LOCUS       NM_001080533            4381 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.
ACCESSION   NM_001080533 XM_930036
VERSION     NM_001080533.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4381)
  AUTHORS   Wu,Q., Li,X., Long,M., Xie,X. and Liu,Q.
  TITLE     Integrated analysis of histone lysine lactylation (Kla)-specific
            genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic
            targets for hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 18642 (2023)
   PUBMED   37903971
  REMARK    GeneRIF: Integrated analysis of histone lysine lactylation
            (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are
            novel therapeutic targets for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4381)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4381)
  AUTHORS   Lokaj,M., Kosling,S.K., Koerner,C., Lange,S.M., van Beersum,S.E.,
            van Reeuwijk,J., Roepman,R., Horn,N., Ueffing,M., Boldt,K. and
            Wittinghofer,A.
  TITLE     The Interaction of CCDC104/BARTL1 with Arl3 and Implications for
            Ciliary Function
  JOURNAL   Structure 23 (11), 2122-2132 (2015)
   PUBMED   26455799
REFERENCE   5  (bases 1 to 4381)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 4381)
  AUTHORS   Constantine,R., Zhang,H., Gerstner,C.D., Frederick,J.M. and
            Baehr,W.
  TITLE     Uncoordinated (UNC)119: coordinating the trafficking of
            myristoylated proteins
  JOURNAL   Vision Res 75, 26-32 (2012)
   PUBMED   23000199
  REMARK    Review article
REFERENCE   7  (bases 1 to 4381)
  AUTHORS   Ismail,S.A., Chen,Y.X., Miertzschke,M., Vetter,I.R., Koerner,C. and
            Wittinghofer,A.
  TITLE     Structural basis for Arl3-specific release of myristoylated ciliary
            cargo from UNC119
  JOURNAL   EMBO J 31 (20), 4085-4094 (2012)
   PUBMED   22960633
REFERENCE   8  (bases 1 to 4381)
  AUTHORS   Wright,K.J., Baye,L.M., Olivier-Mason,A., Mukhopadhyay,S., Sang,L.,
            Kwong,M., Wang,W., Pretorius,P.R., Sheffield,V.C., Sengupta,P.,
            Slusarski,D.C. and Jackson,P.K.
  TITLE     An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the
            primary cilium
  JOURNAL   Genes Dev 25 (22), 2347-2360 (2011)
   PUBMED   22085962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA324219.1, BC070088.1, AC069234.35 and AL137327.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001080533.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070088.1, SRR1803614.210752.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344651.5/ ENSP00000344942.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA324219.1         24-28
            6-788               BC070088.1         1-783
            789-2390            AC069234.35        96546-98147         c
            2391-4381           AL137327.1         1-1991
FEATURES             Location/Qualifiers
     source          1..4381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..4381
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /note="unc-119 lipid binding chaperone B"
                     /db_xref="GeneID:84747"
                     /db_xref="HGNC:HGNC:16488"
                     /db_xref="MIM:620513"
     exon            1..261
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..773
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /note="POC7 centriolar protein homolog B; unc-119 homolog
                     B"
                     /codon_start=1
                     /product="protein unc-119 homolog B"
                     /protein_id="NP_001074002.1"
                     /db_xref="CCDS:CCDS31914.1"
                     /db_xref="GeneID:84747"
                     /db_xref="HGNC:HGNC:16488"
                     /db_xref="MIM:620513"
                     /translation="MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQA
                     PHHAADDGVGAAVTEQELLALDTIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIR
                     DLETGTVLFEIAKPCVSDQEEDEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEF
                     TVGDKPVSNFRMIERHYFREHLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLM
                     IENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ"
     exon            262..375
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /inference="alignment:Splign:2.1.0"
     exon            376..487
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /inference="alignment:Splign:2.1.0"
     exon            488..660
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /inference="alignment:Splign:2.1.0"
     exon            661..4381
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4358..4363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /note="hexamer: AATAAA"
     polyA_site      4381
                     /gene="UNC119B"
                     /gene_synonym="POC7B"
                     /note="major polyA site"
ORIGIN      
        1 atcttggcgg cggagcgatg agcgggtcta acccgaaggc tgcggccgcg gcgtcggcgg
       61 ctgggcccgg ggggctggtg gctggcaagg aggagaagaa gaaggcgggc ggcggcgtcc
      121 tgaaccgcct gaaggcgcgg cggcaggcgc cccaccacgc ggccgacgac ggcgtcgggg
      181 cagcggtcac ggagcaggag ctgctggcgc tggacaccat ccggcccgag cacgtcctgc
      241 gcctcagccg ggtcaccgag aattatttat gtaaacccga agacaacatc tacagtattg
      301 atttcacccg cttcaaaatt cgagatttgg agacagggac agtacttttt gagattgcca
      361 aaccttgcgt ttcagaccag gaggaggatg aggaggaggg aggtggagac gtggacatca
      421 gcgcaggacg ttttgtccgc tatcagttca caccggcatt tctccgcctc cggacagtcg
      481 gggctacggt ggagttcaca gtgggagaca aacctgtttc aaacttccgg atgatcgaac
      541 ggcactattt ccgggaacac ttgctgaaaa actttgactt tgattttggc ttctgcatcc
      601 ccagcagtag gaacacttgt gaacatatct atgagtttcc ccagctttcg gaggatgtca
      661 ttcgtctaat gattgaaaat ccttacgaga cccgctctga cagcttctac tttgttgaca
      721 acaagctgat aatgcacaac aaggctgatt atgcctataa tggaggccag taagtgctgc
      781 aagagtagat aggggaggtg ctttgccgcg gccacaagat cctggcacac ggagatgatc
      841 gaagctgcag tttgtcaaca cacatctgga acctggcccc aggaagccaa ggctggggtg
      901 gcagtttcct gcgcgccaaa ggagctgcca aacagtgctg tgttttcttc cccagtattt
      961 tttcttccct ttttttcctg ccccgtaggt tgcagaggta ctatagtaaa gtaaaaggtt
     1021 aggataaggg tcctggaatc cagataaaaa agtttatttt ccgtagttct ggctgcctgt
     1081 tggttgtctt gacgaccagg catagctgtg cctggtgaga aggctctggc caggcccacc
     1141 agcaggtcag cagctcttaa ggttcctggg tgctgtggga agctgaaagg taggcctctt
     1201 ccaggtagct cctcctctca cctccggcat tgccatcagc gcagtctgcc ctcggtctgt
     1261 gtgaagtctt aaaccaactg gaagacactt gaaagggtgg ggagggaggg aggtgccaag
     1321 agtggaggca ccaaggaatg ggtgatgctg ccaagctgaa gggtctgctt tgtggagagg
     1381 ctgctgctct gtctgacttc cagggtctca gccagccctc ctgggaatag accaagtttt
     1441 cagcctggca gtgccttctg ttcccatttt ggaggacaga caagcttgct ccacatctcc
     1501 tggctcctcc cttctgagtc tcatgaaata gaatgagtca gctctgctca tggaacagta
     1561 gtatctcttg aggccagagc aggtcttgta ttttgttttt ttatttccag acttctttcg
     1621 gggaggtttt ataaaatgac agtggtgttc ccagcatatg tgatatgtgg ttagacttct
     1681 gatagtatca gcttccaggg gctaatctgg cttatgttgg gaggatatgc ttacgaatca
     1741 gcagcagctt tctaaaggag agatttgact tttctctgca ctgcacagcc tggaggattg
     1801 gcttttgatg gggatttgcc tccgaagctc tttgtacatt tcttgtttag gagggttttc
     1861 ctatctacct ttctactgaa gtagtttctg gaactttcct ggtggatcag agttacgtaa
     1921 tgcagtctga gccttcagac tgctagttag aattgtttta ggtgttcaga aagggcaaaa
     1981 taggctgatg tggcctgtca gagtgatgtg ttctcaaaaa agttcacttg cacatctgtg
     2041 ggctgctttt gtcctcagac ccttagtgga cagactccac aaaccctctg atgagacgat
     2101 tgatgtggcc agggtccagt tagcatcagt agaaggatgt cactaggaaa ggcccaggta
     2161 tctggtaagt gactgtgagg tgtcacagta cctgtgacag gagagtgtcc tgatgtgctt
     2221 gggagaaagg ccgtatgggg gccagggatg gaagagacag tgtgtggcca cagaaattcc
     2281 tgtccatcca ccaccagtgc tgctccctgt gtgggcttta gggcgagtgg ccccgaacct
     2341 tggcccagtg ctttgtccca ggccagagtc ttggcaatgc cacatgctgg cagctttctc
     2401 actgagaagg tcctagctta cccctgtgtg ctggccttgg attcagcccc gagagagggg
     2461 agagaccatt cctcctgtgg agtgggttcc ttatcaccag accggccact ctcagaactg
     2521 gcgtccactg taaatccagg tgccttacgt gtggctctgt cccttatgct gcaggggaaa
     2581 gctgcattgc cattgttccc acctcctcac tggcagaaag atgccagggc tgttagcact
     2641 gtctcctcac cttctgtttc tcattgtggc tcctcaaatg ggatttgcat gttcctgtca
     2701 agcgtaacaa caatcccttc tctctttgac agaggcccag gtgggacagt ttctactatt
     2761 tgatatttga gtattatctg ggatgtggtt ctggagctgc ccagagctgt gcttagtaga
     2821 gtgtgtcttg gaaacatgcc cctgggcaca ctgtatctgc tacattagtg ggctatctct
     2881 tatctgcagt gttcgctttt gctagaaaga ggatgtggag gaaggaggag gtgggcaatc
     2941 tggcttgagt tgtgctgtat cctcttcctt gttagcttgc cttagtctca ctggagacca
     3001 tttgcggata gtgcttggtc catgcccagc aggacagggc tttgctgctt ctgaaagtct
     3061 ggtgttctgt atctggggct gtgggttcct gtgtctagct gctcaggaaa tcttgagaag
     3121 cattccactc tggggtgtaa accagtatga gtttgaaatt caagcgtttg tacctgagtt
     3181 ggggagagaa ttgcaaggca tactttctct gaaagtaaca gaaccattca ggctgccatg
     3241 ttattaagga atctgaactg ttgatagcag ttaccttgtg ggtgatacaa tgggaggcgg
     3301 caaaaaaact acctgcatag gagaccctgc cctttgtcaa gagctgggag cacatttcat
     3361 cagagtagca ggcccacctg gtgccagagg gcctgcccct cctgcttctg ttcctttgcc
     3421 ttgcagtctc ctggagagag cctctctttt cctgtacagc ctttgggcca aaatgccctt
     3481 ctagcttctc caaagaagat ccgagtttat ttcattctat gttttaagag gtaaaaggac
     3541 ataacaagtg aaagaagttt tgggctaaag taggctatgt ctccttatgt attactcaat
     3601 actgttttgc agagaaaaca tttttcaagc atgtgcttcc tgaagacacc tcagtctttg
     3661 ggccatttga tttccaatac atagggtgga agaatgtgat tttggggctg accataaact
     3721 ggaaatttgt gaaatggcag tgattgggca atcttcagtt tattttttca gttgaagtgg
     3781 aactcatttc tggaatggat ttaataggct gtgtctaatg tacaaactgg gtgagtcctg
     3841 ccttagtgtg tcctgcccca ccggtacgct tccaggatac tcttttcccc tctgtaaagt
     3901 cactttcttc tgatggccag tgtcactatg atgtcagtga ggtctgggga tgaggacagt
     3961 gtgtcctgaa attcacagga ctgactcctc accccagtgc acgaggattc ctgtggcatc
     4021 aggtgctgct gtacctggtg taggagccta atcattgaac cattgtgtta ctcacattcc
     4081 atgtcacaga acatatcagc ctcaagaagg atttggtgga ggtggattta ccactggttt
     4141 tacaaaggac cgtgtaaagt cattgaagtt gtgaaagtct attttttttc ctgtaaatct
     4201 attttttaca gaatataaga aacatcaatg acctgatctg tccttcctcc tccttcccgc
     4261 ttcccccaaa atcacattcc agtttttatt gtctttgtgt ccaaagtaaa ctaggtgact
     4321 tatttgtata aaatgttatt ttgccacatg agacagtaat aaaagaaaga ttttcacagt
     4381 a
//
