LOCUS       NM_014683               9149 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens unc-51 like autophagy activating kinase 2 (ULK2),
            transcript variant 1, mRNA.
ACCESSION   NM_014683
VERSION     NM_014683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9149)
  AUTHORS   Ghazi,P.C., O'Toole,K.T., Srinivas Boggaram,S., Scherzer,M.T.,
            Silvis,M.R., Zhang,Y., Bogdan,M., Smith,B.D., Lozano,G.,
            Flynn,D.L., Snyder,E.L., Kinsey,C.G. and McMahon,M.
  TITLE     Inhibition of ULK1/2 and KRASG12C controls tumor growth in
            preclinical models of lung cancer
  JOURNAL   Elife 13, 96992 (2024)
   PUBMED   39213022
  REMARK    GeneRIF: Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth
            in preclinical models of lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9149)
  AUTHORS   Lai,J., Yang,C., Shang,C., Chen,W., Chu,M.P., Brandwein,J., Lai,R.
            and Wang,P.
  TITLE     ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High
            Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid
            Leukemia
  JOURNAL   Int J Mol Sci 25 (1), 646 (2024)
   PUBMED   38203816
  REMARK    GeneRIF: ULK2 Is a Key Pro-Autophagy Protein That Contributes to
            the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute
            Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9149)
  AUTHORS   Liang,P., Zhang,J., Wu,Y., Zheng,S., Xu,Z., Yang,S., Wang,J.,
            Ma,S., Xiao,L., Hu,T., Jiang,W., Huang,C., Xing,Q., Kundu,M. and
            Wang,B.
  TITLE     An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer
            cell migration
  JOURNAL   EMBO Rep 24 (11), e56850 (2023)
   PUBMED   37846507
  REMARK    GeneRIF: An ULK1/2-PXN mechanotransduction pathway suppresses
            breast cancer cell migration.
REFERENCE   4  (bases 1 to 9149)
  AUTHORS   Meng,F., Shen,F., Ling,H., Jin,P., Zhou,D. and Li,Q.
  TITLE     CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to
            Facilitate its Effect on Repairing Diabetic Wounds by Sponging
            miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2
  JOURNAL   J Invest Dermatol 142 (7), 1976-1989 (2022)
   PUBMED   34933019
  REMARK    GeneRIF: CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy
            to Facilitate its Effect on Repairing Diabetic Wounds by Sponging
            miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2.
REFERENCE   5  (bases 1 to 9149)
  AUTHORS   Kang,W.S., Lee,S.M., Hwang,D., Park,H.J. and Kim,J.W.
  TITLE     Association between Unc-51-like autophagy activating kinase 2 gene
            polymorphisms and schizophrenia in the Korean population
  JOURNAL   Medicine (Baltimore) 101 (5), e28745 (2022)
   PUBMED   35119028
  REMARK    GeneRIF: Association between Unc-51-like autophagy activating
            kinase 2 gene polymorphisms and schizophrenia in the Korean
            population.
REFERENCE   6  (bases 1 to 9149)
  AUTHORS   Chan,E.Y., Longatti,A., McKnight,N.C. and Tooze,S.A.
  TITLE     Kinase-inactivated ULK proteins inhibit autophagy via their
            conserved C-terminal domains using an Atg13-independent mechanism
  JOURNAL   Mol Cell Biol 29 (1), 157-171 (2009)
   PUBMED   18936157
REFERENCE   7  (bases 1 to 9149)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 9149)
  AUTHORS   Tomoda,T., Kim,J.H., Zhan,C. and Hatten,M.E.
  TITLE     Role of Unc51.1 and its binding partners in CNS axon outgrowth
  JOURNAL   Genes Dev 18 (5), 541-558 (2004)
   PUBMED   15014045
REFERENCE   9  (bases 1 to 9149)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: First identification and naming of ULK2 as an ortholog of
            mouse ULK2.
            Review article
REFERENCE   10 (bases 1 to 9149)
  AUTHORS   Yan,J., Kuroyanagi,H., Tomemori,T., Okazaki,N., Asato,K.,
            Matsuda,Y., Suzuki,Y., Ohshima,Y., Mitani,S., Masuho,Y.,
            Shirasawa,T. and Muramatsu,M.
  TITLE     Mouse ULK2, a novel member of the UNC-51-like protein kinases:
            unique features of functional domains
  JOURNAL   Oncogene 18 (43), 5850-5859 (1999)
   PUBMED   10557072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015726.8, BC039310.1,
            AB014523.1, AK314345.1, DA105030.1, BC034988.1, AC005722.1 and
            AL080134.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_014683.3.
            
            Summary: This gene encodes a protein that is similar to a
            serine/threonine kinase in C. elegans which is involved in axonal
            elongation. The structure of this protein is similar to the C.
            elegans protein in that both proteins have an N-terminal kinase
            domain, a central proline/serine rich (PS) domain, and a C-terminal
            (C) domain. The gene is located within the Smith-Magenis syndrome
            region on chromosome 17. Alternatively spliced transcript variants
            encoding the same protein have been identified. [provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014523.1, SRR14038192.2006613.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395544.9/ ENSP00000378914.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC015726.8         97832-97841         c
            11-19               BC039310.1         11-19
            20-1310             AB014523.1         1-1291
            1311-1626           AK314345.1         824-1139
            1627-2170           DA105030.1         15-558
            2171-3321           AB014523.1         2152-3302
            3322-3670           BC034988.1         2877-3225
            3671-4407           AB014523.1         3652-4388
            4408-8188           AC005722.1         59559-63339
            8189-9149           AL080134.1         2136-3096
FEATURES             Location/Qualifiers
     source          1..9149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..9149
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /note="unc-51 like autophagy activating kinase 2"
                     /db_xref="GeneID:9706"
                     /db_xref="HGNC:HGNC:13480"
                     /db_xref="MIM:608650"
     exon            1..609
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..3630
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ULK2"
                     /protein_id="NP_055498.3"
                     /db_xref="CCDS:CCDS11213.1"
                     /db_xref="GeneID:9706"
                     /db_xref="HGNC:HGNC:13480"
                     /db_xref="MIM:608650"
                     /translation="MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKK
                     NLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT
                     LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFG
                     FARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANS
                     PQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPV
                     KKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQV
                     SKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTV
                     SPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPG
                     SCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSG
                     SPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPS
                     RPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVT
                     RHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPI
                     CRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCT
                     HMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGAS
                     PPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTS
                     AVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPS
                     TAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEM
                     VQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALC
                     HSTATV"
     exon            610..702
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..744
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..777
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..814
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..988
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1062
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1164
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1223
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1306
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1354
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1443
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1615
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1676
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1814
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1960
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2041
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2328
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2516
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2620
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2770
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2979
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3158
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3277
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3435
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3571
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..9149
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9123..9128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /note="hexamer: AATAAA"
     polyA_site      9149
                     /gene="ULK2"
                     /gene_synonym="ATG1B; Unc51.2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgg gagcgggtag cgcgcgcgag ggcgttgggc gccgccgcga ggcggggaag
       61 cgcggggccg cggcggtgcg ggttctaggg cggcggccgt cgccgtcgca gcagcgcccc
      121 gagcggggag ggccgaggag gcccgacgag ctggggatgg agagtaccgg gcccctcact
      181 gcctcagagc gcgtgtgcgg ctctgggcgc gcacagtgac ggtgacggca cccctggccc
      241 ggcagcgccg aggccgcttc gccagacagc cagcggccgg cggcaggccg ggccatgagc
      301 ggcaggggcc gggccgggcc tcgctgaccc tggctccgcg cggcagcttc cccagtttcc
      361 gctccggtct ctcggcatga gagtccgccc gggcccgggg ctgcggctgc cccagacccg
      421 ccgcacgctg gcgcgctccg ggcccgcgga gccgcggtgc tgatacctgc gccgcactgc
      481 gccgcccgcc cgtccgctgt gtgccccggg ggcgcggcca tggaggtggt gggtgacttc
      541 gagtacagca agagggatct cgtgggacac ggggccttcg ccgtggtctt ccgggggcgg
      601 caccgccaga aaactgattg ggaggtagct attaaaagta ttaataaaaa gaacttgtca
      661 aaatcacaaa tactgcttgg aaaggaaatt aaaatcttaa aggaacttca gcatgaaaat
      721 attgtagcac tctatgatgt tcaggaatta cccaactctg tctttttggt gatggagtat
      781 tgcaatggtg gagacctcgc agattatttg caagcgaaag ggactctcag tgaagacacg
      841 atcagagtgt ttctgcatca gattgctgct gccatgcgaa tcctgcacag caaaggaatc
      901 atccacagag atctcaaacc acagaacatc ttgctgtcct atgccaatcg cagaaaatca
      961 agtgtcagtg gtattcgcat caaaatagcg gattttggtt ttgctcgtta cctacatagt
     1021 aacatgatgg ctgcaacact gtgtggatcc ccgatgtaca tggctcctga ggttattatg
     1081 tctcaacatt atgatgctaa ggctgacttg tggagcatag gaacagtgat ataccaatgc
     1141 ctagttggaa aaccaccttt tcaggccaat agtcctcaag acttaaggat gttttatgaa
     1201 aaaaacagga gcttaatgcc tagtattccc agagaaacat caccttattt ggctaatctc
     1261 cttttgggtt tgcttcagag aaaccaaaaa gatagaatgg actttgaagc attttttagc
     1321 catccttttc ttgagcaagg tccagtaaaa aaatcttgcc cagttccagt gcccatgtat
     1381 tctggttctg tctctggaag ctcctgtggc agctctccat cttgtcgttt tgcttctcca
     1441 ccatcccttc cagatatgca gcatattcag gaagaaaact tatcttcccc accattgggt
     1501 cctcccaact atctacaagt ttccaaagat tctgccagta ctagtagcaa gaactcttct
     1561 tgtgacacgg atgactttgt tttggtgcca cacaacatct cgtcagacca ctcatgtgat
     1621 atgccagtgg ggactgctgg cagacgtgct tcaaatgaat tcttggtgtg tggagggcag
     1681 tgtcagccta ctgtgtcacc tcacagcgaa acagcaccaa ttccagttcc tactcaaata
     1741 aggaattatc agcgcataga gcagaatctt acatctactg ccagctcagg cacaaatgta
     1801 catggttctc caagatctgc agtggtacga aggtccaaca ccagccccat gggcttcctc
     1861 cggccgggat catgctcccc agtaccagca gacacagcac agacagttgg acgaaggctc
     1921 tccactgggt cttctaggcc ttactcacct tcccctttgg ttggtaccat tcctgagcaa
     1981 ttcagtcagt gctgctgtgg gcatcctcag ggccatgact ccaggagtag aaactcctca
     2041 ggttctccag tgccacaagc tcagtcccca cagtctctct tatcgggtgc tagactgcag
     2101 agcgccccca ccctcactga catctatcag aacaagcaga agctcagaaa acagcactct
     2161 gaccccgtgt gcccatccca tactggggct gggtacagct actcgcctca gcccagtcgg
     2221 cctggcagcc ttggaacttc tcccaccaag cacttggggt cctctccacg gagttctgac
     2281 tggttcttta aaactccttt gccaacaatc attggctctc ctactaagac cacagctcct
     2341 ttcaaaatcc ctaaaactca agcatcttcc aacctgttag ccttggttac tcgtcatggg
     2401 cctgctgaag aacagtcgaa agatgggaat gagccacggg aatgtgccca ttgcctctta
     2461 gtgcaaggaa gtgagaggca gcgggccgag cagcagagca aggcagtgtt tggcagatct
     2521 gtcagtaccg ggaagttatc agatcaacaa ggaaagactc ctatatgtcg acatcagggc
     2581 agcacagaca gtttaaatac agaacgacca atggatatag ctccggcagg agcctgtggt
     2641 ggtgttctgg cacctcctgc aggtacagca gcaagttcca aggctgtcct cttcactgta
     2701 gggtctcctc cacacagtgc ggcagccccc acttgtaccc acatgttcct tcgaacaaga
     2761 acaacctcag tggggcccag caactccggg ggctctcttt gtgccatgag tggccgcgtg
     2821 tgcgtggggt ccccgcctgg cccaggcttc ggctcttccc ctccaggagc agaggcagct
     2881 cccagcctga gatacgtgcc ttacggtgct tcacccccca gcctagaggg gctcatcacc
     2941 tttgaagccc ctgaactgcc ggaggagacg ctgatggagc gggaacacac agacacctta
     3001 cgccatctga atgtgatgct gatgttcact gagtgtgtgc tggacctgac agccatgagg
     3061 ggaggaaacc ctgagctgtg cacatctgct gtgtccttgt accagatcca ggagagtgtg
     3121 gtggtggacc agatcagtca gctgagcaaa gactgggggc gggtggagca gctggtgttg
     3181 tacatgaaag cagcacagct gcttgcggct tctctgcatc ttgccaaagc ccagatcaag
     3241 tccgggaaac tgagcccatc cacagctgtg aaacaagttg tcaagaatct gaacgaacga
     3301 tataaattct gcatcaccat gtgcaagaaa cttacagaaa agctgaatcg attcttctct
     3361 gacaaacaga ggtttattga tgaaatcaac agtgtgactg cagagaaact catctataat
     3421 tgtgctgtag aaatggttca gtctgcagcc ctggatgaga tgtttcagca gaccgaagat
     3481 attgtttatc gctatcataa ggcagccctt cttttggaag gcctaagtag gattctacag
     3541 gaccctgcag atattgaaaa tgtgcataaa tataaatgta gtattgagag aagactgtcg
     3601 gcgctctgcc atagcaccgc aaccgtgtga gcagcaggct catcccgtgg accggtggtg
     3661 ggaacgtgag gtgatgcctt tgggattaca gcttgagttc tgtcacccca tccccaggaa
     3721 actgtagctt cttaactggt gactaccaaa gaacaagcag tgatttgaaa aaggaaaaac
     3781 aatccaaaaa ctacatattt gtaggaaatc tgccttattg gagaaaatca ccctttccct
     3841 ttttctttgt agaagcagga gcaagagtgt ttggctccca gtttggactt ggtgaataaa
     3901 tgtaccttag aactaggata atcggtacag ttattcttaa agataattaa aaatgaaaca
     3961 aagtgagtgc tcgtcactgg gttcatcaga gcagtgtgtg aaattccatg tgtttgctga
     4021 ggtgtaaagg taaatgtatt cacccctcat ccaggcagtt tgatatttgg agtaagtttg
     4081 tttaaatctg agcatgcatc tttaaacagc tcaggaagaa atagcttaag aagaagtgaa
     4141 acatggatct tggaagaaat tttgaaatct tcaatttgat cctaatatgg atacatgtta
     4201 atcttccaaa atctttcata ttgcactaat ttattaaaac aactgtgtat tggattttgt
     4261 aatttaacta aggcacaatg gacttgttta aaatatttta cttgattgta tacatagacc
     4321 ctttccagaa ttcacatgta atctccagtg aacttttaag tggttaaaac ttgtattcat
     4381 gtgaaccttt gcacattttt tttttttact tctttatcta cacctacaga ttttctcagt
     4441 aatgtttttg ttagcttttg gttccatttt ttattgtgca tgcagaatgt acattgatgc
     4501 ctgtgacctt aggtttatta aaggctaggt ttatttgggc agtattagaa acaaaatcat
     4561 ggatcaagag atactcttga taatttgaat agggccaaaa caaagttggt gacctaaagg
     4621 cttgttagtg atgtggagtt cctacatgca gtgagtggaa aatgaagttc gttttctctt
     4681 aggaaaatgg gcagctgtct tctgcctaat gtgtattttt catgttaatt ctgacagttc
     4741 accaaatagc tagtcatgga gaatgcaggc agttaactta atatccctcc aggaatggtt
     4801 cctacgttgt gtattacttg gtttctttta cttacctgct tgaatacttg aataaaccat
     4861 tcaccaattt taatcctttt attttaatcc ttttacataa aataatctga actctttgac
     4921 aaattgcaca gagctctttg gcattaatct aattttaatg tactgataaa aacaaacatg
     4981 gttttccttt actttgacaa agtaatgtaa tttttacctt atttatctgt atgaaattcc
     5041 agtagttaat ttgaacattt atttatatga cgtttgtatt tttaggtctt taatacagtg
     5101 tttctacctc tcatttgtaa ctgcatgcat tattcttgaa actaggtaaa actcactgaa
     5161 ttgttgtgta atagcctttt tattattgcc tgtacaaatg tatattaagg taaaataaaa
     5221 ctgacaaagt gtttctaggg tgtagctggg tacatattaa gtggcttgtt gagccaggta
     5281 cttccttagt gagtttagag acttggccat gaatatcctt tgtcctgccc caggatttag
     5341 atcttggcta ctgtcatgca ggcttccagg aacatagact gttttacctc cacaacccta
     5401 tttgttatta gtgatacttt attttatata atatttttta ttcacagtga aatttcattc
     5461 atgttctttc agttatcacc tgtgttatct cagttgtagg tttattctat cctctcctct
     5521 tcctctccca tttctttttt aagacaggat gaaacaggtt cagagagggg aagtgattgg
     5581 cctaaagtca ggaactaggc aagtggtcaa gccatgcttt gtgactttca agttaattct
     5641 tcttgttctt gtatattaaa ggtcttgggg tagatggtgt gtgtgaaaca gtgaagtctc
     5701 aacagcagaa aagaacaaaa tgtaaattca tgaataatgg ttctggttat acttccatta
     5761 tcaaggctaa ttaagagatt ttgccttgag tatagcaata ataaacaaat gctttatgtt
     5821 tccctgagta tttttaaatt tcatatcgtg tttcatagag tggaaatgta ccagttcata
     5881 cattcatggg ttgacacctg tattcaagcc ataacctgga aaattgctga ccagctattc
     5941 ctgctctaag ggtttgcttt aactataccc tccactggac tatatataga gagagagcct
     6001 atgctgtata tagttggttt cccacagtcc ctgtcccctc cttccattga gagaagtaac
     6061 tagagcaaca gttgttctcc ctcgctggag tggtgaatag gagccgggag gaggggactg
     6121 ttagggtcgg gctgcctcag tctccacagt aattaagagg aaattgagtt ggatacagcg
     6181 gacatgaggc ctggaatggg taccccaaac ccatgcatct taagtgtctg ggtccccacg
     6241 cccccttctg cctgccagga gtactctgtg cagccatcct gtaactgctt cagtccagag
     6301 aaggatagca tccatccctc cctccagctc gcctctctgc tgaggctttc tcctctccac
     6361 tcagcatttg caacagcttc tctcctggca cttgtctggg aatatcaagt taaaaattac
     6421 aacacccaat tttgataact ttagttgaga gaaacaacct ctagtgaaga ctgataagta
     6481 acttattgcc cgtagtccca tgttcctttg tctccaccaa gaggaattac cagcccagca
     6541 gttctgccct cactagagtc ccgtccagga gcttgagagg agaggatttt tagggctgga
     6601 ttgcctcagt ctgcacagta ataagttgag ttagacacag tggacatgag gacctggact
     6661 cagatatctg aagaatcctt attatttttt tgttggcttg ttttgagaca gagtcaccct
     6721 gttgcccagg ctggagtgca ttggcgcaat cttggctcac tgcaacctct gcctcccagg
     6781 ttcaagtgat tcttcttcct cagcctccca ggtagctagg attacagaca tgcgccacca
     6841 cgctcagcta tttttcgtat ttttagtgga gatggggttt caccatgttg gtcaggctgg
     6901 tcttgaacac cagcctcagc ctccccaagt gctgggatta caggcatgag ccaccgtgcc
     6961 cggccaaaat ccttaatgtt tttgtttttt ggtttttttt tttgagacag tcttgctctg
     7021 tcacccaggc tggagtgcag tggcacaatc ttggctcact gcaagctccg cctccggggt
     7081 tcatgccatt ctcccgcctc agcctcccga gtagctggga ctacaggcgc ctgccaccac
     7141 gcccggctga ttttttgtat tttttagtag aggcagggtt tcaccgtgtt aggatggtct
     7201 cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg
     7261 tgagccaccg cgcccgggct atccttaatg ttgatattag tggttagcac atgttttgga
     7321 ggaggacttc acacttttta aactatgctc cctcgtattt tctataagca gtcttaaatt
     7381 ctttctggaa taaagcaaga ttgatcagta tttctcaagg aggattattt ggcaggcagt
     7441 agctactgct cagagaactt ggtattgtta catgcatcct ggaagtatct gtgcctattt
     7501 ctagacggcc tcagaccact tttttctgag tcctggaccc ttgaatctgc agccaagcaa
     7561 gctcttgggt ccctcccaag tctcatgttt agtaaagccc tgtgagaata attttattgg
     7621 tggaggagtc aagatgatac ttccctcacc tgcatcagag gaaaccacat cagaaacaat
     7681 ccacctagaa aaacactgca tacgggaaag ctgacaactt gccctgagaa atcacagctt
     7741 tggtgcaaga ggtgaagccg aactggtaaa agatcaaagt gaattcagag atcaaactgt
     7801 actagggaaa ggagcagagg ctgagatctt gctgccagcg tgacctctca cagagtggcc
     7861 cagcagaggc tgtgcagaga tggccagagc caggacccag ccctgtggag cccctgggca
     7921 catgtggtcc cgagtgaagc cgtgcctgtt gctctgaaca ggtgggatca atctgtaggt
     7981 ttttccactt ttcacagagt gtggctctct ttaggtctgc actccctctc tgcgcagggc
     8041 ggacctccct gggctctgca gcatgatctc ctgtcccaag acagtcgtgc tcttggacag
     8101 ttagcttctg tcattaggaa gtgcccacat gagctcttgt ttattggaaa ccgtgttcta
     8161 tgcctccttt ggggtttctg caactcaatt tggcaggtag cttagtggtc cacttggtct
     8221 caaattccag ctccaccatg tgcagttgtg tgttctttgg caagttcctc ccctcctccg
     8281 aatctgtcag tgggggaaga gtgcatgtct cacagagttg aggtgagaaa taagttaatg
     8341 aatatgaaat tctttgccca gcccctggca cgtggaaggg ctcagcaatc ctgtatccgt
     8401 tgtagtggtc atcactctgt ggctcttcac tgcttttgtt ttgttttggg agggggtgga
     8461 gaacaatttg ttctgtgttt gtgtggggca aggcctgtct tcagggctct ctccaaccac
     8521 gtacgctctg gctggagctt ctgaaaggac acagttcttg catagaagtt gctttctcca
     8581 gcttgcccac caggcagtct ggcttcagac atctatgttg cccttttaag tcaatttggc
     8641 tgtttaagtg gaatgtttgt gtcagtctga taattgttaa ttcatttgat cctcatacca
     8701 acccttactt gcctcctttt acagatggaa aaatcaaact tggacagtaa tttccacaag
     8761 gaaaagcccc acagctggaa agcggtggga gcaggaggcc acactgggta caggagtacc
     8821 catctcccca caggagcccc acactgtctc acccttagga agcccaaatg ctcactcctt
     8881 gagtttctaa tgcattcttt ctgatgtaca ggaagagggg aaggaaggaa gagcttttcc
     8941 atttggtgct ccaatgtctc ctgctggacc catctgccta gtggaaggca gcaaaatttc
     9001 aagaaacagg tgaggttgag cagcttggtg caaccccatg gggcctggag ttggagctca
     9061 acagcaatgg atttcagaga ccaccctgaa actcccagta aaaaagactt gggagacatg
     9121 ttaataaact caagcatttg atcgaccca
//
