LOCUS       NM_001099436            2580 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens unc-51 like kinase 3 (ULK3), transcript variant 1,
            mRNA.
ACCESSION   NM_001099436 XM_001127720 XM_001134013
VERSION     NM_001099436.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Goruppi,S., Clocchiatti,A., Bottoni,G., Di Cicco,E., Ma,M.,
            Tassone,B., Neel,V., Demehri,S., Simon,C. and Paolo Dotto,G.
  TITLE     The ULK3 kinase is a determinant of keratinocyte self-renewal and
            tumorigenesis targeting the arginine methylome
  JOURNAL   Nat Commun 14 (1), 887 (2023)
   PUBMED   36797248
  REMARK    GeneRIF: The ULK3 kinase is a determinant of keratinocyte
            self-renewal and tumorigenesis targeting the arginine methylome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Mathea,S., Salah,E., Tallant,C., Chatterjee,D., Berger,B.T.,
            Konietzny,R., Muller,S., Kessler,B.M. and Knapp,S.
  TITLE     Conformational plasticity of the ULK3 kinase domain
  JOURNAL   Biochem J 478 (14), 2811-2823 (2021)
   PUBMED   34190988
  REMARK    GeneRIF: Conformational plasticity of the ULK3 kinase domain.
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Han,Y., Wang,B., Cho,Y.S., Zhu,J., Wu,J., Chen,Y. and Jiang,J.
  TITLE     Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog
            Signaling
  JOURNAL   Dev Cell 50 (5), 610-626 (2019)
   PUBMED   31279575
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Maloverjan,A., Piirsoo,M., Kasak,L., Peil,L., Osterlund,T. and
            Kogerman,P.
  TITLE     Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog
            signaling pathway
  JOURNAL   J Biol Chem 285 (39), 30079-30090 (2010)
   PUBMED   20643644
  REMARK    GeneRIF: Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic
            hedgehog signaling pathway.
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Takeuchi,F., Isono,M., Katsuya,T., Yamamoto,K., Yokota,M.,
            Sugiyama,T., Nabika,T., Fujioka,A., Ohnaka,K., Asano,H., Yamori,Y.,
            Yamaguchi,S., Kobayashi,S., Takayanagi,R., Ogihara,T. and Kato,N.
  TITLE     Blood pressure and hypertension are associated with 7 loci in the
            Japanese population
  JOURNAL   Circulation 121 (21), 2302-2309 (2010)
   PUBMED   20479155
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Maloverjan,A., Piirsoo,M., Michelson,P., Kogerman,P. and
            Osterlund,T.
  TITLE     Identification of a novel serine/threonine kinase ULK3 as a
            positive regulator of Hedgehog pathway
  JOURNAL   Exp Cell Res 316 (4), 627-637 (2010)
   PUBMED   19878745
  REMARK    GeneRIF: serine/threonine kinase ULK3 is involved in the SHH
            pathway as a positive regulator of GLI proteins
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Young,A.R., Narita,M., Ferreira,M., Kirschner,K., Sadaie,M.,
            Darot,J.F., Tavare,S., Arakawa,S., Shimizu,S., Watt,F.M. and
            Narita,M.
  TITLE     Autophagy mediates the mitotic senescence transition
  JOURNAL   Genes Dev 23 (7), 798-803 (2009)
   PUBMED   19279323
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: First named and identified as protein kinase of the ULK
            family
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC157884.1, AK293181.1, AK299380.1 and AL117482.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001099436.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.267457.1,
                                           SRR1803615.11612.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440863.7/ ENSP00000400312.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-956               BC157884.1         38-993
            957-957             AK293181.1         865-865
            958-1512            AK299380.1         940-1494
            1513-2580           AL117482.1         1884-2951
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2580
                     /gene="ULK3"
                     /note="unc-51 like kinase 3"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
     exon            1..153
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1470
                     /gene="ULK3"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine-protein kinase ULK3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ULK3 isoform a"
                     /protein_id="NP_001092906.3"
                     /db_xref="CCDS:CCDS45305.1"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
                     /translation="MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIK
                     CVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRF
                     IHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGF
                     AQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSF
                     SELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP
                     SGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKV
                     GQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEA
                     AGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESR
                     WEADTLDKEGLSESVRSSCTLQ"
     exon            154..294
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..415
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            416..520
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..664
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..747
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..903
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1009
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1050
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1153
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1218
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1297
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1338
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1386
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1453
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2580
                     /gene="ULK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2563..2568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULK3"
                     /note="hexamer: ATTAAA"
     polyA_site      2580
                     /gene="ULK3"
                     /note="major polyA site"
ORIGIN      
        1 ggaaccgccg cccgcagcga ggaagcgccc gcgcgggcgc aggcggccgg aatggcgggg
       61 cccggctggg gtcccccgcg cctggacggc ttcatcctca ccgagcgcct gggcagcggc
      121 acgtacgcca cggtgtacaa ggcctacgcc aagaaggaca ctcgtgaagt ggtagccata
      181 aagtgtgtag ccaagaaaag tctgaacaag gcatcggtgg agaacctcct cacggagatt
      241 gagatcctca agggcattcg acatccccac attgtgcagc tgaaagactt tcagtgggac
      301 agtgacaata tctacctcat catggagttt tgcgcagggg gcgacctgtc tcgcttcatc
      361 catacccgca ggattctgcc tgagaaggtg gcgcgtgtct tcatgcagca attagctagc
      421 gccctgcaat tcctgcatga acggaatatc tctcacctgg atctgaagcc acagaacatt
      481 ctactgagct ccttggagaa gccccaccta aaactggcag actttggttt cgcacaacac
      541 atgtccccgt gggatgagaa gcacgtgctc cgtggctccc ccctctacat ggcccccgag
      601 atggtgtgcc agcggcagta tgacgcccgc gtggacctct ggtccatggg ggtcatcctg
      661 tatgaagccc tcttcgggca gccccccttt gcctccaggt cgttctcgga gctggaagag
      721 aagatccgta gcaaccgggt catcgagctc cccttgcggc ccctgctctc ccgagactgc
      781 cgggacctac tgcagcggct cctggagcgg gaccccagcc gtcgcatctc cttccaggac
      841 ttttttgcgc acccctgggt ggacctggag cacatgccca gtggggagag tctggggcga
      901 gcaaccgccc tggtggtgca ggctgtgaag aaagaccagg agggggattc agcagctgcc
      961 ttatcactct actgcaaggc tctggacttc tttgtacctg ccctgcacta tgaagtggat
     1021 gcccagcgga aggaggcaat taaggcaaag gtggggcagt acgtgtcccg ggctgaggag
     1081 ctcaaggcca tcgtctcctc ttccaatcag gccctgctga ggcaggggac ctctgcccga
     1141 gacctgctca gagagatggc ccgggacaag ccacgcctcc tagctgccct ggaagtggct
     1201 tcagctgcca tggccaagga ggaggccgcc ggcggggagc aggatgccct ggacctgtac
     1261 cagcacagcc tgggggagct actgctgttg ctggcagcgg agcccccggg ccggaggcgg
     1321 gagctgcttc acactgaggt tcagaacctc atggcccgag ctgaatactt gaaggagcag
     1381 gtcaagatga gggaatctcg ctgggaagct gacaccctgg acaaagaggg actgtcggaa
     1441 tctgttcgta gctcttgcac ccttcagtga ccctagaaga atgattggac agatgtgagc
     1501 catctggagc agaggggcac taacccaggc tgacgccaag aatgaagtgg cccactgcag
     1561 ccctggcgag caggcttctt ggatggacag tgctgagacc cccatatccc agagtcccca
     1621 gcctccctca ggttactctg caccccacag atggtttgat ggctgtgctg tatactggag
     1681 gggagggcag gactctggga gaacagcact tctttcatga gacctttgtt actcggtggt
     1741 tactgggtcc tgtgcctgtc cgttttgggg catgcagccc tctatcattt ttggctccga
     1801 gaagagggca aggggccccc gcagggtact tctgtgcttg ccctcgccct gccagcaggc
     1861 agctgtgccc ctggcctgcc cttcccggga ccccttattc caactcagct cctctttgca
     1921 ctggaatggg gcactccaac acccctcagg gaccaccctc cccacagtat gcactcagcc
     1981 ccacagaacc caccagtctt tctgggaact cacacctgcc cgccatcttg gtactttagg
     2041 ttaatccctc aagcatgaaa gctggatctt ttggggttta agaagcccaa gccttgttcc
     2101 tgccctggcc tagggagcac tcaggagggt tccttggtcc tcatctctcc cacctccgtt
     2161 ccctctgggc cccacactag ccacagcgcg ggccttgtgc tggagtttga gcctgggaca
     2221 gggagaggga ggcttggaga cagtctgacc cagtgccctc taggccaccc acttctaggc
     2281 ctgccctgcc gccgtggagc cctgggcaag ctctttcccc tttctgggcc tgggtctccc
     2341 catctcttca atggggctga taccttcaca gcccacagca tgggcactta tgaggacaaa
     2401 gtgaatttaa cctggaaaag aatgtatttg agagtttctt ttaaataatc agcgggtgtt
     2461 ggtgatttgt agcccttctg cccttaaatg cttccttggg caagagctgt ctgtcctccc
     2521 tgcaggaggc tgagtgtaaa gagtatcatt cattgtttct ctattaaatt attttctcta
//
