LOCUS       NM_001004416            4879 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens uromodulin like 1 (UMODL1), transcript variant 1,
            mRNA.
ACCESSION   NM_001004416
VERSION     NM_001004416.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4879)
  AUTHORS   Zhu,M.M., Yap,M.K., Ho,D.W., Fung,W.Y., Ng,P.W., Gu,Y.S. and
            Yip,S.P.
  TITLE     Investigating the relationship between UMODL1 gene polymorphisms
            and high myopia: a case-control study in Chinese
  JOURNAL   BMC Med Genet 13, 64 (2012)
   PUBMED   22857148
  REMARK    GeneRIF: It was shown that common UMODL1 polymorphisms are unlikely
            to be important in the genetic susceptibility to high myopia in Han
            Chinese.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4879)
  AUTHORS   Nishizaki,R., Ota,M., Inoko,H., Meguro,A., Shiota,T., Okada,E.,
            Mok,J., Oka,A., Ohno,S. and Mizuki,N.
  TITLE     New susceptibility locus for high myopia is linked to the
            uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3
  JOURNAL   Eye (Lond) 23 (1), 222-229 (2009)
   PUBMED   18535602
  REMARK    GeneRIF: result suggests that rs283971 is located in the frequent
            recombinant region on the UMODL1, and that this region might play a
            critical role in disease susceptibility to high myopia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4879)
  AUTHORS   Di Schiavi,E., Riano,E., Heye,B., Bazzicalupo,P. and Rugarli,E.I.
  TITLE     UMODL1/Olfactorin is an extracellular membrane-bound molecule with
            a restricted spatial expression in olfactory and vomeronasal
            neurons
  JOURNAL   Eur J Neurosci 21 (12), 3291-3300 (2005)
   PUBMED   16026467
REFERENCE   4  (bases 1 to 4879)
  AUTHORS   Shibuya,K., Nagamine,K., Okui,M., Ohsawa,Y., Asakawa,S.,
            Minoshima,S., Hase,T., Kudoh,J. and Shimizu,N.
  TITLE     Initial characterization of an uromodulin-like 1 gene on human
            chromosome 21q22.3
  JOURNAL   Biochem Biophys Res Commun 319 (4), 1181-1189 (2004)
   PUBMED   15194491
  REMARK    GeneRIF: Data report the isolation of a novel gene, designated
            UMODL1, similar to uromodulin (UMOD)/Tamm-Horsfall glycoprotein, on
            human chromosome 21q22.3.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001620.1, AP001621.1 and AP001622.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 18, 2020 this sequence version replaced NM_001004416.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY771620.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408910.7/ ENSP00000386147.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AP001620.1         80058-80133
            77-319              AP001620.1         84746-84988
            320-481             AP001620.1         92826-92987
            482-603             AP001620.1         94033-94154
            604-790             AP001621.1         21984-22170
            791-931             AP001621.1         23988-24128
            932-1186            AP001621.1         32616-32870
            1187-1299           AP001621.1         35856-35968
            1300-1519           AP001621.1         37558-37777
            1520-1657           AP001621.1         43252-43389
            1658-1899           AP001621.1         44570-44811
            1900-2104           AP001621.1         45196-45400
            2105-2362           AP001621.1         47263-47520
            2363-2475           AP001621.1         49563-49675
            2476-2689           AP001621.1         52801-53014
            2690-2827           AP001621.1         54777-54914
            2828-3147           AP001621.1         56521-56840
            3148-3293           AP001621.1         60035-60180
            3294-3530           AP001621.1         60696-60932
            3531-3690           AP001621.1         61362-61521
            3691-3775           AP001621.1         63403-63487
            3776-3978           AP001621.1         71129-71331
            3979-4879           AP001622.1         1223-2123
FEATURES             Location/Qualifiers
     source          1..4879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..4879
                     /gene="UMODL1"
                     /note="uromodulin like 1"
                     /db_xref="GeneID:89766"
                     /db_xref="HGNC:HGNC:12560"
                     /db_xref="MIM:613859"
     CDS             1..3957
                     /gene="UMODL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; olfactorin"
                     /codon_start=1
                     /product="uromodulin-like 1 isoform 1 precursor"
                     /protein_id="NP_001004416.3"
                     /db_xref="CCDS:CCDS42936.1"
                     /db_xref="GeneID:89766"
                     /db_xref="HGNC:HGNC:12560"
                     /db_xref="MIM:613859"
                     /translation="MLRTSGLALLALVSAVGPSQASGFTEKGLSLLGYQLCSHRVTHT
                     VQKVEAVQTSYTSYVSCGGWIPWRRCPKMVYRTQYLVVEVPESRNVTDCCEGYEQLGL
                     YCVLPLNQSGQFTSRPGACPAEGPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPAPQ
                     APERDPVGSWYNVTILVKMDFKELQQVDPRLLNHMRLLHSLVTSALQPMASTVHHLHS
                     APGNASTTVSRLLLGLPRPLPVADVSTLLGDIAKRVYEVISVQVQDVNECFYEELNAC
                     SGRELCANLEGSYWCVCHQEAPATSPRKLNLEWEDCPPVSDYVVLNVTSDSFQVSWRL
                     NSTQNHTFHVRVYRGMELLRSARTQSQALAVAGLEAGVLYRVKTSYQGCGADVSTTLT
                     IKTNAQVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPVVSDLYRSGK
                     LRMQIVSLQAGSVVVRLKLTVQDPGFPMGISTLAPILQPLLASTVFQIDRQGTRVQDW
                     DECVDSAEHDCSPAAWCINLEGSYTCQCRTTRDATPSRAGRACEGDLVSPMGGGLSAA
                     TGVTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRN
                     NTGKGVEQELQGNSIMEPPSWPSPTEDPTGHFLWHATRSTRETLLNPTWLRNEDSGPS
                     GSVDLPLTSTLTALKTPACVPVSIGRIMVSNVTSTGFHLAWEADLAMDSTFQLTLTSM
                     WSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACGKEGARAHLKVRTAARKLIGKVRI
                     KNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATMCQHMDAGGVRMEVVSVTNGSIV
                     VEFHLLIIADVDVQEVSAAFLTAFQTVPLLEVIRGDTFIQDYDECERKEDDCVPGTSC
                     RNTLGSFTCSCEGGAPDFPVEYSERPCEGDSPGNETWATSPERPLTTAGTKAAFVQGT
                     SPTPQGLPQRLNLTGAVRVLCEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHSN
                     GTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGIIHHLKILSPIYCAFQNDLL
                     TSSGFTLEWGVYTIIEDLHGAGNFVTEMQLFIGDSPIPQNYSVSASDDVRIEVGLYRQ
                     KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIENGNSNKAQFKLRIFS
                     FINDSIVYLHCKLRVCMESPGATCKINCNNFRLLQNSETSATHQMSWGPLIRSEGEPP
                     HAEAGLGAGYVVLIVVAIFVLVAGTATLLIVRYQRMNGRYNFKIQSNNFSYQVFYE"
     exon            1..76
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..319
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..481
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..603
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..790
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..931
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1186
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1299
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1519
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1657
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1899
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2104
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2362
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2475
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2689
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2827
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3147
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3293
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3530
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3690
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3775
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3978
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4879
                     /gene="UMODL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UMODL1"
                     /note="hexamer: AATATA"
     polyA_site      4413
                     /gene="UMODL1"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UMODL1"
                     /note="hexamer: AATAAA"
     polyA_site      4879
                     /gene="UMODL1"
                     /note="major polyA site"
ORIGIN      
        1 atgctcagga cctcggggct ggcactgctg gctctggtca gtgctgtggg cccaagccag
       61 gccagcggct tcacagaaaa aggcctctcc ctgttgggct accagctatg cagccaccgt
      121 gtgacccaca ctgtacagaa ggtggaggcc gtgcagacgt cctacacgtc ctatgtgtcc
      181 tgcggcggct ggatcccctg gaggcggtgc cctaagatgg tttaccggac acagtacctg
      241 gtagtggagg tccccgagtc caggaacgtg actgactgct gtgagggcta tgaacagctc
      301 ggcctctact gtgtcttgcc cctgaatcag tccgggcagt tcacgtcaag acctggggcc
      361 tgccccgcag aggggcctga accatccacc tccccctgca gcttggacat cgactgtcct
      421 ggacttgaga agtgctgccc ctggtcaggg gggcgctact gcatggcccc tgcaccccaa
      481 gctccagaga gggaccctgt gggctcctgg tacaacgtca ccatactggt gaaaatggac
      541 ttcaaggaac tccagcaagt ggaccccagg ctcctgaacc acatgcgcct tctgcattcc
      601 ttggtcacca gcgccctgca accaatggcc tccaccgtcc accacctgca ctcagcccct
      661 gggaacgcct ccaccacagt gtcgcggctg ctactgggcc tgccacggcc actgcctgtg
      721 gctgacgtct ccaccctgct gggtgacatt gcgaagcgtg tctatgaagt gatcagcgtc
      781 caggtgcaag atgtcaatga gtgtttctat gaggagctca atgcctgctc tggaagggaa
      841 ctgtgcgcaa acctggaggg ctcgtactgg tgcgtctgtc accaggaagc tccagccacg
      901 tctccacgga agctgaacct ggagtgggaa gattgtcctc cagtcagtga ctacgtggtc
      961 ctcaacgtca ccagtgacag ttttcaagta tcctggcgtt taaattctac acagaaccac
     1021 actttccatg tccgggttta ccggggtatg gagttgctca ggagcgccag gacacagagc
     1081 caggcactgg cagtggctgg gctggaggct ggagtgctgt acagggtgaa gaccagctac
     1141 caggggtgcg gggccgacgt ctccaccacg ctgaccatca aaaccaatgc ccaggtattt
     1201 gaagtcacaa taaagattgt aaaccacaac ctgacggaga agttactcaa ccgcagcagt
     1261 gtggagtacc aggacttttc tagacaactg cttcacgagg tcgagagctc cttcccacca
     1321 gtggtgtctg acttgtaccg aagtgggaag ctgagaatgc agatcgtgtc tctccaggcg
     1381 ggaagtgtgg tcgtgaggct caagctcacc gtgcaggacc ccgggtttcc catgggcatc
     1441 tccacgctgg cccccatact ccagcccctg ttggcaagca cagtgttcca gattgaccgg
     1501 caggggacac gcgtgcaaga ctgggacgag tgtgtggaca gcgcggaaca cgactgctca
     1561 ccggctgcct ggtgcatcaa cctggagggc tcctacacct gccagtgccg taccaccagg
     1621 gacgccaccc cctcccgcgc aggccgggcc tgtgagggtg acctggtgag ccccatgggc
     1681 ggtggactgt ctgcggcaac aggggtaacg gtcccaggtc ttggcacggg aacagcagcc
     1741 ctcggcctag agaacttcac cttgtcaccc agtcctgggt accctcaggg caccccggca
     1801 gcaggccagg cctggacccc agagccctca cccagaagag ggggcagcaa tgtggtcggg
     1861 tatgacagga acaacacagg aaaaggcgtg gagcaggagc tacagggaaa ctccatcatg
     1921 gagccaccct cctggccttc ccctactgag gaccccaccg gccacttcct gtggcatgcc
     1981 acccgttcca cccgggaaac acttctgaat cccacgtggc tgcgaaatga ggacagtgga
     2041 ccctccggtt ctgtagacct gccattgacc tccaccctca cagctctgaa gacccccgcc
     2101 tgtgttcctg tctccattgg gaggatcatg gtctccaatg tgaccagcac cggcttccac
     2161 ctggcatggg aggcggatct tgctatggac tccaccttcc agctcactct gacttccatg
     2221 tggagccctg ctgtggtcct agagacctgg aacacgagtg tgacactgtc ggggctggag
     2281 cctggggtct tgcacctggt tgagatcatg gccaaagcat gtgggaaaga aggtgccaga
     2341 gctcatctga aagtgaggac agcagcccgg aagctcattg gaaaggtcag aatcaaaaat
     2401 gtcaggtact cagaatcctt tcgcaacgca agcagccagg agtatcgaga tttcctagaa
     2461 ctattcttca ggatggtgcg gggctccctg ccagccacca tgtgtcagca catggacgct
     2521 ggtggggtca ggatggaagt cgtcagcgtc accaacggca gcatcgtggt ggagtttcac
     2581 ttgctgataa tcgcagatgt ggatgtccag gaggtgtcag ctgcatttct caccgccttc
     2641 cagaccgtgc ctctgctgga ggtgatcaga ggcgacacct tcatacagga ttacgatgag
     2701 tgtgaaagga aggaggacga ctgtgtgccg gggacatcct gtcgaaacac cctcgggtct
     2761 ttcacttgta gctgcgaggg aggagccccc gacttccctg tggaatattc tgagagaccc
     2821 tgtgaaggtg actctcctgg caatgaaacc tgggccacca gcccagagag gcctctcacc
     2881 acagcaggga ccaaggctgc ctttgtgcaa ggcaccagcc ccacccccca aggcctgccc
     2941 cagcggctga acctgaccgg agcagtcagg gtgctctgtg agatcgagaa ggtggttgtc
     3001 gccatccaga agcgcttcct gcagcaggaa tccatccccg agtcctcgtt gtacctcagc
     3061 cacccctcct gcaacgtgag ccacagcaat ggcacacacg tgctcctgga ggccggctgg
     3121 agcgagtgtg ggaccctcat gcagagcaac atgacgaaca ccgtggtgag gaccacgctg
     3181 aggaacgacc tgtcccagga gggcatcatc caccacctga agatcctgag ccccatctac
     3241 tgcgccttcc agaatgacct gctgacatcc tccggcttca ccctggagtg gggggtttac
     3301 accatcatcg aggacctcca cggcgctggg aattttgtta ccgaaatgca gttgtttatc
     3361 ggagactctc ccatacctca gaattatagc gtgtctgcca gtgacgatgt caggatcgaa
     3421 gtggggctct acaggcagaa aagcaacctc aaggtggtcc tgacggagtg ctgggcaacc
     3481 ccgtctagca acgcccggga ccccatcacc ttcagcttca ttaacaacag ctgccctgtg
     3541 cccaacacat acaccaacgt gattgagaac ggcaactcca ataaggccca gttcaagctg
     3601 aggatctttt cctttatcaa cgactccatc gtctacctgc actgcaaact ccgcgtctgc
     3661 atggaatccc ccggagccac gtgcaaaatc aattgcaata actttcggtt gctgcaaaat
     3721 agtgaaacct ctgccacaca ccagatgtcc tggggacccc tcatccggtc tgaaggtgag
     3781 cctcctcatg cagaagcagg cctgggtgcc ggttatgtgg tccttattgt ggtggccatc
     3841 ttcgtgctgg tggcgggaac agccaccctt ctgatcgtgc gctaccagag aatgaatggg
     3901 agatacaact ttaaaatcca gtccaacaac ttcagctacc aggtgttcta cgaataggag
     3961 gcgcaggctg acaggaaggt cgccgtgagt caagctgcct ccagaacctc agagcttccc
     4021 tggtgggctc ccccgggatc cccagtgtct ctctgcacct ccacccatcc ctcggttctt
     4081 aactcttcaa gccttaacgg aggtctgctc tgacgggtgg gctctgccag agcccgggtg
     4141 agcccagaaa ggaagacagc agccaccgtc tgtcccgaag aggcaggccg tcctgtaggt
     4201 cctagaggag ccacagccca ggggcagatg aaggggctgc ggaagacggg ggcagtcctg
     4261 ggggtgctgc ggctacacca ccacccgcgc ggcccccgca gcctagacct cccaggcctg
     4321 tgaccctcca caccagccct cagaaccctc ctgggcttgc cctcccttgg cgtccgtcac
     4381 cctttggcaa atatagaata tttcacattc tcagagagac ccgaccgcgc tcttgatgct
     4441 ctttcgaaaa taggtcagtc ttagaaatac actgctaatg ttatttttag tggatgttta
     4501 tgctgtttga cttttctcct gtgtaccaag gtattgcttt tatttacacg acagcgactc
     4561 aaaaggcact cgattaatgt gacaaccttt tcaataagca gaaataacgt aggtacacat
     4621 cactctttac atttttctaa gcattttcac agccgtttct tcatataatc cgaccacagt
     4681 gggaggtgtg atttacccat tacacaatga gaaaccagag gagccgatga gttacttaat
     4741 tgaggtcaca gaatgaatta gcaagaaaat ggttctaaaa tctaagtatt ttagtctaga
     4801 attttctcca ttacatcatc ctaagagata atgctctgta cttcatttga aataaactgg
     4861 aattgtatta gatagctca
//
