LOCUS       NM_001080421            9985 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens unc-13 homolog A (UNC13A), transcript variant 1, mRNA.
ACCESSION   NM_001080421 XM_038604
VERSION     NM_001080421.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9985)
  AUTHORS   Agra Almeida Quadros,A.R., Li,Z., Wang,X., Ndayambaje,I.S.,
            Aryal,S., Ramesh,N., Nolan,M., Jayakumar,R., Han,Y., Stillman,H.,
            Aguilar,C., Wheeler,H.J., Connors,T., Lopez-Erauskin,J.,
            Baughn,M.W., Melamed,Z., Beccari,M.S., Olmedo Martinez,L.,
            Canori,M., Lee,C.Z., Moran,L., Draper,I., Kopin,A.S., Oakley,D.H.,
            Dickson,D.W., Cleveland,D.W., Hyman,B.T., Das,S., Ertekin-Taner,N.
            and Lagier-Tourenne,C.
  TITLE     Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological
            hallmark of TDP-43-associated Alzheimer's disease
  JOURNAL   Acta Neuropathol 147 (1), 9 (2024)
   PUBMED   38175301
  REMARK    GeneRIF: Cryptic splicing of stathmin-2 and UNC13A mRNAs is a
            pathological hallmark of TDP-43-associated Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9985)
  AUTHORS   Fu,R.H., Chen,H.J. and Hong,S.Y.
  TITLE     Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related
            Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding
            Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced
            Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment
  JOURNAL   Cells 12 (20), 2476 (2023)
   PUBMED   37887320
  REMARK    GeneRIF: Interaction of the C9orf72-Amyotrophic Lateral
            Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with
            the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A
            Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by
            Betulin Treatment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9985)
  AUTHORS   Brown,A.L., Wilkins,O.G., Keuss,M.J., Hill,S.E., Zanovello,M.,
            Lee,W.C., Bampton,A., Lee,F.C.Y., Masino,L., Qi,Y.A.,
            Bryce-Smith,S., Gatt,A., Hallegger,M., Fagegaltier,D., Phatnani,H.,
            Newcombe,J., Gustavsson,E.K., Seddighi,S., Reyes,J.F., Coon,S.L.,
            Ramos,D., Schiavo,G., Fisher,E.M.C., Raj,T., Secrier,M.,
            Lashley,T., Ule,J., Buratti,E., Humphrey,J., Ward,M.E. and
            Fratta,P.
  CONSRTM   NYGC ALS Consortium
  TITLE     TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of
            UNC13A
  JOURNAL   Nature 603 (7899), 131-137 (2022)
   PUBMED   35197628
  REMARK    GeneRIF: TDP-43 loss and ALS-risk SNPs drive mis-splicing and
            depletion of UNC13A.
            Erratum:[Nature. 2024 Jul;631(8020):E7. doi:
            10.1038/s41586-024-07577-9.. PMID: 38890465]
REFERENCE   4  (bases 1 to 9985)
  AUTHORS   Ma,X.R., Prudencio,M., Koike,Y., Vatsavayai,S.C., Kim,G.,
            Harbinski,F., Briner,A., Rodriguez,C.M., Guo,C., Akiyama,T.,
            Schmidt,H.B., Cummings,B.B., Wyatt,D.W., Kurylo,K., Miller,G.,
            Mekhoubad,S., Sallee,N., Mekonnen,G., Ganser,L., Rubien,J.D.,
            Jansen-West,K., Cook,C.N., Pickles,S., Oskarsson,B.,
            Graff-Radford,N.R., Boeve,B.F., Knopman,D.S., Petersen,R.C.,
            Dickson,D.W., Shorter,J., Myong,S., Green,E.M., Seeley,W.W.,
            Petrucelli,L. and Gitler,A.D.
  TITLE     TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A
  JOURNAL   Nature 603 (7899), 124-130 (2022)
   PUBMED   35197626
  REMARK    GeneRIF: TDP-43 represses cryptic exon inclusion in the FTD-ALS
            gene UNC13A.
REFERENCE   5  (bases 1 to 9985)
  AUTHORS   You,Y., Katti,S., Yu,B., Igumenova,T.I. and Das,J.
  TITLE     Probing the Diacylglycerol Binding Site of Presynaptic Munc13-1
  JOURNAL   Biochemistry 60 (16), 1286-1298 (2021)
   PUBMED   33818064
  REMARK    GeneRIF: Probing the Diacylglycerol Binding Site of Presynaptic
            Munc13-1.
REFERENCE   6  (bases 1 to 9985)
  AUTHORS   Diekstra,F.P., van Vught,P.W., van Rheenen,W., Koppers,M.,
            Pasterkamp,R.J., van Es,M.A., Schelhaas,H.J., de Visser,M.,
            Robberecht,W., Van Damme,P., Andersen,P.M., van den Berg,L.H. and
            Veldink,J.H.
  TITLE     UNC13A is a modifier of survival in amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Aging 33 (3), 630 (2012)
   PUBMED   22118904
  REMARK    GeneRIF: Our results further corroborate the role of UNC13A in
            amyotrophic lateral sclerosis pathogenesis.
REFERENCE   7  (bases 1 to 9985)
  AUTHORS   van Es,M.A., Veldink,J.H., Saris,C.G., Blauw,H.M., van Vught,P.W.,
            Birve,A., Lemmens,R., Schelhaas,H.J., Groen,E.J., Huisman,M.H., van
            der Kooi,A.J., de Visser,M., Dahlberg,C., Estrada,K.,
            Rivadeneira,F., Hofman,A., Zwarts,M.J., van Doormaal,P.T.,
            Rujescu,D., Strengman,E., Giegling,I., Muglia,P., Tomik,B.,
            Slowik,A., Uitterlinden,A.G., Hendrich,C., Waibel,S., Meyer,T.,
            Ludolph,A.C., Glass,J.D., Purcell,S., Cichon,S., Nothen,M.M.,
            Wichmann,H.E., Schreiber,S., Vermeulen,S.H., Kiemeney,L.A.,
            Wokke,J.H., Cronin,S., McLaughlin,R.L., Hardiman,O., Fumoto,K.,
            Pasterkamp,R.J., Meininger,V., Melki,J., Leigh,P.N., Shaw,C.E.,
            Landers,J.E., Al-Chalabi,A., Brown,R.H. Jr., Robberecht,W.,
            Andersen,P.M., Ophoff,R.A. and van den Berg,L.H.
  TITLE     Genome-wide association study identifies 19p13.3 (UNC13A) and
            9p21.2 as susceptibility loci for sporadic amyotrophic lateral
            sclerosis
  JOURNAL   Nat Genet 41 (10), 1083-1087 (2009)
   PUBMED   19734901
  REMARK    GeneRIF: rs12608932 Single Nucleotide Polymorphism is located at
            19p13.3 and maps to a haplotype block within the boundaries of
            UNC13A, which regulates the release of neurotransmitters such as
            glutamate at neuromuscular synapses.
            GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 9985)
  AUTHORS   Rossner,S., Fuchsbrunner,K., Lange-Dohna,C., Hartlage-Rubsamen,M.,
            Bigl,V., Betz,A., Reim,K. and Brose,N.
  TITLE     Munc13-1-mediated vesicle priming contributes to secretory amyloid
            precursor protein processing
  JOURNAL   J Biol Chem 279 (27), 27841-27844 (2004)
   PUBMED   15123597
REFERENCE   9  (bases 1 to 9985)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   10 (bases 1 to 9985)
  AUTHORS   Sheu,L., Pasyk,E.A., Ji,J., Huang,X., Gao,X., Varoqueaux,F.,
            Brose,N. and Gaisano,H.Y.
  TITLE     Regulation of insulin exocytosis by Munc13-1
  JOURNAL   J Biol Chem 278 (30), 27556-27563 (2003)
   PUBMED   12871971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008761.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2020 this sequence version replaced NM_001080421.2.
            
            Summary: This gene encodes a member of the UNC13 family. UNC13
            proteins bind to phorbol esters and diacylglycerol and play
            important roles in neurotransmitter release at synapses. Single
            nucleotide polymorphisms in this gene may be associated with
            sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb
            2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028955.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519716.7/ ENSP00000429562.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC008761.8         98575-98751         c
            178-207             AC008761.8         86409-86438         c
            208-307             AC008761.8         85054-85153         c
            308-425             AC008761.8         82775-82892         c
            426-549             AC008761.8         79950-80073         c
            550-623             AC008761.8         78514-78587         c
            624-678             AC008761.8         77047-77101         c
            679-714             AC008761.8         73929-73964         c
            715-922             AC008761.8         68459-68666         c
            923-1438            AC008761.8         66280-66795         c
            1439-1547           AC008761.8         65671-65779         c
            1548-1594           AC008761.8         63028-63074         c
            1595-1673           AC008761.8         59906-59984         c
            1674-1679           AC008761.8         59736-59741         c
            1680-1751           AC008761.8         59309-59380         c
            1752-1971           AC008761.8         58828-59047         c
            1972-2199           AC008761.8         57662-57889         c
            2200-2341           AC008761.8         56367-56508         c
            2342-2511           AC008761.8         56071-56240         c
            2512-2627           AC008761.8         53242-53357         c
            2628-2791           AC008761.8         51790-51953         c
            2792-2942           AC008761.8         50908-51058         c
            2943-3011           AC008761.8         50237-50305         c
            3012-3101           AC008761.8         49833-49922         c
            3102-3236           AC008761.8         49480-49614         c
            3237-3370           AC008761.8         46421-46554         c
            3371-3456           AC008761.8         43505-43590         c
            3457-3583           AC008761.8         43179-43305         c
            3584-3680           AC008761.8         41051-41147         c
            3681-3824           AC008761.8         40542-40685         c
            3825-3908           AC008761.8         39637-39720         c
            3909-3986           AC008761.8         38260-38337         c
            3987-4075           AC008761.8         37906-37994         c
            4076-4228           AC008761.8         37030-37182         c
            4229-4352           AC008761.8         35226-35349         c
            4353-4358           AC008761.8         33939-33944         c
            4359-4397           AC008761.8         32229-32267         c
            4398-4427           AC008761.8         31090-31119         c
            4428-4484           AC008761.8         29303-29359         c
            4485-4565           AC008761.8         28818-28898         c
            4566-4713           AC008761.8         28099-28246         c
            4714-4806           AC008761.8         22160-22252         c
            4807-4966           AC008761.8         20337-20496         c
            4967-9985           AC008761.8         11733-16751         c
FEATURES             Location/Qualifiers
     source          1..9985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..9985
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /note="unc-13 homolog A"
                     /db_xref="GeneID:23025"
                     /db_xref="HGNC:HGNC:23150"
                     /db_xref="MIM:609894"
     exon            1..177
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..5267
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein unc-13 homolog A"
                     /codon_start=1
                     /product="protein unc-13 homolog A isoform 1"
                     /protein_id="NP_001073890.2"
                     /db_xref="CCDS:CCDS46013.2"
                     /db_xref="GeneID:23025"
                     /db_xref="HGNC:HGNC:23150"
                     /db_xref="MIM:609894"
                     /translation="MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPS
                     WEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQ
                     VIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQ
                     DEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQ
                     PNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQGSSQL
                     SEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEE
                     EELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAP
                     TEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKAN
                     WLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAM
                     SLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTY
                     CYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNII
                     MVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITV
                     VCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKV
                     RVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAI
                     RLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDE
                     TAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
                     TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDL
                     LTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKK
                     GEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMW
                     NLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFE
                     PFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIK
                     KLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEKVPCILMNNTQQL
                     RVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMG
                     DILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKEL
                     WKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKEL
                     GQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSL
                     RYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVV
                     AANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADA
                     GPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTV
                     LRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP"
     exon            178..207
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..307
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..425
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..549
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..623
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..678
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..714
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..922
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1438
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1547
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1594
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1673
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1679
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1751
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1971
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2199
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2341
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2511
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2627
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2791
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2942
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3011
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3101
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3236
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3370
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3456
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3583
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3680
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3824
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3908
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..3986
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4075
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4228
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4352
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4358
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4359..4397
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4427
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4484
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4565
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4566..4713
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4714..4806
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4966
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..9985
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9961..9966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /note="hexamer: ATTAAA"
     polyA_site      9985
                     /gene="UNC13A"
                     /gene_synonym="Munc13-1"
                     /note="major polyA site"
ORIGIN      
        1 gcccccggtg ctgaaccaag atggccggtg gcggccgggc cccggcgtga gccaagcgcg
       61 ggctgcagcc gggagatgcc ccagcccagc ggccgctgag cccgacccga cagagccggc
      121 ccggccgcct ccggcccacc tgcgagctcg gagacatgtc tctgctttgc gttggagtca
      181 aaaaagccaa gtttgatggt gcccaagaga aattcaacac gtacgtgacc ctgaaagtgc
      241 agaatgtcaa gagcacgacc atcgcggtgc ggggcagcca gcccagctgg gagcaggatt
      301 tcatgttcga gattaaccgt ctggatttgg gactgacggt ggaggtgtgg aataagggtc
      361 tcatctggga cacaatggtg ggcactgtgt ggatcccact gaggaccatc cgccagtcca
      421 atgaggaggg ccctggagag tggctgacgc tggactccca ggtcatcatg gcagacagtg
      481 agatctgtgg caccaaggac cccaccttcc accgcatcct cctggacacg cgctttgagc
      541 tacccttaga cattcctgaa gaggaggctc gctactgggc caagaagctg gagcagctca
      601 atgctatgcg ggaccaggat gaatattcgt tccaagatga gcaagacaag cctctgcctg
      661 tccccagcaa ccagtgctgc aactggaatt attttggctg gggtgagcag cacaacgatg
      721 accccgacag tgcagtggat gatcgtgaca gtgactaccg cagtgaaacg agcaacagca
      781 tcccgccgcc ctattatact acgtcacaac ccaacgcctc agtccaccaa tattctgttc
      841 gcccaccacc cctgggctcc cgggagtcct acagtgactc catgcacagt tacgaggagt
      901 tctctgagcc acaagccctc agccccacgg gtagcagccg ctatgcctct tccggggagc
      961 tgagccaggg aagctctcag ctgagcgagg acttcgaccc tgacgagcac agcctgcagg
     1021 gctccgacat ggaggatgag cgggaccggg actcctacca ctcctgccac agctcggtca
     1081 gctaccacaa agactcgcct cgctgggacc aggatgagga agagctggag gaggacctgg
     1141 aggacttcct ggaggaggag gagctgcctg aagatgagga ggagctggag gaggaggagg
     1201 aggaggtgcc tgacgatttg ggcagctatg cccagcgtga agacgtagct gtggctgagc
     1261 ccaaagactt caaacgcatc agcctcccgc cagctgcccc agggaaggag gacaaggccc
     1321 cagtggcacc caccgaggcc cccgacatgg ccaaggtggc ccccaagcca gccacgcccg
     1381 acaaggtgcc tgcagctgag cagatccctg aggctgagcc acccaaggac gaggagagtt
     1441 tcaggccgag agaggatgag gaaggccagg aggggcagga ctccatgtcc agggccaagg
     1501 ccaactggct gcgtgccttc aacaaggtgc ggatgcagct gcaggaggcc cggggagaag
     1561 gagagatgtc taaatcccta tggttcaaag gcggcccagg gggcggtctc atcatcatcg
     1621 acagcatgcc agacatccgc aagaggaaac ctatcccact cgtgagcgac ttggccatgt
     1681 ccctggtcca gtccaggaaa gcgggcatca cctcggcctt ggcctccagc acgttgaaca
     1741 acgaggagct gaaaaaccac gtttacaaga agaccctgca agccttaatc taccccatct
     1801 cgtgcacgac gccacacaac ttcgaagtgt ggacggccac cacgcccacc tactgctacg
     1861 agtgcgaggg gctgctgtgg ggcatcgcga ggcagggcat gcgctgcacc gagtgcggtg
     1921 tcaagtgcca cgagaagtgc caggacctgc tcaacgccga ctgcctgcag cgggctgcgg
     1981 agaagagctc caagcacggg gcggaggacc ggacacagaa catcatcatg gtgctcaagg
     2041 accgcatgaa gatccgggag cgcaacaagc ccgagatctt cgagctcatc caggagatct
     2101 tcgcggtgac caagacggcg cacacgcagc agatgaaggc ggtcaagcag agcgtgctgg
     2161 acggcacgtc caagtggtcc gccaagatca gcatcaccgt ggtctgcgcc cagggcttgc
     2221 aggcaaagga caagacagga tccagtgacc cctatgtcac cgtccaggtc gggaagacca
     2281 agaaacggac aaaaaccatc tatgggaacc tcaacccggt gtgggaggag aatttccact
     2341 ttgaatgtca caattcctcc gaccgcatca aggtgcgcgt ctgggacgag gatgacgaca
     2401 tcaaatcccg cgtgaaacag aggttcaaga gggaatctga cgatttcctg gggcagacga
     2461 tcattgaggt gcggacgctc agcggcgaga tggacgtgtg gtacaacctg gacaagcgaa
     2521 ctgacaaatc tgccgtgtcg ggtgccatcc ggctccacat cagtgtggag atcaaaggcg
     2581 aggagaaggt ggccccgtac catgtccagt acacctgtct gcatgagaac ctgttccact
     2641 tcgtgaccga cgtgcagaac aatggggtcg tgaagatccc agatgccaag ggtgacgatg
     2701 cctggaaggt ttactacgat gagacagccc aggagattgt ggacgagttt gccatgcgct
     2761 acggcgtcga gtccatctac caagccatga cccactttgc ctgcctctcc tccaagtata
     2821 tgtgcccagg ggtgcctgcc gtcatgagca ccctgctcgc caacatcaat gcctactacg
     2881 cacacaccac cgcctccacc aacgtgtctg cctccgaccg cttcgccgcc tccaactttg
     2941 ggaaagagcg cttcgtgaaa ctcctggacc agctgcataa ctccctgcgg attgacctct
     3001 ccatgtaccg gaataacttc ccagccagca gcccggagag actccaggac ctcaaatcca
     3061 ctgtggacct tctcaccagc atcaccttct ttcggatgaa ggtacaagaa ctccagagcc
     3121 cgccccgagc cagccaggtg gtaaaggact gtgtgaaagc ctgccttaat tctacctacg
     3181 agtacatctt caataactgc catgaactgt acagccggga gtaccagaca gacccggcca
     3241 agaaggggga agttctccca gaggaacagg ggcccagcat caagaacctc gacttctggt
     3301 ccaagctgat taccctcata gtgtccatca ttgaggaaga caagaattcc tacactccct
     3361 gcctcaacca gtttccccag gagctgaatg tgggtaaaat cagcgctgaa gtgatgtgga
     3421 atctgtttgc ccaagacatg aagtacgcca tggaggagca cgacaagcat cgtctatgca
     3481 agagtgccga ctacatgaac ctccacttca aggtgaaatg gctctacaat gagtatgtga
     3541 cggaacttcc cgccttcaag gaccgcgtgc ctgagtaccc tgcatggttt gaacccttcg
     3601 tcatccagtg gctggatgag aatgaggagg tgtcccggga tttcctgcac ggtgccctgg
     3661 agcgagacaa gaaggatggg ttccagcaga cctcagagca tgccctattc tcctgctccg
     3721 tggtggatgt tttctcccaa ctcaaccaga gctttgaaat catcaagaaa ctcgagtgtc
     3781 ccgaccctca gatcgtgggg cactacatga ggcgctttgc caagaccatc agtaatgtgc
     3841 tcctccagta tgcagacatc atctccaagg actttgcctc ctactgctcc aaggagaagg
     3901 agaaagtgcc ctgcattctc atgaataaca ctcaacagct acgagttcag ctggagaaga
     3961 tgttcgaagc catgggagga aaggagctgg atgctgaagc cagtgacatc ctgaaggagc
     4021 ttcaggtgaa actcaataac gtcttggatg agctcagccg ggtgtttgct accagcttcc
     4081 agccgcacat tgaagagtgt gtcaaacaga tgggtgacat ccttagccag gttaagggca
     4141 caggcaatgt gccagccagt gcctgcagca gcgtggccca ggacgcggac aatgtgttgc
     4201 agcccatcat ggacctgctg gacagcaacc tgaccctctt tgccaaaatc tgtgagaaga
     4261 ctgtgctgaa gcgagtgctg aaggagctgt ggaagctggt tatgaacacc atggagaaaa
     4321 ccatcgtcct gccgcccctc actgaccaga cgatgatcgg gaacctcttg agaaaacatg
     4381 gcaagggatt agaaaagggc agggtgaaat tgccaagcca ctcagacgga acccagatga
     4441 tcttcaatgc agccaaggag ctgggtcagc tgtccaaact caaggatcac atggtacgag
     4501 aagaagccaa gagcttgacc ccaaagcagt gcgcggttgt tgagttggcc ctggacacca
     4561 tcaagcaata tttccacgcg ggtggcgtgg gcctcaagaa gaccttcctg gagaagagcc
     4621 cggacctgca atccttgcgc tatgccctgt cgctctacac gcaggccacc gacctgctaa
     4681 tcaagacctt tgtacagacg caatcggccc agggcttggg tgtagaagac cctgtgggtg
     4741 aagtctctgt ccatgttgag ctgttcactc atccaggaac tggggaacac aaggtcacag
     4801 tgaaagtggt ggctgccaat gacctcaagt ggcagacttc tggcatcttc cggccgttca
     4861 tcgaggtcaa catcattggg ccccagctca gcgacaagaa acgcaagttt gcgaccaaat
     4921 ccaagaacaa tagctgggct cccaagtaca atgagagctt ccagttcacg ctgagcgccg
     4981 acgcgggtcc cgagtgctat gagctgcagg tgtgcgtcaa ggactactgc ttcgcgcgcg
     5041 aggaccgcac ggtggggctg gccgtgctgc agctgcgtga gctggcccag cgcgggagcg
     5101 ccgcctgctg gctgccgctc ggccgccgca tccacatgga cgacacgggc ctcacggtgc
     5161 tgcgaatcct ctcgcagcgc agcaacgacg aggtggccaa ggagttcgtg aagctcaagt
     5221 cggacacgcg ctccgccgag gagggcggtg ccgcgcctgc gccttagcgc gggcggtcgg
     5281 ccgagcggca ctgcgcctgc gcggagggcg ctgggcgggg agggacgggg cttgcgcctt
     5341 ggtgggacct ccccaggggc ggggctcggg gggctccacg ccaagggtgg gctgcgccta
     5401 cgcccttgac tcagctttcc cttttgggga attaggaatg gaggatgccc cgccctctcg
     5461 ggaggccacg cccaagggcg cgacgaagga aggagccaca tccccaactt gaggccacgc
     5521 ccccagcacc tagggggcat tttgagctgg gatgggggaa acctcgtccc tatggaggag
     5581 gccacatccc ggggctctgg taccgggagg caccacctca tgtcccctgg aaaagccata
     5641 agatgggacc cagacccctg ggaccccaga ccaattgcca agtatggaaa tctcagctcc
     5701 ctcgaggggg ggccctgggc aaggggtagg gctctctgga gcgcccctct aggtggcctg
     5761 gggactggag ggaccaggat gctggttgga gggccccgga ataccggagt ccctttagat
     5821 atttgtgcaa aaaataaatg gggggagggg ggaggatggg atttcaaaag cacatgcgcc
     5881 cttgggcgcc caaaccctgg gggccgaggg gacggctctg gttccccacg ctgcccctac
     5941 ttccctttgg gagtttgcct ctccctctcc cccaacaaac ccagtcctca tatcatagag
     6001 ttcaacacac ccatttgaca gatggcaaaa ctgaggctta aagagctgct tgagacttgg
     6061 ccaaggttcc aggtgccata ccctctgtgc ccctccctta ggcctgtgtg ccccatggaa
     6121 gggtgggctg agatcgggat gacctgacac agctccctat tgctgctaat tccccctcgg
     6181 cctcctccaa ggggtgggaa ttccaggcca agacccctac ttcgcctttc cttctccggc
     6241 tgccaagcag gacctttgcc ctcagccctt tctcctggga tctccatggg ggatgccatg
     6301 agggcctccc accacaaaag agaatttggg atcccctggt cccaggtttc tccatccctt
     6361 cttccttttc cagaattttc caaataggaa agaacagaag gagaccagaa actctagggg
     6421 ggagaaagag aatgagagaa agagaatgag agagagagaa acacaaacac agtgacacag
     6481 tgagagctta gtctccaaga gcctattcat tgattcaaac acccaagcca caggatacct
     6541 cagatggccc tcttgccagc tggaagctct ttctccaatg agcaaagtta cagtgacctg
     6601 gctggagtta cctggtgcac ataggacctt aggggaaagt tcagcgtgga ctacacttgc
     6661 tctgggatct gcttttccac atgtgtgtat ggcacgcctt tttctgctgg attgggaagg
     6721 acaagatttt gctgtgctag ggagaaatga aaacggggtg agctgagtag ctgggtttct
     6781 ggaggataga acatcagatg gggaggcttt ccgaggtgaa gaatgagagg gaaccactta
     6841 ctagagagaa aagagctcca ggcctgggga acagcacgtg cgaaggccag gagagaagaa
     6901 ctgttgaaac aacgagaagg gtggcacggc tggagctgag ccagcaaggg ggatcgtgag
     6961 gagccttggg gttggggaga tctgcagaag catcagacca ggcagggcct cgtacgcagt
     7021 cctgaggagt tttactttta ttctaagaca gttggggagc tccaggagct gttttaagtt
     7081 ggggagagac tggattccag cctgcaaaag ctgttttgtg aagactaaaa ccagtgagga
     7141 gaggtggagg tgctttgggg acactgaaat ggattcttgg aaagattctg aaggctgtgt
     7201 tgaaaagaca cctatagctg tggggacatg actataatcc cagcatttgg ggagaccgag
     7261 gctggcagat cacttaaggt caggagtttg agaccagcct ggccaacatg gcgaaacccc
     7321 atctctgcta aaaatacaaa aattagctgg gtgcagtggt gcatgcctgt agtcccagct
     7381 actcaggaga ctgaggcggg agaattgttt gaaccctgga ggcagaggtt gtagtgagtc
     7441 gtgatcacac aactgcactc cagcctgggc aacagaacaa tactccattc cctcccctct
     7501 accccaccaa aaaaaaaaaa aaatcctgcc cttagatgag ctctagggct gctgagtaca
     7561 gttgtcccag ttgcacagtg cccaagggtt tggcattgct aagaaggcca cgtgcaaatc
     7621 ctagatattg agtgttgtat gtttgtgacg ttggtttccc gacatgtgaa tggcccaagt
     7681 gtctggaaga agtggcgcca ctttctaatt tgcttggaga tgttgcatgt cccttaaatt
     7741 cagacaggtg caggtaactg gaggttctga accaaaggtt aaaatgcaaa ttctcataca
     7801 gggttgggaa gttgtagcca gggataagct tatgtgactg ttatatggac tgaggagcag
     7861 atgtgaattt cgaaccatga catggctgag ggtaggggtc gggtggatgg atgattcagg
     7921 gttgtaaccc atagagccca aaggggaagt gatctgtgac ctggggtgag ggtgatctgg
     7981 aagatttttg gatggctgga aagaaatggg gaagtcgagc tgcctgagag agccaagtta
     8041 tttcccaaaa gattccttag gagtctttct gttcaagacc tccgtgtgtg tgtgtgtgtg
     8101 tttagggttc cccagcaatg gcccaggcat gtgaaggaaa caagcttctt cagggaatat
     8161 ttgttgaatg agttttcctg actcccaggc tagaactgtt tttgcaattt ccaccctctt
     8221 ttctttcccc cagagaactc ctattcgtcc ttcaaaaccc atcacggaaa cccctcttgg
     8281 agaaaaccct ccttccttcc cctcaggact ttcccagcca ccgtctctcc tccagtccag
     8341 cctgatgcca tgggactggg ggtttctctg tccagctctg tttctcccag actggggtct
     8401 gaggactctc aggaccccca actttaccta gcacaggctg ggcacaagtg ggtgacaggg
     8461 agtctacgcc tagtggaatt atgtattggg gcagggtcag tgtgagaata cacatccgca
     8521 tgcatgtctg tccatgtctg tccgtaccaa ccttcccctt ccacacggac ctgggcacat
     8581 aggaggtgtc tgagcctgac acatgggaca gagagtggac atggctgaga cacggacaga
     8641 gaaaagacaa ggagtccagg gggctgaaag ccttttgaaa tcaggaagtt cctgtattgg
     8701 cagaacaaag cccagagagg agcagggctt tcctcaacgc cacccagcaa gtggacacag
     8761 agcccggcct tggatgacac ctccagggtt ctgaaccctg gacctcgctt tatgcaagga
     8821 gctggcccca catttccatg aatcggggaa acagcacaag aaggttggcc tgtggcaggg
     8881 caagggttaa aggggtgaca ttgagggatg cctcagagtc aaagtcccct gaccaagagg
     8941 aatagagtag aaaacacaga gacagagggt gagatcacgc cccgatgagg acggagagag
     9001 acagagatgg agagagacat agaggtggaa atatacagag aaagataaat gcagagacca
     9061 aggcagggag tgtcggggga agtaaagagg gtgtcctgaa gaaagaagga tctgttcact
     9121 cttaccagtc tgtcctcgaa tgatttgcat aaaatgagga ggtgcctgtc cacaccccca
     9181 attcctctct caggccccag agcctgagac ctcaccatgc ccccatcaga gatgcaaaaa
     9241 actaaacacc caactagaaa tccttgggac ctctctcggc tgggatctca gagcctttct
     9301 gtcccctacc cctaccccat gtgctgtcga ttttgcagat ggggacaacc tggggcctcc
     9361 cggaactctg ccaccctggg gaagttgggg gagggcctta gtcccggatc acaaccccgt
     9421 ctgctcccca gaatcctttc ctaagaatcg ttgaggacca aagttgtctt tgctgacacg
     9481 tgttgctttt ctctttgcct tttattgttt cagagaaaaa tcaagttgac tgtgtcaagt
     9541 aacaccccac cccttacccc cgtccagcca tagtggctct ctggagacac aggtcacagg
     9601 cggagggtcc cctgatcatc cccaaccaca cagccagggg gacttgaccc ctgtccaccc
     9661 ctgtctcgtg ctccctcaga cccccacaaa ccggccaagc agtccgggga ggcttcccct
     9721 ccacacaact cttagcatgt gattgcagat gtgaaatcaa aacgttgttt gttttttgtt
     9781 ttgttttgat tctaccccgt cggtccagtg tctgcacaga cgccttcatt tctctgtaaa
     9841 tatgtgactt ggaacaaatg tttaacacaa acgagaagtg gtcatgaatg catggtgttg
     9901 agatgttttg cactattctg actttttggt ctctgtaaaa atattttatt aacagcagac
     9961 attaaaaaaa gaaaaaccac acaca
//
