytic
            lymphohistiocytosis.
REFERENCE   4  (bases 1 to 4080)
  AUTHORS   Luo,H., Liu,D., Liu,W., Wang,G., Chen,L., Cao,Y., Wei,J., Xiao,M.,
            Liu,X., Huang,G., Wang,W., Zhou,J. and Wang,Q.F.
  TITLE     Germline variants in UNC13D and AP3B1 are enriched in COVID-19
            patients experiencing severe cytokine storms
  JOURNAL   Eur J Hum Genet 29 (8), 1312-1315 (2021)
   PUBMED   33867526
  REMARK    GeneRIF: Germline variants in UNC13D and AP3B1 are enriched in
            COVID-19 patients experiencing severe cytokine storms.
REFERENCE   5  (bases 1 to 4080)
  AUTHORS   Kalinichenko,A., Perinetti Casoni,G., Dupre,L., Trotta,L.,
            Huemer,J., Galgano,D., German,Y., Haladik,B., Pazmandi,J.,
            Thian,M., Yuce Petronczki,O., Chiang,S.C., Taskinen,M., Hekkala,A.,
            Kauppila,S., Lindgren,O., Tapiainen,T., Kraakman,M.J.,
            Vettenranta,K., Lomakin,A.J., Saarela,J., Seppanen,M.R.J.,
            Bryceson,Y.T. and Boztug,K.
  TITLE     RhoG deficiency abrogates cytotoxicity of human lymphocytes and
            causes hemophagocytic lymphohistiocytosis
  JOURNAL   Blood 137 (15), 2033-2045 (2021)
   PUBMED   33513601
REFERENCE   6  (bases 1 to 4080)
  AUTHORS   Yamamoto,K., Ishii,E., Sako,M., Ohga,S., Furuno,K., Suzuki,N.,
            Ueda,I., Imayoshi,M., Yamamoto,S., Morimoto,A., Takada,H., Hara,T.,
            Imashuku,S., Sasazuki,T. and Yasukawa,M.
  TITLE     Identification of novel MUNC13-4 mutations in familial
            haemophagocytic lymphohistiocytosis and functional analysis of
            MUNC13-4-deficient cytotoxic T lymphocytes
  JOURNAL   J Med Genet 41 (10), 763-767 (2004)
   PUBMED   15466010
  REMARK    GeneRIF: MUNC13-4 mutations play a role in the development of
            familial haemophagocytic lymphohistiocytosis subtype 3 through a
            defective cytotoxic pathway
REFERENCE   7  (bases 1 to 4080)
  AUTHORS   Shirakawa,R., Higashi,T., Tabuchi,A., Yoshioka,A., Nishioka,H.,
            Fukuda,M., Kita,T. and Horiuchi,H.
  TITLE     Munc13-4 is a GTP-Rab27-binding protein regulating dense core
            granule secretion in platelets
  JOURNAL   J Biol Chem 279 (11), 10730-10737 (2004)
   PUBMED   14699162
  REMARK    GeneRIF: Rab27 regulates the dense core granule secretion in
            platelets by employing its binding protein, Munc13-4
REFERENCE   8  (bases 1 to 4080)
  AUTHORS   Feldmann,J., Callebaut,I., Raposo,G., Certain,S., Bacq,D.,
            Dumont,C., Lambert,N., Ouachee-Chardin,M., Chedeville,G.,
            Tamary,H., Minard-Colin,V., Vilmer,E., Blanche,S., Le Deist,F.,
            Fischer,A. and de Saint Basile,G.
  TITLE     Munc13-4 is essential for cytolytic granules fusion and is mutated
            in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
  JOURNAL   Cell 115 (4), 461-473 (2003)
   PUBMED   14622600
  REMARK    GeneRIF: HMunc13-4 mutations were shown to cause familial
            hemophagocytic lymphohistiocytosis; HMunc13-4 is essential for the
            priming step of cytolytic granules secretion preceding vesicle
            membrane fusion.
REFERENCE   9  (bases 1 to 4080)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   10 (bases 1 to 4080)
  AUTHORS   Zhang,K., Astigarraga,I., Bryceson,Y., Lehmberg,K., Machowicz,R.,
            Marsh,R., Sieni,E., Wang,Z. and Nichols,K.E.
  TITLE     Familial Hemophagocytic Lymphohistiocytosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087289.9.
            
            On Feb 27, 2020 this sequence version replaced NM_199242.2.
            
            Summary: This gene encodes a protein that is a member of the UNC13
            family, containing similar domain structure as other family members
            but lacking an N-terminal phorbol ester-binding C1 domain present
            in other Munc13 proteins. The protein appears to play a role in
            vesicle maturation during exocytosis and is involved in regulation
            of cytolytic granules secretion. Mutations in this gene are
            associated with familial hemophagocytic lymphohistiocytosis type 3,
            a genetically heterogeneous, rare autosomal recessive disorder.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067084.1, AJ578444.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000207549.9/ ENSP00000207549.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC087289.9         108983-109166
            185-220             AC087289.9         109868-109903
            221-328             AC087289.9         110121-110228
            329-388             AC087289.9         110314-110373
            389-455             AC087289.9         110464-110530
            456-636             AC087289.9         110774-110954
            637-681             AC087289.9         112386-112430
            682-750             AC087289.9         112557-112625
            751-820             AC087289.9         112811-112880
            821-925             AC087289.9         113058-113162
            926-1018            AC087289.9         113277-113369
            1019-1122           AC087289.9         113445-113548
            1123-1240           AC087289.9         116469-116586
            1241-1365           AC087289.9         116691-116815
            1366-1456           AC087289.9         116958-117048
            1457-1513           AC087289.9         117131-117187
            1514-1611           AC087289.9         117278-117375
            1612-1663           AC087289.9         117481-117532
            1664-1794           AC087289.9         117610-117740
            1795-1915           AC087289.9         117858-117978
            1916-2059           AC087289.9         118324-118467
            2060-2158           AC087289.9         118671-118769
            2159-2365           AC087289.9         118856-119062
            2366-2434           AC087289.9         119244-119312
            2435-2514           AC087289.9         120342-120421
            2515-2620           AC087289.9         122039-122144
            2621-2692           AC087289.9         122218-122289
            2693-2776           AC087289.9         122726-122809
            2777-2897           AC087289.9         122905-123025
            2898-3021           AC087289.9         123236-123359
            3022-3218           AC087289.9         124404-124600
            3219-4080           AC087289.9         125301-126162
FEATURES             Location/Qualifiers
     source          1..4080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..4080
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /note="unc-13 homolog D"
                     /db_xref="GeneID:201294"
                     /db_xref="HGNC:HGNC:23147"
                     /db_xref="MIM:608897"
     exon            1..184
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..3340
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /codon_start=1
                     /product="protein unc-13 homolog D"
                     /protein_id="NP_954712.1"
                     /db_xref="CCDS:CCDS11730.1"
                     /db_xref="GeneID:201294"
                     /db_xref="HGNC:HGNC:23147"
                     /db_xref="MIM:608897"
                     /translation="MATLLSHPQQRPPFLRQAIKIRRRRVRDLQDPPPQMAPEIQPPS
                     HHFSPEQRALLYEDALYTVLHRLGHPEPNHVTEASELLRYLQEAFHVEPEEHQQTLQR
                     VRELEKPIFCLKATVKQAKGILGKDVSGFSDPYCLLGIEQGVGVPGGSPGSRHRQKAV
                     VRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRQKLG
                     ELTDLHGLRRIFKEARKDKGQDDFLGNVVLRLQDLRCREDQWYPLEPRTETYPDRGQC
                     HLQFQLIHKRRATSASRSQPSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATV
                     LFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQ
                     EELAASFSSLLTYGLSLIRRFRSVFPLSVSDSPARLQSLLRVLVQMCKMKAFGELCPN
                     TAPLPQLVTEALQTGTTEWFHLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRT
                     WDKIFHNTLKIHLFSMAFRELQWLVAKRVQDHTTVVGDVVSPEMGESLFQLYISLKEL
                     CQLRMSSSERDGVLALDNFHRWFQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELT
                     KHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARAR
                     ELSSGQKDQGQAANMLCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNT
                     LHAQLQSALAGLGHEIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAILPLMKFL
                     EVELCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASQRSSSLASNRLKIALQNLEIC
                     FHAEGCGLPPKALHTATFQALQRDLELQAASSRELIRKYFCSRIQQQAETTSEELGAV
                     TVKASYRASEQKLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHK
                     KDLHPLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPGLSG
                     SEEPGEVPQTRLPLTYPAPNGDPILQLLEGRKGDREAQVFVRLRRHRAKQASQHALRP
                     AP"
     exon            185..220
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            221..328
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..388
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            389..455
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            456..636
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..681
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..750
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            751..820
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            821..925
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1018
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1122
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1240
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1365
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1456
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1513
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1611
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1663
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1794
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1915
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2059
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2158
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2365
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2434
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2514
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2620
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2692
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2776
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2897
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3021
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3218
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..4080
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4057..4062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /note="hexamer: AACAAA"
     polyA_site      4080
                     /gene="UNC13D"
                     /gene_synonym="FHL3; HLH3; HPLH3; Munc13-4"
                     /note="major polyA site"
ORIGIN      
        1 gcataatcct gtggcttcgc tgtcttcacc cagcaccagc ggacagggaa gggcagagaa
       61 ggccaccatg gcgacactcc tctcccatcc gcagcagcgc cctcccttct tgcgccaggc
      121 catcaagata aggcgccgca gagtcagaga tctacaggat cccccgcccc aaatggcccc
      181 ggagatccag cctccatccc accacttctc ccccgagcag cgggccctgc tctacgagga
      241 cgcactctac actgtcttgc accgcctggg tcatcctgag cccaaccatg tgacggaggc
      301 ctctgagctg ctgcgatacc tgcaggaggc cttccacgtg gagcccgagg agcaccagca
      361 gacactgcag cgggtcaggg agcttgagaa gccaatattt tgtctgaagg caacagtgaa
      421 acaggccaag ggcattctgg gcaaagatgt cagtgggttc agcgacccct actgcctgct
      481 gggcattgag cagggggtag gtgtgccagg gggcagcccc gggtcccggc atcggcagaa
      541 ggctgtggtg aggcacacca tccccgagga ggagacccac cgcacgcagg tcatcaccca
      601 gacactcaac cccgtctggg acgagacctt catcctggag tttgaggaca tcaccaatgc
      661 gagctttcat ctggacatgt gggacctgga cactgtggag tctgtccgac agaagcttgg
      721 ggagctcacg gatctgcatg ggcttcgcag gatctttaaa gaggcccgga aggacaaagg
      781 ccaggacgac tttctgggga acgtggttct gaggctgcag gacctgcgct gccgagagga
      841 ccagtggtac cccctggaac cccgcactga gacctaccca gaccgaggcc agtgccacct
      901 ccagttccaa ctcatccata agcggagagc cacttcggcc agccgctcgc agccgagcta
      961 caccgtgcac ctccacctcc tgcagcagct tgtgtcccac gaggtcaccc agcacgaggc
     1021 gggaagcacc tcctgggacg ggtcgctgag tccccaggct gccaccgtcc tctttctgca
     1081 cgccacacag aaggacctat ccgacttcca ccagtccatg gcgcagtggc tggcctacag
     1141 ccgcctctac cagagcctgg agttccccag cagctgcctc ctgcacccca tcaccagcat
     1201 cgagtaccag tggatccagg gtcggctcaa ggcagaacag caggaggagc tggccgcctc
     1261 attcagctcc ctgctgacct acggcctctc cctcatccgg aggttccgct ctgtcttccc
     1321 cctctctgtc tcggactccc cagcccggct gcagtctctt ctcagggtcc tggtacagat
     1381 gtgcaagatg aaggcctttg gagaactgtg ccccaacacc gccccattgc cccagctggt
     1441 gactgaggcc ctgcagactg gcaccactga atggttccac ctgaagcagc agcaccatca
     1501 acccatggtg cagggcatcc cggaggcagg caaggccttg ctgggcctgg tacaggatgt
     1561 cattggcgac ctgcaccagt gccagcgcac atgggacaag atcttccaca ataccctcaa
     1621 gatccacctc ttctccatgg ctttccggga gctgcagtgg ctggtggcca agcgggtgca
     1681 ggaccacacg acggttgtgg gtgatgtagt gtccccagag atgggcgaga gtctgttcca
     1741 gctctacatc agcctcaagg agctctgcca gctgcgcatg agctcctcag agagggatgg
     1801 agtcctggcc ctggataatt tccaccgctg gttccagccg gccatcccct cctggctgca
     1861 gaagacgtac aacgaggccc tggcgcgggt gcagcgcgct gtgcagatgg atgagctggt
     1921 gcccctgggt gaactgacca agcacagcac atcagcggtg gatctatcca cctgctttgc
     1981 ccagatcagc cacactgccc ggcagctgga ctggccagac ccagaggagg ccttcatgat
     2041 taccgtcaag tttgtggagg acacctgtcg cctggccctg gtgtactgca gccttataaa
     2101 ggcccgggcc cgcgagctct cttcaggcca gaaggaccaa ggccaggcag ccaacatgct
     2161 gtgtgtggtg gtgaatgaca tggagcagct gcggctggtg atcggcaagt tgcccgccca
     2221 gctggcatgg gaggccctgg agcagcgggt aggggccgtg ctggagcagg ggcagctgca
     2281 gaacacgctg catgcccagc tgcagagcgc gctggccggg ctgggccatg agatccgcac
     2341 tggcgtccgc accctggccg agcagttgga ggtgggcatc gccaagcaca tccagaaact
     2401 ggtgggcgtc agggagtctg tcctgcctga ggatgccatt ctgcccctga tgaagttcct
     2461 ggaggtggag ctttgctaca tgaacaccaa cttggtgcag gagaacttca gcagcctcct
     2521 gaccctgctc tggacccaca cactcacagt gctggtggag gcggccgcct cccagcgcag
     2581 ctcatccctg gcttccaaca ggctgaagat tgccctgcag aacctggaga tctgcttcca
     2641 cgctgagggc tgtggcctgc cacccaaggc cctgcacact gccaccttcc aggctctgca
     2701 gagggacctg gagctgcagg cggcctccag ccgggaactc atccggaagt acttctgcag
     2761 ccgaatccag cagcaggcag aaaccacctc tgaggagctg ggggctgtga cagtcaaggc
     2821 ctcctaccgc gcctctgagc agaagctgcg tgtggagctg ctcagcgcct ccagcctgct
     2881 gcccctggac tccaatggct ccagcgaccc ctttgtccag ctgaccttgg agcccaggca
     2941 tgagttccct gagctggccg cccgggagac ccagaagcac aagaaggacc ttcacccatt
     3001 gtttgatgag acctttgaat tcctggtgcc tgctgagccg tgccgcaagg ctggggcatg
     3061 cctcctgctc accgtgctgg actacgacac gctgggggcc gacgacctgg aaggcgaggc
     3121 cttcctgccg ctgcgtgagg tgcccgggct gagtggctct gaggagcctg gtgaggtgcc
     3181 tcagacccgc ctgcccctca cgtaccccgc acccaacggg gacccaatcc tgcagctgct
     3241 ggagggccgg aagggtgacc gagaagccca ggtctttgtg aggctgcggc ggcaccgggc
     3301 caagcaggcc tcccagcatg ccttgcggcc ggcaccgtag ccgtagaggt ttgcggtggg
     3361 gctgggtccc cggtggggac ttgcaagggc tttcctgtag ggtctggggc ttccccgcca
     3421 catcgcggcc ctccagcctg gcctaacact tggggagccc cagcatgcgg agtgcccaga
     3481 gtgcagacct cccctgcctc ccatggtgat gggggctcag cagcgacatc tctactcccg
     3541 cctccctgcc tccagccctg gctgcaatgt ctctaccaca tcccagcacc agggggagca
     3601 aaccctgccc ctgcccgcct ctcagaaaag ctgctgtggt gggcagggga ttgggccatc
     3661 tgtctcctgg ccctggccca tctgcctcct ggccttcctg ttccagccac tggggtgggg
     3721 gccaggttca ctgggaccag ggctacaggc acagagtctc ctggaaaagg gagaggggac
     3781 cctgccaaag atgaggctcc agctgccctg gggggagggt ggtggccatt actagagggg
     3841 gcctgggtcc tctccccagg ggctgccagc atccaggcca ggaagcctgg agccaagaac
     3901 cttctggctc tgagggagca agagctggca ggcggcaggg ctggcacaga cagacggaag
     3961 cagaaaggac agtttggctg ctgtgtctgc tgcgcacgcc ccctccccgg acagcacctg
     4021 ccacctagaa actttcttag caaaaaaatt aataaaaaca aatccattgt cctcttaaaa
//
