LOCUS       NM_001371188            5360 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens unc-13 homolog B (UNC13B), transcript variant 5, mRNA.
ACCESSION   NM_001371188 XM_017014191
VERSION     NM_001371188.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5360)
  AUTHORS   Grushin,K., Kalyana Sundaram,R.V., Sindelar,C.V. and Rothman,J.E.
  TITLE     Munc13 structural transitions and oligomers that may choreograph
            successive stages in vesicle priming for neurotransmitter release
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35135883
  REMARK    GeneRIF: Munc13 structural transitions and oligomers that may
            choreograph successive stages in vesicle priming for
            neurotransmitter release.
REFERENCE   2  (bases 1 to 5360)
  AUTHORS   Wang,J., Qiao,J.D., Liu,X.R., Liu,D.T., Chen,Y.H., Wu,Y., Sun,Y.,
            Yu,J., Ren,R.N., Mei,Z., Liu,Y.X., Shi,Y.W., Jiang,M., Lin,S.M.,
            He,N., Li,B., Bian,W.J., Li,B.M., Yi,Y.H., Su,T., Liu,H.K., Gu,W.Y.
            and Liao,W.P.
  TITLE     UNC13B variants associated with partial epilepsy with favourable
            outcome
  JOURNAL   Brain 144 (10), 3050-3060 (2021)
   PUBMED   33876820
  REMARK    GeneRIF: UNC13B variants associated with partial epilepsy with
            favourable outcome.
            Erratum:[Brain. 2022 Apr 18;145(2):e5. doi: 10.1093/brain/awab427..
            PMID: 34897376]
REFERENCE   3  (bases 1 to 5360)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5360)
  AUTHORS   Xie,J., An,S.W., Jin,X., Gui,Y. and Huang,C.L.
  TITLE     Munc13 mediates klotho-inhibitable diacylglycerol-stimulated
            exocytotic insertion of pre-docked TRPC6 vesicles
  JOURNAL   PLoS One 15 (3), e0229799 (2020)
   PUBMED   32134975
  REMARK    GeneRIF: TRPC6 exocytosis by targeting to the C1 domain of
            Munc13-2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5360)
  AUTHORS   Wang,Y., Tan,J., Liu,D., Yang,Y. and Wu,H.
  TITLE     The Association of UNC13B Gene Polymorphisms and Diabetic Kidney
            Disease in a Chinese Han Population
  JOURNAL   Med Sci Monit 25, 8527-8533 (2019)
   PUBMED   31713534
  REMARK    GeneRIF: There were no significant differences in the distribution
            of allele or genotype frequencies in the five UNC13B SNP markers
            (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999)
            between the Diabetic Kidney Disease group and control group of
            patients with type 2 diabetes mellitus .
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5360)
  AUTHORS   Mochida,S., Orita,S., Sakaguchi,G., Sasaki,T. and Takai,Y.
  TITLE     Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter
            release process
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11418-11422 (1998)
   PUBMED   9736751
REFERENCE   7  (bases 1 to 5360)
  AUTHORS   Sakaguchi,G., Orita,S., Naito,A., Maeda,M., Igarashi,H., Sasaki,T.
            and Takai,Y.
  TITLE     A novel brain-specific isoform of beta spectrin: isolation and its
            interaction with Munc13
  JOURNAL   Biochem Biophys Res Commun 248 (3), 846-851 (1998)
   PUBMED   9704016
REFERENCE   8  (bases 1 to 5360)
  AUTHORS   Song,Y., Ailenberg,M. and Silverman,M.
  TITLE     Cloning of a novel gene in the human kidney homologous to rat
            munc13s: its potential role in diabetic nephropathy
  JOURNAL   Kidney Int 53 (6), 1689-1695 (1998)
   PUBMED   9607201
REFERENCE   9  (bases 1 to 5360)
  AUTHORS   Orita,S., Naito,A., Sakaguchi,G., Maeda,M., Igarashi,H., Sasaki,T.
            and Takai,Y.
  TITLE     Physical and functional interactions of Doc2 and Munc13 in
            Ca2+-dependent exocytotic machinery
  JOURNAL   J Biol Chem 272 (26), 16081-16084 (1997)
   PUBMED   9195900
REFERENCE   10 (bases 1 to 5360)
  AUTHORS   Betz,A., Okamoto,M., Benseler,F. and Brose,N.
  TITLE     Direct interaction of the rat unc-13 homologue Munc13-1 with the N
            terminus of syntaxin
  JOURNAL   J Biol Chem 272 (4), 2520-2526 (1997)
   PUBMED   8999968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160274.9.
            
            On Oct 9, 2020 this sequence version replaced NM_001371188.1.
            
            Summary: This gene is expressed in the kidney cortical epithelial
            cells and is upregulated by hyperglycemia. The encoded protein
            shares a high level of similarity to the rat homolog, and contains
            3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia
            increases the levels of diacylglycerol, which has been shown to
            induce apoptosis in cells transfected with this gene and thus
            contribute to the renal cell complications of hyperglycemia.
            Studies in other species also indicate a role for this protein in
            the priming step of synaptic vesicle exocytosis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.284584.1,
                                           SRR14038196.3184397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AL160274.9         47818-48266
            450-496             AL160274.9         72869-72915
            497-575             AL160274.9         76240-76318
            576-650             AL160274.9         81049-81123
            651-870             AL160274.9         81950-82169
            871-1098            AL160274.9         83390-83617
            1099-1240           AL160274.9         84217-84358
            1241-1410           AL160274.9         86392-86561
            1411-1526           AL160274.9         87022-87137
            1527-1690           AL160274.9         87478-87641
            1691-1841           AL160274.9         88279-88429
            1842-1910           AL160274.9         90168-90236
            1911-2000           AL160274.9         91646-91735
            2001-2129           AL160274.9         92087-92215
            2130-2257           AL160274.9         95768-95895
            2258-2343           AL160274.9         96551-96636
            2344-2470           AL160274.9         102398-102524
            2471-2567           AL160274.9         102763-102859
            2568-2711           AL160274.9         103089-103232
            2712-2789           AL160274.9         103557-103634
            2790-2867           AL160274.9         104133-104210
            2868-2956           AL160274.9         104476-104564
            2957-3109           AL160274.9         104804-104956
            3110-3233           AL160274.9         105083-105206
            3234-3290           AL160274.9         105314-105370
            3291-3371           AL160274.9         105571-105651
            3372-3519           AL160274.9         106218-106365
            3520-3612           AL160274.9         109089-109181
            3613-3772           AL160274.9         109362-109521
            3773-5360           AL160274.9         109670-111257
FEATURES             Location/Qualifiers
     source          1..5360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..5360
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /note="unc-13 homolog B"
                     /db_xref="GeneID:10497"
                     /db_xref="HGNC:HGNC:12566"
                     /db_xref="MIM:605836"
     exon            1..449
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..4058
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     homolog of rat Munc13 (diacylglycerol-binding); protein
                     unc-13 homolog B; unc-13-like"
                     /codon_start=1
                     /product="protein unc-13 homolog B isoform 5"
                     /protein_id="NP_001358117.1"
                     /db_xref="GeneID:10497"
                     /db_xref="HGNC:HGNC:12566"
                     /db_xref="MIM:605836"
                     /translation="MVLIFFFNFLNPYFGCSSKIPDDGDPSLPQWLPEGPAGGLYGID
                     SMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPI
                     SCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQR
                     AAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVK
                     QSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPV
                     WEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMD
                     VWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGG
                     VRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAV
                     MSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNN
                     FPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIF
                     NNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFP
                     QELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLP
                     VLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVV
                     DVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEK
                     LPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSF
                     QVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVC
                     EKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVRE
                     ETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDT
                     LIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMF
                     RPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKD
                     YCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVA
                     REFVKLKSESRSTEEGS"
     exon            450..496
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..575
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..650
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..870
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1098
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1240
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1410
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1526
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1690
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1841
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1910
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2000
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2129
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2257
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2343
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2470
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2567
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2711
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2789
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2867
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2956
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3109
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3233
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3290
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3371
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3519
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3612
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3772
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..5360
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5342..5347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /note="hexamer: AATAAA"
     polyA_site      5360
                     /gene="UNC13B"
                     /gene_synonym="MUNC13; munc13-2; UNC13; Unc13h2"
                     /note="major polyA site"
ORIGIN      
        1 agtctcaaag cccagaatcg attgagttag aattccacat ccagttgaag tttggctgct
       61 gttgccttca gcaggctgat ctcagaatcc cccttgccag agaggtgtgg accaggttag
      121 atttctacgt ttgcagccag tgagactcct gccaagccct tcactgaggg gtttttttgc
      181 agggcattgt ttctgtcatc aactttgtgc cgtggagcca gccagctggg tgcaactgag
      241 aatattagct ccttgggtct gtttgtcggt tgggcaagca gtggtgcttt ggctcagaaa
      301 gttcgtcctg tggcttctct gtcaaaccaa ggagtgctcc tggatggatt tcctcttaaa
      361 gacagcattt gccttctaaa acttgagaat tcatggtttt aatttttttt tttaatttcc
      421 ttaaccctta ttttggttgc agcagcaaga ttccagatga tggtgacccc tctctgcctc
      481 agtggctccc ggaagggcca gccggagggc tctatggcat tgacagcatg ccagatttac
      541 gcagaaagaa gccactgcca cttgtcagtg atctgtcact ggtccagtct cggaaggcag
      601 gaatcacttc tgcaatggct acacgcactt ctcttaagga cgaagagctg aaatcccacg
      661 tgtataagaa aaccctgcag gccttaatct accccatttc gtgcaccact cctcataact
      721 ttgaggtctg gacggccact accccaacct actgctatga gtgtgaaggc ctgctctggg
      781 gcattgcccg gcagggcatg cgctgcagcg aatgtggagt caagtgccat gagaagtgcc
      841 aggatctgct caatgctgac tgcctgcagc gggctgcaga aaagagctgt aaacatggag
      901 ctgaggaccg gacccagaac attatcatgg ccatgaagga ccgcatgaag atccgagagc
      961 gaaataagcc agagatcttt gaagttatcc gggacgtctt cacagtgaac aaagctgccc
     1021 atgtgcagca gatgaaaaca gtgaagcaga gtgtactgga tggcacctcc aaatggtcag
     1081 ccaagatcac cattactgtg gtgtgtgccc agggcctaca agccaaggac aaaacaggat
     1141 ccagtgaccc ttacgtgact gtgcaagtca gcaaaactaa gaagcgtacc aagaccattt
     1201 ttggaaactt gaatcctgtt tgggaggaga agttccattt tgagtgccac aactcctctg
     1261 accgcattaa ggtgcgtgta tgggatgagg atgatgacat caagtcaaga gtaaagcaac
     1321 gcctaaagcg agagtctgat gatttccttg gccaaaccat cattgaggtt cggaccctaa
     1381 gtggcgagat ggacgtctgg tacaacttgg agaagaggac agacaaatca gccgtctcag
     1441 gggctatccg actacaaatc agtgtggaga tcaaggggga ggagaaagta gccccatacc
     1501 acgtgcagta tacatgtctc catgagaatc ttttccatta cctcacagac attcagggca
     1561 gtggaggagt ccgcatccct gaagctcgag gagacgatgc ctggaaggtg tactttgatg
     1621 agacagccca agaaattgtg gatgaatttg ccatgcgtta tggcattgag tccatatatc
     1681 aggccatgac gcactttgca tgtttatcat ccaagtacat gtgtcctggt gtgccagcag
     1741 tgatgagcac cttactggcc aacatcaacg cctactatgc ccacacaact gcctctacca
     1801 atgtctctgc atctgatcgc tttgcagcct ccaactttgg gaaagagaga tttgtaaaac
     1861 tgctggacca gctacacaac tcactgagga tcgacctctc tacatacagg aataatttcc
     1921 ctgctgggag tcctgaacgg cttcaggact taaaatccac agtggatttg ctgaccagca
     1981 ttactttctt cagaatgaag gtacaagaac tgcaaagccc tccaagagcc agccaggtgg
     2041 taaaggattg tgtgaaggcc tgtttgaact ccacatatga atatatcttc aacaactgcc
     2101 acgacttata cagccgccag taccagctga agcaggagct acctccagag gaacaagggc
     2161 ccagcattcg gaacctggat ttctggccca agctcatcac actcatcgtg tcaatcatag
     2221 aggaagataa gaattcctac acacctgttc tgaaccagtt tcctcaggag ttgaatgtgg
     2281 gaaaagtcag cgcagaagtg atgtggcatt tgtttgccca agacatgaaa tatgcattgg
     2341 aggagcatga gaaagaccac ctgtgtaaaa gtgctgacta catgaacctg cacttcaagg
     2401 tgaagtggct ccacaatgaa tacgtgcggg atctgcctgt cctccagggg caggtgcctg
     2461 agtacccagc gtggtttgag cagttcgtgc tacaatggct ggatgagaat gaggatgtat
     2521 ccctggaatt cctgcgtggg gccctggaac gagataagaa ggatggattc cagcagacat
     2581 cagagcatgc actcttttcc tgctctgtgg tggatgtctt cacacaactc aatcagagct
     2641 ttgagatcat ccggaagctg gaatgcccag accccagcat ccttgcccac tacatgagga
     2701 ggtttgctaa gaccatcggg aaggtgctga tgcagtatgc agacatcttg tcaaaggact
     2761 tcccagccta ttgcacaaag gagaaactgc cctgcatcct gatgaacaac gtgcagcaac
     2821 tgagggtcca gctggagaaa atgtttgagg ccatgggagg caaggagctg gaccttgaag
     2881 ctgcagacag tctgaaggag ctgcaggtga aactgaatac ggttctggat gagctcagca
     2941 tggtgtttgg aaacagtttc caggtacgga ttgatgagtg tgttcgacaa atggccgaca
     3001 tcctgggcca ggttcggggc acagggaatg catctccaga cgccagggcc tcagcggctc
     3061 aggatgcaga tagcgtactc cggcctctca tggacttcct ggatggcaac ctcaccctct
     3121 ttgccactgt gtgtgagaag acggttctga agcgtgtact gaaggagctc tggcgcgtgg
     3181 tgatgaacac aatggagagg atgattgttc tgcccccact cactgaccag acgggcaccc
     3241 agctgatctt cactgctgcc aaggagctga gccatctttc caaactcaag gatcacatgg
     3301 tacgagagga aacacggaat ctcactccaa agcagtgtgc agtccttgac ctcgccctgg
     3361 acaccatcaa gcaatacttc catgcaggag gcaatgggct gaagaaaacc ttcctggaga
     3421 agagcccaga tctgcagtct ctacgctatg ccctgtctct gtacacacag actactgaca
     3481 ctctcatcaa gacctttgtg cgctcgcaga ccacccaagg gtctggtgtg gacgatcctg
     3541 tgggagaagt ctctattcag gtggacttgt ttacacaccc tggtactggg gagcacaagg
     3601 tcacagtgaa agtggtggct gccaatgacc tcaagtggca gacagcgggt atgttccggc
     3661 ctttcgtgga ggtgactatg gttggcccac accaaagtga taagaagagg aagttcacaa
     3721 ccaaatccaa aagcaacaac tgggccccca agtacaatga gacattccac ttcctcctgg
     3781 gaaatgagga ggggcccgag tcctatgagt tgcagatatg cgtgaaggat tactgctttg
     3841 cccgggaaga tcgcgtgcta gggctggctg tgatgcctct gagggatgtc acagccaagg
     3901 gcagctgtgc ctgctggtgc cccttgggcc ggaagatcca tatggatgag acaggcctga
     3961 ccattctccg gattttatct cagaggagca atgacgaggt ggcccgagaa tttgtgaaac
     4021 tcaaatcaga gtctcgttcc acggaggagg ggagctgaac accttcgact cctgtgccaa
     4081 tcaggcagca gcaatttcac aaatcagggc cagtgggagt tagctgtgta accggcttag
     4141 ggtctttgca gtcaagaggc tgaccccttc agttaaagat atttaaggaa aaatttgggg
     4201 tggtgataat atggcttttc acagaaaggg tcatgaagcc ctggcccaac aggactgtgg
     4261 tactaggggc tgggatgtgg ggttaccaca tggagagatt ttccattaag agagaaggac
     4321 aaacatttct gagagtgtca gccattcttg gtagacacct ctccactcct catcccacct
     4381 ctacccatct ccatgccaca ccttatccag ttagacacat acataccaat cattagaaga
     4441 acaagtttag aaggtgtgga acttgtgcct ggctggctgg gtagtcagct gagcctgttg
     4501 ctgagcccgg tggtctggat tggagtatgg ccagggcagg agtacacaga atagaattta
     4561 gactgtccct tgagtagaat ccactgattt tctgtggctc cagtgagaac aaggctttga
     4621 aactgaacaa gataacttct agaaatgaac tgtactaatc cctttcccca gattgtatca
     4681 tgagtagaat caggttcacg tggtgcttca aagccctgag aagaatattt ctttggaccc
     4741 caggcactag gggccacctg cctgggagtc tccctgcctc actcctctag gcaggggagt
     4801 gatgcttcag gacgtgacag gctgttctaa catgtgtcta cctgagggct agttgaagga
     4861 tccaggagta ttttcttctt gggtgggccc tgaacaaagc caaaaattgt agaaaccagt
     4921 ctagaaaaag tcctgctcat ctgtggccac tgccttctag ccgtcctcca ccttgcagaa
     4981 agaatctagc ctttggtctc tctctctctc atcggggtca tttgctattc ccctctgata
     5041 ttcaacccta tagaaggagc ctggactctg atccctctgt acaggctgga tggaaggggc
     5101 cctccacact tcctgggagg tcagagacaa actgtttcag agagtcagat ggacttccca
     5161 agacttgttg agagatgtga catggttctt ggatttcctc tgtagcagcc tcctggactt
     5221 cctgaggact cgacattgtc cacagatgta ctggccatta catgaaacaa gaaaccaagc
     5281 atctttgctg ttgttaatta ttatatgtgc cattgttaca ggagattata ggctagtctg
     5341 taataaatta tcttatagca
//
