LOCUS       NM_005148               1379 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens unc-119 lipid binding chaperone (UNC119), transcript
            variant 1, mRNA.
ACCESSION   NM_005148
VERSION     NM_005148.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Shimizu,T., Nakamura,T., Inaba,H., Iwasa,H., Maruyama,J.,
            Arimoto-Matsuzaki,K., Nakata,T., Nishina,H. and Hata,Y.
  TITLE     The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53
            axis and antagonizes RAS-mediated malignant transformation
  JOURNAL   J Biol Chem 295 (32), 11214-11230 (2020)
   PUBMED   32554467
  REMARK    GeneRIF: The RAS-interacting chaperone UNC119 drives the
            RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant
            transformation.
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Higashide,T. and Inana,G.
  TITLE     Characterization of the gene for HRG4 (UNC119), a novel
            photoreceptor synaptic protein homologous to unc-119
  JOURNAL   Genomics 57 (3), 446-450 (1999)
   PUBMED   10329014
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Swanson,D.A., Chang,J.T., Campochiaro,P.A., Zack,D.J. and Valle,D.
  TITLE     Mammalian orthologs of C. elegans unc-119 highly expressed in
            photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 39 (11), 2085-2094 (1998)
   PUBMED   9761287
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Higashide,T., McLaren,M.J. and Inana,G.
  TITLE     Localization of HRG4, a photoreceptor protein homologous to
            Unc-119, in ribbon synapse
  JOURNAL   Invest Ophthalmol Vis Sci 39 (5), 690-698 (1998)
   PUBMED   9538874
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Higashide,T., Murakami,A., McLaren,M.J. and Inana,G.
  TITLE     Cloning of the cDNA for a novel photoreceptor protein
  JOURNAL   J Biol Chem 271 (3), 1797-1804 (1996)
   PUBMED   8576185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM848267.1 and AF028788.1.
            
            On Aug 31, 2019 this sequence version replaced NM_005148.3.
            
            Summary: This gene is specifically expressed in the photoreceptors
            in the retina. The encoded product shares strong homology with the
            C. elegans unc119 protein and it can functionally complement the C.
            elegans unc119 mutation. It has been localized to the photoreceptor
            synapses in the outer plexiform layer of the retina, and suggested
            to play a role in the mechanism of photoreceptor neurotransmitter
            release through the synaptic vesicle cycle. Two transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the most abundant
            transcript, and encodes the full-length isoform (a) of 240 aa.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027176.1, AF028788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335765.9/ ENSP00000337040.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BM848267.1         5-68
            65-1379             AF028788.1         1-1315
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1379
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /note="unc-119 lipid binding chaperone"
                     /db_xref="GeneID:9094"
                     /db_xref="HGNC:HGNC:12565"
                     /db_xref="MIM:604011"
     exon            1..287
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..790
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /note="isoform a is encoded by transcript variant 1; POC7
                     centriolar protein homolog A; unc-119 homolog; retinal
                     protein 4; protein unc-119 homolog A"
                     /codon_start=1
                     /product="protein unc-119 homolog A isoform a"
                     /protein_id="NP_005139.1"
                     /db_xref="CCDS:CCDS11233.1"
                     /db_xref="GeneID:9094"
                     /db_xref="HGNC:HGNC:12565"
                     /db_xref="MIM:604011"
                     /translation="MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPD
                     AGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVL
                     FEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR
                     MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDS
                     FYFVDDRLVMHNKADYSYSGTP"
     exon            288..401
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            402..504
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            505..677
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1379
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="UNC119"
                     /gene_synonym="CORD24; HRG4; IMD13; POC7; POC7A"
                     /note="major polyA site"
ORIGIN      
        1 cttcccccgg ctccagccgg cgcaggcagc ggcggcagca gcaggcgagc ctcggccccg
       61 caaggccatg aaggtgaaga agggcggcgg tggggccggg acggcgacgg agtccgctcc
      121 ggggccctcg ggccagagcg tggcccccat accacagccg cctgcggaat ccgaatctgg
      181 gtccgagtcg gagccggacg caggcccagg gcccaggccg gggccgctgc agaggaagca
      241 gccgatcggg ccggaggacg tgctggggct gcagcggatc accggtgact acctctgctc
      301 ccctgaggag aatatctaca agatcgactt tgtcaggttt aagattcggg acatggactc
      361 aggcactgtc ctctttgaaa tcaagaagcc cccagtctca gaacggttgc ccatcaaccg
      421 gcgggacctg gaccccaatg ctgggcgctt tgtccgctac cagttcacgc ctgccttcct
      481 ccgcctgagg caggtgggag ccacggtgga gttcacagtg ggagacaagc ctgtcaacaa
      541 cttccgcatg atcgagaggc actacttccg caaccagcta ctcaaaagct tcgacttcca
      601 ctttggcttc tgcatcccca gcagcaagaa cacctgcgag cacatttacg acttcccccc
      661 tctctccgag gagctgatca gcgagatgat ccgccacccg tatgagaccc agtctgacag
      721 cttctacttc gtggatgacc ggctggtgat gcacaataaa gcagactatt cctacagcgg
      781 gacaccctga ccccacggct gccctgaccc caggaggctc cagttctggg ctgggagctg
      841 tgacctcccc aacgctcacc cctcaacccc aagtcctctg cttggggagt tctccaggag
      901 ctccggaccc tgagtcaatg ttgggaggaa gggtacctgg tgtccccagt caagcccatg
      961 aagcccatgc ggcctgctac atggggtggg gtcgtaggga ggctgtttgc ctccacgtct
     1021 aggaaggcct gtgagaggag cagtcaggac ttccggacaa cttagctggg ccctacttgg
     1081 gcccaagttt cagaatagtg ttcccctatc aaggctgtga ctagatcagg cagggatcca
     1141 ttccctgtcc cctgcccact accttcaggc catttagagt tgtaaattta caaagatcca
     1201 cggtgggctc cagctgccaa gccacccaag ggagtctggg ccctaggcct agccccatcc
     1261 ctccccatga ggggccaaga cactgcctaa ggtgtgggag ggactggctg agattgcagc
     1321 ccatggtagg agctggacca actgtatata gttttcaata aactttttcc ttttctgtt
//
